C1q: A fresh look upon an old molecule

Complement: a key system for immune surveillance and homeostasis

Ricklin, D., Hajishengallis, G., Yang, K., & Lambris, J. D. (2010) · Nature Immunology · doi:10.1038/ni.1923 · Cited by 3,654 · cited 1× · see citing works

Complement and microglia mediate early synapse loss in Alzheimer mouse models

Hong, S., Beja-Glasser, V. F., Nfonoyim, B. M., Frouin, A., Li, S., Ramakrishnan, S., Merry, K. M., Shi, Q., Rosenthal, A., Barres, B. A., et al. (2016) · Science · doi:10.1126/science.aad8373 · Cited by 3,343 · cited 2× · see citing works

The Classical Complement Cascade Mediates CNS Synapse Elimination

Stevens, B., Allen, N. J., Vazquez, L. E., Howell, G. R., Christopherson, K. S., Nouri, N., Micheva, K. D., Mehalow, A. K., Huberman, A. D., Stafford, B., et al. (2007) · Cell · doi:10.1016/j.cell.2007.10.036 · Cited by 3,313 · see citing works

Schizophrenia risk from complex variation of complement component 4

Sekar, A., Bialas, A. R., de Rivera, H., Davis, A., Hammond, T. R., Kamitaki, N., Tooley, K., Presumey, J., Baum, M., Van Doren, V., et al. (2016) · Nature · doi:10.1038/nature16549 · Cited by 2,394 · see citing works

Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus

Baechler, E. C., Batliwalla, F., Karypis, G., Gaffney, P. M., Ortmann, W. A., Espe, K. J., Shark, K. B., Grande, W. J., Hughes, K. M. H., Kapur, V., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0337679100 · Cited by 2,246 · see citing works

Siglecs and their roles in the immune system

Crocker, P. R., Paulson, J. C., & Varki, A. P. (2007) · Nature reviews. Immunology · doi:10.1038/nri2056 · Cited by 2,032 · see citing works

Complement System Part I – Molecular Mechanisms of Activation and Regulation

Merle, N. S., Church, S. E., Fremeaux-Bacchi, V., & Roumenina, L. T. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00262 · Cited by 1,620 · see citing works

Cell-Surface Calreticulin Initiates Clearance of Viable or Apoptotic Cells through trans-Activation of LRP on the Phagocyte

Gardai, S. J., McPhillips, K. A., Frasch, S. C., Janssen, W. J., Starefeldt, A., Murphy-Ullrich, J. E., Bratton, D. L., Oldenborg, P.-A., Michalak, M., & Henson, P. M. (2005) · Cell · doi:10.1016/j.cell.2005.08.032 · Cited by 1,473 · see citing works

Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies

Botto, M., Dell' Agnola, C., Bygrave, A. E., Thompson, E. M., Cook, H. T., Petry, F., Loos, M., Pandolfi, P. P., & Walport, M. J. (1998) · Nature Genetics · doi:10.1038/ng0598-56 · Cited by 1,434 · see citing works

The Uterine Spiral Arteries In Human Pregnancy: Facts and Controversies

Pijnenborg, R., Vercruysse, L., & HANSSENS, M. C. A. J. A. (2006) · Placenta · doi:10.1016/j.placenta.2005.12.006 · Cited by 1,201 · see citing works

C1q and Mannose Binding Lectin Engagement of Cell Surface Calreticulin and Cd91 Initiates Macropinocytosis and Uptake of Apoptotic Cells

Ogden, C. A., deCathelineau, A. M., Hoffmann, P. R., Bratton, D. L., Ghebrehiwet, B., Fadok, V. A., & Henson, P. M. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.6.781 · Cited by 1,148 · see citing works

The Complement System: An Unexpected Role in Synaptic Pruning During Development and Disease

Stephan, A. H., Barres, B. A., & Stevens, B. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113810 · Cited by 1,113 · see citing works

Inflammation in Alzheimer Disease--A Brief Review of the Basic Science and Clinical Literature

Wyss-Coray, T., & Rogers, J. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006346 · Cited by 975 · see citing works

Advances in skin grafting and treatment of cutaneous wounds

Sun, B. K., Siprashvili, Z., & Khavari, P. A. (2014) · Science · doi:10.1126/science.1253836 · Cited by 972 · see citing works

Modulation of the antitumor immune response by complement

Markiewski, M. M., DeAngelis, R. A., Benencia, F., Ricklin-Lichtsteiner, S. K., Koutoulaki, A., Gerard, C. J., Coukos, G., & Lambris, J. D. (2008) · Nature Immunology · doi:10.1038/ni.1655 · Cited by 770 · see citing works

Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation

Lui, H., Zhang, J., Makinson, S. R., Cahill, M. K., Kelley, K. W., Huang, H.-Y., Shang, Y., Oldham, M. C., Martens, L. H., Gao, F., et al. (2016) · Cell · doi:10.1016/j.cell.2016.04.001 · Cited by 729 · see citing works

INTERACTION OF AGGREGATED γ-GLOBULIN WITH B LYMPHOCYTES

Dickler, H. B., & Kunkel, H. G. (1972) · The Journal of Experimental Medicine · doi:10.1084/jem.136.1.191 · Cited by 673 · see citing works

A complement–microglial axis drives synapse loss during virus-induced memory impairment

Vasek, M. J., Garber, C., Dorsey, D., Durrant, D. M., Bollman, B., Soung, A., Yu, J., Perez-Torres, C., Frouin, A., Wilton, D. K., et al. (2016) · Nature · doi:10.1038/nature18283 · Cited by 671 · see citing works

C1q binds directly and specifically to surface blebs of apoptotic human keratinocytes: complement deficiency and systemic lupus erythematosus revisited

Korb, L. C., & Ahearn, J. M. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.10.4525 · Cited by 659 · see citing works

The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor

Shapiro, L. S., & Scherer, P. E. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70133-2 · Cited by 652 · see citing works

The Role of Complement in the Development of Systemic Lupus Erythematosus

Manderson, A. P., Botto, M., & Walport, M. J. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104549 · Cited by 538 · see citing works

Role of Surfactant Proteins A, D, and C1q in the Clearance of Apoptotic Cells In Vivo and In Vitro: Calreticulin and CD91 as a Common Collectin Receptor Complex

Vandivier, R. W., Ogden, C. A., Fadok, V. A., Hoffmann, P. R., Brown, K. K., Botto, M., Walport, M. J., Fisher, J. H., Henson, P. M., & Greene, K. E. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.7.3978 · Cited by 517 · see citing works

Complement in the brain

Veerhuis, R., Nielsen, H. M., & Tenner, A. J. (2011) · Molecular Immunology · doi:10.1016/j.molimm.2011.04.003 · Cited by 420 · see citing works

CHROMATOGRAPHIC RESOLUTION OF THE FIRST COMPONENT OF HUMAN COMPLEMENT INTO THREE ACTIVITIES

Lepow, I. H., Naff, G. B., Todd, E. W., Pensky, J., & Hinz, C. F. (1963) · The Journal of Experimental Medicine · doi:10.1084/jem.117.6.983 · Cited by 378 · see citing works

Complement<i>C3</i>-Deficient Mice Fail to Display Age-Related Hippocampal Decline

Shi, Q., Colodner, K. J., Matousek, S. B., Merry, K., Hong, S., Kenison, J. E., Frost, J. L., Le, K. X., Li, S., Dodart, J.-C., et al. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.1698-15.2015 · Cited by 368 · see citing works

Complement activation and inhibition: a delicate balance

Sjöberg, A. P., Trouw, L. A., & Blom, A. M. (2009) · Trends in Immunology · doi:10.1016/j.it.2008.11.003 · Cited by 364 · see citing works

The Crystal Structure of the Globular Head of Complement Protein C1q Provides a Basis for Its Versatile Recognition Properties

Gaboriaud, C., Juanhuix, J., Gruez, A., Lacroix, M., Darnault, C., Pignol, D., Verger, D., Fontecilla-Camps, J. C., & Arlaud, G. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307764200 · Cited by 362 · see citing works

Isolation, cDNA cloning, and overexpression of a 33-kD cell surface glycoprotein that binds to the globular "heads" of C1q.

Ghebrehiwet, B., Lim, B. L., Peerschke, E. I. B., Willis, A. C., & Reid, K. B. M. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.6.1809 · Cited by 347 · see citing works

Cell-specific deletion of C1qa identifies microglia as the dominant source of C1q in mouse brain

Fonseca, M. I., Chu, S.-H., Hernandez, M. X., Fang, M. J., Modarresi, L., Selvan, P., MacGregor, G. R., & Tenner, A. J. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0814-9 · Cited by 337 · see citing works

Subunit composition and structure of subcomponent C1q of the first component of human complement

Reid, K. B. M., & Porter, R. (1976) · Biochemical Journal · doi:10.1042/bj1550019 · Cited by 329 · see citing works

CR3: a general purpose adhesion-recognition receptor essential for innate immunity

Ehlers, M. R. (2000) · Microbes and Infection · doi:10.1016/s1286-4579(00)00299-9 · Cited by 323 · see citing works

Complement C1q Activates Canonical Wnt Signaling and Promotes Aging-Related Phenotypes

Naito, A. T., Sumida, T., Nomura, S., Liu, M.-L., Higo, T., Nakagawa, A., Okada, K., Sakai, T., Hashimoto, A., Hara, Y., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.047 · Cited by 320 · see citing works

Complement, C1q, and C1q-Related Molecules Regulate Macrophage Polarization

Bohlson, S. S., Oâ€TMConner, S. D., Hulsebus, H. J., Ho, M.-M., & Fraser, D. A. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00402 · Cited by 299 · see citing works

C1q acts in the tumour microenvironment as a cancer-promoting factor independently of complement activation

Bulla, R., Tripodo, C., Rami, D., Ling, G. S., Agostinis, C., Guarnotta, C., Zorzet, S., Durigutto, P., Botto, M., & Tedesco, F. (2016) · Nature Communications · doi:10.1038/ncomms10346 · Cited by 295 · see citing works

Human Pulmonary Surfactant Protein (SP-A), a Protein Structurally Homologous to C1q, Can Enhance FcR- and CR1-mediated Phagocytosis

Tenner, A. J., Robinson, S. L., Borchelt, J. D., & Wright, J. R. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)80088-6 · Cited by 294 · see citing works

The inhibitory collagen receptor LAIR-1 (CD305)

Meyaard, L. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0907609 · Cited by 290 · see citing works

The Globular Heads of C1q Specifically Recognize Surface Blebs of Apoptotic Vascular Endothelial Cells

Navratil, J. S., Watkins, S. C., Wisnieski, J. J., & Ahearn, J. M. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.5.3231 · Cited by 262 · see citing works

Structure–function relationships of complement receptor type 1

Krych‐Goldberg, M., & Atkinson, J. P. (2001) · Immunological Reviews · doi:10.1034/j.1600-065x.2001.1800110.x · Cited by 259 · see citing works

Molecular and Cellular Characterization of the Membrane Attack Complex, C5b-9, in Alzheimer’s Disease

Webster, S. D., Lue, L., Brachova, L., Tenner, A. J., McGeer, P. L., Terai, K., Walker, D. G., Bradt, B. M., Cooper, N. R., & Rogers, J. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00042-0 · Cited by 258 · see citing works

Complement Receptor Type 1 (CR1, CD35) Is a Receptor for C1q

Klickstein, L. B., Barbashov, S. F., Liu, T., Jack, R. M., & Nicholson-Weller, A. (1997) · Immunity · doi:10.1016/s1074-7613(00)80356-8 · Cited by 257 · see citing works

Complement Protein C1q Directs Macrophage Polarization and Limits Inflammasome Activity during the Uptake of Apoptotic Cells

Benoit, M. E., Clarke, E. V., Morgado, P., Fraser, D. A., & Tenner, A. J. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103760 · Cited by 245 · see citing works

Phosphodiesterase-4D Knock-Out and RNA Interference-Mediated Knock-Down Enhance Memory and Increase Hippocampal Neurogenesis via Increased cAMP Signaling

Li, Y., Cheng, Y., Huang, Y., Conti, M., Wilson, S. P., O’Donnell, J. M., & Zhang, H. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5236-10.2011 · Cited by 233 · see citing works

RAGE in tissue homeostasis, repair and regeneration

Sorci, G., Riuzzi, F., Giambanco, I., & Donato, R. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.10.021 · Cited by 229 · see citing works

The scavenger receptor SCARF1 mediates the clearance of apoptotic cells and prevents autoimmunity

Ramirez‐Ortiz, Z. G., Pendergraft, W. F., Prasad, A., Byrne, M. H., Iram, T., Blanchette, C. J., Luster, A. D., Hacohen, N., Khoury, J. B. E., & Means, T. K. (2013) · Nature Immunology · doi:10.1038/ni.2670 · Cited by 214 · see citing works

Characterization and organization of the genes encoding the A-, B- and C-chains of human complement subcomponent C1q. The complete derived amino acid sequence of human C1q

Sellar, G., Blake, D. J., & Reid, K. B. M. (1991) · Biochemical Journal · doi:10.1042/bj2740481 · Cited by 211 · see citing works

Complement proteins C1q and MBL are pattern recognition molecules that signal immediate and long-term protective immune functions

Bohlson, S. S., Fraser, D. A., & Tenner, A. J. (2006) · Molecular Immunology · doi:10.1016/j.molimm.2006.06.021 · Cited by 199 · see citing works

C1q enhances microglial clearance of apoptotic neurons and neuronal blebs, and modulates subsequent inflammatory cytokine production

Fraser, D. A., Pisalyaput, K., & Tenner, A. J. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06494.x · Cited by 196 · see citing works

Role of Complement Component C1q in the Onset of Preeclampsia in Mice

Singh, J. K., Ahmed, A., & Girardi, G. (2011) · Hypertension · doi:10.1161/hypertensionaha.111.175919 · Cited by 185 · see citing works

The complement system in the pathophysiology of pregnancy

Girardi, G., Bulla, R., Salmon, J. E., & Tedesco, F. (2005) · Molecular Immunology · doi:10.1016/j.molimm.2005.06.017 · Cited by 184 · see citing works

The physiological role of DC-SIGN: A tale of mice and men

García-Vallejo, J. J., & van Kooyk, Y. (2013) · Trends in Immunology · doi:10.1016/j.it.2013.03.001 · Cited by 183 · see citing works

Inhibition of the classical pathway of the complement cascade prevents early dendritic and synaptic degeneration in glaucoma

Williams, P. A., Tribble, J. R., Pepper, K. W., Cross, S. D., Morgan, B. P., Morgan, J. E., John, S. W. M., & Howell, G. R. (2016) · Molecular Neurodegeneration · doi:10.1186/s13024-016-0091-6 · Cited by 183 · see citing works

C1q limits dendritic cell differentiation and activation by engaging LAIR-1

Son, M., Santiago‐Schwarz, F., Al‐Abed, Y., & Diamond, B. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1212753109 · Cited by 179 · see citing works

C1q and HMGB1 reciprocally regulate human macrophage polarization

Son, M., Porat, A., He, M., Suurmond, J., Santiago‐Schwarz, F., Andersson, U., Coleman, T. R., Volpe, B. T., Tracey, K. J., Al‐Abed, Y., et al. (2016) · Blood · doi:10.1182/blood-2016-05-719757 · Cited by 177 · see citing works

Emerging and Novel Functions of Complement Protein C1q

Kouser, L., Madhukaran, S. P., Shastri, A., Saraon, A., Ferluga, J., Al-Mozaini, M., & Kishore, U. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00317 · Cited by 175 · see citing works

Megf10 Is a Receptor for C1Q That Mediates Clearance of Apoptotic Cells by Astrocytes

Iram, T., Ramirez‐Ortiz, Z. G., Byrne, M. H., Coleman, U. A., Kingery, N. D., Means, T. K., Frenkel, D., & Khoury, J. B. E. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3850-15.2016 · Cited by 175 · see citing works

Modulation of FcR function by complement: subcomponent C1q enhances the phagocytosis of IgG-opsonized targets by human monocytes and culture-derived macrophages.

Bobak, D., Gaither, T., Frank, M. M., & Tenner, A. (1987) · Journal of Immunology · doi:10.4049/jimmunol.138.4.1150 · Cited by 171 · see citing works

An Alternative Role of C1q in Cell Migration and Tissue Remodeling: Contribution to Trophoblast Invasion and Placental Development

Agostinis, C., Bulla, R., Tripodo, C., Gismondi, A., Stabile, H., Bossi, F., Guarnotta, C., Garlanda, C., Seta, F. D., Spessotto, P., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903215 · Cited by 169 · see citing works

Stimulation of Neurogenesis and Synaptogenesis by Bilobalide and Quercetin via Common Final Pathway in Hippocampal Neurons

Tchantchou, F., Lacor, P. N., Cao, Z., Lao, L., Hou, Y., Cui, C., Klein, W. L., & Luo, Y. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1189 · Cited by 163 · see citing works

Mannose binding protein (MBP) enhances mononuclear phagocyte function via a receptor that contains the 126,000 Mr component of the Clq receptor

Tenner, A. J., Robinson, S. L., & Ezekowitz, R. A. B. (1995) · Immunity · doi:10.1016/1074-7613(95)90177-9 · Cited by 162 · see citing works

Circular-dichroism and electron-microscopy studies of human subcomponent C1q before and after limited proteolysis by pepsin

Brodsky-Doyle, B., Leonard, K., & Reid, K. B. M. (1976) · Biochemical Journal · doi:10.1042/bj1590279 · Cited by 159 · see citing works

Complement Protein C1q-Mediated Neuroprotection Is Correlated with Regulation of Neuronal Gene and MicroRNA Expression

Benoit, M. E., & Tenner, A. J. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3932-10.2011 · Cited by 159 · see citing works

C1q-induced LRP1B and GPR6 Proteins Expressed Early in Alzheimer Disease Mouse Models, Are Essential for the C1q-mediated Protection against Amyloid-β Neurotoxicity

Benoit, M. E., Hernandez, M. X., Dinh, M. L., Benavente, F., Vasquez, O., & Tenner, A. J. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.400168 · Cited by 155 · see citing works

C1q as a unique player in angiogenesis with therapeutic implication in wound healing

Bossi, F., Tripodo, C., Rizzi, L., Bulla, R., Agostinis, C., Guarnotta, C., Munaut, C., Baldassarre, G., Papa, G., Zorzet, S., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1311968111 · Cited by 154 · see citing works

C1q Deficiency Leads to the Defective Suppression of IFN-α in Response to Nucleoprotein Containing Immune Complexes

Santer, D. M., Hall, B. E., George, T. C., Tangsombatvisit, S., Liu, C. L., Arkwright, P. D., & Elkon, K. B. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001731 · Cited by 151 · see citing works

Interaction of C1q with IgG1, C-reactive Protein and Pentraxin 3: Mutational Studies Using Recombinant Globular Head Modules of Human C1q A, B, and C Chains

Roumenina, L. T., Ruseva, M. M., Zlatarova, A. S., Ghai, R., Kolev, M. V., Olova, N. N., Gadjeva, M. G., Agrawal, A. C., Bottazzi, B., Mantovani, A., et al. (2006) · Biochemistry · doi:10.1021/bi052646f · Cited by 148 · see citing works

Murine CD93 (C1qRp) Contributes to the Removal of Apoptotic Cells In Vivo but Is Not Required for C1q-Mediated Enhancement of Phagocytosis

Norsworthy, P. J., Fossati‐Jimack, L., Cortés-Hernández, J., Taylor, P. R., Bygrave, A. E., Thompson, R. D., Nourshargh, S., Walport, M. J., & Botto, M. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.6.3406 · Cited by 146 · see citing works

SREC-I, a Type F Scavenger Receptor, Is an Endocytic Receptor for Calreticulin

Berwin, B. L., Delneste, Y., Lovingood, R. V., Post, S. R., & Pizzo, S. V. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406202200 · Cited by 138 · see citing works

Reaction between the isolated globular sub-units of the complement component Clq and IgG-complexes

Hughes-Jones, N. C., & Gardner, B. (1979) · Molecular Immunology · doi:10.1016/0161-5890(79)90010-5 · Cited by 135 · see citing works

Sialic acid on the neuronal glycocalyx prevents complement C1 binding and complement receptor-3-mediated removal by microglia

Linnartz, B., Kopatz, J., Tenner, A. J., & Neumann, H. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.3830-11.2012 · Cited by 134 · see citing works

Biosynthesis in vitro of complement subcomponents C1q, C1s and C1 inhibitor by resting and stimulated human monocytes

Bensa, J., Reboul, A., & Colomb, M. G. (1983) · Biochemical Journal · doi:10.1042/bj2160385 · Cited by 128 · see citing works

Complete amino acid sequences of the three collagen-like regions present in subcomponent C1q of the first component of human complement

Reid, K. B. M. (1979) · Biochemical Journal · doi:10.1042/bj1790367 · Cited by 127 · see citing works

THE MACROMOLECULAR NATURE OF THE FIRST COMPONENT OF HUMAN COMPLEMENT

Naff, G. B., Pensky, J., & Lepow, I. H. (1964) · The Journal of Experimental Medicine · doi:10.1084/jem.119.4.593 · Cited by 122 · see citing works

Human C1qRp Is Identical with CD93 and the mNI-11 Antigen But Does Not Bind C1q

McGreal, E. P., Ikewaki, N., Akatsu, H., Morgan, B. P., & Gasque, P. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.10.5222 · Cited by 120 · see citing works

Cell-surface protein identified on phagocytic cells modulates the C1q-mediated enhancement of phagocytosis.

Guan, E., Robinson, S. L., Goodman, E. B., & Tenner, A. J. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.8.4005 · Cited by 119 · see citing works

Complement C1q Activates Tumor Suppressor WWOX to Induce Apoptosis in Prostate Cancer Cells

Hong, Q., Sze, C., Lin, S., Lee, M.-H., He, R., Schultz, L., Chang, J.-Y., Chen, S.-J., Boackle, R. J., Hsu, L., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005755 · Cited by 119 · see citing works

Modular Organization of the Carboxyl-Terminal, Globular Head Region of Human C1q A, B, and C Chains

Kishore, U., Gupta, S. K., Perdikoulis, M. V., Kojouharova, M. S., Urban, B. C., & Reid, K. B. M. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.2.812 · Cited by 118 · see citing works

Clinical presentation of human C1q deficiency: How much of a lupus?

Stegert, M., Bock, M., & Trendelenburg, M. (2015) · Molecular Immunology · doi:10.1016/j.molimm.2015.03.007 · Cited by 117 · see citing works

Reconstitution of the Complement Function in C1q-Deficient (C1qa−/−) Mice with Wild-Type Bone Marrow Cells

Petry, F., Botto, M., Holtappels, R., Walport, M. J., & Loos, M. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.7.4033 · Cited by 117 · see citing works

Ultrastructure of the Human Complement Component, Clq

Shelton, E., Yonemasu, K., & Stroud, R. M. (1972) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.69.1.65 · Cited by 115 · see citing works

Insight into Schmid Metaphyseal Chondrodysplasia from the Crystal Structure of the Collagen X NC1 Domain Trimer

Bogin, O., Kvansakul, M., Rom, E., Singer, J., Yayon, A., & Hohenester, E. (2002) · Structure · doi:10.1016/s0969-2126(02)00697-4 · Cited by 114 · see citing works

Structure and homology of human C1q receptor (collectin receptor).

Malhotra, R., Willis, A. C., Jensenius, J. C., Jackson, J., & Sim, R. B. (1993) · PubMed Central · Cited by 111 · see citing works

The C1q Family of Proteins: Insights into the Emerging Non-Traditional Functions

Ghebrehiwet, B., Hosszu, K., Valentino, A., & Peerschke, E. I. B. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00052 · Cited by 106 · see citing works

C1q and phagocytosis: the perfect complement to a good meal

Galvan, M. D., Greenlee‐Wacker, M. C., & Bohlson, S. S. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.0212099 · Cited by 105 · see citing works

Antibody-Mediated Phagocytosis of the Amyloid β-Peptide in Microglia Is Differentially Modulated by C1q

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Complement component C1q inhibits β‐amyloid‐ and serum amyloid P‐induced neurotoxicity via caspase‐ and calpain‐independent mechanisms

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Complement protein C1q bound to apoptotic cells suppresses human macrophage and dendritic cell-mediated Th17 and Th1 T cell subset proliferation

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Decidual endothelial cells express surface-bound C1q as a molecular bridge between endovascular trophoblast and decidual endothelium

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Allostery in trypsin-like proteases suggests new therapeutic strategies

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SREC-II, a New Member of the Scavenger Receptor Type F Family, Trans-interacts with SREC-I through Its Extracellular Domain

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Measurement of the association constants of the complexes formed between intact C1q or pepsin-treated C1q stalks and the unactivated or activated C1r2C1s2 tetramers

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Investigations on the C1q–Calreticulin–Phosphatidylserine Interactions Yield New Insights into Apoptotic Cell Recognition

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Calreticulin Is at the Surface of Circulating Neutrophils and Uses CD59 as an Adaptor Molecule

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Contribution of complement activation pathways to neuropathology differs among mouse models of Alzheimer's disease

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The Human C1q Globular Domain: Structure and Recognition of Non-Immune Self Ligands

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Identification of human CD93 as the phagocytic C1q receptor (C1qRp) by expression cloning

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Complement Component C1q Regulates Macrophage Expression of Mer Tyrosine Kinase To Promote Clearance of Apoptotic Cells

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Bispecific antibodies targeting tumor-associated antigens and neutralizing complement regulators increase the efficacy of antibody-based immunotherapy in mice

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Prognostic stromal gene signatures in breast cancer

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Pericytes and immune cells contribute to complement activation in tubulointerstitial fibrosis

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Novel collectin/C1q receptor mediates mast cell activation and innate immunity

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Mutational Analyses of the Recombinant Globular Regions of Human C1q A, B, and C Chains Suggest an Essential Role for Arginine and Histidine Residues in the C1q-IgG Interaction

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Molecular cloning and characterization of the complementary DNA and gene coding for the B-chain of subcomponent C1q of the human complement system

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Murine Low-Density Lipoprotein Receptor-Related Protein 1 (LRP) Is Required for Phagocytosis of Targets Bearing LRP Ligands but Is Not Required for C1q-Triggered Enhancement of Phagocytosis

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Immune modulation of human dendritic cells by complement

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Two way communication between neutrophils and dendritic cells.

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Siglec functions of microglia

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VE-cadherin is a critical molecule for trophoblast?endothelial cell interaction in decidual spiral arteries

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C1q, antibodies and anti-C1q autoantibodies

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Complement modulation of T cell immune responses during homeostasis and disease

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RAGE binds C1q and enhances C1q-mediated phagocytosis

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Leukocyte-associated Ig-like receptor-1 is a novel inhibitory receptor for surfactant protein D

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Synthesis of classical pathway complement components by chondrocytes.

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C1q regulation of dendritic cell development from monocytes with distinct cytokine production and T cell stimulation

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C1q-Mediated Repression of Human Monocytes Is Regulated by Leukocyte-Associated Ig-Like Receptor 1 (LAIR-1)

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Completion of the amino acid sequences of the A and B chains of subcomponent C1q of the first component of human complement

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Evidence That C1q Binds Specifically to CH2-like Immunoglobulin γ Motifs Present in the Autoantigen Calreticulin and Interferes with Complement Activation

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Expression of recombinant human complement C1q allows identification of the C1r/C1s-binding sites

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Clq acts synergistically with phorbol dibutyrate to activate CR1‐mediated phagocytosis by human mononuclear phagocytes

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β-Adrenergic receptor-induced activation of nerve growth factor gene transcription in rat cerebral cortex involves CCAAT/enhancer-binding protein δ

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DC-SIGN, C1q, and gC1qR form a trimolecular receptor complex on the surface of monocyte-derived immature dendritic cells

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Plasmacytoid Dendritic Cells and C1q Differentially Regulate Inflammatory Gene Induction by Lupus Immune Complexes

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The Complement System at the Embryo Implantation Site: Friend or Foe?

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Evidence for C1q-mediated crosslinking of CD33/LAIR-1 inhibitory immunoreceptors and biological control of CD33/LAIR-1 expression

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Interaction of the globular domain of human C1q with Salmonella typhimurium lipopolysaccharide

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Angiotensin II receptor blockade promotes repair of skeletal muscle through down-regulation of aging-promoting C1q expression

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Localization of ligand-binding sites on human C1q globular head region using recombinant globular head fragments and single-chain antibodies

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Human C1q Induces Apoptosis in an Ovarian Cancer Cell Line via Tumor Necrosis Factor Pathway

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gC1qR Expression in Normal and Pathologic Human Tissues

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Deciphering Complement Receptor Type 1 Interactions with Recognition Proteins of the Lectin Complement Pathway

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Direct interaction between CD91 and C1q

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Decreased apopto-phagocytic gene expression in the macrophages of systemic lupus erythematosus patients

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Ultrastructure of Human C1q Protein

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Analysis of Human C1q by Combined Bottom-up and Top-down Mass Spectrometry

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C1q Regulatory Region Polymorphism Down-Regulating Murine C1q Protein Levels with Linkage to Lupus Nephritis

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The non-inflammatory role of C1q during Her2/neu-driven mammary carcinogenesis

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Existence of Different but Overlapping IgG- and IgM-Binding Sites on the Globular Domain of Human C1q

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Physical and Functional Interaction Between Cell-Surface Calreticulin and the Collagen Receptors Integrin α2β1 and Glycoprotein VI in Human Platelets

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The production and secretion of complement component C1q by human mast cells

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SIGN-R1, a C-type lectin, enhances apoptotic cell clearance through the complement deposition pathway by interacting with C1q in the spleen

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C1q triggers neutrophil superoxide production by a unique CD18-dependent mechanism

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Uncoupling complement C1s activation from C1q binding in apoptotic cell phagocytosis and immunosuppressive capacity

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Complement research in the 18th–21st centuries: Progress comes with new technology

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CD91 interacts with mannan‐binding lectin (MBL) through the MBL‐associated serine protease‐binding site

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The complement system of elasmobranches revealed by liver transcriptome analysis of a hammerhead shark, Sphyrna zygaena

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Structural basis for selective recognition of endogenous and microbial polysaccharides by macrophage receptor SIGN-R1.

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Structural and Functional Characterization of a Single-Chain Form of the Recognition Domain of Complement Protein C1q

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C1q-Dependent Dendritic Cell Cross-Presentation of In Vivo–Formed Antigen–Antibody Complexes

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Leukocyte integrins αLβ2, αMβ2 and αXβ2 as collagen receptors—Receptor activation and recognition of GFOGER motif

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Differential Binding of IgG and of a HIV gp41 Peptide by the B Chain and A Chain Globular Head Sequences of C1q, Respectively

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Inhibition of the Classical and Lectin Pathway of the Complement System by Recombinant LAIR-2

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Complement Component C1q Programs a Pro-Efferocytic Phenotype while Limiting TNFα Production in Primary Mouse and Human Macrophages

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De Novo Transcriptomic Analysis of Peripheral Blood Lymphocytes from the Chinese Goose: Gene Discovery and Immune System Pathway Description

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Generation of Novel Long-Acting Globular Adiponectin Molecules

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Complement Protein C1q Interacts with DC-SIGN via Its Globular Domain and Thus May Interfere with HIV-1 Transmission

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Preeclampsia is associated with defective production of C1q by invasive trophoblast

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Human c1q induces apoptosis in an ovarian cancer cell line via tumor necrosis factor pathway

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Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer’s Disease

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Neuroinflammation in Alzheimer disease

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Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injury

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New insights into the immune functions of complement

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The good, the bad, and the opportunities of the complement system in neurodegenerative disease

Schartz, N. D., & Tenner, A. J. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-02024-8 · Cited by 283 · see citing works

Single-cell reconstruction of follicular remodeling in the human adult ovary

Fan, X., Bialecka, M., Moustakas, I., Lam, E., Torrens-Juaneda, V., Borggreven, N. V., Trouw, L. A., Louwe, L. A., Pilgram, G. S. K., Mei, H., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11036-9 · Cited by 282 · see citing works

Tumor Cells Hijack Macrophage-Produced Complement C1q to Promote Tumor Growth

Roumenina, L. T., Daugan, M. V., Noé, R., Petitprez, F., Vano, Y. A., Sánchez-Salas, R., Becht, É., Meilleroux, J., Clec'h, B. L., Giraldo, N. A., et al. (2019) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-18-0891 · Cited by 273 · see citing works

Therapeutic Targeting of the Complement System: From Rare Diseases to Pandemics

Garred, P., Tenner, A. J., & Mollnes, T. E. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000072 · Cited by 215 · see citing works

C1q restrains autoimmunity and viral infection by regulating CD8 ⁺ T cell metabolism

Ling, G. S., Crawford, G., Buang, N., Bartok, I., Tian, K., Thielens, N. M., Bally, I., Harker, J. A., Ashton-Rickardt, P. G., Rutschmann, S., et al. (2018) · Science · doi:10.1126/science.aao4555 · Cited by 199 · see citing works

Mitochondrial C5aR1 activity in macrophages controls IL-1β production underlying sterile inflammation

Niyonzima, N., Rahman, J., Kunz, N., West, E. E., Freiwald, T., Desai, J. V., Merle, N. S., Gidon, A., Sporsheim, B., Lionakis, M. S., et al. (2021) · Science Immunology · doi:10.1126/sciimmunol.abf2489 · Cited by 171 · see citing works

Surface Proteins ofStaphylococcus aureus

Foster, T. J. (2019) · Microbiology Spectrum · doi:10.1128/microbiolspec.gpp3-0046-2018 · Cited by 160 · see citing works

Hide and Seek: Nanomaterial Interactions With the Immune System

Fadeel, B. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00133 · Cited by 145 · see citing works

Characterization of the interactions of chemically-modified therapeutic nucleic acids with plasma proteins using a fluorescence polarization assay

Gaus, H. J., Gupta, R., Chappell, A. E., Østergaard, M. E., Swayze, E. E., & Seth, P. P. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky1260 · Cited by 144 · see citing works

The Complement System and Preeclampsia

Regal, J. F., Burwick, R. M., & Fleming, S. D. (2017) · Current Hypertension Reports · doi:10.1007/s11906-017-0784-4 · Cited by 117 · see citing works

Complement C3-Targeted Gene Therapy Restricts Onset and Progression of Neurodegeneration in Chronic Mouse Glaucoma

Bosco, A., Anderson, S., Breen, K., Romero, C. O., Steele, M. R., Chiodo, V. A., Boye, S. L., Hauswirth, W. W., Tomlinson, S., & Vetter, M. L. (2018) · Molecular Therapy · doi:10.1016/j.ymthe.2018.08.017 · Cited by 110 · see citing works

The complement cascade in the regulation of neuroinflammation, nociceptive sensitization, and pain

Warwick, C. A., Keyes, A. L., Woodruff, T. M., & Usachev, Y. M. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101085 · Cited by 112 · see citing works

Complement Component C1q: Historical Perspective of a Functionally Versatile, and Structurally Unusual, Serum Protein

Reid, K. B. M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00764 · Cited by 102 · see citing works

Complement-Mediated Events in Alzheimer’s Disease: Mechanisms and Potential Therapeutic Targets

Tenner, A. J. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.1901068 · Cited by 99 · see citing works

Complement in the Brain: Contributions to Neuroprotection, Neuronal Plasticity, and Neuroinflammation

Bohlson, S. S., & Tenner, A. J. (2023) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101921-035639 · Cited by 101 · see citing works

Complement Nomenclature—Deconvoluted

Bohlson, S. S., Garred, P., Kemper, C., & Tenner, A. J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01308 · Cited by 97 · see citing works

The C1q Receptors: Focus on gC1qR/p33 (C1qBP, p32, HABP-1)1.

Ghebrehiwet, B., Geisbrecht, B., Xu, X., Savitt, A. G., & Peerschke, E. (2019) · Seminars in Immunology · doi:10.1016/j.smim.2019.101338 · Cited by 76 · see citing works

HMGB1–C1q complexes regulate macrophage function by switching between leukotriene and specialized proresolving mediator biosynthesis

Liu, T., Xiang, A., Peng, T., Doran, A. C., Tracey, K. J., Barnes, B. J., Tabas, I. A., Son, M., & Diamond, B. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1907490116 · Cited by 93 · see citing works

The role of mitochondria in rheumatic diseases

Becker, Y. L. C., Duvvuri, B., Fortin, P. R., Lood, C., & Boilard, E. (2022) · Nature Reviews Rheumatology · doi:10.1038/s41584-022-00834-z · Cited by 81 · see citing works

Complement in breast milk modifies offspring gut microbiota to promote infant health

Xu, D., Zhou, S., Liu, Y., Scott, A. L., Yang, J., & Wan, F. (2024) · Cell · doi:10.1016/j.cell.2023.12.019 · Cited by 88 · see citing works

Status epilepticus triggers long-lasting activation of complement C1q-C3 signaling in the hippocampus that correlates with seizure frequency in experimental epilepsy

Schartz, N. D., Wyatt‐Johnson, S. K., Price, L. R., Colin, S. A., & Brewster, A. L. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.10.012 · Cited by 87 · see citing works

Contribution of adaptive immunity to human COPD and experimental models of emphysema

Kheradmand, F., Zhang, Y., & Corry, D. B. (2022) · Physiological Reviews · doi:10.1152/physrev.00036.2021 · Cited by 87 · see citing works

Be on Target: Strategies of Targeting Alternative and Lectin Pathway Components in Complement-Mediated Diseases

Dobó, J., Kocsis, A., & Gál, P. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01851 · Cited by 83 · see citing works

Surface loops of trypsin-like serine proteases as determinants of function

Goettig, P., Brandstetter, H., & Magdolen, V. (2019) · Biochimie · doi:10.1016/j.biochi.2019.09.004 · Cited by 83 · see citing works

Is the Complement Protein C1q a Pro- or Anti-tumorigenic Factor? Bioinformatics Analysis Involving Human Carcinomas

Mangogna, A., Agostinis, C., Bonazza, D., Belmonte, B., Zacchi, P., Zito, G., Romano, A., Zanconati, F., Ricci, G., Kishore, U., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00865 · Cited by 72 · see citing works

The Immunopathology of Complement Proteins and Innate Immunity in Autoimmune Disease

Defendi, F., Thielens, N. M., Clavarino, G., Cesbron, J.-Y., & Dumestre‐Pérard, C. (2019) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-019-08774-5 · Cited by 70 · see citing works

Soluble defense collagens: Sweeping up immune threats

Casals, C., García-Fojeda, B., & Minutti, C. M. (2019) · Molecular Immunology · doi:10.1016/j.molimm.2019.06.007 · Cited by 68 · see citing works

Targeting Microglia to Treat Degenerative Eye Diseases

Wang, S. K., & Cepko, C. L. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.843558 · Cited by 64 · see citing works

Role of intracellular complement activation in kidney fibrosis

Portilla, D., & Xavier, S. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15408 · Cited by 59 · see citing works

The complement system in neurodegenerative diseases

Nimmo, J., Byrne, R. A. J., Daskoulidou, N., Watkins, L. M., Carpanini, S. M., Zelek, W. M., & Morgan, B. P. (2024) · Clinical Science · doi:10.1042/cs20230513 · Cited by 59 · see citing works

CD38, CD157, and RAGE as Molecular Determinants for Social Behavior

Higashida, H., Hashii, M., Tanaka, Y., Matsukawa, S., Higuchi, Y., Gabata, R., Tsubomoto, M., Seishima, N., Teramachi, M., Kamijima, T., et al. (2019) · Cells · doi:10.3390/cells9010062 · Cited by 58 · see citing works

Circulating C1q levels in health and disease, more than just a biomarker

van de Bovenkamp, F. S., Dijkstra, D. J., van Kooten, C., Gelderman, K. A., & Trouw, L. A. (2021) · Molecular Immunology · doi:10.1016/j.molimm.2021.10.010 · Cited by 57 · see citing works

The influence of shape and charge on protein corona composition in common gold nanostructures

Bewersdorff, T., Glitscher, E. A., Bergueiro, J., Eravci, M., Miceli, E., Haase, A., & Calderón, M. (2020) · Materials Science and Engineering C · doi:10.1016/j.msec.2020.111270 · Cited by 57 · see citing works

Resolution therapy: Harnessing efferocytic macrophages to trigger the resolution of inflammation

Saas, P., Vetter, M., Maraux, M., Bonnefoy, F., & Perruche, S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1021413 · Cited by 52 · see citing works

Microglia Regulate Pruning of Specialized Synapses in the Auditory Brainstem

Milinkeviciute, G., Henningfield, C. M., Muniak, M. A., Chokr, S. M., Green, K. N., & Cramer, K. S. (2019) · Frontiers in Neural Circuits · doi:10.3389/fncir.2019.00055 · Cited by 51 · see citing works

Complement's favourite organelle—Mitochondria?

Rahman, J., Singh, P., Merle, N. S., Niyonzima, N., & Kemper, C. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15238 · Cited by 49 · see citing works

Making the Correct Diagnosis in Thrombotic Microangiopathy: A Narrative Review

McFarlane, P., Bitzan, M. M., Broome, C. M., Baran, D., Garland, J. S., Girard, L., Grewal, K. S., Lapeyraque, A., Patriquin, C. J., Pavenski, K., et al. (2021) · Canadian Journal of Kidney Health and Disease · doi:10.1177/20543581211008707 · Cited by 50 · see citing works

Ocular Dominance Plasticity in Binocular Primary Visual Cortex Does Not Require C1q

Welsh, C. A., Stephany, C.-É., Sapp, R. W., & Stevens, B. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.1011-19.2019 · Cited by 49 · see citing works

Precise Delineation and Transcriptional Characterization of Bovine Blood Dendritic-Cell and Monocyte Subsets

Talker, S. C., Baumann, A., Barut, G. T., Keller, I., Bruggmann, R., & Summerfield, A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02505 · Cited by 49 · see citing works

Highly modified and immunoactive N-glycans of the canine heartworm

Martini, F., Eckmair, B., Štefanić, S., Jin, C., Garg, M., Yan, S., Jiménez-Castells, C., Hykollari, A., Neupert, C., Venco, L., et al. (2019) · Nature Communications · doi:10.1038/s41467-018-07948-7 · Cited by 48 · see citing works

Role of local complement activation in kidney fibrosis and repair

Portilla, D., Sabapathy, V., & Chauss, D. (2025) · Journal of Clinical Investigation · doi:10.1172/jci188345 · Cited by 46 · see citing works

Is there a link between genetic defects in the complement cascade and Porphyromonas gingivalis in Alzheimer’s disease?

Olsen, I., & Singhrao, S. K. (2019) · Journal of Oral Microbiology · doi:10.1080/20002297.2019.1676486 · Cited by 47 · see citing works

Cigarette smoke–induced reduction of C1q promotes emphysema

Yuan, X., Chang, C.-Y., You, R., Shan, M., Gu, B. H., Madison, M. C., Diehl, G. E., Perusich, S., Song, L., Cornwell, L. D., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.124317 · Cited by 45 · see citing works

Utilization of Biomarkers in Lupus Nephritis

Caster, D. J., & Powell, D. W. (2019) · Advances in Chronic Kidney Disease · doi:10.1053/j.ackd.2019.09.001 · Cited by 45 · see citing works

Increased serum levels of complement C1q in major depressive disorder

Yao, Q., & Li, Y. (2020) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2020.110105 · Cited by 42 · see citing works

Neuroprotective versus Neuroinflammatory Roles of Complement: From Development to Disease

Kanmogne, M., & Klein, R. S. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2020.10.003 · Cited by 41 · see citing works

Understanding the contextual functions of C1q and LAIR-1 and their applications

Son, M. (2022) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00774-4 · Cited by 42 · see citing works

Knowing the enemy: strategic targeting of complement to treat Alzheimer disease

Tenner, A. J., & Petrisko, T. J. (2025) · Nature Reviews Neurology · doi:10.1038/s41582-025-01073-y · Cited by 44 · see citing works

Macrophages regulate gastrointestinal motility through complement component 1q

Pendse, M., Selle, H. D., Võ, N. H., Quinn, G. M., Dende, C., Li, Y., Salinas, C. N., Srinivasan, T., Propheter, D. C., Crofts, A. A., et al. (2023) · eLife · doi:10.7554/elife.78558 · Cited by 36 · see citing works

Intracortical Administration of the Complement C3 Receptor Antagonist Trifluoroacetate Modulates Microglia Reaction after Brain Injury

Surugiu, R., Cătălin, B., Dumbrava, D., Greșiță, A., Olaru, D. G., Hermann, D. M., & Popa-Wagner, A. (2019) · Neural Plasticity · doi:10.1155/2019/1071036 · Cited by 38 · see citing works

The Classical Complement Pathway Is Required to Control Borrelia burgdorferi Levels During Experimental Infection

Zhi, H., Xie, J., & Skare, J. T. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00959 · Cited by 34 · see citing works

Potent TRIM21 and complement-dependent intracellular antiviral immunity requires the IgG3 hinge

Foss, S., Jonsson, A., Bottermann, M., Watkinson, R., Lode, H. E., McAdam, M. B., Michaelsen, T. E., Sandlie, I., James, L. C., & Andersen, J. T. (2022) · Science Immunology · doi:10.1126/sciimmunol.abj1640 · Cited by 33 · see citing works

Genomic Mapping Identifies Mutations in RYR2 and AHNAK as Associated with Favorable Outcome in Basal-Like Breast Tumors Expressing PD1/PD-L1

Cimas, F. J., Manzano, A., Baliu‐Piqué, M., García, E. G., Pérez‐Segura, P., Nagy, Á. M., Pandiella, A., Győrffy, B., & Ocaña, A. (2020) · Cancers · doi:10.3390/cancers12082243 · Cited by 32 · see citing works

C1q inhibits differentiation of oligodendrocyte progenitor cells via Wnt/β-catenin signaling activation in a cuprizone-induced mouse model of multiple sclerosis

Gao, Z., Zhang, C., Feng, Z., Liu, Z., Yang, Y., Yang, K., Chen, L., & Yao, R. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113947 · Cited by 32 · see citing works

Complement protein C1q activates lung fibroblasts and exacerbates silica-induced pulmonary fibrosis in mice

Ogawa, T., Shichino, S., Ueha, S., Ogawa, S., & Matsushima, K. (2022) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2022.02.090 · Cited by 30 · see citing works

Functional and Structural Characterization of a Potent C1q Inhibitor Targeting the Classical Pathway of the Complement System

Laursen, N. S., Pedersen, D. V., Gytz, H., Zarantonello, A., Jensen, J. M. B., Hansen, A. G., Thiel, S., & Andersen, G. R. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01504 · Cited by 30 · see citing works

Efferocytosis of vascular cells in cardiovascular disease

Cabrera, J. T. O., & Makino, A. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107919 · Cited by 31 · see citing works

Persistent Intracellular Staphylococcus aureus in Keratinocytes Lead to Activation of the Complement System with Subsequent Reduction in the Intracellular Bacterial Load

Abu-Humaidan, A. H. A., Elvén, M., Sonesson, A., Garred, P., & Sørensen, O. E. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00396 · Cited by 31 · see citing works

Is primary membranous nephropathy a complement mediated disease?

Reinhard, L., Stahl, R. A. K., & Hoxha, E. (2020) · Molecular Immunology · doi:10.1016/j.molimm.2020.10.017 · Cited by 30 · see citing works

The collagen structure of C1q induces wound healing by engaging discoidin domain receptor 2

Hayuningtyas, R. A., Han, M., Choi, S., Kwak, M. S., Park, I. H., Lee, J.-H., Choi, J. E., Kim, D. K., Son, M., & Shin, J. (2021) · Molecular Medicine · doi:10.1186/s10020-021-00388-y · Cited by 29 · see citing works

Cation−π Interactions and Their Role in Assembling Collagen Triple Helices

Cole, C. C., Misiura, M. M., Hulgan, S. A. H., Peterson, C. M., Williams, J. W., Kolomeisky, A. B., & Hartgerink, J. D. (2022) · Biomacromolecules · doi:10.1021/acs.biomac.2c00856 · Cited by 29 · see citing works

Trichinella spiralis Calreticulin S-Domain Binds to Human Complement C1q to Interfere With C1q-Mediated Immune Functions

Shao, S., Hao, C., Zhan, B., Zhuang, Q., Zhao, L., Chen, Y., Huang, J., & Zhu, X. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.572326 · Cited by 28 · see citing works

The role of complement in the tumor microenvironment

Ain, D., Shaikh, T., Manimala, S., & Ghebrehiwet, B. (2021) · Faculty Reviews · doi:10.12703/r/10-80 · Cited by 26 · see citing works

The relevance of complement in pemphigoid diseases: A critical appraisal

Papara, C., Karsten, C. M., Ujiie, H., Schmidt, E., Schmidt‐Jiménez, L. F., Baican, A. L., Freire, P. C., Izumi, K., Bieber, K., Peipp, M., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.973702 · Cited by 26 · see citing works

Surface antibody changes protein corona both in human and mouse serum but not final opsonization and elimination of targeted polymeric nanoparticles

Capolla, S., Colombo, F., Maso, L. D., Mauro, P., Bertoncin, P., Kähne, T., Engler, A., Núñez, L., Spretz, R., Larsen, G. F., et al. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-02134-4 · Cited by 25 · see citing works

Molecular and Cellular Interactions of Scavenger Receptor SR-F1 With Complement C1q Provide Insights Into Its Role in the Clearance of Apoptotic Cells

Wicker‐Planquart, C., Dufour, S., Tacnet‐Delorme, P., Bally, I., Delneste, Y., Frachet, P., Housset, D., & Thielens, N. M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00544 · Cited by 25 · see citing works

Complement as a powerful “influencer” in the brain during development, adulthood and neurological disorders

Petrisko, T. J., Gómez-Arboledas, Á., & Tenner, A. J. (2021) · Advances in immunology · doi:10.1016/bs.ai.2021.09.003 · Cited by 22 · see citing works

Hollow Octadecameric Self-Assembly of Collagen-like Peptides

Yu, L. T., Hancu, M. C., Kreutzberger, M. A. B., Henrickson, A., Demeler, B., Egelman, E. H., & Hartgerink, J. D. (2023) · Journal of the American Chemical Society · doi:10.1021/jacs.2c12931 · Cited by 24 · see citing works

The cholesteryl ester transfer protein (CETP) raises cholesterol levels in the brain

Oestereich, F., Yousefpour, N., Yang, E., Phénix, J., Nezhad, Z. S., Nitu, A., Cobá, A. V., Ribeiro‐da‐Silva, A., Chaurand, P., & Munter, L. M. (2022) · Journal of Lipid Research · doi:10.1016/j.jlr.2022.100260 · Cited by 23 · see citing works

C1q and Mannose-Binding Lectin Interact with CR1 in the Same Region on CCP24-25 Modules

Jacquet, M., Cioci, G., Fouët, G., Bally, I., Thielens, N. M., Gaboriaud, C., & Rossi, V. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00453 · Cited by 23 · see citing works

Complement C1r serine protease contributes to kidney fibrosis

Xavier, S., Sahu, R. K., Bontha, S. V., Mas, V., Taylor, R. P., Megyesi, J. K., Thielens, N. M., & Portilla, D. (2019) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00357.2019 · Cited by 24 · see citing works

CX3CR1 + Macrophage Facilitates the Resolution of Allergic Lung Inflammation via Interacting CCL26

Moon, H., Kim, S.-J., Kim, K.-H., Kim, Y.-M., Rehman, J., Lee, H., Wu, Y.-C., Lee, S. Y., Christman, J. W., Ackerman, S. J., et al. (2023) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202209-1670oc · Cited by 22 · see citing works

The systematic identification and mRNA expression profiles post viral or bacterial challenge of complement system in grass carp Ctenopharyngodon idella

Liao, Z., Wan, Q., Yuan, G., & Su, J. (2018) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2018.11.032 · Cited by 23 · see citing works

Molecular Basis of Complement C1q Collagen-Like Region Interaction with the Immunoglobulin-Like Receptor LAIR-1

Fouët, G., Bally, I., Chouquet, A., Reiser, J., Thielens, N. M., Gaboriaud, C., & Rossi, V. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105125 · Cited by 23 · see citing works

Recombinant C1q variants modulate macrophage responses but do not activate the classical complement pathway

Espericueta, V., Manughian-Peter, A. O., Bally, I., Thielens, N. M., & Fraser, D. A. (2019) · Molecular Immunology · doi:10.1016/j.molimm.2019.10.008 · Cited by 22 · see citing works

Complement System and Alarmin HMGB1 Crosstalk: For Better or Worse

Gaboriaud, C., Lorvellec, M., Rossi, V., Dumestre‐Pérard, C., & Thielens, N. M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.869720 · Cited by 23 · see citing works

Initiators of Classical and Lectin Complement Pathways Are Differently Engaged after Traumatic Brain Injury—Time-Dependent Changes in the Cortex, Striatum, Thalamus and Hippocampus in a Mouse Model

Ciechanowska, A., Ciapała, K., Pawlik, K., Oggioni, M., Mercurio, D., Simoni, M.-G. D., & Mika, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010045 · Cited by 21 · see citing works

C1q, a small molecule with high impact on brain development: putative role for aging processes and the occurrence of Alzheimer’s disease

Rupprecht, C., Rupprecht, R., & Rammes, G. (2021) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-021-01273-9 · Cited by 21 · see citing works

HIV Tat causes synapse loss in a mouse model of HIV‐associated neurocognitive disorder that is independent of the classical complement cascade component C1q

Hammond, J. W., Qiu, W. Q., Marker, D. F., Chamberlain, J. M., Greaves‐Tunnell, W., Bellizzi, M. J., Lu, S., & Gelbard, H. A. (2018) · Glia · doi:10.1002/glia.23511 · Cited by 20 · see citing works

ADAM28: Another ambivalent protease in cancer

Hubeau, C., Rocks, N., & Cataldo, D. D. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.08.031 · Cited by 20 · see citing works

Systematic Review and Meta-Analysis on MS-Based Proteomics Applied to Human Peripheral Fluids to Assess Potential Biomarkers of Bipolar Disorder

Rodrigues, J. E., Martinho, A., Santos, V., Santa, C., Madeira, N. G. G. F., Martins, M. J., Pato, C. N., Macedo, A., & Manadas, B. J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105460 · Cited by 21 · see citing works

Effects of Surface-Bound Collagen-Mimetic Peptides on Macrophage Uptake and Immunomodulation

Rowley, A. T., Meli, V. S., Wu-Woods, N. J., Chen, E. Y., Liu, W. F., & Wang, S. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00747 · Cited by 20 · see citing works

A novel C1qDC (PoC1qDC) with a collagen domain in Paralichthys olivaceus mediates complement activation and against bacterial infection

Li, M.-F., Zhang, H., & Sun, J. (2022) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2022.108472 · Cited by 19 · see citing works

Systemic and pulmonary C1q as biomarker of progressive disease in experimental non-human primate tuberculosis

Dijkman, K., Lubbers, R., Borggreven, N. V., Ottenhoff, T. H. M., Joosten, S. A., Trouw, L. A., & Verreck, F. A. W. (2020) · Scientific Reports · doi:10.1038/s41598-020-63041-4 · Cited by 19 · see citing works

Nanobodies Provide Insight into the Molecular Mechanisms of the Complement Cascade and Offer New Therapeutic Strategies

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Microarray-based analysis of renal complement components reveals a therapeutic target for lupus nephritis

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