Chan, David C.

Guidelines for the use and interpretation of assays for monitoring autophagy

Klionsky, D. J., Abdalla, F. C., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Aguirre-Ghiso, J. A., et al. (2012) · Autophagy

Autophagy in Disease and TherapyCalcium signaling and nucleotide metabolism

Cited by 3,996

Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development

Chen, H., Detmer, S. A., Ewald, A. J., Griffin, E. E., Fraser, S. E., & Chan, D. C. (2003) · The Journal of Cell Biology

Mitochondrial Function and PathologyAutophagy in Disease and Therapy

Cited by 2,601

Mitochondria: Dynamic Organelles in Disease, Aging, and Development

Chan, D. C. (2006) · Cell

Mitochondrial Function and PathologyAutophagy in Disease and Therapy

Cited by 1,987

Mitochondrial Dynamics and Its Involvement in Disease

Chan, D. C. (2020) · Annual Review of Pathology: Mechanisms of Disease

Mitochondrial Function and PathologyAutophagy in Disease and Therapy

Cited by 1,416

Disruption of Fusion Results in Mitochondrial Heterogeneity and Dysfunction

Chen, H., Chomyn, A., & Chan, D. C. (2005) · Journal of Biological Chemistry

Mitochondrial Function and PathologyAutophagy in Disease and Therapy

Cited by 1,376

Functions and dysfunctions of mitochondrial dynamics

Detmer, S. A., & Chan, D. C. (2007) · Nature Reviews Molecular Cell Biology

Mitochondrial Function and PathologyAutophagy in Disease and Therapy

Cited by 1,369

Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission

Losón, O. C., Song, Z., Chen, H., & Chan, D. C. (2013) · Molecular Biology of the Cell

Mitochondrial Function and PathologyAutophagy in Disease and Therapy

Cited by 1,235

Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations

Chen, H., Vermulst, M., Wang, Y. E., Chomyn, A., Prolla, T. A., McCaffery, J. M., & Chan, D. C. (2010) · Cell

Mitochondrial Function and PathologyAutophagy in Disease and Therapy

Cited by 1,211

Fusion and fission: interlinked processes critical for mitochondrial health

Chan, D. C. (2012) · Annual Review of Genetics

Mitochondrial Function and PathologyAutophagy in Disease and Therapy

Cited by 1,196

AMP-activated protein kinase mediates mitochondrial fission in response to energy stress

Toyama, E. Q., Herzig, S., Courchet, J., Lewis, T. L., Losón, O. C., Hellberg, K., Young, N. P., Chen, H., Polleux, F., Chan, D. C., et al. (2016) · Science

Mitochondrial Function and PathologyAutophagy in Disease and Therapy

Cited by 1,085

Broad activation of the ubiquitin–proteasome system by Parkin is critical for mitophagy

Chan, N. C., Salazar, A. M., Pham, A. H., Sweredoski, M. J., Kolawa, N. J., Graham, R. L. J., Hess, S., & Chan, D. C. (2011) · Human Molecular Genetics

Autophagy in Disease and TherapyUbiquitin and proteasome pathways

Cited by 993

Mitochondrial Fusion and Fission in Mammals

Chan, D. C. (2006) · Annual Review of Cell and Developmental Biology

Mitochondrial Function and PathologyAutophagy in Disease and Therapy

Cited by 972

Mitochondrial fusion protects against neurodegeneration in the cerebellum

Chen, H., McCaffery, J. M., & Chan, D. C. (2007) · Cell

Mitochondrial Function and PathologyHereditary Neurological Disorders

Cited by 924

Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine

Kim, K. H., Jeong, Y. T., Oh, H., Kim, S. H., Cho, J. M., Kim, Y.-N., Kim, S. S., Kim, D. H., Hur, K. Y., Kim, H. K., et al. (2013) · Nature Medicine

Fibroblast Growth Factor ResearchAutophagy in Disease and Therapy

Cited by 774

Mitofusins and OPA1 mediate sequential steps in mitochondrial membrane fusion

Song, Z., Ghochani, M., McCaffery, J. M., Frey, T. G., & Chan, D. C. (2009) · Molecular Biology of the Cell

Mitochondrial Function and PathologyAutophagy in Disease and Therapy

Cited by 623

Proteolytic Cleavage of Opa1 Stimulates Mitochondrial Inner Membrane Fusion and Couples Fusion to Oxidative Phosphorylation

Mishra, P., Carelli, V., Manfredi, G., & Chan, D. C. (2014) · Cell Metabolism

Mitochondrial Function and PathologyAutophagy in Disease and Therapy

Cited by 473

SIRT3 Deacetylates and Activates OPA1 To Regulate Mitochondrial Dynamics during Stress

Samant, S. A., Zhang, H. J., Hong, Z., Pillai, V. B., Sundaresan, N. R., Wolfgeher, D., Archer, S. L., Chan, D. C., & Gupta, M. P. (2014) · Molecular and Cellular Biology

Mitochondrial Function and PathologySirtuins and Resveratrol in Medicine

Cited by 446

Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis

Karbowski, M., Arnoult, D., Chen, H., Chan, D. C., Smith, C. L., & Youle, R. J. (2004) · The Journal of Cell Biology

Mitochondrial Function and PathologyCell death mechanisms and regulation

Cited by 433

Evidence for a Mitochondrial Regulatory Pathway Defined by Peroxisome Proliferator–Activated Receptor-γ Coactivator-1α, Estrogen-Related Receptor-α, and Mitofusin 2

Soriano, F. X., Liesa, M., Bach, D., Chan, D. C., Palacín, M., & Zorzano, A. (2006) · Diabetes

Adipose Tissue and MetabolismMitochondrial Function and Pathology

Cited by 343

MFN1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion

Cao, Y.-L., Meng, S., Chen, Y., Feng, J.-X., Gu, D.-D., Yu, B., Li, Y.-J., Yang, J.-Y., Liao, S., Chan, D. C., et al. (2017) · Nature

Mitochondrial Function and PathologyAutophagy in Disease and Therapy

Cited by 326

Solving neurodegeneration: common mechanisms and strategies for new treatments

Wareham, L. K., Liddelow, S. A., Temple, S., Benowitz, L. I., Di Polo, A., Wellington, C., Goldberg, J. L., He, Z., Duan, X., Bu, G., et al. (2022) · Molecular Neurodegeneration

Glaucoma and retinal disordersNeuroinflammation and Neurodegeneration Mechanisms

Cited by 324

Mitochondrial Dynamics Is a Distinguishing Feature of Skeletal Muscle Fiber Types and Regulates Organellar Compartmentalization

Mishra, P., Varuzhanyan, G., Pham, A. H., & Chan, D. C. (2015) · Cell Metabolism

Mitochondrial Function and PathologyMuscle Physiology and Disorders

Cited by 290

Titration of mitochondrial fusion rescues Mff -deficient cardiomyopathy

Chen, H., Ren, S., Clish, C., Jain, M., Mootha, V., McCaffery, J. M., & Chan, D. C. (2015) · Journal of Cell Biology

Mitochondrial Function and PathologyAutophagy in Disease and Therapy

Cited by 168

MIRO-1 Determines Mitochondrial Shape Transition upon GPCR Activation and Ca2+ Stress

Nemani, N., Carvalho, E., Tomar, D., Dong, Z., Ketschek, A., Breves, S. L., Jaña, F., Worth, A. M., Heffler, J., Palaniappan, P., et al. (2018) · Cell Reports

Mitochondrial Function and PathologyAutophagy in Disease and Therapy

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