Thielens, Nicole M.

C1q: A fresh look upon an old molecule

Thielens, N. M., Tedesco, F., Bohlson, S. S., Gaboriaud, C., & Tenner, A. J. (2017) · Molecular Immunology

Complement system in diseasesBiomarkers in Disease Mechanisms

Cited by 237

C1q restrains autoimmunity and viral infection by regulating CD8 + T cell metabolism

Ling, G. S., Crawford, G., Buang, N., Bartok, I., Tian, K., Thielens, N. M., Bally, I., Harker, J. A., Ashton-Rickardt, P. G., Rutschmann, S., et al. (2018) · Science

Complement system in diseasesSystemic Lupus Erythematosus Research

Cited by 199

Periodontal Ehlers-Danlos Syndrome Is Caused by Mutations in C1R and C1S , which Encode Subcomponents C1r and C1s of Complement

Kapferer-Seebacher, I., Pepin, M., Werner, R., Aitman, T. J., Nordgren, A., Stoiber, H., Thielens, N., Gaboriaud, C., Amberger, A., Schossig, A., et al. (2016) · The American Journal of Human Genetics

Complement system in diseasesOral microbiology and periodontitis research

Cited by 123

The crystal structure of the zymogen catalytic domain of complement protease C1r reveals that a disruptive mechanical stress is required to trigger activation of the C1 complex

Budayova‐Spano, M., Lacroix, M., Thielens, N. M., Arlaud, G. J., Fontecilla‐Camps, J. C., & Gaboriaud, C. (2002) · The EMBO Journal

Complement system in diseasesEnzyme Structure and Function

Cited by 111

Deciphering the Fine Details of C1 Assembly and Activation Mechanisms: “Mission Impossible”?

Gaboriaud, C., Ling, W. L., Thielens, N. M., Bally, I., & Rossi, V. (2014) · Frontiers in Immunology

Complement system in diseasesBiomarkers in Disease Mechanisms

Cited by 64

C1R mutations trigger constitutive complement 1 activation in periodontal Ehlers-Danlos syndrome

Gröbner, R., Kapferer-Seebacher, I., Amberger, A., Redolfi, R., Dalonneau, F., Björck, E., Milnes, D., Bally, I., Rossi, V., Thielens, N., et al. (2019) · Frontiers in Immunology

Complement system in diseasesCoagulation, Bradykinin, Polyphosphates, and Angioedema

Cited by 35

Human complement subcomponent C2: purification and proteolytic cleavage in fluid phase by C1̄s, C1̄r2–C1̄s2 AND 1̄

Thielens, N. M., Villiers, M.-B., Reboul, A., Villiers, C. L., & Colomb, M. G. (1982) · FEBS Letters

Complement system in diseasesCoagulation, Bradykinin, Polyphosphates, and Angioedema

Cited by 27

Classical Complement Pathway Components C1r and C1s: Purification from Human Serum and in Recombinant Form and Functional Characterization

Rossi, V., Bally, I., Lacroix, M., Arlaud, G. J., & Thielens, N. M. (2014) · Methods in Molecular Biology

Complement system in diseasesBiomarkers in Disease Mechanisms

Cited by 23