Saffitz, Jeffrey E.

Diagnosis of Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia: Proposed Modification of the Task Force Criteria

Marcus, F. I., McKenna, W. J., Sherrill, D., Basso, C., Bauce, B., Bluemke, D. A., Calkins, H., Corrado, D., Cox, M. G. P. J., Daubert, J. P., et al. (2010) · Circulation

Cardiovascular Effects of ExerciseCardiomyopathy and Myosin Studies

Cited by 2,676

Peroxisome proliferator–activated receptor γ coactivator-1 promotes cardiac mitochondrial biogenesis

Lehman, J. J., Barger, P. M., Kovacs, A., Saffitz, J. E., Medeiros, D. M., & Kelly, D. P. (2000) · Journal of Clinical Investigation

Adipose Tissue and MetabolismMitochondrial Function and Pathology

Cited by 1,285

PGC-1α Deficiency Causes Multi-System Energy Metabolic Derangements: Muscle Dysfunction, Abnormal Weight Control and Hepatic Steatosis

Leone, T. C., Lehman, J. J., Finck, B. N., Schaeffer, P. J., Wende, A. R., Boudina, S., Courtois, M., Wozniak, D. F., Sambandam, N., Bernal-Mizrachi, C., et al. (2005) · PLoS Biology

Adipose Tissue and MetabolismPeroxisome Proliferator-Activated Receptors

Cited by 951

A New Diagnostic Test for Arrhythmogenic Right Ventricular Cardiomyopathy

Asimaki, A., Tandri, H., Huang, H., Halushka, M. K., Gautam, S., Basso, C., Thiene, G., Tsatsopoulou, A., Protonotarios, N., McKenna, W. J., et al. (2009) · New England Journal of Medicine

Cardiovascular Effects of ExerciseCardiomyopathy and Myosin Studies

Cited by 456

A gender-related defect in lipid metabolism and glucose homeostasis in peroxisome proliferator- activated receptor alpha- deficient mice.

Djouadi, F., Weinheimer, C. J., Saffitz, J. E., Pitchford, C., Bastin, J., Gonzalez, F. J., & Kelly, D. P. (1998) · Journal of Clinical Investigation

Peroxisome Proliferator-Activated ReceptorsParaoxonase enzyme and polymorphisms

Cited by 410

Cardiac-specific induction of the transcriptional coactivator peroxisome proliferator-activated receptor γ coactivator-1α promotes mitochondrial biogenesis and reversible cardiomyopathy in a developmental stage-dependent manner.

Russell, L. K., Mansfield, C. M., Lehman, J. J., Kovacs, A., Courtois, M., Saffitz, J. E., Medeiros, D. M., Valencik, M. L., McDonald, J. A., & Kelly, D. P. (2004) · Circulation Research

Mitochondrial Function and PathologyAdipose Tissue and Metabolism

Cited by 402

Early-onset multifocal inflammation in the transforming growth factor beta 1-null mouse is lymphocyte mediated.

Diebold, R. J., Eis, M. J., Yin, M., Ormsby, I., Boivin, G. P., Darrow, B. J., Saffitz, J. E., & Doetschman, T. (1995) · Proceedings of the National Academy of Sciences

T-cell and B-cell ImmunologyTGF-β signaling in diseases

Cited by 278

Identification of a New Modulator of the Intercalated Disc in a Zebrafish Model of Arrhythmogenic Cardiomyopathy

Asimaki, A., Kapoor, S., Plovie, E., Karin Arndt, A., Adams, E., Liu, Z., James, C. A., Judge, D. P., Calkins, H., Churko, J., et al. (2014) · Science Translational Medicine

Cardiac electrophysiology and arrhythmiasCardiovascular Effects of Exercise

Cited by 274

Electrophysiological abnormalities precede overt structural changes in arrhythmogenic right ventricular cardiomyopathy due to mutations in desmoplakin-A combined murine and human study

Gomes, J., Finlay, M., Ahmed, A. K., Ciaccio, E. J., Asimaki, A., Saffitz, J. E., Quarta, G., Nobles, M., Syrris, P., Chaubey, S., et al. (2012) · European Heart Journal

Cardiovascular Effects of ExerciseCardiac electrophysiology and arrhythmias

Cited by 194

Altered Desmosomal Proteins in Granulomatous Myocarditis and Potential Pathogenic Links to Arrhythmogenic Right Ventricular Cardiomyopathy

Asimaki, A., Tandri, H., Duffy, E. R., Winterfield, J. R., Mackey-Bojack, S., Picken, M. M., Cooper, L. T., Wilber, D. J., Marcus, F. I., Basso, C., et al. (2011) · Circulation: Arrhythmia and Electrophysiology

Viral Infections and Immunology ResearchCardiovascular Effects of Exercise

Cited by 194

Therapeutic Modulation of the Immune Response in Arrhythmogenic Cardiomyopathy

Chelko, S. P., Asimaki, A., Lowenthal, J., Bueno-Beti, C., Bedja, D., Scalco, A., Amat-Alarcon, N., Andersen, P., Judge, D. P., Tung, L., et al. (2019) · Circulation

Cardiovascular Effects of ExerciseCardiomyopathy and Myosin Studies

Cited by 192

Central role for GSK3β in the pathogenesis of arrhythmogenic cardiomyopathy

Chelko, S. P., Asimaki, A., Andersen, P., Bedja, D., Amat-Alarcon, N., DeMazumder, D., Jasti, R., MacRae, C. A., Leber, R., Kleber, A. G., et al. (2016) · JCI Insight

Cardiovascular Effects of ExerciseCardiomyopathy and Myosin Studies

Cited by 180

Remodeling of the cardiac sodium channel, connexin43, and plakoglobin at the intercalated disk in patients with arrhythmogenic cardiomyopathy

Noorman, M., Hakim, S., Kessler, E., Groeneweg, J. A., Cox, M. G. P. J., Asimaki, A., van Rijen, H. V. M., van Stuijvenberg, L., Chkourko, H., van der Heyden, M. A. G., et al. (2013) · Heart Rhythm

Cardiovascular Effects of ExerciseCardiac electrophysiology and arrhythmias

Cited by 154

Exercise triggers CAPN1-mediated AIF truncation, inducing myocyte cell death in arrhythmogenic cardiomyopathy

Chelko, S. P., Keceli, G., Carpi, A., Doti, N., Agrimi, J., Asimaki, A., Beti, C. B., Miyamoto, M., Amat-Codina, N., Bedja, D., et al. (2021) · Science Translational Medicine

Cardiac electrophysiology and arrhythmiasCardiovascular Effects of Exercise

Cited by 92

Altered Electrical, Biomolecular, and Immunologic Phenotypes in a Novel Patient-Derived Stem Cell Model of Desmoglein-2 Mutant ARVC

Hawthorne, R. N., Blazeski, A., Lowenthal, J., Kannan, S., Teuben, R., DiSilvestre, D., Morrissette-McAlmon, J., Saffitz, J. E., Boheler, K. R., James, C. A., et al. (2021) · Journal of Clinical Medicine

Cardiovascular Effects of ExerciseCardiac electrophysiology and arrhythmias

Cited by 41

GJA1-20k Rescues Cx43 Localization and Arrhythmias in Arrhythmogenic Cardiomyopathy

Palatinus, J. A., Valdez, S., Taylor, L., Whisenant, C., Selzman, C. H., Drakos, S. G., Ranjan, R., Hong, T., Saffitz, J. E., & Shaw, R. M. (2023) · Circulation Research

Cardiac electrophysiology and arrhythmiasConnexins and lens biology

Cited by 40

NFĸB signaling drives myocardial injury via CCR2+ macrophages in a preclinical model of arrhythmogenic cardiomyopathy

Chelko, S. P., Penna, V. R., Engel, M., Shiel, E. A., Centner, A. M., Farra, W., Cannon, E. N., Landim-Vieira, M., Schaible, N., Lavine, K., et al. (2024) · Journal of Clinical Investigation

Cardiac electrophysiology and arrhythmiasCardiovascular Effects of Exercise

Cited by 32