Discovery, Synthesis, and Biological Evaluation of Orally Active Pyrrolidone Derivatives as Novel Inhibitors of p53–MDM2 Protein–Protein Interaction

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Discovery of benzothiazole derivatives as novel non-sulfamide NEDD8 activating enzyme inhibitors by target-based virtual screening

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Enols as Feasible Acid Components in the Ugi Condensation

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Ligand Binding Mode Prediction by Docking: Mdm2/Mdmx Inhibitors as a Case Study

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De Novo Synthesis of 3-Pyrrolin-2-Ones

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Chemical Variations on the p53 Reactivation Theme

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Stereoselective Synthesis of Quaternary Pyrrolidine-2,3-diones and β-Amino Acids

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Photocatalytic Cyclization/Defluorination Domino Sequence to Access 3-Fluoro-1,5-dihydro-2 H -pyrrol-2-one Scaffold

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Palladium-catalyzed tandem reaction of 2-chloroquinoline-3-carbaldehydes and isocyanides

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Design, synthesis and in vitro and in vivo antitumour activity of 3-benzylideneindolin-2-one derivatives, a novel class of small-molecule inhibitors of the MDM2–p53 interaction

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Synthesis and antitumor activity of novel substituted uracil-1′(N)-acetic acid ester derivatives of 20(S)-camptothecins

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Effective Screening Strategy Using Ensembled Pharmacophore Models Combined with Cascade Docking: Application to p53-MDM2 Interaction Inhibitors

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Recent Synthetic Approaches towards Small Molecule Reactivators of p53

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Design, synthesis and biological evaluation of novel 5-(4-chlorophenyl)-4-phenyl-4H-1,2,4-triazole-3-thiols as an anticancer agent

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Diaryl- and triaryl-pyrrole derivatives: inhibitors of the MDM2–p53 and MDMX–p53 protein–protein interactions

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Design, synthesis and biological evaluation of novel antitumor spirotetrahydrothiopyran–oxindole derivatives as potent p53-MDM2 inhibitors

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Construction of Phosphorothiolated 2-Pyrrolidinones via Photoredox/Copper-Catalyzed Cascade Radical Cyclization/Phosphorothiolation

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Enantioselective synthesis of pyrano[2,3- c ]pyrrole via an organocatalytic [4 + 2] cyclization reaction of dioxopyrrolidines and azlactones

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Design, Synthesis and Biological Evaluation of Sulfamide and Triazole Benzodiazepines as Novel p53-MDM2 Inhibitors

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2,4,5-Tris(alkoxyaryl)imidazoline derivatives as potent scaffold for novel p53-MDM2 interaction inhibitors: Design, synthesis, and biological evaluation

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Assembly of 3-sulfonated 2H-pyrrol-2-ones through the insertion of sulfur dioxide with allenoic amides

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Design, synthesis and biological evaluation of novel antitumor spirodihydrothiopyran-oxindole derivatives

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A Brønsted Acid-Catalyzed Multicomponent Reaction for the Synthesis of Highly Functionalized γ-Lactam Derivatives

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Brönsted Acid Catalyzed Multicomponent Synthesis of Phosphorus and Fluorine-Derived γ-Lactam Derivatives

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p53: An Attractive Therapeutic Target for Cancer

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Mutational analysis of breast cancer: Guiding personalized treatments

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Integrated virtual screening and molecular dynamics simulation revealed promising drug candidates of p53-MDM2 interaction

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Exploring the Synthetic Potential of γ-Lactam Derivatives Obtained from a Multicomponent Reaction—Applications as Antiproliferative Agents

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Discovery of γ-lactam derivatives containing 1,3-benzodioxole unit as potential anti-phytopathogenic fungus agents

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Synthesis and Biological Evaluation of Novel Dispiro-Indolinones with Anticancer Activity

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Recent Advancements in the Discovery of MDM2/MDM2-p53 Interaction Inhibitors for the Treatment of Cancer

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Inhibition of HSP90 sensitizes a novel Raf/ERK dual inhibitor CY-9d in triple-negative breast cancer cells

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A Fluorescent Probe for Imaging p53– MDM 2 Protein–Protein Interaction

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A Multicomponent Protocol for the Synthesis of Highly Functionalized γ-Lactam Derivatives and Their Applications as Antiproliferative Agents

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Post-HTS case report and structural alert: Promiscuous 4-aroyl-1,5-disubstituted-3-hydroxy-2H-pyrrol-2-one actives verified by ALARM NMR

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Ugi‐modified nano NaY zeolite for the synthesis of new 1,5‐dihydro‐2H‐pyrrol‐2‐ones under mild conditions

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An unexpected iron(II)-promoted reaction of N-arylprop-2-yn-1-imines with water: Facile assembly of multi-substituted pyrroles

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A computer-aided drug design approach to discover tumour suppressor p53 protein activators for colorectal cancer therapy

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Selective Synthesis of 3-Substituted Pyrrolidinones by Enol-Passerini and Anomalous Enol-Passerini Condensations

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Discovery of 1-arylpyrrolidone derivatives as potent p53–MDM2 inhibitors based on molecule fusing strategy

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The Therapeutic Potential of Spirooxindoles in Cancer: A Focus on p53–MDM2 Modulation

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Rational Design, Synthesis, Separation, and Characterization of New Spiroxindoles Combined with Benzimidazole Scaffold as an MDM2 Inhibitor

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Discovery of dihydropyrrolidones as novel inhibitors against influenza A virus

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Discovery of Nonpeptide, Environmentally Sensitive Fluorescent Probes for Imaging p53-MDM2 Interactions in Living Cell Lines and Tissue Slice

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Design, synthesis and structure–activity relationship of 4,5-dihydropyrrolo[3,4- c ]pyrazol-6(1 H )-ones as potent p53-MDM2 inhibitors

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Stereo‐ and Regioselective [3+3] Annulation Reaction Catalyzed by Ytterbium: Synthesis of Bicyclic 1,4‐Dihydropyridines

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Multicomponent Synthesis of Unsaturated γ-Lactam Derivatives. Applications as Antiproliferative Agents through the Bioisosterism Approach: Carbonyl vs. Phosphoryl Group

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A novel drug discovery strategy: Mechanistic investigation of an enantiomeric antitumor agent targeting dual p53 and NF-κB pathways

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An Effective Virtual Screening Protocol To Identify Promising p53–MDM2 Inhibitors

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Design, synthesis and biological evaluation of novel pyrrolidone-based derivatives as potent p53-MDM2 inhibitors

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A Brief Review: Advancement in the Synthesis of Amine through the Leuckart Reaction

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Synthesis and in vitro evaluation of novel triazole/azide chalcones

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NAE modulators: A potential therapy for gastric carcinoma

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Polyoxometalate immobilized on MOF‐5 as an environment‐friendly catalyst for the synthesis of poly‐functionalized 3‐pyrrolin‐2‐ones

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Direct Transformation of N-Protected α,β-Unsaturated γ-Amino Amides into γ-Lactams through a Base-Mediated Molecular Rearrangement

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Reactions of 3-pyrrolin-2-ones

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Environment-sensitive turn-on fluorescent probes for p53–MDM2 protein–protein interaction

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Rapid identification of dual p53-MDM2/MDMX interaction inhibitors through virtual screening and hit-based substructure search

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Jellynolide A, pokepola esters, and sponalisolides from the aquaculture sponge Spongia officinalis L

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Synthesis and Biological Evaluation of Novel Synthetic Indolone Derivatives as Anti-Tumor Agents Targeting p53-MDM2 and p53-MDMX

Wang, Y., Ji, B., Cheng, Z., Zhang, L., Cheng, Y., Li, Y., Ren, J. T., Liu, W., & Ma, Y. (2022) · Molecules · doi:10.3390/molecules27123721 · Cited by 7 · see citing works

Design, synthesis and biological evaluation of novel pyrrolidone-based derivatives as potent p53-MDM2 inhibitors

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Discovery of Furopyrimidine‐Pyrazole Hybrid Compounds Targeting p53‐MDM2 Interaction as Anticancer Agents

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Discovery of a novel class of highly potent inhibitors of the p53–MDM2 interaction by structure-based design starting from a conformational argument

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Synthesis and evaluation of novel orally active p53–MDM2 interaction inhibitors

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Diaryl- and triaryl-pyrrole derivatives: inhibitors of the MDM2–p53 and MDMX–p53 protein–protein interactions

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