Mutlu, Gökhan M.

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

Weinberg, F., Hamanaka, R., Wheaton, W. W., Weinberg, S., Joseph, J., Lopez, M., Kalyanaraman, B., Mutlu, G. M., Budinger, G. R. S., & Chandel, N. S. (2010) · Proceedings of the National Academy of Sciences

Cancer, Hypoxia, and MetabolismMitochondrial Function and Pathology

Cited by 1,742

Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span

Misharin, A. V., Morales-Nebreda, L., Reyfman, P. A., Cuda, C. M., Walter, J. M., McQuattie-Pimentel, A. C., Chen, C.-I., Anekalla, K. R., Joshi, N., Williams, K. J. N., et al. (2017) · Journal of Experimental Medicine

Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisTransplantation: Methods and Outcomes

Cited by 1,133

Flow Cytometric Analysis of Macrophages and Dendritic Cell Subsets in the Mouse Lung

Misharin, A. V., Morales-Nebreda, L., Mutlu, G. M., Budinger, G. R. S., & Perlman, H. (2013) · American Journal of Respiratory Cell and Molecular Biology

Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisImmune cells in cancer

Cited by 838

Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio

Emerling, B. M., Weinberg, F., Snyder, C., Burgess, Z., Mutlu, G. M., Viollet, B., Budinger, G. R. S., & Chandel, N. S. (2009) · Free Radical Biology and Medicine

Metabolism, Diabetes, and CancerCancer, Hypoxia, and Metabolism

Cited by 330

The lung microenvironment shapes a dysfunctional response of alveolar macrophages in aging

McQuattie-Pimentel, A. C., Ren, Z., Joshi, N., Watanabe, S., Stoeger, T., Chi, M., Lu, Z., Sichizya, L., Aillon, R. P., Chen, C.-I., et al. (2021) · Journal of Clinical Investigation

Genetics, Aging, and Longevity in Model OrganismsImmune responses and vaccinations

Cited by 177

PAI-1–regulated extracellular proteolysis governs senescence and survival in Klotho mice

Eren, M., Boe, A. E., Murphy, S. B., Place, A. T., Nagpal, V., Morales-Nebreda, L., Urich, D., Quaggin, S. E., Budinger, G. R. S., Mutlu, G. M., et al. (2014) · Proceedings of the National Academy of Sciences

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 176

Transforming Growth Factor (TGF)-β Promotes de Novo Serine Synthesis for Collagen Production

Nigdelioglu, R., Hamanaka, R. B., Meliton, A. Y., O'Leary, E., Witt, L. J., Cho, T., Sun, K., Bonham, C., Wu, D., Woods, P. S., et al. (2016) · Journal of Biological Chemistry

TGF-β signaling in diseasesInterstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Cited by 169

Metformin targets mitochondrial electron transport to reduce air-pollution-induced thrombosis

Soberanes, S., Misharin, A. V., Jairaman, A., Morales-Nebreda, L., McQuattie-Pimentel, A. C., Cho, T., Hamanaka, R. B., Meliton, A. Y., Reyfman, P. A., Walter, J. M., et al. (2019) · Cell Metabolism

Air Quality and Health ImpactsMetabolism, Diabetes, and Cancer

Cited by 131

Wood Smoke Particle Sequesters Cell Iron to Impact a Biological Effect

Ghio, A. J., Soukup, J. M., Dailey, L. A., Tong, H., Kesic, M. J., Budinger, G. R. S., & Mutlu, G. M. (2015) · Chemical Research in Toxicology

Air Quality and Health ImpactsHeavy Metal Exposure and Toxicity

Cited by 41

Sequestration of mitochondrial iron by silica particle initiates a biological effect

Ghio, A. J., Tong, H., Soukup, J. M., Dailey, L. A., Cheng, W.-Y., Samet, J. M., Kesic, M. J., Bromberg, P. A., Turi, J. L., Upadhyay, D., et al. (2013) · American Journal of Physiology-Lung Cellular and Molecular Physiology

Occupational and environmental lung diseasesIron Metabolism and Disorders

Cited by 37