Hirst, Judy

An inhibitor of oxidative phosphorylation exploits cancer vulnerability

Molina, J. R., Sun, Y., Protopopova, M., Gera, S., Bandi, M., Bristow, C., McAfoos, T., Morlacchi, P., Ackroyd, J., Agip, A.-N. A., et al. (2018) · Nature Medicine

Cancer, Hypoxia, and MetabolismMitochondrial Function and Pathology

Cited by 928

Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria

Bridges, H. R., Jones, A. J. Y., Pollak, M. N., & Hirst, J. (2014) · Biochemical Journal

Metabolism, Diabetes, and CancerMitochondrial Function and Pathology

Cited by 661

The production of reactive oxygen species by complex I

Hirst, J., King, M. S., & Pryde, K. R. (2008) · Biochemical Society Transactions

Mitochondrial Function and PathologyCoenzyme Q10 studies and effects

Cited by 312

Interaction of the Mitochondria-targeted Antioxidant MitoQ with Phospholipid Bilayers and Ubiquinone Oxidoreductases

James, A. M., Sharpley, M. S., Manas, A.-R. B., Frerman, F. E., Hirst, J., Smith, R. A. J., & Murphy, M. P. (2007) · Journal of Biological Chemistry

Coenzyme Q10 studies and effectsMitochondrial Function and Pathology

Cited by 262

Preserved respiratory chain capacity and physiology in mice with profoundly reduced levels of mitochondrial respirasomes

Milenkovic, D., Misic, J., Hevler, J. F., Molinié, T., Chung, I., Atanassov, I., Li, X., Filograna, R., Mesaros, A., Mourier, A., et al. (2023) · Cell Metabolism

Mitochondrial Function and PathologyAdipose Tissue and Metabolism

Cited by 68

Preserved respiratory chain capacity and physiology in mice with profoundly reduced levels of mitochondrial respirasomes

Milenkovic, D., Misic, J., Hevler, J. F., Molinié, T., Chung, I., Atanassov, I., Li, X., Filograna, R., Mesaros, A., Mourier, A., et al. (2023) · Cell Metabolism

Mitochondrial Function and PathologyAdipose Tissue and Metabolism

Cited by 68

The mitochondrial-encoded subunits of respiratory complex I (NADH:ubiquinone oxidoreductase): identifying residues important in mechanism and disease

Bridges, H. R., Birrell, J. A., & Hirst, J. (2011) · Biochemical Society Transactions

Mitochondrial Function and PathologyEnzyme Structure and Function

Cited by 38

Subunit NDUFV3 is present in two distinct isoforms in mammalian complex I

Bridges, H. R., Mohammed, K., Harbour, M. E., & Hirst, J. (2017) · Biochimica et Biophysica Acta (BBA) - Bioenergetics

Mitochondrial Function and PathologyEnzyme Structure and Function

Cited by 38

Structure of the turnover-ready state of an ancestral respiratory complex I

Ivanov, B. S., Bridges, H. R., Jarman, O. D., & Hirst, J. (2024) · Nature Communications

Enzyme Structure and FunctionMitochondrial Function and Pathology

Cited by 14