Jost, Marco

A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response

Adamson, B., Norman, T. M., Jost, M., Cho, M. Y., Nuñez, J. K., Chen, Y., Villalta, J. E., Gilbert, L. A., Horlbeck, M. A., Hein, M. Y., et al. (2016) · Cell

Endoplasmic Reticulum Stress and DiseaseSingle-cell and spatial transcriptomics

Cited by 1,193

Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq

Replogle, J. M., Saunders, R. A., Pogson, A. N., Hussmann, J. A., Lenail, A., Guna, A., Mascibroda, L., Wagner, E. J., Adelman, K., Lithwick-Yanai, G., et al. (2022) · Cell

CRISPR and Genetic EngineeringSingle-cell and spatial transcriptomics

Cited by 795

Exploring genetic interaction manifolds constructed from rich single-cell phenotypes

Norman, T. M., Horlbeck, M. A., Replogle, J. M., Ge, A. Y., Xu, A., Jost, M., Gilbert, L. A., & Weissman, J. S. (2019) · Science

Gene Regulatory Network AnalysisBioinformatics and Genomic Networks

Cited by 392

Molecular recording of mammalian embryogenesis

Chan, M. M., Smith, Z. D., Grosswendt, S., Kretzmer, H., Norman, T. M., Adamson, B., Jost, M., Quinn, J. J., Yang, D., Jones, M. G., et al. (2019) · Nature

Single-cell and spatial transcriptomicsDevelopmental Biology and Gene Regulation

Cited by 364

Titrating gene expression using libraries of systematically attenuated CRISPR guide RNAs

Jost, M., Santos, D. A., Saunders, R. A., Horlbeck, M. A., Hawkins, J. S., Scaria, S. M., Norman, T. M., Hussmann, J. A., Liem, C. R., Gross, C. A., et al. (2020) · Nature Biotechnology

CRISPR and Genetic EngineeringRNA Interference and Gene Delivery

Cited by 164

CRISPR Approaches to Small Molecule Target Identification

Jost, M., & Weissman, J. S. (2018) · ACS Chemical Biology

CRISPR and Genetic EngineeringComputational Drug Discovery Methods

Cited by 88

Approaches to maximize sgRNA-barcode coupling in Perturb-seq screens

Adamson, B., Norman, T. M., Jost, M., & Weissman, J. S. (2018) · bioRxiv (Cold Spring Harbor Laboratory)

CRISPR and Genetic EngineeringSingle-cell and spatial transcriptomics

Cited by 34