Guillot, Adrien

Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH

Dudek, M., Pfister, D., Donakonda, S., Filpe, P., Schneider, A., Laschinger, M., Hartmann, D., Hüser, N., Meiser, P., Bayerl, F., et al. (2021) · Nature

Liver Disease Diagnosis and TreatmentLiver Diseases and Immunity

Cited by 518

Differential Effects of Selective- and Pan-PPAR Agonists on Experimental Steatohepatitis and Hepatic Macrophages(☆)

Lefere, S., Puengel, T., Hundertmark, J., Penners, C., Frank, A. K., Guillot, A., de Muynck, K., Heymann, F., Adarbes, V., Defrêne, E., et al. (2020) · Journal of Hepatology

Liver Disease Diagnosis and TreatmentPeroxisome Proliferator-Activated Receptors

Cited by 310

ALDH2 deficiency promotes alcohol-associated liver cancer by activating oncogenic pathways via oxidized DNA-enriched extracellular vesicles

Seo, W., Gao, Y., He, Y., Sun, J., Xu, H., Feng, D., Park, S. H., Cho, Y.-E., Guillot, A., Ren, T., et al. (2019) · Journal of Hepatology

Alcohol Consumption and Health EffectsLiver physiology and pathology

Cited by 218

Acquisition of epithelial plasticity in human chronic liver disease

Gribben, C., Galanakis, V., Calderwood, A., Williams, E. C., Chazarra-Gil, R., Larraz, M., Frau, C., Puengel, T., Guillot, A., Rouhani, F. J., et al. (2024) · Nature

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 142

Hepatic stellate cells control liver zonation, size and functions via R-spondin 3

Sugimoto, A., Saito, Y., Wang, G., Sun, Q., Yin, C., Lee, K. H., Geng, Y., Rajbhandari, P., Hernandez, C., Steffani, M., et al. (2025) · Nature

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 133

Kupffer cell–like syncytia replenish resident macrophage function in the fibrotic liver

Peiseler, M., Araujo David, B., Zindel, J., Surewaard, B. G. J., Lee, W.-Y., Heymann, F., Nusse, Y., Castanheira, F. V. S., Shim, R., Guillot, A., et al. (2023) · Science

Liver physiology and pathologyImmune cells in cancer

Cited by 123

Mapping the hepatic immune landscape identifies monocytic macrophages as key drivers of steatohepatitis and cholangiopathy progression

Guillot, A., Winkler, M., Silva Afonso, M., Aggarwal, A., Lopez, D., Berger, H., Kohlhepp, M. S., Liu, H., Özdirik, B., Eschrich, J., et al. (2023) · Hepatology

Liver Diseases and ImmunityLiver Disease Diagnosis and Treatment

Cited by 116

Nuclear receptors linking metabolism, inflammation, and fibrosis in nonalcoholic fatty liver disease

Puengel, T., Liu, H., Guillot, A., Heymann, F., Tacke, F., & Peiseler, M. (2022) · International Journal of Molecular Sciences

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 95

Monocyte-derived macrophages orchestrate multiple cell-type interactions to repair necrotic liver lesions in disease models

Feng, D., Xiang, X., Guan, Y., Guillot, A., Lu, H., Chang, C., He, Y., Wang, H., Pan, H., Ju, C., et al. (2023) · Journal of Clinical Investigation

Liver physiology and pathologyLiver Diseases and Immunity

Cited by 93

Distinct histopathological phenotypes of severe alcoholic hepatitis suggest different mechanisms driving liver injury and failure

Ma, J., Guillot, A., Yang, Z., Mackowiak, B., Hwang, S., Park, O., Peiffer, B. J., Ahmadi, A. R., Melo, L., Kusumanchi, P., et al. (2022) · Journal of Clinical Investigation

Alcohol Consumption and Health EffectsLiver physiology and pathology

Cited by 90

Angiocrine signaling in sinusoidal homeostasis and liver diseases

Gao, J., Lan, T., Kostallari, E., Guo, Y., Lai, E., Guillot, A., Ding, B., Tacke, F., Tang, C., & Shah, V. H. (2024) · Journal of Hepatology

Liver physiology and pathologyLiver Disease and Transplantation

Cited by 90

Bile acid–activated macrophages promote biliary epithelial cell proliferation through integrin αvβ6 upregulation following liver injury

Guillot, A., Guerri, L., Feng, D., Kim, S.-J., Ahmed, Y. A., Paloczi, J., He, Y., Schuebel, K., Dai, S., Liu, F., et al. (2021) · Journal of Clinical Investigation

Liver physiology and pathologyLiver Diseases and Immunity

Cited by 86

Deciphering the Immune Microenvironment on A Single Archival Formalin-Fixed Paraffin-Embedded Tissue Section by An Immediately Implementable Multiplex Fluorescence Immunostaining Protocol

Guillot, A., Kohlhepp, M., Bruneau, A., Heymann, F., & Tacke, F. (2020) · Cancers

Cancer Immunotherapy and BiomarkersSingle-cell and spatial transcriptomics

Cited by 46

Liver macrophages revisited: The expanding universe of versatile responses in a spatiotemporal context

Guillot, A., & Tacke, F. (2024) · Hepatology Communications

Liver physiology and pathologyImmune cells in cancer

Cited by 45

Inflammation in Alcohol-Associated Hepatitis: Pathogenesis and Therapeutic Targets

Feng, D., Hwang, S., Guillot, A., Wang, Y., Guan, Y., Chen, C., Maccioni, L., & Gao, B. (2024) · Cellular and Molecular Gastroenterology and Hepatology

Alcohol Consumption and Health EffectsLiver physiology and pathology

Cited by 44

Cholangiokines: undervalued modulators in the hepatic microenvironment

Cai, X., Tacke, F., Guillot, A., & Liu, H. (2023) · Frontiers in Immunology

Liver physiology and pathologyLiver Diseases and Immunity

Cited by 40

Spatial dimension of macrophage heterogeneity in liver diseases

Guillot, A., & Tacke, F. (2023) · eGastroenterology

Liver physiology and pathologyImmune cells in cancer

Cited by 40

Interleukins‐17 and 27 promote liver regeneration by sequentially inducing progenitor cell expansion and differentiation

Guillot, A., Gasmi, I., Brouillet, A., Ait‐Ahmed, Y., Calderaro, J., Ruiz, I., Gao, B., Lotersztajn, S., Pawlotsky, J., & Lafdil, F. (2018) · Hepatology Communications

Liver physiology and pathologyLiver Diseases and Immunity

Cited by 38

Modeling Nonalcoholic Fatty Liver Disease in the Dish Using Human-Specific Platforms: Strategies and Limitations

Rezvani, M., Vallier, L., & Guillot, A. (2023) · Cellular and Molecular Gastroenterology and Hepatology

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 34

Interleukin-17 programs liver progenitor cell transformation into cancer stem cells through mir-122 downregulation with increased risk of primary liver cancer initiation

Gasmi, I., Machou, C., Rodrigues, A., Brouillet, A., Nguyen, T. C., Rousseau, B., Guillot, A., Rodriguez, C., Demontant, V., Ait-Ahmed, Y., et al. (2022) · International Journal of Biological Sciences

Liver physiology and pathologyCancer Cells and Metastasis

Cited by 31

Dissecting Acute Drug‐Induced Hepatotoxicity and Therapeutic Responses of Steatotic Liver Disease Using Primary Mouse Liver and Blood Cells in a Liver‐On‐A‐Chip Model

Liu, H., Yin, G., Kohlhepp, M. S., Schumacher, F., Hundertmark, J., Hassan, M. I. A., Heymann, F., Puengel, T., Kleuser, B., Mosig, A. S., et al. (2024) · Advanced Science

Drug-Induced Hepatotoxicity and Protection3D Printing in Biomedical Research

Cited by 30

The contradictory roles of macrophages in non-alcoholic fatty liver disease and primary liver cancer—Challenges and opportunities

Kohlhepp, M. S., Liu, H., Tacke, F., & Guillot, A. (2023) · Frontiers in Molecular Biosciences

Immune cells in cancerLiver physiology and pathology

Cited by 27

Kupffer cell reverse migration into the liver sinusoids mitigates neonatal sepsis and meningitis

Araujo David, B., Atif, J., Vargas e Silva Castanheira, F., Yasmin, T., Guillot, A., Ait Ahmed, Y., Peiseler, M., Hommes, J. W., Salm, L., Brundler, M.-A., et al. (2024) · Science Immunology

Neonatal and Maternal InfectionsImmune cells in cancer

Cited by 25

Reactive cholangiocyte-derived ORM2 drives a pathogenic modulation of the injured biliary niche through macrophage reprogramming

Liu, H., Yin, G., Franco Leonardi, B., Lan, T., Ait Ahmed, Y., Berger, H., Kohlhepp, M. S., Amiridze, N., Martagón Calderón, N., Frau, C., et al. (2025) · Gut

Liver physiology and pathologyLiver Diseases and Immunity

Cited by 23