Kopito, Ron R.

Aggresomes: A Cellular Response to Misfolded Proteins

Johnston, J. A., Ward, C. L., & Kopito, R. R. (1998) · The Journal of Cell Biology

Ubiquitin and proteasome pathwaysHeat shock proteins research

Cited by 2,148

Misfolded proteins partition between two distinct quality control compartments

Kaganovich, D., Kopito, R., & Frydman, J. (2008) · Nature

Heat shock proteins researchAutophagy in Disease and Therapy

Cited by 932

Prion-like transmission of protein aggregates in neurodegenerative diseases

Brundin, P., Melki, R., & Kopito, R. (2010) · Nature Reviews Molecular Cell Biology

Prion Diseases and Protein MisfoldingAlzheimer's disease research and treatments

Cited by 778

HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin.

Iwata, A., Riley, B. E., Johnston, J. A., & Kopito, R. R. (2005) · Journal of Biological Chemistry

Autophagy in Disease and TherapyGenetic Neurodegenerative Diseases

Cited by 719

Protein misfolding in neurodegenerative diseases: Implications and strategies

Sweeney, P., Park, H., Baumann, M., Dunlop, J., Frydman, J., Kopito, R., McCampbell, A., Leblanc, G., Venkateswaran, A., Nurmi, A., et al. (2017) · Translational Neurodegeneration

Heat shock proteins researchAlzheimer's disease research and treatments

Cited by 675

OS-9 and GRP94 deliver mutant α1-antitrypsin to the Hrd1–SEL1L ubiquitin ligase complex for ERAD

Christianson, J. C., Shaler, T. A., Tyler, R. E., & Kopito, R. R. (2008) · Nature Cell Biology

Endoplasmic Reticulum Stress and DiseaseHeat shock proteins research

Cited by 509

Global changes to the ubiquitin system in Huntington's disease

Bennett, E. J., Shaler, T. A., Woodman, B., Ryu, K.-Y., Zaitseva, T. S., Becker, C. H., Bates, G. P., Schulman, H., & Kopito, R. R. (2007) · Nature

Genetic Neurodegenerative DiseasesUbiquitin and proteasome pathways

Cited by 497

Prion-like transmission of neuronal huntingtin aggregates to phagocytic glia in the Drosophila brain

Pearce, M. M. P., Spartz, E. J., Hong, W., Luo, L., & Kopito, R. R. (2015) · Nature Communications

Genetic Neurodegenerative DiseasesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 159

The mouse polyubiquitin gene UbC is essential for fetal liver development, cell‐cycle progression and stress tolerance

Ryu, K., Maehr, R., Gilchrist, C. A., Long, M. A., Bouley, D. M., Mueller, B., Ploegh, H. L., & Kopito, R. R. (2007) · The EMBO Journal

Ubiquitin and proteasome pathwaysAutophagy in Disease and Therapy

Cited by 156

SPFH1 and SPFH2 mediate the ubiquitination and degradation of inositol 1,4,5-trisphosphate receptors in muscarinic receptor-expressing HeLa cells

Wang, Y., Pearce, M. M. P., Sliter, D. A., Olzmann, J. A., Christianson, J. C., Kopito, R. R., Boeckmann, S., Gagen, C., Leichner, G. S., Roitelman, J., et al. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Ubiquitin and proteasome pathwaysEndoplasmic Reticulum Stress and Disease

Cited by 33