Exercise triggers CAPN1-mediated AIF truncation, inducing myocyte cell death in arrhythmogenic cardiomyopathy
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Exercise-induced activation of calpain and nuclear translocation of calpain-cleaved apoptotic factor AIF triggers cardiomyocyte death in ACM.
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Environmental modifiers such as endurance exercise, psychological stress, diet, alcohol, and metabolic dysregulation influence ACM disease penetrance and progression, in part through modulation of inflammatory processes.
“environmental modifiers such as endurance exercise [24,25,26,27,28,29,30], psychological stress [31,32,33], diet [34,35], alcohol [36], and metabolic dysregulation [37,38,39] have been shown to influence disease penetrance and progression, in part, through modulation of inflammatory processes.”
From A Paradigm Shift: Arrhythmogenic Cardiomyopathy Is an Inflammatory Disease (2026) · cites this paper as [29]
The Discussion states that exercise can increase the risk of ACM progression, and the Results report prominent myocardial inflammation and immune-cell infiltration in exercised ACM-model mice (page numbers unavailable). The paper does not establish that inflammation mediates exercise’s effect on progression or demonstrate an effect on disease penetrance. The other listed modifiers have separate citations and are not assessed here. (LLM, conf=0.84)
Experimental — accuracy not yet measuredAn exercise-induced, mitochondrial-mediated pathway involving CAPN1 cleaves mitochondrial-bound AIF; truncated AIF translocates to the nucleus, inducing caspase-independent DNA fragmentation and cell death, a specialized necroptotic cell death program.
“A critical exercise-induced, mitochondrial-mediated pathway was recently uncovered, involving the calcium-dependent cysteine protease, calpain-1 (CAPN1), where CAPN1 cleaves the mitochondrial-bound apoptosis-inducing factor (AIF) [29]. Truncated AIF translocates to the nucleus, inducing caspase-independent DNA fragmentation and cell death, a specialized necroptotic cell death program.”
From A Paradigm Shift: Arrhythmogenic Cardiomyopathy Is an Inflammatory Disease (2026) · cites this paper as [29]
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Experimental — accuracy not yet measuredThis is potentiated by mitochondrial oxidative stress due to depleted TRX2 and TXNRD2 stores, leading to impaired ROS buffering.
“This is potentiated by mitochondrial oxidative stress due to depleted thioredoxin-2 (TRX2) and TRX2 reductase (TXNRD2) stores, leading to impaired ROS buffering [29].”
From A Paradigm Shift: Arrhythmogenic Cardiomyopathy Is an Inflammatory Disease (2026) · cites this paper as [29]
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Cites
Molecular characterization of mitochondrial apoptosis-inducing factor
Susin, S. A., Lorenzo, H. K., Zamzami, N., Marzo, I., Snow, B. E., Brothers, G. M., Mangion, J., Jacotot, E., Costantini, P., Loeffler, M., et al. (1999) · Nature · doi:10.1038/17135 · Cited by 4,060 · see citing works
Heart Disease and Stroke Statistics—2009 Update
WRITING GROUP MEMBERS, Lloyd‐Jones, D. M., Adams, R. J., Carnethon, M. R., SIMONE, G. D., Ferguson, T. B., Flegal, K. M., Ford, E. S., Furie, K. L., Go, A. S., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.191259 · Cited by 3,891 · see citing works
WRITING GROUP MEMBERS, Lloyd-Jones, D., Adams, R., Carnethon, M., De Simone, G., Ferguson, T. B., Flegal, K., Ford, E., Furie, K., Go, A., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.191261 · Cited by 3,140 · see citing works
Goll, D. E., Thompson, V. F., Li, H., WEI, W., & Cong, J. (2003) · Physiological Reviews · doi:10.1152/physrev.00029.2002 · Cited by 2,826 · see citing works
Exercise-Induced Oxidative Stress: Cellular Mechanisms and Impact on Muscle Force Production
Powers, S. K., & Jackson, M. J. (2008) · Physiological Reviews · doi:10.1152/physrev.00031.2007 · Cited by 2,459 · see citing works
Sudden Deaths in Young Competitive Athletes
Maron, B. J., Doerer, J. J., Haas, T. S., Tierney, D. M., & Mueller, F. O. (2009) · Circulation · doi:10.1161/circulationaha.108.804617 · Cited by 2,075 · see citing works
Nakagawa, T., Shimizu, S., Watanabe, T., Yamaguchi, O., Otsu, K., Yamagata, H., Inohara, H., Kubo, T., & Tsujimoto, Y. (2005) · Nature · doi:10.1038/nature03317 · Cited by 1,635 · see citing works
Claycomb, W. C., Lanson, N. A., Stallworth, B. S., Egeland, D. B., Delcarpio, J. B., Bahinski, A., & Izzo, N. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.6.2979 · Cited by 1,546 · see citing works
Reactive Oxygen Species (Ros-Induced) Ros Release
Zorov, D. B., Filburn, C. R., Klotz, L.-O., Zweier, J. L., & Sollott, S. J. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.7.1001 · Cited by 1,412 · see citing works
Juhaszova, M., Zorov, D. B., Kim, S.-H., Pepe, S., Fu, Q., Fishbein, K. W., Ziman, B. D., Wang, S., Kirsti Ytrehus, B., Antos, C. L., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19906 · Cited by 1,029 · see citing works
Heat-shock protein 70 antagonizes apoptosis-inducing factor
Ravagnan, L., Gurbuxani, S. K., Susín, S. A., Maisse, C., Daugas, É., Zamzami, N., Mak, T. W., Jäättelä, M., Penninger, J. M., Garrido, C., et al. (2001) · Nature Cell Biology · doi:10.1038/ncb0901-839 · Cited by 859 · see citing works
Mitochondrio‐nuclear translocation of AIF in apoptosis and necrosis
Daugas, É., Susín, S. A., Zamzami, N., Ferri, K. F., Irinopoulou, T., Larochette, N., Prévost, M., Leber, B. F., Andrews, D. W., Penninger, J. M., et al. (2000) · The FASEB Journal · doi:10.1096/fasebj.14.5.729 · Cited by 776 · see citing works
A mechanistic role for cardiac myocyte apoptosis in heart failure
Wencker, D., Chandra, M., Nguyen, K., Miao, W., Garantziotis, S., Factor, S. M., Shirani, J., Armstrong, R. C., & Kitsis, R. N. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17664 · Cited by 765 · see citing works
Self-citationHMGB1: Endogenous Danger Signaling
Klune, J. R., Dhupar, R., Cardinal, J., Billiar, T. R., & Tsung, A. (2008) · Molecular Medicine · doi:10.2119/2008-00034.klune · Cited by 762 · see citing works
A Unifying Mechanism for Mitochondrial Superoxide Production during Ischemia-Reperfusion Injury
Chouchani, E. T., Pell, V. R., James, A. M., Work, L. M., Saeb-Parsy, K., Frezza, C., Krieg, T., & Murphy, M. P. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.12.009 · Cited by 752 · see citing works
Necroptosis: Mechanisms and Relevance to Disease
Galluzzi, L., Kepp, O., Chan, F. K.-M., & Kroemer, G. (2016) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-052016-100247 · Cited by 721 · see citing works
Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death
Yu, S.-W., Andrabi, S. A., Wang, H., Kim, N. S., Poirier, G. G., Dawson, T. M., & Dawson, V. L. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606528103 · Cited by 718 · see citing works
James, C. A., Bhonsale, A., Tichnell, C., Murray, B., Russell, S. D., Tandri, H., Tedford, R. J., Judge, D. P., & Calkins, H. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.06.033 · Cited by 710 · see citing works
Self-citationThe mitochondrial permeability transition from<i>in vitro</i>artifact to disease target
Bernardi, P., Krauskopf, A., Basso, E., Petronilli, V., Blalchy‐Dyson, E., Di Lisa, F., & Forte, M. A. (2006) · The FEBS Journal · doi:10.1111/j.1742-4658.2006.05213.x · Cited by 627 · see citing works
Garcia-Gras, E. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27751 · Cited by 623 · see citing works
Ricci, J., Muñoz‐Pinedo, C., FITZGERALD, P. J., Bailly‐Maitre, B., Perkins, G. A., Yadava, N., Scheffler, I. E., Ellisman, M. H., & Green, D. R. (2004) · Cell · doi:10.1016/j.cell.2004.05.008 · Cited by 602 · see citing works
Mutations in Desmoglein-2 Gene Are Associated With Arrhythmogenic Right Ventricular Cardiomyopathy
Pilichou, K., Nava, A. K., Basso, C., Beffagna, G., Bauce, B., Lorenzon, A., Frigo, G., Vettori, A., Valente, M., Towbin, J. A., et al. (2006) · Circulation · doi:10.1161/circulationaha.105.583674 · Cited by 574 · see citing works
Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs
Kim, C., Wong, J., Wen, J., Wang, S., Wang, C., Spiering, S., Kan, N. G., Forcales, S. V., Puri, P., Leone, T. C., et al. (2013) · Nature · doi:10.1038/nature11799 · Cited by 529 · see citing works
Self-citationCandé, C., Cohen, I., Daugas, É., Ravagnan, L., Larochette, N., Zamzami, N., & Kroemer, G. (2002) · Biochimie · doi:10.1016/s0300-9084(02)01374-3 · Cited by 514 · see citing works
Groeneweg, J. A., Bhonsale, A., James, C. A., Riele, A. S. J. M. T., Dooijes, D., Tichnell, C., Murray, B. A., Wiesfeld, A. C. P., Sawant, A. C., Kassamali, B., et al. (2015) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.114.001003 · Cited by 492 · see citing works
Self-citationCalpain I Induces Cleavage and Release of Apoptosis-inducing Factor from Isolated Mitochondria
Polster, B. M., Basáñez, G., Etxebarria, A., Hardwick, J. M., & Nicholls, D. G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m413269200 · Cited by 438 · see citing works
Evidence of Apoptosis in Arrhythmogenic Right Ventricular Dysplasia
Mallat, Z., Tedgui, A., Fontaliran, F., Frank, R., Durigon, M., & Fontaine, G. H. (1996) · New England Journal of Medicine · doi:10.1056/nejm199610173351604 · Cited by 415 · see citing works
Ca2+- and mitochondrial-dependent cardiomyocyte necrosis as a primary mediator of heart failure
Nakayama, H., Chen, X., Baines, C. P., Klevitsky, R., Zhang, X., Zhang, H., Jaleel, N., Chua, B. H. L., Hewett, T. E., Robbins, J. M., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31060 · Cited by 405 · see citing works
Sims, N. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb04189.x · Cited by 388 · see citing works
DNA binding is required for the apoptogenic action of apoptosis inducing factor
Ye, H., Candé, C., Stephanou, N. C., Jiang, S., Gurbuxani, S., Larochette, N., Daugas, É., Garrido, C., Kroemer, G., & Wu, H. (2002) · Nature Structural Biology · doi:10.1038/nsb836 · Cited by 369 · see citing works
Calpains — An elaborate proteolytic system
Ono, Y., & Sorimachi, H. (2011) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2011.08.005 · Cited by 347 · see citing works
Mitochondria and ischemia–reperfusion injury of the heart: Fixing a hole
Lisa, F. D., & Bernardi, P. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.01.016 · Cited by 341 · see citing works
Apoptosis-Inducing Factor: Structure, Function, and Redox Regulation
Sevrioukova, I. F. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3445 · Cited by 338 · see citing works
Cerrone, M., Lin, X., Zhang, M., Agulló-Pascual, E., Pfenniger, A., Chkourko, H., Novelli, V., Kim, C., Tirasawadichai, T., Judge, D. P., et al. (2013) · Circulation · doi:10.1161/circulationaha.113.003077 · Cited by 333 · see citing works
Self-citationThioredoxin‐2 (TRX‐2) is an essential gene regulating mitochondria‐dependent apoptosis
Tanaka, T., Hosoi, F., Yamaguchi‐Iwai, Y., Nakamura, H., Masutani, H., Ueda, S., Nishiyama, A., Takeda, S., Wada, H., Spyrou, G., et al. (2002) · The EMBO Journal · doi:10.1093/emboj/21.7.1695 · Cited by 322 · cited 1× · see citing works
“Among the mitochondrial assets that limit myocyte cell death is the TXN2/TXNRD2 ROS buffering system (89).”
Programmed Necrosis, Not Apoptosis, in the Heart
Kung, G., Konstantinidis, K., & Kitsis, R. N. (2011) · Circulation Research · doi:10.1161/circresaha.110.225730 · Cited by 290 · see citing works
Self-citationDi Lisa, F., Blank, P. S., Colonna, R., Gambassi, G., Silverman, H. S., Stern, M. D., & Hansford, R. G. (1995) · The Journal of Physiology · doi:10.1113/jphysiol.1995.sp020786 · Cited by 286 · see citing works
AIF and cyclophilin A cooperate in apoptosis-associated chromatinolysis
Candé, C., Vahsen, N., Kouranti, I., Schmitt, E., Daugas, É., Spahr, C. S., Luban, J., Kroemer, R. T., Giordanetto, F., Garrido, C., et al. (2004) · Oncogene · doi:10.1038/sj.onc.1207279 · Cited by 278 · see citing works
Chen, S. N., Gurha, P., Lombardi, R., Ruggiero, A., Willerson, J. T., & Marian, A. J. (2014) · Circulation Research · doi:10.1161/circresaha.114.302810 · Cited by 275 · see citing works
Inhibition of endogenous thioredoxin in the heart increases oxidative stress and cardiac hypertrophy
Yamamoto, M., Yang, G., Hong, C., Liu, J., Holle, E., Yu, X., Wagner, T. E., Vatner, S. F., & Sadoshima, J. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17700 · Cited by 274 · see citing works
Heat shock protein 70 binding inhibits the nuclear import of apoptosis-inducing factor
Gurbuxani, S. K., Schmitt, E., Candé, C., Parcellier, A., Hammann, A., Daugas, É., Kouranti, I., Spahr, C. S., Pance, A., Kroemer, G., et al. (2003) · Oncogene · doi:10.1038/sj.onc.1206794 · Cited by 266 · see citing works
Awad, M. M., Calkins, H. G., & Judge, D. P. (2008) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio1182 · Cited by 265 · see citing works
Self-citationMatsushima, S., Ide, T., Yamato, M., Matsusaka, H., Hattori, F., Ikeuchi, M., Kubota, T., Sunagawa, K., Hasegawa, Y., Kurihara, T., et al. (2006) · Circulation · doi:10.1161/circulationaha.105.582239 · Cited by 262 · see citing works
Zhang, X., Chen, J., Graham, S. H., Du, L., Kochanek, P. M., Draviam, R. A., Guo, F., Nathaniel, P. D., Szabó, C., Watkins, S. C., et al. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00975.x · Cited by 254 · see citing works
The subunit composition and function of mammalian cytochrome c oxidase
Kadenbach, B., & Hüttemann, M. (2015) · Mitochondrion · doi:10.1016/j.mito.2015.07.002 · Cited by 244 · see citing works
Bano, D., & Prehn, J. H. M. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.03.016 · Cited by 241 · see citing works
Fressart, V., Duthoit, G., Donal, E., Probst, V., Deharo, J., Chevalier, P., Klug, D., Dubourg, O., Delacrétaz, E., Cosnay, P., et al. (2010) · EP Europace · doi:10.1093/europace/euq104 · Cited by 235 · see citing works
Zhu, C., Wang, X., Deinum, J., Huang, Z., Gao, J.-F., Modjtahedi, N., Neagu, M. R., Nilsson, M., Eriksson, P. S., Hagberg, H., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070193 · Cited by 224 · see citing works
Ghezzi, D., Sevrioukova, I. F., Invernizzi, F., Lamperti, C., Mora, M., D’Adamo, P., Novara, F., Zuffardi, O., Uziel, G., & Zeviani, M. (2010) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.03.002 · Cited by 224 · see citing works
Sawant, A. C., Bhonsale, A., te Riele, A. S. J. M., Tichnell, C., Murray, B., Russell, S. D., Tandri, H., Tedford, R. J., Judge, D. P., Calkins, H., et al. (2014) · Journal of the American Heart Association · doi:10.1161/jaha.114.001471 · Cited by 221 · see citing works
Self-citationJoza, N. A., Oudit, G. Y., Brown, D., Bénit, P., Kassiri, Z., Vahsen, N., Benoît, L. A., Patel, M. M., Nowikovsky, K., Vassault, A. J., et al. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.23.10261-10272.2005 · Cited by 206 · see citing works
Stanley, B. A., Sivakumaran, V., Shi, S., McDonald, I., Lloyd, D., Watson, W. H., Aon, M. A., & Paolocci, N. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.284612 · Cited by 197 · see citing works
Self-citationTherapeutic Modulation of the Immune Response in Arrhythmogenic Cardiomyopathy
Chelko, S. P., Asimaki, A., Lowenthal, J., Bueno-Beti, C., Bedja, D., Scalco, A., Amat-Alarcon, N., Andersen, P., Judge, D. P., Tung, L., et al. (2019) · Circulation · doi:10.1161/circulationaha.119.040676 · Cited by 192 · see citing works
Self-citationGarcía‐Rivas, G., Carvajal, K., Correa, F., & Zazueta, C. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706932 · Cited by 186 · see citing works
Central role for GSK3β in the pathogenesis of arrhythmogenic cardiomyopathy
Chelko, S. P., Asimaki, A., Andersen, P., Bedja, D., Amat-Alarcon, N., DeMazumder, D., Jasti, R., MacRae, C. A., Leber, R., Kleber, A. G., et al. (2016) · JCI Insight · doi:10.1172/jci.insight.85923 · Cited by 180 · see citing works
Self-citationLetavernier, E., Perez, J., Bellocq, A., Mesnard, L., Keller, A. C., Haymann, J., & Baud, L. (2008) · Circulation Research · doi:10.1161/circresaha.107.160077 · Cited by 168 · see citing works
Staurosporine-induced Apoptosis in Cardiomyocytes: A Potential Role of Caspase-3
Yue, T., Wang, C., Romanic, A. M., Kikly, K. K., Keller, P. M., DeWolf, W. E., Hart, T. K., Thomas, H. C., Storer, B. L., Gu, J.-L., et al. (1998) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.1997.0614 · Cited by 167 · see citing works
Contribution of calpains to myocardial ischaemia/reperfusion injury
Inserte, J., Hernando, V., & David Garcia-dorado, A. (2012) · Cardiovascular Research · doi:10.1093/cvr/cvs232 · Cited by 153 · see citing works
N-terminal Cleavage of GSK-3 by Calpain
Goñi‐Oliver, P., Lucas, J. J., Avila, J., & Hernández, F. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702793200 · Cited by 146 · see citing works
Ni, R., Zheng, D., Xiong, S., Hill, D. J., Sun, T., Gardiner, R. B., Fan, G., Lu, Y., Abel, E. D., Greer, P. A., et al. (2015) · Diabetes · doi:10.2337/db15-0963 · Cited by 145 · see citing works
Misinterpretation of the mouse ECG: ‘musing the waves of Mus musculus ’
Boukens, B. J., Rivaud, M. R., Rentschler, S., & Coronel, R. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2014.279380 · Cited by 139 · see citing works
Cysteine protease inhibition prevents mitochondrial apoptosis-inducing factor (AIF) release
Yuste, V. J., Moubarak, R. S., Delettre, C., Bras, M., Sancho, P., Robert, N., d’Alayer, J., & Susín, S. A. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401687 · Cited by 134 · see citing works
Cardiomyocyte Degeneration With Calpain Deficiency Reveals a Critical Role in Protein Homeostasis
Galvez, A. S., Diwan, A., Odley, A. M., Hahn, H. S., Osińska, H. E., Meléndez, J., Robbins, J. M., Lynch, R. A., Marreez, Y., & Dorn, G. W. (2007) · Circulation Research · doi:10.1161/01.res.0000261938.28365.11 · Cited by 133 · see citing works
How calpain is activated by calcium
Khorchid, A., & Ikura, M. (2002) · Nature Structural Biology · doi:10.1038/nsb0402-239 · Cited by 121 · see citing works
Blomgren, K., Hallin, U., Andersson, A.-L., Puka‐Sundvall, M., Bahr, B. A., McRae‐Degueurce, A., Saido, T. C., Kawashima, S., & Hagberg, H. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.20.14046 · Cited by 114 · see citing works
Phospho-Tau Bar Code: Analysis of Phosphoisotypes of Tau and Its Application to Tauopathy
Kimura, T., Sharma, G., Ishiguro, K., & Hisanaga, S. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00044 · Cited by 112 · see citing works
Hernando, V., Inserte, J., Sartório, C. L., Parra, V. M., Poncelas, M., & David Garcia-dorado, A. (2010) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2010.02.024 · Cited by 110 · see citing works
Oxidative Stress Inhibits Calpain Activity in Situ
Guttmann, R. P., & Johnson, G. V. W. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.21.13331 · Cited by 103 · see citing works
Wang, Y., Kim, N. S., Li, X., Greer, P. A., Koehler, R. C., Dawson, V. L., & Dawson, T. M. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06167.x · Cited by 102 · see citing works
Cho, G.-S., Lee, D. I., Tampakakis, E., Murphy, S. A., Andersen, P., Uosaki, H., Chelko, S. P., Chakir, K., Hong, I., Seo, K., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2016.12.040 · Cited by 100 · see citing works
Self-citationJohnson, G. V. W., & Guttmann, R. P. (1997) · BioEssays · doi:10.1002/bies.950191111 · Cited by 99 · see citing works
Modulation of the Calpain Autoproteolysis by Calpastatin and Phospholipids
Melloni, E., Michetti, M., Salamino, F., Minafra, R., & Pontremoli, S. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.1779 · Cited by 94 · see citing works
Self-citationChen, Q., Paillard, M., Gomez, L., Ross, T., Hu, Y., Xu, A., & Lesnefsky, E. J. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.10.037 · Cited by 92 · see citing works
Wang, W., Orgeron, G. M., Tichnell, C., Murray, B. A., Crosson, J. E., Monfredi, O., Cadrin‐Tourigny, J., Tandri, H. S., Calkins, H. G., & James, C. A. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.118.008843 · Cited by 91 · see citing works
Self-citationRole of calcineurin in exercise-induced mitochondrial biogenesis
García-Rovés, P. M., Huss, J. M., & Holloszy, J. O. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00633.2005 · Cited by 89 · see citing works
Blocking Caspase-Activated Apoptosis Improves Contractility in Failing Myocardium
Laugwitz, K., Moretti, A., Weig, H., Gillitzer, A., Pinkernell, K., Ott, T., Pragst, I., Städele, C., Seyfarth, M., Schömig, A., et al. (2001) · Human Gene Therapy · doi:10.1089/10430340152677403 · Cited by 88 · see citing works
The Calpain System Is Involved in the Constitutive Regulation of β-Catenin Signaling Functions
Benetti, R., Copetti, T., Dell’Orso, S., Melloni, E., Brancolini, C., Monte, M., & Schneider, C. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501810200 · Cited by 83 · see citing works
Self-citationBénit, P., Gonçalves, S., Dassa, E. P., Brière, J.-J., & Rustin, P. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003208 · Cited by 83 · see citing works
Syed, F. M., Diwan, A., & Hahn, H. S. (2005) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2005.05.001 · Cited by 75 · see citing works
Norberg, E., Gogvadze, V. G., Vakifahmetoglu, H., Orrenius, S., & Zhivotovsky, B. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.12.020 · Cited by 69 · see citing works
Bello, B. D., Moretti, D., Gamberucci, A., & Maellaro, E. (2006) · Oncogene · doi:10.1038/sj.onc.1210079 · Cited by 68 · see citing works
Doti, N., Reuther, C., Scognamiglio, P. L., Dolga, A. M., Plesnila, N., Ruvo, M., & Culmsee, C. (2014) · Cell Death and Disease · doi:10.1038/cddis.2013.518 · Cited by 67 · see citing works
Self-citationFisher‐Wellman, K. H., Mattox, T. A., Thayne, K. A., Katunga, L. A., Favor, J. D. L., Neufer, P. D., Hickner, R. C., Wingard, C. J., & Anderson, E. J. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2013.254193 · Cited by 62 · see citing works
Calpain inhibition preserves myocardial structure and function following myocardial infarction
Mani, S. K., Balasubramanian, S., Zavadzkas, J. A., Jeffords, L. B., Rivers, W. T., Zile, M. R., Mukherjee, R. D., Spinale, F. G., & Kuppuswamy, D. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00338.2009 · Cited by 58 · see citing works
Calpastatin Expression in Porcine Cardiac and Skeletal Muscle and Partial Gene Structure
Parr, T., Sensky, P. L., BARDSLEY, R. G., & BUTTERY, P. J. (2001) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2001.2546 · Cited by 56 · see citing works
Zingarelli, B., Hake, P. W., O’Connor, M., Denenberg, A. G., Kong, S., & Aronow, B. J. (2003) · Molecular Medicine · doi:10.1007/bf03402179 · Cited by 54 · see citing works
Cation dyshomeostasis and cardiomyocyte necrosis: the Fleckenstein hypothesis revisited
Borkowski, B., Cheema, Y., Shahbaz, A. U., Bhattacharya, S. K., & Weber, K. T. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr063 · Cited by 49 · see citing works
Mani, S. K., Shiraishi, H., Balasubramanian, S., Yamane, K., Chellaiah, M. A., Cooper, G., Banik, N. L., Zile, M. R., & Kuppuswamy, D. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00085.2008 · Cited by 49 · see citing works
Precardiac deletion of Numb and Numblike reveals renewal of cardiac progenitors
Shenje, L. T., Andersen, P., Uosaki, H., Fernandez, L., Rainer, P. P., Cho, G.-S., Lee, D., Zhong, W., Harvey, R. P., Kass, D. A., et al. (2014) · eLife · doi:10.7554/elife.02164 · Cited by 47 · see citing works
Self-citationThe Pathobiology of Arrhythmogenic Cardiomyopathy
Saffitz, J. E. (2011) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-011110-130151 · Cited by 46 · see citing works
Self-citationMiyazaki, T., Koya, T., Kigawa, Y., Oguchi, T., Lei, X., Kim‐Kaneyama, J., & Miyazaki, A. (2012) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.14787 · Cited by 41 · see citing works
Li, F., Li, T., Ai, J., Sun, L., Zhu, M., Duan, R., Zhu, L., Liu, Y., & Liu, T. C. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00571 · Cited by 41 · see citing works
Zhang, Q., Deng, C., Rao, F., Modi, R. M., Zhu, J.-N., Liu, X., Mai, L., Tan, H., Yu, X., Lin, Q., et al. (2013) · Molecular Medicine Reports · doi:10.3892/mmr.2013.1594 · Cited by 41 · see citing works
van Opbergen, C. J. M., Delmar, M., & van Veen, T. A. B. (2017) · Netherlands Heart Journal · doi:10.1007/s12471-017-0946-7 · Cited by 40 · see citing works
Roles of calpain-calpastatin system (CCS) in human T cell activation
Mikosik, A., Jasiulewicz, A., Daca, A., Henc, I., Frąckowiak, J. E., Rückemann-Dziurdzińska, K., Foerster, J., Page, A. Y. L., Bryl, E., Fülöp, T., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.13259 · Cited by 37 · see citing works
Arrhythmogenic right ventricular cardiomyopathy: new insights into mechanisms of disease
Saffitz, J. E., Asimaki, A., & Huang, H. (2010) · Cardiovascular Pathology · doi:10.1016/j.carpath.2009.10.006 · Cited by 34 · see citing works
Self-citationDelavallée, L., Mathiah, N., Cabon, L., Mazeraud, A., Brunelle-Navas, M.-N., Lerner, L. K., Tannoury, M., Prola, A., Moreno‐Loshuertos, R., Baritaud, M., et al. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101027 · Cited by 32 · see citing works
Morphological Patterns of Death by Myocytes in Arrhythmogenic Right Ventricular Dysplasia
Runge, M. S., Stouffer, G. A., Sheahan, R. G., Yamamoto, S., James, T. N., & Tsyplenkova, V. G. (2000) · The American Journal of the Medical Sciences · doi:10.1097/00000441-200011000-00003 · Cited by 29 · see citing works
Wanichawan, P., Hafver, T. L., Hodne, K., Aronsen, J. M., Lunde, I. G., Dalhus, B., Lunde, M., Kvaløy, H., Louch, W. E., Tønnessen, T., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.602581 · Cited by 29 · see citing works
Rodríguez, J., Xie, C., Li, T., Sun, Y., Wang, Y., Xu, Y., Li, K., Zhang, S., Zhou, K., Wang, Y., et al. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108088 · Cited by 26 · see citing works
Self-citationTULLIO, R. D., Averna, M., Stifanese, R., Parr, T., BARDSLEY, R. G., Pontremoli, S., & Melloni, E. (2007) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2007.05.007 · Cited by 22 · see citing works
Self-citationKumar, T., Majumdar, A., Das, P., Sarafis, V., & Ghose, M. (2008) · Biotechnic & Histochemistry · doi:10.1080/10520290802336161 · Cited by 21 · see citing works
Sun, Y., Qi, Z., He, Q., Cui, D., Qian, S., Ji, L., & Ding, S. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.06.035 · Cited by 17 · see citing works
Yeste‐Velasco, M., Folch, J., Jiménez, A., Rimbau, V., Pallàs, M., & Camins, A. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.04.019 · Cited by 13 · see citing works
Farina, B., Sturlese, M., Mascanzoni, F., Caporale, A., Monti, A., Sorbo, G. D., Fattorusso, R., Ruvo, M., & Doti, N. (2018) · Biochemical Journal · doi:10.1042/bcj20180177 · Cited by 10 · see citing works
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Lampert, R., Chung, E. H., Ackerman, M. J., Arroyo, A. R., Darden, D., Deo, R., Dolan, J., Etheridge, S. P., Gray, B. R., Harmon, K. G., et al. (2024) · Heart Rhythm · doi:10.1016/j.hrthm.2024.05.018 · Cited by 167 · see citing works
Self-citationHeusch, G., Andreadou, I., Bell, R., Bertero, E., Bøtker, H. E., Davidson, S. M., Downey, J. M., Eaton, P., Ferdinandy, P., Gersh, B. J., et al. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102894 · Cited by 140 · see citing works
Elamipretide: A Review of Its Structure, Mechanism of Action, and Therapeutic Potential
Tung, C., Varzideh, F., Farroni, E., Mone, P., Kansakar, U., Jankauskas, S. S., & Santulli, G. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26030944 · Cited by 117 · see citing works
Emerging role of PARP‐1 and PARthanatos in ischemic stroke
Liu, S., Luo, W., & Wang, Y. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15464 · Cited by 101 · see citing works
Lin, Y.-N., Mesquita, T., Sanchez, L., Chen, Y.-H., Liu, W., Li, C., Rogers, R., Wang, Y., Li, X., Wu, D., et al. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab419 · Cited by 83 · see citing works
Pérez-Hernández, M., van Opbergen, C. J. M., Bagwan, N., Vissing, C. R., Marrón-Liñares, G. M., Zhang, M., Torres Vega, E., Sorrentino, A., Drici, L., Sulek, K., et al. (2022) · Circulation · doi:10.1161/circulationaha.122.060454 · Cited by 72 · see citing works
van Opbergen, C. J. M., Bagwan, N., Maurya, S. R., Kim, J.-C., Smith, A. N., Blackwell, D. J., Johnston, J. N., Knollmann, B. C., Marina Cerrone, Lundby, A., et al. (2022) · Circulation · doi:10.1161/circulationaha.121.057757 · Cited by 64 · see citing works
AIFM1 beyond cell death: An overview of this OXPHOS-inducing factor in mitochondrial diseases
Wischhof, L., Scifo, E., Ehninger, D., & Bano, D. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.104231 · Cited by 57 · see citing works
The intercalated disc: a unique organelle for electromechanical synchrony in cardiomyocytes
Nielsen, M. S., van Opbergen, C. J. M., van Veen, T. A. B., & Delmar, M. (2023) · Physiological Reviews · doi:10.1152/physrev.00021.2022 · Cited by 58 · see citing works
Mitochondrial Quality Control in Health and Disease
Ye, L., Fu, X., & Li, Q. (2025) · MedComm · doi:10.1002/mco2.70319 · Cited by 60 · see citing works
Calpain-Mediated Mitochondrial Damage: An Emerging Mechanism Contributing to Cardiac Disease
Zhang, M., Wang, G., & Peng, T. (2021) · Cells · doi:10.3390/cells10082024 · Cited by 50 · see citing works
Mitochondrial Creatine Kinase Attenuates Pathologic Remodeling in Heart Failure
Keceli, G., Gupta, A., Sourdon, J., Gabr, R. E., Schär, M., Dey, S., Tocchetti, C. G., Stuber, A., Agrimi, J., Zhang, Y., et al. (2022) · Circulation Research · doi:10.1161/circresaha.121.319648 · Cited by 49 · see citing works
Self-citationPharoah, B. M., Zhang, C., Khodade, V. S., Keceli, G., McGinity, C. L., Paolocci, N., & Toscano, J. P. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102625 · Cited by 43 · see citing works
Self-citationBoogerd, C. J. J., Lacraz, G., Vértesy, Á., van Kampen, S. J., Perini, I., de Ruiter, H., Versteeg, D., Brodehl, A., van der Kraak, P. H., Giacca, M., et al. (2022) · Cardiovascular Research · doi:10.1093/cvr/cvac072 · Cited by 44 · see citing works
Zheng, S., Zhao, D. H., Hou, G., Zhao, S., Zhang, W., Wang, X., Li, L., Lin, L., Tang, T.-S., & Hu, Y. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2111380119 · Cited by 41 · see citing works
Hawthorne, R. N., Blazeski, A., Lowenthal, J., Kannan, S., Teuben, R., DiSilvestre, D., Morrissette-McAlmon, J., Saffitz, J. E., Boheler, K. R., James, C. A., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10143061 · Cited by 41 · see citing works
Self-citationMonti, A., Vitagliano, L., Caporale, A., Ruvo, M., & Doti, N. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24097842 · Cited by 40 · see citing works
Self-citationXu, H., Chen, X., Luo, S., Jiang, J., Pan, X., He, Y., Deng, B., Liu, S., Wan, R., Lin, L., et al. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103471 · Cited by 39 · see citing works
p53 contributes to cardiovascular diseases via mitochondria dysfunction: A new paradigm
Wang, H., Yu, W., Wang, Y., Wu, R., Dai, Y., Deng, Y., Wang, S., Yuan, J., & Tan, R. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.09.036 · Cited by 39 · see citing works
Yu, W., Wang, L., Ren, W., Xu, H.-X., Wu, N. N., Yu, D., Reiter, R. J., Zha, W., Guo, Q., & Ren, J. T. (2023) · Acta Pharmacologica Sinica · doi:10.1038/s41401-023-01144-0 · Cited by 37 · see citing works
Inflammation in the Pathogenesis of Arrhythmogenic Cardiomyopathy: Secondary Event or Active Driver?
Meraviglia, V., Alcalde, M., Campuzano, Ó., & Bellin, M. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.784715 · Cited by 36 · see citing works
Chelko, S. P., Penna, V. R., Engel, M., Shiel, E. A., Centner, A. M., Farra, W., Cannon, E. N., Landim-Vieira, M., Schaible, N., Lavine, K., et al. (2024) · Journal of Clinical Investigation · doi:10.1172/jci172014 · Cited by 32 · see citing works
Self-citationPathogenesis of arrhythmogenic cardiomyopathy: role of inflammation
Lin, Y., Ibrahim, A. G.-E., Marbán, E., & Cingolani, E. (2021) · Basic Research in Cardiology · doi:10.1007/s00395-021-00877-5 · Cited by 30 · see citing works
Crosstalk between autophagy and other forms of programmed cell death
Wang, H., Feng, X., He, H., Li, L., Wen, Y., Liu, X., He, B., Hua, S., & Sun, S. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177414 · Cited by 28 · see citing works
Tarasov, K. V., Chakir, K., Riordon, D. R., Lyashkov, A. E., Ahmet, I., Perino, M. G., Silvester, A. J., Zhang, J., Wang, M., Lukyanenko, Y., et al. (2022) · eLife · doi:10.7554/elife.80949 · Cited by 26 · see citing works
Self-citationWan, H., Chen, H., Liu, J., Yang, B., Zhang, Y., Bai, Y., Chen, X., Wang, J., Liu, T., Zhang, Y., et al. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.05.020 · Cited by 23 · see citing works
Impaired Iron–Sulfur Cluster Synthesis Induces Mitochondrial PARthanatos in Diabetic Cardiomyopathy
Wang, M., Zhang, S., Tian, J., Yang, F., Chen, H., Bai, S., Kang, J., Pang, K., Huang, J., Dong, M., et al. (2024) · Advanced Science · doi:10.1002/advs.202406695 · Cited by 22 · see citing works
Desmosomes: emerging pathways and non-canonical functions in cardiac arrhythmias and disease
Zhang, J., Liang, Y., Bradford, W. H., & Sheikh, F. (2021) · Biophysical Reviews · doi:10.1007/s12551-021-00829-2 · Cited by 21 · see citing works
Burtscher, J., Vanderriele, P., Legrand, M. M., Predel, H., Niebauer, J., O’Keefe, J. H., Millet, G. P., & Burtscher, M. (2022) · Sports Medicine · doi:10.1007/s40279-022-01734-8 · Cited by 22 · see citing works
Li, K., Wan, B., Li, S., Chen, Z., Jia, H., Song, Y., Zhang, J., Ju, W., Ma, H., & Wang, Y. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1063556 · Cited by 20 · see citing works
Dei, L., Han, J., Romano, S., Sciarra, L., Asimaki, A., Papadakis, M., Sharma, S., & Finocchiaro, G. (2025) · Journal of the American Heart Association · doi:10.1161/jaha.124.039125 · Cited by 21 · see citing works
Self-citationRusso, L., Mascanzoni, F., Farina, B., Dolga, A. M., Monti, A., Caporale, A., Culmsee, C., Fattorusso, R., Ruvo, M., & Doti, N. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c00777 · Cited by 17 · see citing works
Self-citationMaione, A. S., Faris, P. S., Iengo, L., Catto, V., Bisonni, L., Lodola, F., Negri, S., Casella, M., Guarino, A., Polvani, G., et al. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03742-8 · Cited by 17 · see citing works
Molecular insight into arrhythmogenic cardiomyopathy caused by DSG2 mutations
Zhang, B., Wu, Y., Yang, X., Xiang, Y., & Yang, B. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115448 · Cited by 17 · see citing works
Chen, H., Pu, W., Hu, X., Yang, C., Zhao, G., Hu, H., & Zhang, J. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202301918 · Cited by 16 · see citing works
Coscarella, I. L., Landim-Vieira, M., Pinto, J. R., & Chelko, S. P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158753 · Cited by 16 · see citing works
Self-citationCardio-oncology: Shared Genetic, Metabolic, and Pharmacologic Mechanism
Zhao, Y., Jia, H., Hua, X., An, T., & Song, J. (2023) · Current Cardiology Reports · doi:10.1007/s11886-023-01906-6 · Cited by 18 · see citing works
Chauhan, P. K., & Sowdhamini, R. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1110119 · Cited by 12 · see citing works
Maiti, D., Yu, H., Mochida, Y., Won, S., Yamashita, S., Naito, M., Miyata, K., & Kim, H. J. (2023) · ACS Applied Bio Materials · doi:10.1021/acsabm.3c00304 · Cited by 12 · see citing works
Yadav, P., Beura, S. K., Panigrahi, A. R., Kulkarni, P. P., Yadav, M. K., Munshi, A., & Singh, S. K. (2024) · Cell Biology International · doi:10.1002/cbin.12192 · Cited by 12 · see citing works
Calpains, the proteases of two faces controlling the epithelial homeostasis in mammary gland
García–Trevijano, E. R., Zapater, E. O., Gimeno, A., Vinã, J. R., & Zaragozá, R. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1249317 · Cited by 14 · see citing works
Kuang, Y., Wu, Z., & Liu, Y. (2024) · Food and Chemical Toxicology · doi:10.1016/j.fct.2024.115200 · Cited by 11 · see citing works
Peretto, G., Villatore, A., & Cooper, L. T. (2026) · Immunological Reviews · doi:10.1111/imr.70105 · Cited by 10 · see citing works
Hartley, B., Bassiouni, W., Roczkowsky, A., Fahlman, R. P., Schulz, R., & Julien, O. (2024) · Journal of Proteome Research · doi:10.1021/acs.jproteome.3c00754 · Cited by 9 · see citing works
MicroRNAs at the crossroads of exercise and ferroptosis: a regulatory bridge
Lin, Z. J., & Feng, Z. (2025) · Clinical and Experimental Medicine · doi:10.1007/s10238-025-01766-0 · Cited by 10 · see citing works
Valerio, V., Keceli, G., Moschetta, D., Porro, B., Ciccarelli, M., Massaiu, I., Songia, P., Maione, A. S., Alfieri, V., Myasoedova, V. A., et al. (2022) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0133 · Cited by 9 · see citing works
Self-citationBose, K., Agrawal, R., Sairam, T., Mil, J., Butler, M. P., & Dhandapany, P. S. (2024) · iScience · doi:10.1016/j.isci.2024.109075 · Cited by 8 · see citing works
Targeting arrhythmogenic macrophages: lessons learned from arrhythmogenic cardiomyopathy
Mesquita, T., & Cingolani, E. (2024) · Journal of Clinical Investigation · doi:10.1172/jci180482 · Cited by 8 · see citing works
Centner, A. M., Shiel, E. A., Farra, W., Cannon, E. N., Landim-Vieira, M., Salazar, G., & Chelko, S. P. (2024) · Nutrients · doi:10.3390/nu16132087 · Cited by 8 · see citing works
Self-citationSong, M., Zhang, J., Huo, S., Zhang, X., Cui, Y., & Li, Y. (2023) · Food and Chemical Toxicology · doi:10.1016/j.fct.2023.113762 · Cited by 9 · see citing works
Mechanisms of Innate Immune Injury in Arrhythmogenic CardiomyopathyPreprint
Chelko, S. P., Penna, V. R., Engel, M., Landim-Vieira, M., Cannon, E. N., Lavine, K. J., & Saffitz, J. E. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.12.548682 · Cited by 8 · see citing works
Self-citationLandim-Vieira, M., Kahmini, A. R., Engel, M., Cannon, E. N., Amat-Alarcon, N., Judge, D. P., Pinto, J. R., & Chelko, S. P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232213909 · Cited by 7 · see citing works
Self-citationVencato, S., Romanato, C., Rampazzo, A., & Calore, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25116208 · Cited by 7 · see citing works
Relevance of AIF/CypA Lethal Pathway in SH-SY5Y Cells Treated with Staurosporine
Conte, M., Palumbo, R., Monti, A., Fontana, E., Nebbioso, A., Ruvo, M., Altucci, L., & Doti, N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010265 · Cited by 7 · see citing works
Self-citationGSK3-inhibition improves maximal SERCA activity in a murine model of Arrhythmogenic cardiomyopathy
Hamstra, S. I., Braun, J. L., Chelko, S. P., & Fajardo, V. A. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2022.166536 · Cited by 6 · see citing works
Self-citationPANoptosis in cancer: molecular mechanisms and therapeutic potential
Pu, X., Wu, Y., Chen, P., Sun, X., Zuo, H., Yuan, X., Wang, X., & Xu, M. (2025) · Cancer Gene Therapy · doi:10.1038/s41417-025-00940-6 · Cited by 6 · see citing works
Fabritz, L., Fortmueller, L., Gehmlich, K., Kant, S., Kemper, M., Kucerova, D., Syeda, F., Faber, C., Leube, R. E., Kirchhof, P. F., et al. (2024) · Biomedicines · doi:10.3390/biomedicines12050985 · Cited by 6 · see citing works
Low, B. S. H., & Asimaki, A. (2024) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-024-10567-x · Cited by 5 · see citing works
Self-citationButler, H. M., Keller, E., McCrorey, M. K., Keceli, G., Combs, C. K., Kayed, R., Namakkal-S, R., Paolocci, N., Wolf, B. J., Wold, L. E., et al. (2025) · Communications Biology · doi:10.1038/s42003-025-07701-z · Cited by 6 · see citing works
Self-citationMoccia, F. D., Brunetti, V., Soda, T., Faris, P. S., Scarpellino, G., & Berra‐Romani, R. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12165295 · Cited by 6 · see citing works
Exercise in Inherited Cardiomyopathies: Optimizing the Dose-Response Curve
Rye, E. E., Mitchell, A. M., Santiago, C. F., Gerche, A. L., & Fatkin, D. (2025) · Circulation Research · doi:10.1161/circresaha.125.326396 · Cited by 7 · see citing works
Shiel, E. A., Farra, W., Medarev, S. L., Ariyaratne, G. H. D. N., Cannon, E. N., Steiner, J. L., & Chelko, S. P. (2025) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00416.2025 · Cited by 5 · see citing works
Self-citationAmeer, S. F., Elsaka, M., Kahtoon, S., Kerzabi, R. I., Casu, G., Giordo, R., Zayed, H., & Pintus, G. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.123063 · Cited by 5 · see citing works
Yue, C.-L., Ding, Y.-X., Chen, M., Shen, Y., Hu, A., Huang, H., Zhang, Z., Zhou, Y.-X., & Xu, X. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1487436 · Cited by 4 · see citing works
In Vivo Approaches to Understand Arrhythmogenic Cardiomyopathy: Perspectives on Animal Models
Risato, G., Casas, R. B., Cason, M., Marinas, M. B., Pinci, S., Gaspari, M. D., Visentin, S., Rizzo, S., Thiene, G., Basso, C., et al. (2024) · Cells · doi:10.3390/cells13151264 · Cited by 4 · see citing works
Mitochondrial Dysfunction as a Therapeutic Target in Diabetic Cardiomyopathy: Progress and Prospects
Zhang, F., Li, Z., Wang, Y., Li, C., & Lu, C. (2025) · Cardiovascular Innovations and Applications · doi:10.15212/cvia.2024.0063 · Cited by 4 · see citing works
Zhang, K., Zhang, W., Zhang, L., Hou, X., Tian, R., Hu, Z., Yin, L., & Hu, Z. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06471-w · Cited by 4 · see citing works
Increased Intermembrane Space [Ca 2+ ] Drives Mitochondrial Structural Damage in CPVT
Hamilton, S., Terentyeva, R., Veress, R., Perger, F., Nichtová, Z., Bannister, M. L., Wang, J., Quiggle, S., Battershell, R., Gorr, M. W., et al. (2025) · Circulation Research · doi:10.1161/circresaha.125.326841 · Cited by 4 · see citing works
Molecular Pathogenesis of Arrhythmogenic Cardiomyopathy: Mechanisms and Therapeutic Perspectives
Popa, E., & Hostiuc, S. (2025) · Biomolecules · doi:10.3390/biom15111512 · Cited by 4 · see citing works
Eskandari, N., Delisi, D., Saatloo, M. V., Keceli, G., Pinheiro, N., Eblen, S. T., Paolocci, N., & Gentile, S. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103942 · Cited by 4 · see citing works
Self-citationPérez‐Siles, G., Ellis, M., Ashe, A., Grosz, B. R., Vucic, S., Kiernan, M. C., Morris, K. A., Reddel, S., & Kennerson, M. L. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2021.801253 · Cited by 4 · see citing works
Ischemia/Reperfusion Injury and Oxidative Stress Impair Cardiac Desmin ProteostasisPreprint
Li, Z., Jun, S., Singh, K. K., Calhoun, P. J., Keceli, G., Patel, K., Kadıoğlu, H., Paolocci, N., & Agnetti, G. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.09.540017 · Cited by 4 · see citing works
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Abdellatif, M., & Kroemer, G. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03677-w · Cited by 2 · see citing works
Alur, V. C., Vastrad, B. M., Raju, V., Vastrad, C. M., & Kotrashetti, S. (2025) · Discover Endocrinology and Metabolism · doi:10.1007/s44417-025-00003-2 · Cited by 2 · see citing works
Vastrad, B. M., & Vastrad, C. M. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.11.24.469869 · Cited by 2 · see citing works
Bertoli, G., Phadke, K., Cospito, A., Rizk, J. A., Zhang, M., Miliotou, E., Cammer, M., Deng, Y., Mezzano, V., Alu, M., et al. (2025) · doi:10.1101/2025.10.22.682160 · Cited by 2
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Self-citationMaekawa, Y., Ikeda, Y., Torigoe, M., Shimoura, K., Suo, S., Takeda, R., & Kitaoka, H. (2025) · Future Cardiology · doi:10.1080/14796678.2025.2526279 · Cited by 1 · see citing works
Li, Y., Yang, B., Mei, Z., Deng, P., Fu, T., & Li, J. (2025) · International Dental Journal · doi:10.1016/j.identj.2025.109309 · Cited by 1 · see citing works
Machine learning models enhance detection of arrhythmogenic right ventricular cardiomyopathy
Quansah, K. K., Murphy, S. A., Kwon, E., Anderson, E., Tichnell, C., Murray, B. A., Gaine, S. P., Gasperetti, A., James, C. A., Calkins, H. G., et al. (2026) · Machine Learning Health · doi:10.1088/3049-477x/ae451a · Cited by 1 · see citing works
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Zhang, X., Zhang, X., Chen, Y., Huan, N., Wang, C., & Zhang, D. (2026) · iScience · doi:10.1016/j.isci.2026.115511 · Cited by 1 · see citing works
Desmoglein-2 deficiency drives mitochondrial morphological remodeling in cardiomyocytes
Gonçalves, A., Chen, E. Z., Rastegarpouyani, H., Fernandes, A. A., Alves, I. N., Sequeira, V., Kwon, C., Chelko, S. P., & Landim-Vieira, M. (2026) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00368.2026 · Cited by 1 · see citing works
Self-citationPKP2 orchestrates OXPHOS expression in cardiomyocytes via a PGC1α-dependent mechanism
Han, S. J., van den Berg, D., de Ruiter, H., Tsui, H., Kyriakopoulou, E., Koopmans, T., Perini, I., Monshouwer‐Kloots, J., van Kampen, S. J., Riele, A. S. J. M. T., et al. (2026) · Cardiovascular Research · doi:10.1093/cvr/cvag141 · Cited by 1 · see citing works
Kunišek, L., Matušan‐Ilijaš, K., Medved, I., Ferenčić, A., Erdeljac, D., Arbanas, S., & Kunišek, J. (2021) · Medical Hypotheses · doi:10.1016/j.mehy.2021.110738 · Cited by 1 · see citing works
Simon, L. H., Garritson, J. D., Pullen, N., & Hayward, R. (2024) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000001583
Zhang, C., Kong, H., Ma, X., Jiang, J., Su, Y., Zheng, L., & Xin, H. (2024) · Research Square · doi:10.21203/rs.3.rs-4927724/v1
Machine Learning Models Enhance Prediction of Arrhythmogenic Right Ventricular CardiomyopathyPreprint
Quansah, K. K., Murphy, S. A., Kwon, E., Anderson, E., Tichnell, C., Murray, B., Gaines, S., Gasperetti, A., James, C. A., Calkins, H., et al. (2025) · medRxiv · doi:10.1101/2025.06.16.25329706
Self-citationLandim-Vieira, M., Jani, V., Shiel, E., Rastegarpouyani, H., Engel, M., Cullup, F. P., Chastain, R., Farra, W., Ma, W., Toepfer, C. N., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.03.680335
Self-citationSalamanca, M., Albanesi, M., Paolocci, N., & Salvo, G. D. (2025) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00928.2025
Self-citationShiel, E., Ariyaratne, G. H. D. N., Farra, W., Villatore, A., Cannon, E. N., & Chelko, S. P. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.14.718596
Self-citationMinor, K. E., Lee, C. F., & Nizami, H. L. (2026) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00633.2026
Sport and Exercise (Including CPET Evaluation)
Carriere, C., Baracchini, N., Capovilla, T., Savonitto, G., Tavčar, I., Paldino, A., Luca, A. D., Merlo, M., & Sinagra, G. (2026) · Springer eBooks · doi:10.1007/978-3-032-34334-5_11
- Authors
- Chelko, S. P., Keceli, G., Carpi, A., Doti, N., Agrimi, J., Asimaki, A., Beti, C. B., Miyamoto, M., Amat-Codina, N., Bedja, D., Wei, A.-C., Murray, B., Tichnell, C., Kwon, C., Calkins, H., James, C. A., O’Rourke, B., Halushka, M. K., Melloni, E., Saffitz, J. E., Judge, D. P., Ruvo, M., Kitsis, R. N., Andersen, P., Di Lisa, F., & Paolocci, N.
- Affiliations
- Florida State University (US)
- Johns Hopkins University (US)
- University of Padua (IT)
- Institute of Biostructure and Bioimaging (IT)
- St George's, University of London (GB)
- Molecular and Clinical Sciences Research Institute, St. George’s, University of London, London WC1E 6BS, UK.
- Division of Cardiology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
- University of Genoa (IT)
- Beth Israel Deaconess Medical Center (US)
- Albert Einstein College of Medicine (US)
- Department of Biomedical Sciences, University of Padova, Padova 35122, Italy.
- Corresponding author
- Chelko, Stephen P.
- Paolocci, Nazareno
- ORCID
- Chelko, Stephen P.
- Keceli, Gizem
- Doti, Nunzianna
- Agrimi, Jacopo
- Asimaki, Angeliki
- Miyamoto, Matthew
- Bedja, Djahida
- Wei, An-Chi
- Murray, Brittney
- Tichnell, Crystal
- Kwon, Chulan
- Calkins, Hugh
- James, Cynthia A.
- O’Rourke, Brian
- Halushka, Marc K.
- Saffitz, Jeffrey E.
- Judge, Daniel P.
- Ruvo, Menotti
- Kitsis, Richard N.
- Andersen, Peter
- Paolocci, Nazareno
- Venue
- Science Translational Medicine
- Published
- 2021-02-17
- Volume
- 13
- Issue
- 581
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC8936193
- OpenAlex
- W3129563346
- Cited by
- 92
- References
- 107
- Citations by year
- 2026: 10 · 2025: 21 · 2024: 18 · 2023: 17 · 2022: 14 · 2021: 12
- FWCI
- 10.39
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- St George's Online Research Archive (St George's University of London) (acceptedVersion)
- Padua Research Archive (University of Padova) (submittedVersion, other-oa)
- Funders
- National Institutes of Health (RO1 HL136918, R01 HL063030, R01 HL137259, T32 AG058527, R01 HD086026)
- American Heart Association (19CDA34760185, 17GRNT33670405)
- Magic That Matters Fund (MTMF)
- Fondation Leducq (16CVD02, 16CVD04)
- Maryland Stem Cell Research Fund (2015-MSCRFI-1622)
- Gilead Foundation (Gilead Research Scholars in Cardiovascular Disease Fund)
- University of Padova Strategico Grant (DYCENDI)
- Heart Rhythm Society (Cardiac Pacing and Electrophysiology Fellowship Award)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- arrhythmogenic cardiomyopathy, calpain-1, calpain, apoptosis, necrosis, cyclophilin A, PPIA, AIF nuclear translocation, myocyte death, physical activity, heart failure, cardiomyopathy
- MeSH terms
- Animals, Calpain, Mitochondria, Cardiomyopathies, Physical Conditioning, Animal, Cell Death, Myocytes, Cardiac, Apoptosis Inducing Factor, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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