Sedation and Anesthesia Mediated by Distinct GABA A Receptor Isoforms

Molecular and cellular mechanisms of general anaesthesia

Franks, N. P., & Lieb, W. R. (1994) · Nature · doi:10.1038/367607a0 · Cited by 1,786 · see citing works

GABAA receptors: immunocytochemical distribution of 13 subunits in the adult rat brain

Pirker, S., Schwarzer, C., Wieselthaler, A., Sieghart, W., & Sperk, G. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00442-5 · Cited by 1,344 · see citing works

A<i>cre</i>-transgenic mouse strain for the ubiquitous deletion of<i>loxP</i>-flanked gene segments including deletion in germ cells

Schwenk, F., Baron, U., & Rajewsky, K. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.24.5080 · Cited by 1,289 · see citing works

Which GABAA-receptor subtypes really occur in the brain?

McKernan, R. M., & Whiting, P. J. (1996) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)80023-3 · Cited by 1,222 · see citing works

Benzodiazepine actions mediated by specific γ-aminobutyric acidA receptor subtypes

Rudolph, U., Crestani, F., Benke, D., Brünig, I., Benson, J. A., Fritschy, J.-M., Martin, J. R., Bluethmann, H., & Möhler, H. (1999) · Nature · doi:10.1038/44579 · Cited by 1,172 · see citing works

The distribution of thirteen GABAA receptor subunit mRNAs in the rat brain. III. Embryonic and postnatal development

Laurie, D., Wisden, W., & Seeburg, P. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-11-04151.1992 · Cited by 1,144 · see citing works

Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABAA receptor α1 subtype

McKernan, R. M., Rosahl, T. W., Reynolds, D. S., Sur, C., Wafford, K. A., Atack, J. R., Farrar, S., Myers, J., Cook, G., Ferris, P., et al. (2000) · Nature Neuroscience · doi:10.1038/75761 · Cited by 944 · see citing works

The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. II. Olfactory bulb and cerebellum

Laurie, D., Seeburg, P., & Wisden, W. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-03-01063.1992 · Cited by 668 · see citing works

Enhanced Learning and Memory and Altered GABAergic Synaptic Transmission in Mice Lacking the α5 Subunit of the GABA _A Receptor

Collinson, N., Kuenzi, F. M., Jarolimek, W., Maubach, K. A., Cothliff, R., Sur, C., Smith, A., Otu, F. M., Howell, O., Atack, J. R., et al. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-13-05572.2002 · Cited by 628 · see citing works

The sedative component of anesthesia is mediated by GABAA receptors in an endogenous sleep pathway

Nelson, L. E., Guo, T. Z., Lu, J., Saper, C. B., Franks, N. P., & Maze, M. (2002) · Nature Neuroscience · doi:10.1038/nn913 · Cited by 568 · see citing works

General anesthetic actions <i>in vivo</i> strongly attenuated by a point mutation in the GABA _A receptor β3 subunit

Jurd, R., Arrasa, M., Lambert, S., Drexler, B., Siegwart, R., Crestani, F., Zaugg, M., Vogt, K. E., Ledermann, B., Antkowiak, B., et al. (2003) · The FASEB Journal · doi:10.1096/fj.02-0611fje · Cited by 558 · see citing works

Mice devoid of γ-aminobutyrate type A receptor β3 subunit have epilepsy, cleft palate, and hypersensitive behavior

Homanics, G. E., DeLorey, T. M., Firestone, L. L., Quinlan, J. J., Handforth, A., Harrison, N. L., Krasowski, M. D., Rick, C., Korpi, E. R., Mäkelä, R., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.8.4143 · Cited by 469 · see citing works

Mice Lacking the β3Subunit of the GABAAReceptor Have the Epilepsy Phenotype and Many of the Behavioral Characteristics of Angelman Syndrome

DeLorey, T. M., Handforth, A., Anagnostaras, S., Homanics, G. E., Minassian, B. A., Asatourian, A., Fanselow, M. S., Delgado‐Escueta, A. V., Ellison, G., & Olsen, R. W. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-20-08505.1998 · Cited by 459 · see citing works

The interaction of the general anesthetic etomidate with the γ-aminobutyric acid type A receptor is influenced by a single amino acid

Belelli, D., Lambert, J. J., Peters, J. A., Wafford, K. A., & Whiting, P. J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.20.11031 · Cited by 392 · see citing works

General anaesthetic actions on ligand-gated ion channels

Krasowski, M. D., & Harrison, N. L. (1999) · Cellular and Molecular Life Sciences (CMLS) · doi:10.1007/s000180050371 · Cited by 384 · see citing works

Reciprocal Inhibitory Connections and Network Synchrony in the Mammalian Thalamus

Huntsman, M. M., Porcello, D. M., Homanics, G. E., DeLorey, T. M., & Huguenard, J. R. (1999) · Science · doi:10.1126/science.283.5401.541 · Cited by 361 · see citing works

Functional Dynamics of GABAergic Inhibition in the Thalamus

Kim, U., Sanchez-Vives, M. V., & McCormick, D. A. (1997) · Science · doi:10.1126/science.278.5335.130 · Cited by 338 · see citing works

Short-term synaptic plasticity is altered in mice lacking synapsin I

Rosahl, T. (1993) · Cell · doi:10.1016/0092-8674(93)90487-b · Cited by 328 · see citing works

Mechanism of action of the hypnotic zolpidem in vivo

Crestani, F., Martin, J. R., Möhler, H., & Rudolph, U. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703717 · Cited by 307 · see citing works

Optimization of intraperitoneal injection anesthesia in mice: drugs, dosages, adverse effects, and anesthesia depth.

Arras, M., Autenried, P., Rettich, A., Späni, D., & Rülicke, T. (2001) · PubMed · Cited by 267 · see citing works

The modulatory action of loreclezole at the gamma-aminobutyric acid type A receptor is determined by a single amino acid in the beta 2 and beta 3 subunit.

Wingrove, P. B., Wafford, K. A., Bain, C., & Whiting, P. J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.10.4569 · Cited by 242 · see citing works

Subunit‐dependent interaction of the general anaesthetic etomidate with the γ‐aminobutyric acid type A receptor

Hill‐Venning, C., Belelli, D., Peters, J. A., & Lambert, J. J. (1997) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0700927 · Cited by 239 · see citing works

Loss of the Major GABA A Receptor Subtype in the Brain Is Not Lethal in Mice

Sur, C., Wafford, K. A., Reynolds, D. S., Hadingham, K. L., Bromidge, F. A., Macaulay, A. J., Collinson, N., O’Meara, G. F., Howell, O. W., Newman, R. J., et al. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-10-03409.2001 · Cited by 229 · see citing works

Stereoselective Effects of Etomidate Optical Isomers on Gamma-aminobutyric Acid Type A Receptors and Animals

Tomlin, S. L., Jenkins, A., Lieb, W. R., & Franks, N. P. (1998) · Anesthesiology · doi:10.1097/00000542-199803000-00022 · Cited by 167 · see citing works

Anesthesia Sensitivity in Mice that Lack the β3 Subunit of the γ-Aminobutyric Acid Type A Receptor

Quinlan, J. J., Homanics, G. E., & Firestone, L. L. (1998) · Anesthesiology · doi:10.1097/00000542-199803000-00030 · Cited by 158 · see citing works

I.v. anaesthesia and EEG burst suppression in rats: bolus injections and closed-loop infusions

Vijn, P. C. M., & Sneyd, J. R. (1998) · British Journal of Anaesthesia · doi:10.1093/bja/81.3.415 · Cited by 101 · see citing works

Chemokine production by human vascular smooth muscle cells: modulation by IL‐13

Jordan, N., Watson, M., Williams, R. J., Roach, A. G., Yoshimura, T., & Westwick, J. K. (1997) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0701433 · Cited by 90 · see citing works

The in vitro and in vivo enantioselectivity of etomidate implicates the GABAA receptor in general anaesthesia

Belelli, D. (2003) · Neuropharmacology · doi:10.1016/s0028-3908(03)00144-8 · Cited by 70 · see citing works

Effects of Aging and Housing in an Enriched Environment on Sleep-Wake Patterns in Rats

van Gool, W. A., & Mirmiran, M. (1986) · SLEEP · doi:10.1093/sleep/9.2.335 · Cited by 68 · see citing works

GABAAReceptor β3 Subunit Deletion Decreases α2/3 Subunits and IPSC Duration

Ramadan, E., Fu, Z., Losi, G., Homanics, G. E., Neale, J. H., & Vicini, S. (2003) · Journal of Neurophysiology · doi:10.1152/jn.00700.2002 · Cited by 55 · see citing works

Neural Mechanisms of Anesthesia

Antognini, J. F., Carstens, E. E., & Raines, D. E. (2002) · Humana Press eBooks · doi:10.1385/1592593224 · Cited by 52 · see citing works

Mechanism of action of general anaesthetics — new information from molecular pharmacology

Thompson, S. (2001) · Current Opinion in Pharmacology · doi:10.1016/s1471-4892(01)00013-3 · Cited by 38 · see citing works

Facilitation of recurrent inhibition in rat hippocampus by barbiturate and related nonbarbiturate depressant drugs.

Dunwiddie, T. V., Worth, T. S., & Olsen, R. W. (1986) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)25012-1 · Cited by 35 · see citing works

GABAA α1 subunit knock-out mice do not show a hyperlocomotor response following amphetamine or cocaine treatment

Reynolds, D. S. (2003) · Neuropharmacology · doi:10.1016/s0028-3908(02)00370-2 · Cited by 30 · see citing works

Anesthesia, the Spinal Cord and Motor Responses to Noxious Stimulation

Antognini, J. F., & Carstens, E. E. (2003) · Humana Press eBooks · doi:10.1007/978-1-59259-322-4_11 · Cited by 1 · see citing works

Anesthesia, the Spinal Cord and Motor Responses to Noxious Stimulation

Antognini, J. F., & Carstens, E. E. (2003) · Humana Press eBooks · doi:10.1385/1-59259-322-4:183 · Cited by 1 · see citing works

General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal

Franks, N. P. (2008) · Nature reviews. Neuroscience · doi:10.1038/nrn2372 · Cited by 1,266 · see citing works

Neurosteroids: endogenous regulators of the GABAA receptor

Belelli, D., & Lambert, J. J. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1703 · Cited by 1,159 · see citing works

International Union of Pharmacology. LXX. Subtypes of γ-Aminobutyric AcidA Receptors: Classification on the Basis of Subunit Composition, Pharmacology, and Function. Update

Olsen, R. W., & Sieghart, W. (2008) · Pharmacological Reviews · doi:10.1124/pr.108.00505 · Cited by 1,064 · see citing works

GABAA receptors: Subtypes provide diversity of function and pharmacology

Olsen, R. W., & Sieghart, W. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.07.045 · Cited by 986 · see citing works

Molecular and neuronal substrates for general anaesthetics

Rudolph, U., & Antkowiak, B. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1496 · Cited by 771 · see citing works

Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by α5 subunit-containing γ-aminobutyric acid type A receptors

Caraiscos, V. B., Elliott, E. M., You-Ten, K. E., Cheng, V., Belelli, D., Newell, J. G., Jackson, M. F., Lambert, J. J., Rosahl, T. W., Wafford, K. A., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307231101 · Cited by 571 · see citing works

Emerging molecular mechanisms of general anesthetic action

Hemmings, H. C., Akabas, M. H., Goldstein, P. A., Trudell, J. R., Orser, B. A., & Harrison, N. L. (2005) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2005.08.006 · Cited by 542 · see citing works

GABA-based therapeutic approaches: GABAA receptor subtype functions

RUDOLPH, U., & MOHLER, H. (2006) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2005.10.003 · Cited by 499 · see citing works

Neurosteroid modulation of GABAA receptors

Lambert, J. J., Belelli, D., Peden, D. R., Vardy, A., & Peters, J. A. (2003) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2003.09.001 · Cited by 489 · see citing works

Ethanol enhances α 4 β 3 δ and α 6 β 3 δ γ-aminobutyric acid type A receptors at low concentrations known to affect humans

Wallner, M., Hanchar, H. J., & Olsen, R. W. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2435171100 · Cited by 463 · see citing works

GABAA receptors: structure, function, pharmacology, and related disorders

Ghit, A., Assal, D., Al‐Shami, A. S., & Hussein, D. E. (2021) · Journal of Genetic Engineering and Biotechnology · doi:10.1186/s43141-021-00224-0 · Cited by 413 · see citing works

Shared structural mechanisms of general anaesthetics and benzodiazepines

Kim, J. J., Gharpure, A., Teng, J., Zhuang, Y., Howard, R. J., Zhu, S., Noviello, C., Walsh, R. M., Lindahl, E. R., & Hibbs, R. E. (2020) · Nature · doi:10.1038/s41586-020-2654-5 · Cited by 382 · see citing works

Molecular targets underlying general anaesthesia

Franks, N. P. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706441 · Cited by 376 · see citing works

GABAA receptor diversity and pharmacology

Möhler, H. (2006) · Cell and Tissue Research · doi:10.1007/s00441-006-0284-3 · Cited by 359 · see citing works

Clinical and Molecular Pharmacology of Etomidate

Forman, S. A., & Warner, D. S. (2011) · Anesthesiology · doi:10.1097/aln.0b013e3181ff72b5 · Cited by 362 · see citing works

GABAA receptor: Positive and negative allosteric modulators

Olsen, R. W. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.01.036 · Cited by 353 · see citing works

Structure, Pharmacology, and Function of GABAA Receptor Subtypes

Sieghart, W. (2006) · Advances in pharmacology · doi:10.1016/s1054-3589(06)54010-4 · Cited by 321 · see citing works

Update on Bispectral Index monitoring

Johansen, J. W. (2006) · Best practice & research. Clinical anaesthesiology · doi:10.1016/j.bpa.2005.08.004 · Cited by 308 · see citing works

Identification of a GABA A Receptor Anesthetic Binding Site at Subunit Interfaces by Photolabeling with an Etomidate Analog

Li, G., Chiara, D. C., Sawyer, G. W., Husain, S. S., Olsen, R. W., & Cohen, J. B. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3467-06.2006 · Cited by 289 · see citing works

GABAA Receptor Channel Pharmacology

Johnston, G. A. R. (2005) · Current Pharmaceutical Design · doi:10.2174/1381612054021024 · Cited by 274 · see citing works

Extrasynaptic GABA A Receptors of Thalamocortical Neurons: A Molecular Target for Hypnotics

Belelli, D., Peden, D. R., Rosahl, T. W., Wafford, K. A., & Lambert, J. J. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2679-05.2005 · Cited by 252 · see citing works

α5GABA A Receptors Mediate the Amnestic But Not Sedative-Hypnotic Effects of the General Anesthetic Etomidate

Cheng, V., Martin, L. J., Elliott, E. M., Kim, J. H., Mount, H. T. J., Taverna, F. A., Roder, J., MacDonald, J. F., Bhambri, A., Collinson, N., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.5024-05.2006 · Cited by 246 · see citing works

International Union of Basic and Clinical Pharmacology. CVI: GABAA Receptor Subtype- and Function-selective Ligands: Key Issues in Translation to Humans

Sieghart, W., & Savić, M. M. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.014449 · Cited by 211 · see citing works

Neurosteroid modulation of synaptic and extrasynaptic GABAA receptors

Herd, M. B., Belelli, D., & Lambert, J. J. (2007) · Pharmacology &amp; Therapeutics · doi:10.1016/j.pharmthera.2007.03.007 · Cited by 206 · see citing works

The Howling Cortex: Seizures and General Anesthetic Drugs

Voss, L. J., Sleigh, J. W., Barnard, J. P. M., & Kirsch, H. E. (2008) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e3181852595 · Cited by 194 · see citing works

Neurosteroids: Endogenous allosteric modulators of GABAA receptors

Lambert, J. J., Cooper, M. A., Simmons, R. D. J., Weir, C. J., & Belelli, D. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.08.009 · Cited by 180 · see citing works

The complexity of the GABAA receptor shapes unique pharmacological profiles

D’Hulst, C., Atack, J. R., & Kooy, R. F. (2009) · Drug Discovery Today · doi:10.1016/j.drudis.2009.06.009 · Cited by 178 · see citing works

Neocortex is the major target of sedative concentrations of volatile anaesthetics: strong depression of firing rates and increase of GABAA receptor‐mediated inhibition

Hentschke, H., Schwarz, C., & Antkowiak, B. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03843.x · Cited by 163 · see citing works

The Biology of General Anesthesia from Paramecium to Primate

Kelz, M. B., & Mashour, G. A. (2019) · Current Biology · doi:10.1016/j.cub.2019.09.071 · Cited by 151 · see citing works

γ-Aminobutyric acid A receptor subunit mutant mice: new perspectives on alcohol actions

Boehm, S. L., Ponomarev, I., Jennings, A. W., Whiting, P. J., Rosahl, T. W., Garrett, E. M., Blednov, Y. A., & Harris, R. A. (2004) · Biochemical Pharmacology · doi:10.1016/j.bcp.2004.07.023 · Cited by 155 · see citing works

Gaboxadol — a new awakening in sleep

Wafford, K. A., & Ebert, B. (2005) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2005.10.004 · Cited by 149 · see citing works

GABAA receptors: structure and function in the basal ganglia

Goetz, T., Arslan, A., Wisden, W., & Wulff, P. (2007) · Progress in brain research · doi:10.1016/s0079-6123(06)60003-4 · Cited by 149 · see citing works

Role of GABAAreceptors in the physiology and pharmacology of sleep

Winsky‐Sommerer, R. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06716.x · Cited by 144 · see citing works

The molecular mechanisms of general anaesthesia: dissecting the GABAA receptor

Weir, C. J. (2006) · Continuing Education in Anaesthesia Critical Care & Pain · doi:10.1093/bjaceaccp/mki068 · Cited by 143 · see citing works

Early developmental alterations in GABAergic protein expression in fragile X knockout mice

Adusei, D. C., Pacey, L. K. K., Chen, D., & Hampson, D. R. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.05.002 · Cited by 139 · see citing works

Direct Structural Insights into GABAA Receptor Pharmacology

Kim, J. J., & Hibbs, R. E. (2021) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2021.01.011 · Cited by 139 · see citing works

GABAA receptor subtypes as targets for neuropsychiatric drug development

Korpi, E. R., & Sinkkonen, S. T. (2005) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.05.009 · Cited by 137 · see citing works

Molecular regulation of cognitive functions and developmental plasticity: impact of GABAAreceptors

Möhler, H. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04454.x · Cited by 137 · see citing works

Correlating the clinical actions and molecular mechanisms of general anesthetics

Solt, K., & Forman, S. A. (2007) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0b013e32816678a5 · Cited by 129 · see citing works

Major Role For Tonic GABAA Conductances in Anesthetic Suppression of Intrinsic Neuronal Excitability

Bieda, M. C., & MacIver, M. B. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00223.2004 · Cited by 127 · see citing works

The brain GABA-benzodiazepine receptor alpha-5 subtype in autism spectrum disorder: A pilot [11C]Ro15-4513 positron emission tomography study

Méndez, M. A., Horder, J., Myers, J., Coghlan, S., Stokes, P. R. A., Erritzøe, D., Howes, O. D., Lingford-Hughes, A. R., Murphy, D., & Nutt, D. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.04.008 · Cited by 127 · see citing works

Specific GABAA circuits in brain development and therapy

Möhler, H., Fritschy, J., Crestani, F., Hensch, T. K., & Rudolph, U. (2004) · Biochemical Pharmacology · doi:10.1016/j.bcp.2004.07.025 · Cited by 124 · see citing works

The Contraceptive Agent Provera Enhances GABAAReceptor-Mediated Inhibitory Neurotransmission in the Rat Hippocampus: Evidence for Endogenous Neurosteroids?

Belelli, D., & Herd, M. B. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-31-10013.2003 · Cited by 123 · see citing works

Neurosteroid modulation of GABAA receptors: Molecular determinants and significance in health and disease

Mitchell, E. A., Herd, M. B., Gunn, B. G., Lambert, J. J., & Belelli, D. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.10.007 · Cited by 120 · see citing works

GABAA receptors as molecular targets of general anesthetics: identification of binding sites provides clues to allosteric modulation

Olsen, R. W., & Li, G. (2010) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/s12630-010-9429-7 · Cited by 115 · see citing works

Anxiety and depression: Mouse genetics and pharmacological approaches to the role of GABAA receptor subtypes

Smith, K. S., & Rudolph, U. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.07.026 · Cited by 115 · see citing works

The expression of GABAAβ subunit isoforms in synaptic and extrasynaptic receptor populations of mouse dentate gyrus granule cells

Herd, M. B., Haythornthwaite, A. R., Rosahl, T. W., Wafford, K. A., Homanics, G. E., Lambert, J. J., & Belelli, D. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.146746 · Cited by 113 · see citing works

Essential oil of Ocimum gratissimum L.: Anesthetic effects, mechanism of action and tolerance in silver catfish, Rhamdia quelen

Silva, L. D. L., Parodi, T. V., Reckziegel, P., Garcia, V. D. O., Bürger, M. E., Baldisserotto, B., Mallmann, C. A., Pereira, A. M. S., & Heinzmann, B. M. (2012) · Aquaculture · doi:10.1016/j.aquaculture.2012.04.012 · Cited by 111 · see citing works

Molecular and systemic mechanisms of general anaesthesia: the ‘multi-site and multiple mechanisms’ concept

Grasshoff, C., Rudolph, U., & Antkowiak, B. (2005) · Current Opinion in Anaesthesiology · doi:10.1097/01.aco.0000174961.90135.dc · Cited by 112 · see citing works

Randomized, controlled, cross-over clinical trial comparing intravenous midazolam sedation with nitrous oxide sedation in children undergoing dental extractions

Wilson, K., Girdler, N. M., & Welbury, R. R. (2003) · British Journal of Anaesthesia · doi:10.1093/bja/aeg278 · Cited by 110 · see citing works

GABAergic Inhibition of Histaminergic Neurons Regulates Active Waking But Not the Sleep–Wake Switch or Propofol-Induced Loss of Consciousness

Zecharia, A. Y., Yu, X., Götz, T., Ye, Z., Carr, D. R., Wulff, P., Bettler, B., Vyssotski, A. L., Brickley, S. G., Franks, N. P., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2931-12.2012 · Cited by 106 · see citing works

Excitatory pathways from the lateral habenula enable propofol-induced sedation

Gelegen, C., Miracca, G., Ran, M. Z., Harding, E. C., Ye, Z., Yu, X., Tossell, K., Houston, C. M., Yustos, R., Hawkins, E. D., et al. (2018) · Current Biology · doi:10.1016/j.cub.2017.12.050 · Cited by 100 · see citing works

Sleep and general anesthesia

Franks, N. P., & Zecharia, A. Y. (2010) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/s12630-010-9420-3 · Cited by 103 · see citing works

Low dose acute alcohol effects on GABAA receptor subtypes

Wallner, M., Hanchar, H. J., & Olsen, R. W. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2006.05.004 · Cited by 103 · see citing works

New insights into the molecular mechanisms of general anaesthetics

Chau, P.-L. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00891.x · Cited by 96 · see citing works

A novel GABAAreceptor pharmacology: drugs interacting with the α+β‐interface

Sieghart, W., Ramerstorfer, J., Sarto‐Jackson, I., Varagić, Z., & Ernst, M. C. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01779.x · Cited by 95 · see citing works

Current and Developing Methods of Patient-Controlled Analgesia

Palmer, P. P., & Miller, R. D. (2010) · Anesthesiology Clinics · doi:10.1016/j.anclin.2010.08.010 · Cited by 91 · see citing works

GABAA receptor subtype involvement in addictive behaviour

Stephens, D. N., King, S. L., Lambert, J. J., Belelli, D., & Duka, T. (2016) · Genes Brain & Behavior · doi:10.1111/gbb.12321 · Cited by 92 · see citing works

The interaction of anaesthetic steroids with recombinant glycine and GABA A receptors †

Weir, C. J., Ling, A., Belelli, D., Wildsmith, J. A. W., Peters, J. A., & Lambert, J. J. (2004) · British Journal of Anaesthesia · doi:10.1093/bja/aeh125 · Cited by 90 · see citing works

Nitrous oxide analgesia for minor pediatric surgical procedures: an effective alternative to conscious sedation?

Burnweit, C. A., Zerpa, J., Nahmad, M., Lankau, C. A., Weinberger, M., Malvezzi, L., Smith, L., Shapiro, T., & Thayer, K. (2004) · Journal of Pediatric Surgery · doi:10.1016/j.jpedsurg.2003.11.037 · Cited by 90 · see citing works

GABAA receptor subtypes underlying general anesthesia

Bonin, R. P., & Orser, B. A. (2008) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2007.12.011 · Cited by 85 · see citing works

GABA Receptors and the Pharmacology of Sleep

Wisden, W., Yu, X., & Franks, N. P. (2017) · Handbook of experimental pharmacology · doi:10.1007/164_2017_56 · Cited by 83 · see citing works

Stress and GABAAreceptors

Skilbeck, K. J., Johnston, G. A. R., & Hinton, T. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06539.x · Cited by 85 · see citing works

Distinct molecular targets for the central respiratory and cardiac actions of the general anesthetics etomidate and propofol

Zeller, A., Arras, M., Lazaris, A., Jurd, R., & Rudolph, U. (2005) · The FASEB Journal · doi:10.1096/fj.04-3443fje · Cited by 83 · see citing works

Numerous Classes of General Anesthetics Inhibit Etomidate Binding to γ-Aminobutyric Acid Type A (GABAA) Receptors

Li, G., Chiara, D. C., Cohen, J. B., & Olsen, R. W. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.074708 · Cited by 82 · see citing works

Allosteric Ligands and Their Binding Sites Define γ-Aminobutyric Acid (GABA) Type A Receptor Subtypes

Olsen, R. W. (2015) · Advances in pharmacology · doi:10.1016/bs.apha.2014.11.005 · Cited by 80 · see citing works

HCN Subunit-Specific and cAMP-Modulated Effects of Anesthetics on Neuronal Pacemaker Currents

Chen, X. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1153-05.2005 · Cited by 81 · see citing works

The EEG effects of THIP (Gaboxadol) on sleep and waking are mediated by the GABAAδ‐subunit‐containing receptors

Winsky‐Sommerer, R., Vyazovskiy, V. V., Homanics, G. E., & Tobler, I. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05455.x · Cited by 80 · see citing works

Tryptophan Mutations at Azi-Etomidate Photo-Incorporation Sites on α1 or β2 Subunits Enhance GABAA Receptor Gating and Reduce Etomidate Modulation

Stewart, D. S., Desai, R., Cheng, Q., Liu, A., & Forman, S. A. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.050500 · Cited by 80 · see citing works

CaMKII phosphorylation of the GABAA receptor: receptor subtype‐ and synapse‐specific modulation

Houston, C. M., He, Q., & Smart, T. G. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.171603 · Cited by 79 · see citing works

Motoneuronal TASK channels contribute to immobilizing effects of inhalational general anesthetics

Lazarenko, R. M., Willcox, S. C., Shu, S., Berg, A. P., Jevtovic-Todorovic, V., Talley, E. M., Chen, X., & Bayliss, D. A. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1655-10.2010 · Cited by 79 · see citing works

Identification of Binding Sites in the Nicotinic Acetylcholine Receptor for [3H]Azietomidate, a Photoactivatable General Anesthetic

Ziebell, M. R., Nirthanan, S., Husain, S. S., Miller, K. W., & Cohen, J. B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313886200 · Cited by 77 · see citing works

Role of GABAA receptor subtypes in the behavioural effects of intravenous general anaesthetics

Weir, C. J., Mitchell, S. J., & Lambert, J. J. (2017) · British Journal of Anaesthesia · doi:10.1093/bja/aex369 · Cited by 78 · see citing works

A randomised, controlled, crossover trial of oral midazolam and nitrous oxide for paediatric dental sedation

Wilson, K. E., Welbury, R. R., & Girdler, N. M. (2002) · Anaesthesia · doi:10.1046/j.1365-2044.2002.02784.x · Cited by 77 · see citing works

Impact of ε and θ subunits on pharmacological properties of α3β1 GABAA receptors expressed in Xenopus oocytes

Ranna, M., Sinkkonen, S. T., Möykkynen, T. P., Uusi‐Oukari, M., & Korpi, E. R. (2006) · BMC Pharmacology · doi:10.1186/1471-2210-6-1 · Cited by 75 · see citing works

Identification of a Molecular Target Mediating the General Anesthetic Actions of Pentobarbital

Zeller, A., Arras, M., Jurd, R., & Rudolph, U. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.030049 · Cited by 74 · see citing works

Extrasynaptic GABAA Receptors Are Critical Targets for Sedative-Hypnotic Drugs

Orser, B. A. (2006) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.26526 · Cited by 75 · see citing works

Preemptive Analgesia at the Crossroad

Kissin, I. (2005) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000144429.39988.9b · Cited by 75 · see citing works

Brain stem excitatory and inhibitory signaling pathways regulating bronchoconstrictive responses

Haxhiu, M. A., Kc, P., Moore, C. T., Acquah, S. S., Wilson, C. G., Zaidi, S. I. A., Massari, V. J., & Ferguson, D. G. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01340.2004 · Cited by 73 · see citing works

Determination of the EC50Amnesic Concentration of Etomidate and Its Diffusion Profile in Brain Tissue

Benkwitz, C., Liao, M. Y., Laster, M. J., Sonner, J. M., Eger, E. I., & Pearce, R. A. (2007) · Anesthesiology · doi:10.1097/00000542-200701000-00020 · Cited by 71 · see citing works

Neurosteroids Allosterically Modulate Binding of the Anesthetic Etomidate to γ-Aminobutyric Acid Type A Receptors

Li, G., Chiara, D. C., Cohen, J. B., & Olsen, R. W. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.c900016200 · Cited by 71 · see citing works

Endozepines and their receptors: Structure, functions and pathophysiological significance

Tonon, M., Vaudry, H., Chuquet, J., Guillebaud, F., Fan, J., Masmoudi‐Kouki, O., Vaudry, D., Lanfray, D., Morin, F., Prévot, V., et al. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.06.008 · Cited by 70 · see citing works

Realising the therapeutic potential of neuroactive steroid modulators of the GABAA receptor

Belelli, D., Hogenkamp, D., Gee, K. W., & Lambert, J. J. (2020) · Neurobiology of Stress · doi:10.1016/j.ynstr.2019.100207 · Cited by 67 · see citing works

Sleep and Sedative States Induced by Targeting the Histamine and Noradrenergic Systems

Yu, X., Franks, N. P., & Wisden, W. (2018) · Frontiers in Neural Circuits · doi:10.3389/fncir.2018.00004 · Cited by 68 · see citing works

General anesthetics cause mitochondrial dysfunction and reduction of intracellular ATP levels

Kishikawa, J.-I., Inoue, Y., Fujikawa, M., Nishimura, K. J., Nakanishi, A., Tanabe, T., Imamura, H., & Yokoyama, K. (2018) · PLoS ONE · doi:10.1371/journal.pone.0190213 · Cited by 65 · see citing works

A comparison of oral midazolam and nitrous oxide sedation for dental extractions in children

Wilson, K. E., Girdler, N. M., & Welbury, R. R. (2006) · Anaesthesia · doi:10.1111/j.1365-2044.2006.04835.x · Cited by 67 · see citing works

General Anesthetics and Molecular Mechanisms of Unconsciousness

Forman, S. A., & Chin, V. A. (2008) · International Anesthesiology Clinics · doi:10.1097/aia.0b013e3181755da5 · Cited by 63 · see citing works

An Isoflurane- and Alcohol-Insensitive Mutant GABAA Receptor α1 Subunit with Near-Normal Apparent Affinity for GABA: Characterization in Heterologous Systems and Production of Knockin Mice

Borghese, C. M., Werner, D. F., Topf, N., Baron, N. V., Henderson, L. A., Boehm, S. L., Blednov, Y. A., Saad, A., Dai, S., Pearce, R. A., et al. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.104406 · Cited by 63 · see citing works

γ-Amino Butyric Acid Type A Receptor Mutations at β2N265 Alter Etomidate Efficacy While Preserving Basal and Agonist-dependent Activity

Desai, R., Ruesch, D., & Forman, S. A. (2009) · Anesthesiology · doi:10.1097/aln.0b013e3181b55fae · Cited by 62 · see citing works

General anesthesia mediated by effects on ion channels

Zhou, C. (2012) · World Journal of Critical Care Medicine · doi:10.5492/wjccm.v1.i3.80 · Cited by 61 · see citing works

Status epilepticus in mice deficient for succinate semialdehyde dehydrogenase: GABAAreceptor–mediated mechanisms

Wu, Y., Buzzi, A., Frantseva, M. V., Perez-Velazquez, J. L., Cortez, M. A., Liu, C.-C., Shen, L., Gibson, K. M., & Snead, O. C. (2005) · Annals of Neurology · doi:10.1002/ana.20686 · Cited by 61 · see citing works

The Locus Coeruleus Modulates Intravenous General Anesthesia of Zebrafish via a Cooperative Mechanism

Du, W., Zhang, R., Li, J. X., Zhang, B., Peng, X., Cao, S., Yuan, J., Yuan, C.-D., Yu, T., & Du, J. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.08.046 · Cited by 53 · see citing works

α1 Subunit-Containing GABA Type A Receptors in Forebrain Contribute to the Effect of Inhaled Anesthetics on Conditioned Fear

Sonner, J. M., Cascio, M., Xing, Y., Fanselow, M. S., Kralic, J. E., Morrow, A. L., Korpi, E. R., Hardy, S. L., Sloat, B. R., Eger, E. I., et al. (2005) · Molecular Pharmacology · doi:10.1124/mol.104.009936 · Cited by 56 · see citing works

Transformations of Electrosensory Encoding Associated with an Adaptive Filter

Sawtell, N. B., & Williams, A. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4946-07.2008 · Cited by 61 · see citing works

Contemporary dental photography: selection and application.

Terry, D. A., Snow, S. R., & McLaren, E. A. (2008) · PubMed · Cited by 56 · see citing works

Etomidate, propofol and the neurosteroid THDOC increase the GABA efficacy of recombinant α4β3δ and α4β3 GABAA receptors expressed in HEK cells

Meera, P., Olsen, R. W., Otis, T. S., & Wallner, M. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.08.011 · Cited by 54 · see citing works

CaMK‐II modulation of GABAAreceptors expressed in HEK293, NG108‐15 and rat cerebellar granule neurons

Houston, C. M., & Smart, T. G. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05145.x · Cited by 54 · see citing works

Determinants of the Anesthetic Sensitivity of Two-pore Domain Acid-sensitive Potassium Channels

Andres-Enguix, I., Caley, A., Yustos, R., Schumacher, M. A., Spanu, P. D., Dickinson, R., Maze, M., & Franks, N. P. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610692200 · Cited by 52 · see citing works

Population based models of cortical drug response: insights from anaesthesia

Foster, B. L., Bojak, I., & Liley, D. T. J. (2008) · Cognitive Neurodynamics · doi:10.1007/s11571-008-9063-z · Cited by 52 · see citing works

A partially blinded randomised controlled trial of patient‐maintained propofol sedation and operator controlled midazolam sedation in third molar extractions

Leitch, J., Anderson, K., Gambhir, S., Millar, K., Robb, N. D., McHugh, S., & Kenny, G. N. C. (2004) · Anaesthesia · doi:10.1111/j.1365-2044.2004.03761.x · Cited by 51 · see citing works

The GABA-A β3 subunit mediates anaesthesia induced by etomidate

O’Meara, G. F., Newman, R. J., Fradley, R. L., Dawson, G. R., & Reynolds, D. S. (2004) · Neuroreport · doi:10.1097/01.wnr.0000134842.56131.fe · Cited by 24 · see citing works

Closing the Gap Between the Molecular and Systemic Actions of Anesthetic Agents

Antkowiak, B. (2014) · Advances in pharmacology · doi:10.1016/bs.apha.2014.10.009 · Cited by 7 · see citing works

The GABAA receptor: An important target for the general anaesthetic etomidate

Lambert, J. J., Haythornthwaite, A. R., Peden, D. R., Herd, M. B., Wafford, K. A., Rosahl, T. W., & Belelli, D. (2005) · International Congress Series · doi:10.1016/j.ics.2005.07.071

The interaction of the general anesthetic etomidate with the γ-aminobutyric acid type A receptor is influenced by a single amino acid

Belelli, D., Lambert, J. J., Peters, J. A., Wafford, K. A., & Whiting, P. J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.20.11031 · Cited by 392 · see citing works

β3-containing GABAA receptors mediate the immobilizing and, in part, the hypnotic actions of etomidate and propofol

Jurd, R., Arras, M., Zeller, A., Lambert, S., Lazaris, A., Crestani, F., Drexler, B., Siegwart, R., Vogt, K. E., Antkowiak, B., et al. (2005) · International Congress Series · doi:10.1016/j.ics.2005.07.076