Koff, Andrew

p53 Regulates Hematopoietic Stem Cell Quiescence

Liu, Y., Elf, S. E., Miyata, Y., Sashida, G., Liu, Y., Huang, G., Di Giandomenico, S., Lee, J. M., Deblasio, A., Menendez, S., et al. (2009) · Cell Stem Cell

Hematopoietic Stem Cell TransplantationCancer-related Molecular Pathways

Cited by 547

Targeted Disruption of CDK4 Delays Cell Cycle Entry with Enhanced p27 Kip1 Activity

Tsutsui, T., Hesabi, B., Moons, D. S., Pandolfi, P. P., Hansel, K. S., Koff, A., & Kiyokawa, H. (1999) · Molecular and Cellular Biology

Cancer-related Molecular PathwaysProtein Kinase Regulation and GTPase Signaling

Cited by 395

CDK4/6 Inhibitors: The Mechanism of Action May Not Be as Simple as Once Thought

Klein, M. E., Kovatcheva, M., Davis, L. E., Tap, W. D., & Koff, A. (2018) · Cancer Cell

Advanced Breast Cancer TherapiesPI3K/AKT/mTOR signaling in cancer

Cited by 378

MDM2 turnover and expression of ATRX determine the choice between quiescence and senescence in response to CDK4 inhibition

Kovatcheva, M., Liu, D. D., Dickson, M. A., Klein, M. E., O’Connor, R., Wilder, F. O., Socci, N. D., Tap, W. D., Schwartz, G. K., Singer, S., et al. (2015) · Oncotarget

Cancer-related Molecular PathwaysTelomeres, Telomerase, and Senescence

Cited by 142

ATRX is a regulator of therapy induced senescence in human cells

Kovatcheva, M., Liao, W., Klein, M. E., Robine, N., Geiger, H., Crago, A. M., Dickson, M. A., Tap, W. D., Singer, S., & Koff, A. (2017) · Nature Communications

Telomeres, Telomerase, and SenescenceGenomics and Chromatin Dynamics

Cited by 89

Pilot study of bempegaldesleukin in combination with nivolumab in patients with metastatic sarcoma

D’Angelo, S. P., Richards, A. L., Conley, A. P., Woo, H. J., Dickson, M. A., Gounder, M., Kelly, C., Keohan, M. L., Movva, S., Thornton, K., et al. (2022) · Nature Communications

Cancer Immunotherapy and BiomarkersSarcoma Diagnosis and Treatment

Cited by 60

Cyclin D1 and cdk4 mediate development of neurologically destructive oligodendroglioma

Ciznadija, D., Liu, Y., Pyonteck, S. M., Holland, E. C., & Koff, A. (2011) · Cancer Research

Glioma Diagnosis and TreatmentCancer-related Molecular Pathways

Cited by 44

Hdm2- and proteasome-dependent turnover limits p21 accumulation during S phase

Ciznadija, D., Zhu, X.-H., & Koff, A. (2011) · Cell Cycle

Cancer-related Molecular PathwaysUbiquitin and proteasome pathways

Cited by 11