McKernan, Ruth M.

Which GABAA-receptor subtypes really occur in the brain?

McKernan, R. M., & Whiting, P. J. (1996) · Trends in Neurosciences

Neuroscience and Neuropharmacology ResearchNicotinic Acetylcholine Receptors Study

Cited by 1,222

Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABAA receptor α1 subtype

McKernan, R. M., Rosahl, T. W., Reynolds, D. S., Sur, C., Wafford, K. A., Atack, J. R., Farrar, S., Myers, J., Cook, G., Ferris, P., et al. (2000) · Nature Neuroscience

Neuroscience and Neuropharmacology ResearchNicotinic Acetylcholine Receptors Study

Cited by 944

Enhanced Learning and Memory and Altered GABAergic Synaptic Transmission in Mice Lacking the α5 Subunit of the GABA A Receptor

Collinson, N., Kuenzi, F. M., Jarolimek, W., Maubach, K. A., Cothliff, R., Sur, C., Smith, A., Otu, F. M., Howell, O., Atack, J. R., et al. (2002) · The Journal of Neuroscience

Neuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

Cited by 628

Sedation and Anesthesia Mediated by Distinct GABA A Receptor Isoforms

Reynolds, D. S., Rosahl, T. W., Cirone, J., O'Meara, G. F., Haythornthwaite, A., Newman, R. J., Myers, J., Sur, C., Howell, O., Rutter, A. R., et al. (2003) · The Journal of Neuroscience

Anesthesia and Sedative AgentsNeuroscience and Neuropharmacology Research

Cited by 318

Evidence for a Significant Role of α3-Containing GABAAReceptors in Mediating the Anxiolytic Effects of Benzodiazepines

Dias, R., Sheppard, W. F. A., Fradley, R. L., Garrett, E. M., Stanley, J. L., Tye, S. J., Goodacre, S., Lincoln, R. J., Cook, S. M., Conley, R., et al. (2005) · The Journal of Neuroscience

Neuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

Cited by 247

TPA023 [7-(1,1-Dimethylethyl)-6-(2-ethyl-2 H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine], an Agonist Selective for α2- and α3-Containing GABAA Receptors, Is a Nonsedating Anxiolytic in Rodents and Primates

Atack, J. R., Wafford, K. A., Tye, S. J., Cook, S. M., Sohal, B., Pike, A., Sur, C., Melillo, D., Bristow, L., Bromidge, F., et al. (2006) · The Journal of Pharmacology and Experimental Therapeutics

Neuroscience and Neuropharmacology ResearchPharmacological Receptor Mechanisms and Effects

Cited by 188

Differences in Agonist/Antagonist Binding Affinity and Receptor Transduction Using Recombinant Human γ-Aminobutyric Acid Type A Receptors

Ebert, B., Thompson, S. A., Saounatsou, K., McKernan, R., Krogsgaard-Larsen, P., & Wafford, K. A. (1997) · Molecular Pharmacology

Neuroscience and Neuropharmacology ResearchReceptor Mechanisms and Signaling

Cited by 145

Benzodiazepine Binding Site Occupancy by the Novel GABAA Receptor Subtype-Selective Drug 7-(1,1-Dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine (TPA023) in Rats, Primates, and Humans

Atack, J. R., Wong, D. F., Fryer, T. D., Ryan, C., Sanabria, S., Zhou, Y., Dannals, R. F., Eng, W.-S., Gibson, R. E., Burns, H. D., et al. (2010) · The Journal of Pharmacology and Experimental Therapeutics

Neuroscience and Neuropharmacology ResearchPharmacological Receptor Mechanisms and Effects

Cited by 36

All roads lead to glutamate: NMDA and AMPA receptors as targets for rapid-acting antidepressants

Freudenberg, F., Reif-Leonhard, C., Dawson, G. R., McKernan, R. M., & Reif, A. (2025) · Pharmacological Research

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 23

RAT PHARMACOKINETICS AND PHARMACODYNAMICS OF A SUSTAINED RELEASE FORMULATION OF THE GABAA α5-SELECTIVE COMPOUND L-655,708

Atack, J. R., Pike, A., Clarke, A., Cook, S. M., Sohal, B., McKernan, R. M., & Dawson, G. R. (2006) · Drug Metabolism and Disposition

Neuroscience and Neuropharmacology ResearchPharmacogenetics and Drug Metabolism

Cited by 23