Giacomelli, Andrew O.

Mutational processes shape the landscape of TP53 mutations in human cancer

Giacomelli, A. O., Yang, X., Lintner, R. E., McFarland, J. M., Duby, M., Kim, J., Howard, T. P., Takeda, D. Y., Ly, S. H., Kim, E., et al. (2018) · Nature Genetics

Cancer-related Molecular PathwaysCancer Genomics and Diagnostics

Cited by 556

A dominant-negative effect drives selection of TP53 missense mutations in myeloid malignancies

Boettcher, S., Miller, P. G., Sharma, R., McConkey, M., Leventhal, M., Krivtsov, A. V., Giacomelli, A. O., Wong, W., Kim, J., Chao, S., et al. (2019) · Science

Cancer-related Molecular PathwaysAcute Myeloid Leukemia Research

Cited by 441

Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism.

Schauer, N. J., Liu, X., Magin, R. S., Doherty, L. M., Chan, W. C., Ficarro, S. B., Hu, W., Roberts, R. M., Iacob, R. E., Stolte, B., et al. (2020) · Scientific Reports

Ubiquitin and proteasome pathwaysCancer-related Molecular Pathways

Cited by 125

Massively parallel phenotyping of coding variants in cancer with Perturb-seq

Ursu, O., Neal, J. T., Shea, E., Thakore, P. I., Jerby-Arnon, L., Nguyen, L., Dionne, D., Diaz, C., Bauman, J., Mosaad, M. M., et al. (2022) · Nature Biotechnology

Cancer Genomics and DiagnosticsSingle-cell and spatial transcriptomics

Cited by 96