Sheng, Chunquan

Molecular Glues for Targeted Protein Degradation: From Serendipity to Rational Discovery

Dong, G., Ding, Y., He, S., & Sheng, C. (2021) · Journal of Medicinal Chemistry

Protein Degradation and InhibitorsChemical Synthesis and Analysis

Cited by 369

State-of-the-art strategies for targeting protein–protein interactions by small-molecule inhibitors

Sheng, C., Dong, G., Miao, Z., Zhang, W., & Wang, W. (2015) · Chemical Society Reviews

Chemical Synthesis and AnalysisProtein Degradation and Inhibitors

Cited by 165

Discovery, Synthesis, and Biological Evaluation of Orally Active Pyrrolidone Derivatives as Novel Inhibitors of p53–MDM2 Protein–Protein Interaction

Zhuang, C., Miao, Z., Zhu, L., Dong, G., Guo, Z., Wang, S., Zhang, Y., Wu, Y., Yao, J., Sheng, C., et al. (2012) · Journal of Medicinal Chemistry

Cancer-related Molecular PathwaysHeterocyclic Compound Synthesis and Bioactivity

Cited by 131

Faecalibacterium prausnitzii Abrogates Intestinal Toxicity and Promotes Tumor Immunity to Increase the Efficacy of Dual CTLA4 and PD-1 Checkpoint Blockade

Gao, Y., Xu, P., Sun, D., Jiang, Y., Lin, X.-L., Han, T., Yu, J., Sheng, C., Chen, H., Hong, J., et al. (2023) · Cancer Research

Cancer Immunotherapy and BiomarkersGut microbiota and health

Cited by 116

Homo-PROTAC mediated suicide of MDM2 to treat non-small cell lung cancer

He, S., Ma, J., Fang, Y., Liu, Y., Wu, S., Dong, G., Wang, W., & Sheng, C. (2021) · Acta Pharmaceutica Sinica B

Protein Degradation and InhibitorsCancer-related Molecular Pathways

Cited by 91

Fragment Informatics and Computational Fragment‐Based Drug Design: An Overview and Update

Sheng, C., & Zhang, W. (2013) · Medicinal Research Reviews

Computational Drug Discovery MethodsChemical Synthesis and Analysis

Cited by 80

Double-Edged Swords as Cancer Therapeutics: Novel, Orally Active, Small Molecules Simultaneously Inhibit p53–MDM2 Interaction and the NF-κB Pathway

Zhuang, C., Miao, Z., Wu, Y., Guo, Z., Li, J., Yao, J., Xing, C., Sheng, C., & Zhang, W. (2014) · Journal of Medicinal Chemistry

Cancer-related Molecular PathwaysHeterocyclic Compound Synthesis and Bioactivity

Cited by 50

Structural Biology-Inspired Discovery of Novel KRAS–PDEδ Inhibitors

Jiang, Y., Zhuang, C., Chen, L., Lu, J., Dong, G., Miao, Z., Zhang, W., Li, J., & Sheng, C. (2017) · Journal of Medicinal Chemistry

Phosphodiesterase function and regulationProtein Kinase Regulation and GTPase Signaling

Cited by 34

Discovery of Novel KRAS-PDEδ Inhibitors by Fragment-Based Drug Design

Chen, L., Zhuang, C., Lu, J., Jiang, Y., & Sheng, C. (2018) · Journal of Medicinal Chemistry

Phosphodiesterase function and regulationComputational Drug Discovery Methods

Cited by 33

Discovery of novel KRAS‒PDEδ inhibitors with potent activity in patient-derived human pancreatic tumor xenograft models

Chen, L., Zhang, J., Wang, X., Li, Y., Zhou, L., Lu, X., Dong, G., & Sheng, C. (2022) · Acta Pharmaceutica Sinica B

Phosphodiesterase function and regulationProtein Kinase Regulation and GTPase Signaling

Cited by 20