Yu, Ruth T.

Peroxisome-Proliferator-Activated Receptor δ Activates Fat Metabolism to Prevent Obesity

Wang, Y.-X., Lee, C.-H., Tiep, S., Yu, R. T., Ham, J., Kang, H., & Evans, R. M. (2003) · Cell

Peroxisome Proliferator-Activated ReceptorsAdipose Tissue and Metabolism

Cited by 1,296

AMPK and PPARδ Agonists Are Exercise Mimetics

Narkar, V. A., Downes, M., Yu, R. T., Embler, E., Wang, Y.-X., Banayo, E., Mihaylova, M. M., Nelson, M. C., Zou, Y., Juguilon, H., et al. (2008) · Cell

Peroxisome Proliferator-Activated ReceptorsMetabolism, Diabetes, and Cancer

Cited by 1,222

Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor

Inagaki, T., Moschetta, A., Lee, Y.-K., Peng, L., Zhao, G., Downes, M., Yu, R. T., Shelton, J. M., Richardson, J. A., Repa, J. J., et al. (2006) · Proceedings of the National Academy of Sciences

Drug Transport and Resistance MechanismsGut microbiota and health

Cited by 1,164

Vitamin D Receptor-Mediated Stromal Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy

Sherman, M. H., Yu, R. T., Engle, D. D., Ding, N., Atkins, A. R., Tiriac, H., Collisson, E. A., Connor, F., Van Dyke, T., Kozlov, S., et al. (2014) · Cell

Pancreatic and Hepatic Oncology ResearchPancreatitis Pathology and Treatment

Cited by 1,158

Regulation of Muscle Fiber Type and Running Endurance by PPARδ

Wang, Y.-X., Zhang, C.-L., Yu, R. T., Cho, H. K., Nelson, M. C., Bayuga-Ocampo, C. R., Ham, J., Kang, H., & Evans, R. M. (2004) · PLoS Biology

Peroxisome Proliferator-Activated ReceptorsAdipose Tissue and Metabolism

Cited by 1,089

Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β

Cho, H., Zhao, X., Hatori, M., Yu, R. T., Barish, G. D., Lam, M. T., Chong, L.-W., DiTacchio, L., Atkins, A. R., Glass, C. K., et al. (2012) · Nature

Circadian rhythm and melatoninPeroxisome Proliferator-Activated Receptors

Cited by 1,037

Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network

Bookout, A. L., Jeong, Y., Downes, M., Yu, R. T., Evans, R. M., & Mangelsdorf, D. J. (2006) · Cell

Nuclear Receptors and SignalingEstrogen and related hormone effects

Cited by 1,015

Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

Fang, S., Suh, J. M., Reilly, S. M., Yu, E., Osborn, O., Lackey, D., Yoshihara, E., Perino, A., Jacinto, S., Lukasheva, Y., et al. (2015) · Nature Medicine

Adipose Tissue and MetabolismDrug Transport and Resistance Mechanisms

Cited by 738

A vitamin D receptor/SMAD genomic circuit gates hepatic fibrotic response

Ding, N., Yu, R. T., Subramaniam, N., Sherman, M. H., Wilson, C., Rao, R., Leblanc, M., Coulter, S., He, M., Scott, C., et al. (2013) · Cell

Liver physiology and pathologyTGF-β signaling in diseases

Cited by 622

Cryptochromes mediate rhythmic repression of the glucocorticoid receptor

Lamia, K. A., Papp, S. J., Yu, R. T., Barish, G. D., Uhlenhaut, N. H., Jonker, J. W., Downes, M., & Evans, R. M. (2011) · Nature

Circadian rhythm and melatoninEstrogen and related hormone effects

Cited by 590

Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity

Shalapour, S., Lin, X.-J., Bastian, I. N., Brain, J., Burt, A. D., Aksenov, A. A., Vrbanac, A. F., Li, W., Perkins, A., Matsutani, T., et al. (2017) · Nature

Cancer Immunotherapy and BiomarkersT-cell and B-cell Immunology

Cited by 589

Fibroblast Growth Factor-21 Regulates PPARγ Activity and the Antidiabetic Actions of Thiazolidinediones

Dutchak, P. A., Katafuchi, T., Bookout, A. L., Choi, J. H., Yu, R. T., Mangelsdorf, D. J., & Kliewer, S. A. (2012) · Cell

Fibroblast Growth Factor ResearchPeroxisome Proliferator-Activated Receptors

Cited by 537

The starvation hormone, fibroblast growth factor-21, extends lifespan in mice

Zhang, Y., Xie, Y., Berglund, E. D., Coate, K. C., He, T. T., Katafuchi, T., Xiao, G., Potthoff, M. J., Wei, W., Wan, Y., et al. (2012) · eLife

Fibroblast Growth Factor ResearchGenetics, Aging, and Longevity in Model Organisms

Cited by 420

Immune-evasive human islet-like organoids ameliorate diabetes

Yoshihara, E., O’Connor, C., Gasser, E., Wei, Z., Oh, T. G., Tseng, T. W., Wang, D., Cayabyab, F., Dai, Y., Yu, R. T., et al. (2020) · Nature

Pancreatic function and diabetesPluripotent Stem Cells Research

Cited by 333

Modulation of the intestinal bile acid/farnesoid X receptor/fibroblast growth factor 15 axis improves alcoholic liver disease in mice

Hartmann, P., Hochrath, K., Horvath, A., Chen, P., Seebauer, C. T., Llorente, C., Wang, L., Alnouti, Y., Fouts, D. E., Stärkel, P., et al. (2018) · Hepatology

Gut microbiota and healthAlcohol Consumption and Health Effects

Cited by 290

Insights into negative regulation by the glucocorticoid receptor from genome-wide profiling of inflammatory cistromes

Uhlenhaut, N. H., Barish, G. D., Yu, R. T., Downes, M., Karunasiri, M., Liddle, C., Schwalie, P., Hübner, N., & Evans, R. M. (2013) · Molecular Cell

Estrogen and related hormone effectsGenomics and Chromatin Dynamics

Cited by 265

PPARγ activation in adipocytes is sufficient for systemic insulin sensitization

Sugii, S., Olson, P., Sears, D. D., Saberi, M., Atkins, A. R., Barish, G. D., Hong, S.-H., Castro, G. L., Yin, Y.-Q., Nelson, M. C., et al. (2009) · Proceedings of the National Academy of Sciences

Peroxisome Proliferator-Activated ReceptorsAdipokines, Inflammation, and Metabolic Diseases

Cited by 255

BRD4 is a novel therapeutic target for liver fibrosis

Ding, N., Hah, N., Yu, R. T., Sherman, M. H., Benner, C., Leblanc, M., He, M., Liddle, C., Downes, M., & Evans, R. M. (2015) · Proceedings of the National Academy of Sciences

Liver physiology and pathologyProtein Degradation and Inhibitors

Cited by 211

PPARδ Promotes Running Endurance by Preserving Glucose

Fan, W., Waizenegger, W., Lin, C. S., Sorrentino, V., He, M.-X., Wall, C. E., Li, H., Liddle, C., Yu, R. T., Atkins, A. R., et al. (2017) · Cell Metabolism

Peroxisome Proliferator-Activated ReceptorsAdipose Tissue and Metabolism

Cited by 198

Obesity causes mitochondrial fragmentation and dysfunction in white adipocytes due to RalA activation

Xia, W., Veeragandham, P., Cao, Y., Xu, Y., Rhyne, T. E., Qian, J., Hung, C.-W., Zhao, P., Jones, Y., Gao, H., et al. (2024) · Nature Metabolism

Adipose Tissue and MetabolismMitochondrial Function and Pathology

Cited by 176

Protection from liver fibrosis by a peroxisome proliferator-activated receptor δ agonist

Iwaisako, K., Haimerl, M., Paik, Y.-H., Taura, K., Kodama, Y., Sirlin, C., Yu, E., Yu, R. T., Downes, M., Evans, R. M., et al. (2012) · Proceedings of the National Academy of Sciences

Peroxisome Proliferator-Activated ReceptorsLiver physiology and pathology

Cited by 157

Stromal cues regulate the pancreatic cancer epigenome and metabolome

Sherman, M. H., Yu, R. T., Tseng, T. W., Sousa, C. M., Liu, S., Truitt, M. L., He, N., Ding, N., Liddle, C., Atkins, A. R., et al. (2017) · Proceedings of the National Academy of Sciences

Pancreatic and Hepatic Oncology ResearchCancer Cells and Metastasis

Cited by 147

Dependence of hippocampal function on ERRγ-regulated mitochondrial metabolism

Pei, L., Mu, Y., Leblanc, M., Alaynick, W., Barish, G. D., Pankratz, M., Tseng, T. W., Kaufman, S., Liddle, C., Yu, R. T., et al. (2015) · Cell Metabolism

Neuroscience and Neuropharmacology ResearchMitochondrial Function and Pathology

Cited by 65