Rahman, Irfan

Guidelines for the use and interpretation of assays for monitoring autophagy

Klionsky, D. J., Abdalla, F. C., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Aguirre-Ghiso, J. A., et al. (2012) · Autophagy

Autophagy in Disease and TherapyCalcium signaling and nucleotide metabolism

Cited by 3,996

Systemic oxidative stress in asthma, COPD, and smokers

Rahman, I., Morrison, D., Donaldson, K., & MacNee, W. (1996) · American Journal of Respiratory and Critical Care Medicine

Antioxidant Activity and Oxidative StressChronic Obstructive Pulmonary Disease (COPD) Research

Cited by 774

Vapors produced by electronic cigarettes and e-juices with flavorings induce toxicity, oxidative stress, and inflammatory response in lung epithelial cells and in mouse lung

Lerner, C. A., Sundar, I. K., Yao, H., Gerloff, J., Ossip, D. J., McIntosh, S., Robinson, R., & Rahman, I. (2015) · PLOS ONE

Smoking Behavior and CessationAntioxidant Activity and Oxidative Stress

Cited by 666

SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease

Rajendrasozhan, S., Yang, S.-R., Kinnula, V. L., & Rahman, I. (2008) · American Journal of Respiratory and Critical Care Medicine

Sirtuins and Resveratrol in MedicineChronic Obstructive Pulmonary Disease (COPD) Research

Cited by 520

Redox modulation of chromatin remodeling: impact on histone acetylation and deacetylation, NF-κB and pro-inflammatory gene expression

Rahman, I., Marwick, J., & Kirkham, P. (2004) · Biochemical Pharmacology

Histone Deacetylase Inhibitors ResearchGenomics and Chromatin Dynamics

Cited by 507

Redox regulation of SIRT1 in inflammation and cellular senescence

Hwang, J.-W., Yao, H., Caito, S., Sundar, I. K., & Rahman, I. (2013) · Free Radical Biology and Medicine

Sirtuins and Resveratrol in MedicineNitric Oxide and Endothelin Effects

Cited by 503

Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells

Kode, A., Rajendrasozhan, S., Caito, S., Yang, S.-R., Megson, I. L., & Rahman, I. (2008) · American Journal of Physiology-Lung Cellular and Molecular Physiology

Genomics, phytochemicals, and oxidative stressSirtuins and Resveratrol in Medicine

Cited by 447

SenNet recommendations for detecting senescent cells in different tissues

Suryadevara, V., Hudgins, A. D., Rajesh, A., Pappalardo, A., Karpova, A., Dey, A. K., Hertzel, A., Agudelo, A., Rocha, A., Soygur, B., et al. (2024) · Nature Reviews Molecular Cell Biology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 408

Sirtuin regulates cigarette smoke-induced proinflammatory mediator release via RelA/p65 NF-κB in macrophages in vitro and in rat lungs in vivo: implications for chronic inflammation and aging

Yang, S.-R., Wright, J., Bauter, M., Seweryniak, K., Kode, A., & Rahman, I. (2007) · American Journal of Physiology-Lung Cellular and Molecular Physiology

Sirtuins and Resveratrol in MedicineNF-κB Signaling Pathways

Cited by 391

SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice

Yao, H., Chung, S., Hwang, J.-W., Rajendrasozhan, S., Sundar, I. K., Dean, D. A., McBurney, M. W., Guarente, L., Gu, W., Rönty, M., et al. (2012) · Journal of Clinical Investigation

Sirtuins and Resveratrol in MedicineChronic Obstructive Pulmonary Disease (COPD) Research

Cited by 358

Nrf2 reduces levels of phosphorylated tau protein by inducing autophagy adaptor protein NDP52

Jo, C., Gundemir, S., Pritchard, S., Jin, Y. N., Rahman, I., & Johnson, G. V. W. (2014) · Nature Communications

Alzheimer's disease research and treatmentsGenomics, phytochemicals, and oxidative stress

Cited by 323

Histone deacetylase 6–mediated selective autophagy regulates COPD-associated cilia dysfunction

Lam, H. C., Cloonan, S. M., Bhashyam, A. R., Haspel, J. A., Singh, A., Sathirapongsasuti, J. F., Cervo, M., Yao, H., Chung, A. L., Mizumura, K., et al. (2013) · Journal of Clinical Investigation

Autophagy in Disease and TherapyCystic Fibrosis Research Advances

Cited by 307

Impaired mitophagy leads to cigarette smoke stress‐induced cellular senescence: implications for chronic obstructive pulmonary disease

Ahmad, T., Sundar, I. K., Lerner, C. A., Gerloff, J., Tormos, A. M., Yao, H., & Rahman, I. (2015) · The FASEB Journal

Autophagy in Disease and TherapyTelomeres, Telomerase, and Senescence

Cited by 264

Characterization of Regulatory Extracellular Vesicles from Osteoclasts

Huynh, N., VonMoss, L., Smith, D., Rahman, I., Felemban, M. F., Zuo, J., Rody, W. J., McHugh, K. P., & Holliday, L. S. (2016) · Journal of Dental Research

Extracellular vesicles in diseaseBone Metabolism and Diseases

Cited by 196

Lysine deacetylation in ischaemic preconditioning: the role of SIRT1

Nadtochiy, S. M., Redman, E., Rahman, I., & Brookes, P. S. (2011) · Cardiovascular Research

Cardiac Ischemia and ReperfusionSirtuins and Resveratrol in Medicine

Cited by 130

NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health.

SenNet Consortium, Writing Group, Lee, P. J., Benz, C. C., Blood, P., Börner, K., Campisi, J., Chen, F., Daldrup-Link, H., De Jager, P., et al. (2022) · Nature Aging

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 122

Pharmacological antioxidant strategies as therapeutic interventions for COPD

Rahman, I. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Chronic Obstructive Pulmonary Disease (COPD) ResearchAntioxidant Activity and Oxidative Stress

Cited by 117

SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism

Yao, H., Sundar, I. K., Ahmad, T., Lerner, C., Gerloff, J., Friedman, A. E., Phipps, R. P., Sime, P. J., McBurney, M. W., Guarente, L., et al. (2014) · American Journal of Physiology-Lung Cellular and Molecular Physiology

Sirtuins and Resveratrol in MedicineChronic Obstructive Pulmonary Disease (COPD) Research

Cited by 104

Metformin: Experimental and Clinical Evidence for a Potential Role in Emphysema Treatment

Polverino, F., Wu, T. D., Rojas-Quintero, J., Wang, X., Mayo, J., Tomchaney, M., Tram, J., Packard, S., Zhang, D., Cleveland, K. H., et al. (2021) · American Journal of Respiratory and Critical Care Medicine

Chronic Obstructive Pulmonary Disease (COPD) ResearchMetabolism, Diabetes, and Cancer

Cited by 100

IKKα Causes Chromatin Modification on Pro-Inflammatory Genes by Cigarette Smoke in Mouse Lung

Yang, S.-R., Valvo, S., Yao, H., Kode, A., Rajendrasozhan, S., Edirisinghe, I., Caito, S., Adenuga, D., Henry, R., Fromm, G., et al. (2008) · American Journal of Respiratory Cell and Molecular Biology

NF-κB Signaling PathwaysGenomics and Chromatin Dynamics

Cited by 98

Free radical activity of industrial fibers: role of iron in oxidative stress and activation of transcription factors.

Gilmour, P. S., Brown, D. M., Beswick, P. H., MacNee, W., Rahman, I., & Donaldson, K. (1997) · Environmental Health Perspectives

Occupational and environmental lung diseasesRedox biology and oxidative stress

Cited by 86

Chemical constituents involved in e-cigarette, or vaping product use-associated lung injury (EVALI)

Muthumalage, T., Friedman, M. R., McGraw, M. D., Friedman, A. E., & Rahman, I. (2020) · Toxics

Smoking Behavior and CessationForensic Toxicology and Drug Analysis

Cited by 82

Shelterin Telomere Protection Protein 1 Reduction Causes Telomere Attrition and Cellular Senescence via Sirtuin 1 Deacetylase in Chronic Obstructive Pulmonary Disease

Ahmad, T., Sundar, I. K., Tormos, A. M., Lerner, C. A., Gerloff, J., Yao, H., & Rahman, I. (2017) · American Journal of Respiratory Cell and Molecular Biology

Telomeres, Telomerase, and SenescenceSirtuins and Resveratrol in Medicine

Cited by 67

Lung cellular senescence is independent of aging in a mouse model of COPD/emphysema

Rashid, K., Sundar, I. K., Gerloff, J., Li, D., & Rahman, I. (2018) · Scientific Reports

Chronic Obstructive Pulmonary Disease (COPD) ResearchTelomeres, Telomerase, and Senescence

Cited by 58