Mellone, Massimiliano

mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype

Herranz, N., Gallage, S., Mellone, M., Wuestefeld, T., Klotz, S., Hanley, C. J., Raguz, S., Acosta, J. C., Innes, A. J., Banito, A., et al. (2015) · Nature Cell Biology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 788

NOX4 inhibition potentiates immunotherapy by overcoming cancer-associated fibroblast-mediated CD8 T-cell exclusion from tumors

Ford, K., Hanley, C. J., Mellone, M., Szyndralewiez, C., Heitz, F., Wiesel, P., Wood, O., Machado, M., Lopez, M.-A., Ganesan, A.-P., et al. (2020) · Cancer Research

Cancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses

Cited by 411

Targeting the Myofibroblastic Cancer-Associated Fibroblast Phenotype Through Inhibition of NOX4

Hanley, C. J., Mellone, M., Ford, K., Thirdborough, S. M., Mellows, T., Frampton, S. J., Smith, D. M., Harden, E., Szyndralewiez, C., Bullock, M., et al. (2018) · JNCI: Journal of the National Cancer Institute

Cancer Cells and MetastasisTGF-β signaling in diseases

Cited by 195

Exosomal microRNAs derived from colorectal cancer-associated fibroblasts: role in driving cancer progression

Bhome, R., Goh, R. W., Bullock, M. D., Pillar, N., Thirdborough, S. M., Mellone, M., Mirnezami, R., Galea, D., Veselkov, K., Gu, Q., et al. (2017) · Aging

Extracellular vesicles in diseaseMicroRNA in disease regulation

Cited by 155

Induction of fibroblast senescence generates a non-fibrogenic myofibroblast phenotype that differentially impacts on cancer prognosis

Mellone, M., Hanley, C. J., Thirdborough, S., Mellows, T., Garcia, E., Woo, J., Tod, J., Frampton, S., Jenei, V., Moutasim, K. A., et al. (2016) · Aging

Telomeres, Telomerase, and SenescenceTGF-β signaling in diseases

Cited by 114

A miR-335/COX-2/PTEN axis regulates the secretory phenotype of senescent cancer-associated fibroblasts

Kabir, T. D., Leigh, R. J., Tasena, H., Mellone, M., Coletta, R. D., Parkinson, E. K., Prime, S. S., Thomas, G. J., Paterson, I. C., Zhou, D., et al. (2016) · Aging

Telomeres, Telomerase, and SenescenceMicroRNA in disease regulation

Cited by 78

Profiling the MicroRNA Payload of Exosomes Derived from Ex Vivo Primary Colorectal Fibroblasts

Bhome, R., Goh, R., Pickard, K., Mellone, M., Sayan, A. E., & Mirnezami, A. (2017) · Methods in Molecular Biology

Extracellular vesicles in diseaseMicroRNA in disease regulation

Cited by 12