Eigenbrot, Charles

Oncogenic ERBB3 mutations in human cancers.

Jaiswal, B. S., Kljavin, N. M., Stawiski, E. W., Chan, E., Parikh, C., Durinck, S., Chaudhuri, S., Pujara, K., Guillory, J., Edgar, K. A., et al. (2013) · Cancer Cell

HER2/EGFR in Cancer ResearchLung Cancer Treatments and Mutations

Cited by 350

Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition

Boudreau, A., Purkey, H. E., Hitz, A., Robarge, K., Peterson, D., Labadie, S., Kwong, M., Hong, R., Gao, M., Del Nagro, C., et al. (2016) · Nature Chemical Biology

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 280

Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity

Dendrou, C. A., Cortes, A., Shipman, L., Evans, H. G., Attfield, K. E., Jostins, L., Barber, T., Kaur, G., Kuttikkatte, S. B., Leach, O. A., et al. (2016) · Science Translational Medicine

Genetic Associations and EpidemiologyRheumatoid Arthritis Research and Therapies

Cited by 264

Structure of the pseudokinase-kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition

Lupardus, P. J., Ultsch, M., Wallweber, H., Bir Kohli, P., Johnson, A. R., & Eigenbrot, C. (2014) · Proceedings of the National Academy of Sciences

Cytokine Signaling Pathways and InteractionsProtein Kinase Regulation and GTPase Signaling

Cited by 229

Structural Basis of Signaling Blockade by Anti-IL-13 Antibody Lebrikizumab

Ultsch, M., Bevers, J., Nakamura, G., Vandlen, R., Kelley, R. F., Wu, L. C., & Eigenbrot, C. (2013) · Journal of Molecular Biology

Cytokine Signaling Pathways and InteractionsMonoclonal and Polyclonal Antibodies Research

Cited by 174

Battling Btk mutants with noncovalent inhibitors that overcome Cys481 and Thr474 mutations

Johnson, A. R., Kohli, P. B., Katewa, A., Gogol, E., Belmont, L. D., Choy, R., Penuel, E., Burton, L., Eigenbrot, C., Yu, C., et al. (2016) · ACS Chemical Biology

Chronic Lymphocytic Leukemia ResearchProtein Degradation and Inhibitors

Cited by 137

Structure of Crenezumab Complex with Aβ Shows Loss of β-Hairpin

Ultsch, M., Li, B., Maurer, T., Mathieu, M., Adolfsson, O., Muhs, A., Pfeifer, A., Pihlgren, M., Bainbridge, T. W., Reichelt, M., et al. (2016) · Scientific Reports

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 124