Woodruff, Trent M.

Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice

Gordon, R., Albornoz, E. A., Christie, D. C., Langley, M. R., Kumar, V., Mantovani, S., Robertson, A. A. B., Butler, M. S., Rowe, D. B., O’Neill, L. A., et al. (2018) · Science Translational Medicine

Parkinson's Disease Mechanisms and TreatmentsInflammasome and immune disorders

Cited by 897

Treatment with a C5aR Antagonist Decreases Pathology and Enhances Behavioral Performance in Murine Models of Alzheimer’s Disease

Fonseca, M. I., Ager, R. R., Chu, S.-H., Yazan, O., Sanderson, S. D., LaFerla, F. M., Taylor, S. M., Woodruff, T. M., & Tenner, A. J. (2009) · The Journal of Immunology

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 268

The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins

Deora, V., Lee, J. D., Albornoz, E. A., McAlary, L., Jagaraj, C. J., Robertson, A. A. B., Atkin, J. D., Cooper, M. A., Schroder, K., Yerbury, J. J., et al. (2020) · Glia

Inflammasome and immune disordersNeuroinflammation and Neurodegeneration Mechanisms

Cited by 245

Dendritic cell function in allostimulation is modulated by C5aR signaling

Peng, Q., Li, K., Wang, N., Li, Q., Asgari, E., Lu, B., Woodruff, T. M., Sacks, S. H., & Zhou, W. (2009) · The Journal of Immunology

Immunotherapy and Immune ResponsesImmune Response and Inflammation

Cited by 116

Absence of toll-like receptor 4 (TLR4) extends survival in the hSOD1G93A mouse model of amyotrophic lateral sclerosis

Lee, J. Y., Lee, J. D., Phipps, S., Noakes, P. G., & Woodruff, T. M. (2015) · Journal of Neuroinflammation

Amyotrophic Lateral Sclerosis ResearchNeuroinflammation and Neurodegeneration Mechanisms

Cited by 89

Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology

Aguado, J., Amarilla, A. A., Taherian Fard, A., Albornoz, E. A., Tyshkovskiy, A., Schwabenland, M., Chaggar, H. K., Modhiran, N., Gómez-Inclán, C., Javed, I., et al. (2023) · Nature Aging

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 80

Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology

Aguado, J., Amarilla, A. A., Taherian Fard, A., Albornoz, E. A., Tyshkovskiy, A., Schwabenland, M., Chaggar, H. K., Modhiran, N., Gómez-Inclán, C., Javed, I., et al. (2023) · Nature Aging

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 80

Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology

Aguado, J., Amarilla, A., Fard, A. T., Albornoz, E., Tyshkovskiy, A., Schwabenland, M., Chaggar, H., Modhiran, N., Gómez-Inclán, C., Javed, I., et al. (2023) · Nature Aging

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 80

C5aR2 Activation Broadly Modulates the Signaling and Function of Primary Human Macrophages

Li, X. X., Clark, R. J., & Woodruff, T. M. (2020) · The Journal of Immunology

Complement system in diseasesImmune Response and Inflammation

Cited by 62

Gut microbiota in ALS: possible role in pathogenesis?

McCombe, P. A., Henderson, R. D., Lee, A., Lee, J. D., Woodruff, T. M., Restuadi, R., McRae, A., Wray, N. R., Ngo, S., & Steyn, F. J. (2019) · Expert Review of Neurotherapeutics

Gut microbiota and healthAmyotrophic Lateral Sclerosis Research

Cited by 46

Absence of Receptor for Advanced Glycation End Product (RAGE) Reduces Inflammation and Extends Survival in the hSOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis

Lee, J. D., McDonald, T. S., Fung, J. N. T., & Woodruff, T. M. (2020) · Molecular Neurobiology

Amyotrophic Lateral Sclerosis ResearchAdvanced Glycation End Products research

Cited by 35

A Commentary On: “NFκB-Activated Astroglial Release of Complement C3 Compromises Neuronal Morphology and Function Associated with Alzheimer’s Disease”. A cautionary note regarding C3aR

Woodruff, T. M., & Tenner, A. J. (2015) · Frontiers in Immunology

Neuroinflammation and Neurodegeneration MechanismsComplement system in diseases

Cited by 26