Cited by 97Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model OrganismsSirtuins and Resveratrol in Medicine

Cellular senescence in gastrointestinal diseases: from pathogenesis to therapeutics

Frey, Nina, Venturelli, Sascha, Zender, Lars, Bitzer, Michael·2018·Nature Reviews Gastroenterology & Hepatology

Abstract

Senescence is a durable cell cycle arrest that can be induced in response to various stress factors, such as telomere erosion, DNA damage or the aberrant activation of oncogenes. In addition to its well-established role as a stress response programme, research has revealed important physiological roles of senescence in nondisease settings, such as embryonic development, wound healing, tissue repair and ageing. Senescent cells secrete various cytokines, chemokines, matrix remodelling proteases and growth factors, a phenotype collectively referred to as the senescence-associated secretory phenotype. These factors evoke immune responses that, depending on the pathophysiological context, can either prevent or even fuel disease and tumorigenesis. Remarkably, even the gut microbiota can influence senescence in various organs. In this Review, we provide an introduction to cellular senescence, addressed particularly to gastroenterologists and hepatologists, and discuss the implications of senescence for the pathogenesis of malignant and nonmalignant gastrointestinal and hepatobiliary diseases. We conclude with an outlook on how modulation of cellular senescence might be used for therapeutic purposes.

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Crossref · 10.1038/nrgastro.2017.146

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Authors
Frey, N., Venturelli, S., Zender, L., & Bitzer, M.
Affiliations
  • University of Tübingen (DE)
  • German Cancer Research Center (DE)
Corresponding author
  • Zender, Lars
  • Bitzer, Michael
Venue
Nature Reviews Gastroenterology & Hepatology
Published
2017-11-29
Volume
15
Issue
2
Pages
81-95
ISSN
  • 1759-5045 (ISSN-L)
  • 1759-5053
OpenAlex
W2770536443
Cited by
97
References
166
Citations by year
2026: 10 · 2025: 6 · 2024: 20 · 2023: 11 · 2022: 11 · 2021: 18 · 2020: 13 · 2019: 5 · 2018: 3
FWCI
0.70
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Reviews Gastroenterology & Hepatology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Keywords
cellular senescence, gastrointestinal diseases, hepatobiliary diseases, senescence-associated secretory phenotype, carcinogenesis, telomere shortening, DNA damage, oncogene activation, gut microbiota, tissue repair, aging
MeSH terms
Gastrointestinal Microbiome, Gastrointestinal Diseases, Humans, Immunity, Cellular, Liver Diseases, Pancreatic Neoplasms, Biomarkers, Tumor, Cytokines, Cellular Senescence, Chemokines, Carcinogenesis

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