Lysosomal proteolysis is the primary degradation pathway for cytosolic ferritin and cytosolic ferritin degradation is necessary for iron exit

Zhang, Yinghui; Mikhael, Marc; Xu, Dongxue; Li, Yiye; Soe-Lin, Shan; Ning, Bo; Li, Wei; Nie, Guangjun; Zhao, Yuliang; Ponka, Prem

doi:10.1089/ars.2010.3129

Cited by 120Iron Metabolism and DisordersNeurological diseases and metabolismFerroptosis and cancer prognosis

Lysosomal proteolysis is the primary degradation pathway for cytosolic ferritin and cytosolic ferritin degradation is necessary for iron exit

Zhang, Yinghui, Mikhael, Marc, Xu, Dongxue, Li, Yiye, Soe-Lin, Shan, Ning, Bo, Li, Wei, Nie, Guangjun +2 more·2010·Antioxidants & Redox Signaling

DOI 10.1089/ars.2010.3129

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Abstract

Cytosolic ferritins sequester and store iron, consequently protecting cells against iron-mediated free radical damage. However, the mechanisms of iron exit from the ferritin cage and reutilization are largely unknown. In a previous study, we found that mitochondrial ferritin (MtFt) expression led to a decrease in cytosolic ferritin. Here we showed that treatment with inhibitors of lysosomal proteases largely blocked cytosolic ferritin loss in both MtFt-expressing and wild-type cells. Moreover, cytosolic ferritin in cells treated with inhibitors of lysosomal proteases was found to store more iron than did cytosolic ferritins in untreated cells. The prevention of cytosolic ferritin degradation in MtFt-expressing cells significantly blocked iron mobilization from the protein cage induced by MtFt expression. These studies also showed that blockage of cytosolic ferritin loss by leupeptin resulted in decreased cytosolic ferritin synthesis and prolonged cytosolic ferritin stability, potentially resulting in diminished iron availability. Lastly, we found that proteasomes were responsible for cytosolic ferritin degradation in cells pretreated with ferric ammonium citrate. Thus, the current studies suggest that cytosolic ferritin degradation precedes the release of iron in MtFt-expressing cells; that MtFt-induced cytosolic ferritin decrease is partially preventable by lysosomal protease inhibitors; and that both lysosomal and proteasomal pathways may be involved in cytosolic ferritin degradation.

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These results are consistent with lysosome-mediated ferritin degradation in MEFs as previously reported.
“These results are consistent with lysosome-mediated ferritin degradation in MEFs as previously reported [51], [54], [55].”
From Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis (2018) · cites this paper as [55]

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Molecular Mechanism of CYTOSOLIC FERRITIN Degradation and Iron release
Marc, M., Mikhae, Shan, S., Soe-Lin, Prem, & Ponka (2009) · Acta Biophysica Sinica

Authors: Zhang, Y., Mikhael, M., Xu, D., Li, Y., Soe-Lin, S., Ning, B., Li, W., Nie, G., Zhao, Y., & Ponka, P.
Affiliations: Xizang Minzu University (CN)
Jewish General Hospital (CA)
Jilin University (CN)
Chinese Academy of Sciences (CN)
Corresponding author: Nie, Guangjun
ORCID: Zhang, Yinghui
Xu, Dongxue
Li, Yiye
Ning, Bo
Li, Wei
Nie, Guangjun
Zhao, Yuliang
Ponka, Prem
Venue: Antioxidants & Redox Signaling
Publisher: SAGE Publications
Published: 2010-10
Volume: 13
Issue: 7
Pages: 999-1009
ISSN: 1523-0864 (ISSN-L)
1557-7716
DOI: 10.1089/ars.2010.3129
OpenAlex: W2022266635
Cited by: 120
References: 55
Citations by year: 2026: 2 · 2025: 4 · 2024: 6 · 2023: 14 · 2022: 10 · 2021: 8 · 2020: 10 · 2019: 3 · 2018: 10 · 2017: 12 · 2016: 6 · 2015: 6 · 2014: 5 · 2013: 10 · 2012: 7
FWCI: 4.81
Type: journal article
Language: en
Open access: closed
Locations: Antioxidants and Redox Signaling (publishedVersion)
PubMed (publishedVersion)
Funders: Chinese Academy of Sciences
Canadian Institutes of Health Research
Topics: Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Ferroptosis and cancer prognosis
Keywords: ferritin degradation, lysosomal proteolysis, proteasome, mitochondrial ferritin, iron mobilization, iron storage, leupeptin, ferric ammonium citrate, iron availability
MeSH terms: Quaternary Ammonium Compounds, Cell Line, Cytosol, Ferric Compounds, Ferritins, Humans, Iron, Leupeptins, Lysosomes, Mitochondria, Peptide Hydrolases, Protease Inhibitors, Proteasome Endopeptidase Complex

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Lysosomal proteolysis is the primary degradation pathway for cytosolic ferritin and cytosolic ferritin degradation is necessary for iron exit

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