Komuro, Issei

Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure

Oka, T., Hikoso, S., Yamaguchi, O., Taneike, M., Takeda, T., Tamai, T., Oyabu, J., Murakawa, T., Nakayama, H., Nishida, K., et al. (2012) · Nature

Autophagy in Disease and TherapyCardiac Fibrosis and Remodeling

Cited by 1,201

Endothelial Cell Senescence in Human Atherosclerosis: Role of Telomere in Endothelial Dysfunction

Minamino, T., Miyauchi, H., Yoshida, T., Ishida, Y., Yoshida, H., & Komuro, I. (2002) · Circulation

Telomeres, Telomerase, and SenescenceNitric Oxide and Endothelin Effects

Cited by 1,061

A crucial role for adipose tissue p53 in the regulation of insulin resistance

Minamino, T., Orimo, M., Shimizu, I., Kunieda, T., Yokoyama, M., Ito, T., Nojima, A., Nabetani, A., Oike, Y., Matsubara, H., et al. (2009) · Nature Medicine

Adipokines, Inflammation, and Metabolic DiseasesTelomeres, Telomerase, and Senescence

Cited by 891

Vascular Cell Senescence: Contribution to Atherosclerosis

Minamino, T., & Komuro, I. (2007) · Circulation Research

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 542

Inhibition of autophagy in the heart induces age-related cardiomyopathy

Taneike, M., Yamaguchi, O., Nakai, A., Hikoso, S., Takeda, T., Mizote, I., Oka, T., Tamai, T., Oyabu, J., Murakawa, T., et al. (2010) · Autophagy

Autophagy in Disease and TherapyGenetics, Aging, and Longevity in Model Organisms

Cited by 450

Increased insulin sensitivity and hypoglycaemia in mice lacking the p85α subunit of phosphoinositide 3–kinase

Terauchi, Y., Tsuji, Y., Satoh, S., Minoura, H., Murakami, K., Okuno, A., Inukai, K., Asano, T., Kaburagi, Y., Ueki, K., et al. (1999) · Nature Genetics

Metabolism, Diabetes, and CancerPI3K/AKT/mTOR signaling in cancer

Cited by 399

Complement C1q Activates Canonical Wnt Signaling and Promotes Aging-Related Phenotypes

Naito, A. T., Sumida, T., Nomura, S., Liu, M.-L., Higo, T., Nakagawa, A., Okada, K., Sakai, T., Hashimoto, A., Hara, Y., et al. (2012) · Cell

Wnt/β-catenin signaling in development and cancerGenetics, Aging, and Longevity in Model Organisms

Cited by 320

Angiotensin II Induces Premature Senescence of Vascular Smooth Muscle Cells and Accelerates the Development of Atherosclerosis via a p21-Dependent Pathway

Kunieda, T., Minamino, T., Nishi, J.-I., Tateno, K., Oyama, T., Katsuno, T., Miyauchi, H., Orimo, M., Okada, S., Takamura, M., et al. (2006) · Circulation

Renin-Angiotensin System StudiesTelomeres, Telomerase, and Senescence

Cited by 302

Adipose natural regulatory B cells negatively control adipose tissue inflammation

Nishimura, S., Manabe, I., Takaki, S., Nagasaki, M., Otsu, M., Yamashita, H., Sugita, J., Yoshimura, K., Eto, K., Komuro, I., et al. (2013) · Cell Metabolism

Adipokines, Inflammation, and Metabolic DiseasesT-cell and B-cell Immunology

Cited by 251

Heart failure and chronic kidney disease manifestation and mortality risk associations in type 2 diabetes: A large multinational cohort study

Birkeland, K. I., Bodegard, J., Eriksson, J. W., Norhammar, A., Haller, H., Linssen, G. C. M., Banerjee, A., Thuresson, M., Okami, S., Garal‐Pantaler, E., et al. (2020) · Diabetes, Obesity and Metabolism

Chronic Kidney Disease and DiabetesDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 223

Cardiac Nonmyocytes in the Hub of Cardiac Hypertrophy

Kamo, T., Akazawa, H., & Komuro, I. (2015) · Circulation Research

Cardiac Fibrosis and RemodelingSignaling Pathways in Disease

Cited by 171

Semaglutide and cardiovascular outcomes by baseline and changes in adiposity measurements: a prespecified analysis of the SELECT trial

Deanfield, J., Lincoff, A. M., Kahn, S. E., Emerson, S. S., Lingvay, I., Scirica, B. M., Plutzky, J., Kushner, R. F., Colhoun, H. M., Hovingh, G. K., et al. (2025) · The Lancet

Diabetes Treatment and ManagementPharmacology and Obesity Treatment

Cited by 143

Phosphatidylinositol 3-Kinase–Akt Pathway Plays a Critical Role in Early Cardiomyogenesis by Regulating Canonical Wnt Signaling

Naito, A. T., Akazawa, H., Takano, H., Minamino, T., Nagai, T., Aburatani, H., & Komuro, I. (2005) · Circulation Research

Wnt/β-catenin signaling in development and cancerCongenital heart defects research

Cited by 121

Incidence, Predictors, and Subsequent Mortality Risk of Recurrent Myocardial Infarction in Patients Following Discharge for Acute Myocardial Infarction

Nakatani, D., Sakata, Y., Suna, S., Usami, M., Matsumoto, S., Shimizu, M., Sumitsuji, S., Kawano, S., Ueda, Y., Hamasaki, T., et al. (2013) · Circulation Journal

Acute Myocardial Infarction ResearchCoronary Interventions and Diagnostics

Cited by 108

Apixaban for the treatment of Japanese subjects with acute venous thromboembolism (AMPLIFY-J Study)

Nakamura, M., Nishikawa, M., Komuro, I., Kitajima, I., Uetsuka, Y., Yamagami, T., Minamiguchi, H., Yoshimatsu, R., Tanabe, K., Matsuoka, N., et al. (2015) · Circulation Journal

Venous Thromboembolism Diagnosis and ManagementBlood Coagulation and Thrombosis Mechanisms

Cited by 67

A pain-mediated neural signal induces relapse in murine autoimmune encephalomyelitis, a multiple sclerosis model

Arima, Y., Kamimura, D., Atsumi, T., Harada, M., Kawamoto, T., Nishikawa, N., Stofkova, A., Ohki, T., Higuchi, K., Morimoto, Y., et al. (2015) · eLife

Multiple Sclerosis Research StudiesPain Mechanisms and Treatments

Cited by 66

Cost-Effectiveness of Statin Plus Eicosapentaenoic Acid Combination Therapy for Cardiovascular Disease Prevention in Japanese Patients With Hypercholesterolemia ― An Analysis Based on the Japan Eicosapentaenoic Acid Lipid Intervention Study (JELIS) ―

Kodera, S., Morita, H., Kiyosue, A., Ando, J., & Komuro, I. (2018) · Circulation Journal

Health Systems, Economic Evaluations, Quality of LifeLipoproteins and Cardiovascular Health

Cited by 21

Genomic and transcriptomic analyses of aortic stenosis enhance therapeutic target discovery and disease prediction

Small, A. M., Yang, T.-Y., Itoh, S., Thériault, S., Dufresne, L., Kurosawa, R., Komuro, I., Matsuda, K., Vy, H. M. T., Farber-Eger, E. H., et al. (2026) · Nature Genetics

Cardiac Valve Diseases and TreatmentsGenetic Associations and Epidemiology

Cited by 18

Early Initiation of Feeding and In-Hospital Outcomes in Patients Hospitalized for Acute Heart Failure

Kaneko, H., Itoh, H., Morita, K., Sugimoto, T., Konishi, M., Kamiya, K., Kiriyama, H., Kamon, T., Fujiu, K., Michihata, N., et al. (2021) · The American Journal of Cardiology

Clinical Nutrition and GastroenterologyHeart Failure Treatment and Management

Cited by 13

Neovascularization induced by hypoxia inducible transcription factor is associated with the improvement of cardiac dysfunction in experimental autoimmune myocarditis

Tada, Y., Ogawa, M., Watanabe, R., Zempo, H., Takamura, C., Suzuki, J.-I., Dan, T., Miyata, T., Isobe, M., & Komuro, I. (2014) · Expert Opinion on Investigational Drugs

Viral Infections and Immunology ResearchCardiac Fibrosis and Remodeling

Cited by 9

Diurnal body temperature rise is reduced in diabetes with autonomic neuropathy

Amiya, E., Watanabe, M., Takata, M., Nakao, T., Hosoya, Y., Watanabe, S., Nagai, R., & Komuro, I. (2014) · Clinical Autonomic Research

Circadian rhythm and melatoninHeart Rate Variability and Autonomic Control

Cited by 2