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The C5a/C5aR2 axis promotes renal inflammation and tissue damage

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Complement Alternative Pathway Deficiency in Recipients Protects Kidney Allograft From Ischemia/Reperfusion Injury and Alloreactive T Cell Response

Casiraghi, F., Azzollini, N., Todeschini, M., Fiori, S., Cavinato, R. A., Cassis, P., Solini, S., Pezzuto, F., Mister, M., Thurman, J. M., et al. (2017) · American Journal of Transplantation · doi:10.1111/ajt.14262 · Cited by 48 · see citing works

Molecular mechanisms of the antitumor effects of anti-CD20 antibodies

Winiarska, M. (2010) · Frontiers in bioscience · doi:10.2741/3688 · Cited by 46 · see citing works

Bruch’s Membrane: A Key Consideration with Complement-Based Therapies for Age-Related Macular Degeneration

Hammadi, S., Tzoumas, N., Ferrara, M., Meschede, I. P., Lo, K., Harris, C., Lako, M., & Steel, D. H. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12082870 · Cited by 44 · see citing works

C5aR1 promotes acute pyelonephritis induced by uropathogenic E. coli

Li, K., Wu, K., Wu, W., Wang, N., Zhang, T., Choudhry, N., Song, Y., Farrar, C. A., Ma, L., Wei, L., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.97626 · Cited by 44 · see citing works

Complement Regulation of T-Cell Alloimmunity

Cravedi, P., van der Touw, W., & Heeger, P. S. (2013) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2013.08.007 · Cited by 40 · see citing works

The complement system, toll-like receptors and inflammasomes in host defense: three musketeers’ one target

Kumar, V. (2019) · International Reviews of Immunology · doi:10.1080/08830185.2019.1609962 · Cited by 39 · see citing works

Properdin and factor H production by human dendritic cells modulates their T‐cell stimulatory capacity and is regulated by IFN‐γ

Dixon, K. O., O'Flynn, J., Klar‐Mohamad, N., Daha, M. R., & van Kooten, C. (2017) · European Journal of Immunology · doi:10.1002/eji.201646703 · Cited by 38 · see citing works

Bacillus anthracis Spore Surface Protein BclA Mediates Complement Factor H Binding to Spores and Promotes Spore Persistence

Wang, Y., Jenkins, S. A., Gu, C., Shree, A., Martinez-Moczygemba, M., Herold, J., Botto, M., Wetsel, R. A., & Xu, Y. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005678 · Cited by 38 · see citing works

C5a receptor signalling in dendritic cells controls the development of maladaptive Th2 and Th17 immunity in experimental allergic asthma

Schmudde, I., Ströver, H. A., Vollbrandt, T., König, P., Karsten, C. M., Laumonnier, Y., & Köhl, J. (2012) · Mucosal Immunology · doi:10.1038/mi.2012.119 · Cited by 37 · see citing works

Immunoglobulin M: Restrainer of Inflammation and Mediator of Immune Evasion by Plasmodium falciparum Malaria

Pleass, R. J., Moore, S. C., Stevenson, L., & Hviid, L. (2015) · Trends in Parasitology · doi:10.1016/j.pt.2015.09.007 · Cited by 36 · see citing works

Transcriptional profiling reveals functional dichotomy between human slan+ non-classical monocytes and myeloid dendritic cells

van Leeuwen-Kerkhoff, N., Lundberg, K., Westers, T. M., Kordasti, S. Y., Bontkes, H. J., de Gruijl, T. D., Lindstedt, M., & van de Loosdrecht, A. A. (2017) · Journal of Leukocyte Biology · doi:10.1189/jlb.3ma0117-037r · Cited by 36 · see citing works

Targeting Complement at the Time of Transplantation

Sacks, S. H., Karegli, J., Farrar, C. A., Asgari, E., Schwaeble, W., Zhou, W., & Smith, R. A. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-4118-2_17 · Cited by 36 · see citing works

C5a and Bradykinin Receptor Cross-Talk Regulates Innate and Adaptive Immunity in Trypanosoma cruzi Infection

Schmitz, V., de Almeida, L. N., Svensjö, E., Monteiro, A. C., Köhl, J., & Scharfstein, J. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302417 · Cited by 35 · see citing works

Crosstalk between Toll like receptors and C5a receptor in human monocyte derived DCs suppress inflammatory cytokine production

Zaal, A., Lissenberg-Thunnissen, S. N., van Schijndel, G., Wouters, D., Ham, S. M. V., & ten Brinke, A. (2013) · Immunobiology · doi:10.1016/j.imbio.2012.02.014 · Cited by 33 · see citing works

γδT-cell function in sepsis is modulated by C5a receptor signalling

Han, G., Geng, S., Li, Y., Chen, G., Wang, R., Li, X., Ma, Y., Shen, B., & Li, Y. (2011) · Immunology · doi:10.1111/j.1365-2567.2011.03445.x · Cited by 32 · see citing works

Innate and adaptive immunologic functions of complement in the host response to Listeria monocytogenes infection

Calame, D. G., Mueller‐Ortiz, S. L., & Wetsel, R. A. (2016) · Immunobiology · doi:10.1016/j.imbio.2016.07.004 · Cited by 31 · see citing works

Mechanisms of rejection

Farrar, C. A., & Sacks, S. H. (2013) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0000000000000037 · Cited by 29 · see citing works

Transgenic expression of human CD 46: does it reduce the primate T‐cell response to pig endothelial cells?

Ezzelarab, M. B., Ayares, D., & Cooper, D. K. C. (2015) · Xenotransplantation · doi:10.1111/xen.12209 · Cited by 28 · see citing works

Dendritic cells of myeloid lineage

Morelli, A. E. (2013) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0000000000000039 · Cited by 27 · see citing works

Complement C5a Regulates Prolabor Mediators in Human Placenta1

Lappas, M., Woodruff, T. M., Taylor, S. M., & Permezel, M. (2012) · Biology of Reproduction · doi:10.1095/biolreprod.111.098475 · Cited by 26 · see citing works

Combination of a TLR4 ligand and anaphylatoxin C5a for the induction of antigen-specific cytotoxic T cell responses

Rudilla, F., Fayolle, C., Casares, N., Durántez, M., Arribillaga, L., Lozano, T., Villanueva, L., Pı́o, R., Sarobe, P., Leclerc, C., et al. (2012) · Vaccine · doi:10.1016/j.vaccine.2012.02.052 · Cited by 25 · see citing works

Glutamine Modulates Sepsis-Induced Changes to Intestinal Intraepithelial γδT Lymphocyte Expression in Mice

Lee, W.-Y., Hu, Y., Ko, T.-L., Yeh, S., & Yeh, C. (2012) · Shock · doi:10.1097/shk.0b013e3182655932 · Cited by 24 · see citing works

Glutamine modulates CD8αα+ TCRαβ+ intestinal intraepithelial lymphocyte expression in mice with polymicrobial sepsis

Tung, J.-N., Lee, W.-Y., Pai, M., Chen, W.-J., Yeh, C., & Yeh, S. (2013) · Nutrition · doi:10.1016/j.nut.2013.01.001 · Cited by 22 · see citing works

Differential regulation of C5a receptor 1 in innate immune cells during the allergic asthma effector phase

Ender, F., Wiese, A. V., Schmudde, I., Sun, J., Vollbrandt, T., König, P., Laumonnier, Y., & Köhl, J. (2017) · PLoS ONE · doi:10.1371/journal.pone.0172446 · Cited by 22 · see citing works

Complement regulation of T-cell alloimmunity

Raedler, H., & Heeger, P. S. (2010) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0b013e3283425419 · Cited by 22 · see citing works

The diverging roles of dendritic cells in kidney allotransplantation

Podestà, M. A., Cucchiari, D., & Ponticelli, C. E. (2015) · Transplantation Reviews · doi:10.1016/j.trre.2015.04.001 · Cited by 21 · see citing works

Association of complement 5 genetic polymorphism with renal allograft outcomes in Korea

Jeong, J. C., Hwang, Y., Kim, H., Ro, H., Park, H. C., Kim, Y. J., Kim, M.-G., Ha, J., Park, M. H., Chae, D., et al. (2011) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfr025 · Cited by 21 · see citing works

Complement Receptor 3 Has Negative Impact on Tumor Surveillance through Suppression of Natural Killer Cell Function

Liu, C.-F., Min, X.-Y., Wang, N., Wang, J., Ma, N., Dong, X., Zhang, B., Wu, W., Li, Z., Zhou, W., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01602 · Cited by 20 · see citing works

Differential effects of anaphylatoxin C5a on antigen presenting cells, roles for C5aR1 and C5aR2

Zaal, A., van Ham, S. M., & ten Brinke, A. (2019) · Immunology Letters · doi:10.1016/j.imlet.2019.03.014 · Cited by 20 · see citing works

Emerging role of the mannose-binding lectin-dependent pathway of complement activation in clinical organ transplantation

Berger, S. P., & Daha, M. R. (2010) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0b013e3283425509 · Cited by 20 · see citing works

Differential capacity for complement receptor‐mediated immune evasion by Porphyromonas gingivalis depending on the type of innate leukocyte

Hajishengallis, G., Krauss, J. L., Jotwani, R., & Lambris, J. D. (2016) · Molecular Oral Microbiology · doi:10.1111/omi.12161 · Cited by 20 · see citing works

An Essential Role for C5aR Signaling in the Optimal Induction of a Malaria-Specific CD4+ T Cell Response by a Whole-Killed Blood-Stage Vaccine

Liu, T., Xu, G., Guo, B., Fu, Y., Qiu, Y., Ding, Y. P., Zheng, H., Fu, X., Wu, Y., & Xu, W. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1201190 · Cited by 19 · see citing works

Cell-intrinsic C5a synergizes with Dectin-1 in macrophages to mediate fungal killing

Li, X. X., Fung, J. N., Clark, R. J., Lee, J. D., & Woodruff, T. M. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2314627121 · Cited by 18 · see citing works

C5a/C5aR1 mediates IMQ‐induced psoriasiform skin inflammation by promoting IL‐17A production from γδ‐T cells

Zheng, Q., Xu, F., Yang, Y., Sun, D., Zhong, Y., Wu, S., Li, G., Gao, W., Wang, T., Xu, G., et al. (2020) · The FASEB Journal · doi:10.1096/fj.202000384r · Cited by 18 · see citing works

Complement regulates conventional DC ‐mediated NK ‐cell activation by inducing TGF ‐β1 in G r‐1+ myeloid cells

Qing, X., Koo, G. C., & Salmon, J. E. (2012) · European Journal of Immunology · doi:10.1002/eji.201142290 · Cited by 17 · see citing works

Complement factor and T-cell interactions during alloimmune inflammation in transplantation

Khan, M. A., & Shamma, T. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.5ru0718-288r · Cited by 17 · see citing works

Old game, new players: Linking classical theories to new trends in transplant immunology

da Silva, M. D., da Cunha, F. F., Terra, F., & Câmara, N. (2017) · World journal of transplantation · doi:10.5500/wjt.v7.i1.1 · Cited by 17 · see citing works

The relationship of anti-phospholipase A2 receptor antibody and C5a complement with disease activity and short-term outcome in idiopathic membranous nephropathy

Ni, J., Lai, T., Wu, C., Fu, T. Y., Chou, Y., Chiu, Y., Lin, W., Chiang, W., Chen, Y. M., & Wu, M. (2019) · Journal of the Formosan Medical Association · doi:10.1016/j.jfma.2018.12.026 · Cited by 17 · see citing works

Anaphylatoxins in organ transplantation

Li, K., & Zhou, W. (2013) · Seminars in Immunology · doi:10.1016/j.smim.2013.04.013 · Cited by 16 · see citing works

Complement in basic processes of the cell

Jiménez-Reinoso, A., Marín, A. V., & Regueiro, J. R. (2016) · Molecular Immunology · doi:10.1016/j.molimm.2016.11.011 · Cited by 16 · see citing works

TLR4 and C5aR crosstalk in dendritic cells induces a core regulatory network of RSK2, PI3Kβ, SGK1, and FOXO transcription factors

Zaal, A., Nota, B., Moore, K., Dieker, M. C., van Ham, S. M., & ten Brinke, A. (2017) · Journal of Leukocyte Biology · doi:10.1189/jlb.2ma0217-058r · Cited by 16 · see citing works

Glutamine modulates acute dextran sulphate sodium-induced changes in small-intestinal intraepithelial γδ-T-lymphocyte expression in mice

Pai, M., Liu, J., Yeh, S., Chen, W.-J., & Yeh, C. (2013) · British Journal Of Nutrition · doi:10.1017/s0007114513003425 · Cited by 16 · see citing works

Complement—here, there and everywhere, but what about the transplanted organ?

Montero, R., Sacks, S. H., & Smith, R. A. (2016) · Seminars in Immunology · doi:10.1016/j.smim.2016.04.007 · Cited by 15 · see citing works

Anaphylatoxin C5a Regulates 6-Sulfo-LacNAc Dendritic Cell Function in Human through Crosstalk with Toll-Like Receptor-Induced CREB Signaling

Zaal, A., Dieker, M. C., Oudenampsen, M., Turksma, A. W., Lissenberg‐Thunnissen, S. N., Wouters, D., van Ham, S. M., & ten Brinke, A. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00818 · Cited by 14 · see citing works

C5L2 Receptor Represses Brain-Derived Neurotrophic Factor Secretion in Lipoteichoic Acid-Stimulated Pulp Fibroblasts

Chmilewsky, F., About, I., & Chung, S. (2016) · Journal of Dental Research · doi:10.1177/0022034516673832 · Cited by 14 · see citing works

Immunity and Coagulation in COVID-19

Авдонин, П. П., Blinova, M. S., Serkova, A. A., Komleva, L. A., & Avdonin, P. V. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252011267 · Cited by 16 · see citing works

Systematic assessment of the influence of complement gene polymorphisms on kidney transplant outcome

Ermini, L., Weale, M. E., Brown, K., Mesa, I. R., Howell, W. M., Vaughan, R., Chowdhury, P., Sacks, S. H., & Sheerin, N. (2015) · Immunobiology · doi:10.1016/j.imbio.2015.12.006 · Cited by 10 · see citing works

Biomarkers of the Complement System Activation (C3a, C5a, sC5b-9) in Serum of Patients before and after Liver Transplantation

Budkowska, M., Ostrycharz, E., Serwin, N. M., Nazarewski, Ł., Cecerska‐Heryć, E., Poręcka, M., Rykowski, P., Pietrzak, R., Zieniewicz, K., Siennicka, A., et al. (2023) · Biomedicines · doi:10.3390/biomedicines11072070 · Cited by 8 · see citing works

Circulating extracellular vesicles containing S100A9 reflect histopathology, immunophenotype and therapeutic responses of liver metastasis in colorectal cancer patients

Tsamchoe, M., Lazaris, A., Kim, D. H., Krzywoń, L., Bloom, J., Mayer, T. Z., Petrillo, S. K., Dejgaard, K., Gao, Z., Rak, J. W., et al. (2023) · BJC Reports · doi:10.1038/s44276-023-00007-9 · Cited by 8 · see citing works

Complement C5a and C5a receptor 1 mediates glomerular damage in focal segmental glomerulosclerosis

Gong, X., Huang, J., Shu, Y. L., Wang, M., Ji, J., Yang, L., Zhao, M., & Cui, Z. (2025) · Clinical Immunology · doi:10.1016/j.clim.2025.110459 · Cited by 8 · see citing works

Complement C5a: Impact on the field of veterinary medicine

Noor, M. H. M., Shiels, I. A., Rolfe, B. E., & Mills, P. C. (2012) · The Veterinary Journal · doi:10.1016/j.tvjl.2011.12.008 · Cited by 8 · see citing works

Systemic complement activation influences outcomes after allogeneic hematopoietic cell transplantation: A prospective French multicenter trial

Notarantonio, A., D’Aveni, M., Pagliuca, S., Ashraf, Y., Galimard, J., Xhaard, A., Marçais, A., Suárez, F., Brissot, É., Feugier, P., et al. (2023) · American Journal of Hematology · doi:10.1002/ajh.27030 · Cited by 8 · see citing works

Functional modulation of human monocytes derived DCs by anaphylatoxins C3a and C5a

Li, K., Fazekasova, H., Wang, N., Peng, Q., Sacks, S. H., Lombardi, G., & Zhou, W. (2012) · Immunobiology · doi:10.1016/j.imbio.2011.07.033 · Cited by 108 · see citing works

Up‐regulation of C5a receptor expression and function on human monocyte derived dendritic cells by prostaglandin E2

Weinmann, O., Gutzmer, R., Zwirner, J., Wittmann, M., Langer, K., Lisewski, M., Mommert, S., Kapp, A., & Werfel, T. (2003) · Immunology · doi:10.1111/j.1365-2567.2003.01764.x · Cited by 20 · see citing works

TLR4 and C5aR crosstalk in dendritic cells induces a core regulatory network of RSK2, PI3Kβ, SGK1, and FOXO transcription factors

Zaal, A., Nota, B., Moore, K., Dieker, M. C., van Ham, S. M., & ten Brinke, A. (2017) · Journal of Leukocyte Biology · doi:10.1189/jlb.2ma0217-058r · Cited by 16 · see citing works

C5a receptor‐deficient dendritic cells promote induction of Treg and Th17 cells

Weaver, D. J., Reis, E. S., Pandey, M. K., Köhl, G., Harris, N. L., Gerard, C. J., & Köhl, J. (2009) · European Journal of Immunology · doi:10.1002/eji.200939333 · Cited by 124 · see citing works

Anaphylatoxin C5a Regulates 6-Sulfo-LacNAc Dendritic Cell Function in Human through Crosstalk with Toll-Like Receptor-Induced CREB Signaling

Zaal, A., Dieker, M. C., Oudenampsen, M., Turksma, A. W., Lissenberg‐Thunnissen, S. N., Wouters, D., van Ham, S. M., & ten Brinke, A. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00818 · Cited by 14 · see citing works