Ponka, Prem

Mitochondrial iron trafficking and the integration of iron metabolism between the mitochondrion and cytosol

Richardson, D. R., Lane, D. J. R., Becker, E. M., Huang, M. L.-H., Whitnall, M., Rahmanto, Y. S., Sheftel, A. D., & Ponka, P. (2010) · Proceedings of the National Academy of Sciences

Iron Metabolism and DisordersMitochondrial Function and Pathology

Cited by 536

Cellular and subcellular localization of the Nramp2 iron transporter in the intestinal brush border and regulation by dietary iron.

Canonne-Hergaux, F., Gruenheid, S., Ponka, P., & Gros, P. (1999) · Blood

Iron Metabolism and DisordersTrace Elements in Health

Cited by 451

Identification of a hypoxia response element in the transferrin receptor gene

Lok, C. N., & Ponka, P. (1999) · Journal of Biological Chemistry

Cancer, Hypoxia, and MetabolismIron Metabolism and Disorders

Cited by 380

Elucidation of the mechanism of mitochondrial iron loading in Friedreich's ataxia by analysis of a mouse mutant

Huang, M. L.-H., Becker, E. M., Whitnall, M., Rahmanto, Y. S., Ponka, P., & Richardson, D. R. (2009) · Proceedings of the National Academy of Sciences

Iron Metabolism and DisordersNeurological diseases and metabolism

Cited by 212

Dysregulation of Iron Homeostasis in the CNS Contributes to Disease Progression in a Mouse Model of Amyotrophic Lateral Sclerosis

Jeong, S. Y., Rathore, K. I., Schulz, K., Ponka, P., Arosio, P., & David, S. (2009) · The Journal of Neuroscience

Amyotrophic Lateral Sclerosis ResearchNeurological diseases and metabolism

Cited by 174

Characterization of the iron transporter DMT1 (NRAMP2/DCT1) in red blood cells of normal and anemic mk/mkmice

Canonne-Hergaux, F., Zhang, A.-S., Ponka, P., & Gros, P. (2001) · Blood

Iron Metabolism and DisordersTrace Elements in Health

Cited by 169

Nramp1 promotes efficient macrophage recycling of iron following erythrophagocytosis in vivo

Soe-Lin, S., Apte, S. S., Andriopoulos, B., Andrews, M. C., Schranzhofer, M., Kahawita, T., Garcia-Santos, D., & Ponka, P. (2009) · Proceedings of the National Academy of Sciences

Iron Metabolism and DisordersNeurological diseases and metabolism

Cited by 167

Nrf2 controls iron homoeostasis in haemochromatosis and thalassaemia via Bmp6 and hepcidin

Lim, P. J., Duarte, T. L., Arezes, J., Garcia-Santos, D., Hamdi, A., Pasricha, S.-R., Armitage, A. E., Mehta, H., Wideman, S., Santos, A. G., et al. (2019) · Nature Metabolism

Iron Metabolism and DisordersGenomics, phytochemicals, and oxidative stress

Cited by 147

Lysosomal proteolysis is the primary degradation pathway for cytosolic ferritin and cytosolic ferritin degradation is necessary for iron exit

Zhang, Y., Mikhael, M., Xu, D., Li, Y., Soe-Lin, S., Ning, B., Li, W., Nie, G., Zhao, Y., & Ponka, P. (2010) · Antioxidants & Redox Signaling

Iron Metabolism and DisordersNeurological diseases and metabolism

Cited by 120

Both Nramp1 and DMT1 are necessary for efficient macrophage iron recycling

Soe-Lin, S., Apte, S. S., Mikhael, M. R., Kayembe, L. K., Nie, G., & Ponka, P. (2010) · Experimental Hematology

Iron Metabolism and DisordersNeurological diseases and metabolism

Cited by 69

Hydrolysis of pyridoxal isonicotinoyl hydrazone and its analogs

Buss, J. L., & Ponka, P. (2003) · Biochimica et Biophysica Acta (BBA) - General Subjects

Iron Metabolism and DisordersMetal complexes synthesis and properties

Cited by 47

Pyridoxal isonicotinoyl hydrazone analogs induce apoptosis in hematopoietic cells due to their iron-chelating properties

Buss, J. L., Neuzil, J., Gellert, N., Weber, C., & Ponka, P. (2003) · Biochemical Pharmacology

Cell death mechanisms and regulationIron Metabolism and Disorders

Cited by 42

Lipophilicity of analogs of pyridoxal isonicotinoyl hydrazone (PIH) determines the efflux of iron complexes and toxicity in K562 cells

Buss, J. L., Arduini, E., Shephard, K. C., & Ponka, P. (2003) · Biochemical Pharmacology

Iron Metabolism and DisordersHemoglobinopathies and Related Disorders

Cited by 41

Orally effective iron chelators for the treatment of iron overload disease: The case for a further look at pyridoxal isonicotinoyl hydrazone and its analogs

Richardson, D. R., & Ponka, P. (1998) · Journal of Laboratory and Clinical Medicine

Iron Metabolism and DisordersHemoglobinopathies and Related Disorders

Cited by 25