Dichgans, Martin

Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition

Colombo, A. V., Sadler, R. K., Llovera, G., Singh, V., Roth, S., Heindl, S., Sebastian Monasor, L., Verhoeven, A., Peters, F., Parhizkar, S., et al. (2021) · eLife

Alzheimer's disease research and treatmentsGut microbiota and health

Cited by 354

Machine learning analysis of whole mouse brain vasculature

Todorov, M. I., Paetzold, J. C., Schoppe, O., Tetteh, G., Shit, S., Efremov, V., Todorov-Völgyi, K., Düring, M., Dichgans, M., Piraud, M., et al. (2020) · Nature Methods

Medical Image Segmentation TechniquesCell Image Analysis Techniques

Cited by 338

Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer’s disease

Ewers, M., Franzmeier, N., Suárez-Calvet, M., Morenas-Rodriguez, E., Caballero, M. A. A., Kleinberger, G., Piccio, L., Cruchaga, C., Deming, Y., Dichgans, M., et al. (2019) · Science Translational Medicine

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 327

Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

de Rojas, I., Moreno-Grau, S., Tesi, N., Grenier-Boley, B., Andrade, V., Jansen, I. E., Pedersen, N. L., Stringa, N., Zettergren, A., Hernández, I., et al. (2021) · Nature Communications

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 324

A novel Alzheimer disease locus located near the gene encoding tau protein

Jun, G., Ibrahim-Verbaas, C. A., Vronskaya, M., Lambert, J.-C., Chung, J., Naj, A. C., Kunkle, B. W., Wang, L.-S., Bis, J. C., Bellenguez, C., et al. (2016) · Molecular Psychiatry

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 297

Cerebral Microbleeds in CADASIL: A Gradient-Echo Magnetic Resonance Imaging and Autopsy Study

Dichgans, M., Holtmannspötter, M., Herzog, J., Peters, N., Bergmann, M., & Yousry, T. A. (2002) · Stroke

Cerebrovascular and genetic disordersIntracerebral and Subarachnoid Hemorrhage Research

Cited by 293

Meta-analysis of Genome-wide Association Studies Identifies 1q22 as a Susceptibility Locus for Intracerebral Hemorrhage

Woo, D., Falcone, G. J., Devan, W. J., Brown, W. M., Biffi, A., Howard, T. D., Anderson, C. D., Brouwers, H. B., Valant, V., Battey, T. W. K., et al. (2014) · The American Journal of Human Genetics

Intracerebral and Subarachnoid Hemorrhage ResearchGenetic Associations and Epidemiology

Cited by 290

Donepezil in patients with subcortical vascular cognitive impairment: a randomised double-blind trial in CADASIL

Dichgans, M., Markus, H. S., Salloway, S., Verkkoniemi, A., Moline, M., Wang, Q., Posner, H., & Chabriat, H. S. (2008) · The Lancet Neurology

Dementia and Cognitive Impairment ResearchNeurological Disease Mechanisms and Treatments

Cited by 264

Quantifying blood‐brain barrier leakage in small vessel disease: Review and consensus recommendations

Thrippleton, M. J., Backes, W. H., Sourbron, S., Ingrisch, M., van Osch, M. J. P., Dichgans, M., Fazekas, F., Ropele, S., Frayne, R., van Oostenbrugge, R. J., et al. (2019) · Alzheimer's & Dementia

Barrier Structure and Function StudiesCerebrovascular and genetic disorders

Cited by 252

Common variation in PHACTR1 is associated with susceptibility to cervical artery dissection

International Stroke Genetics Consortium, Debette, S., the CADISP group, Kamatani, Y., Metso, T. M., Kloss, M., Chauhan, G., Engelter, S. T., Pezzini, A., Thijs, V., et al. (2015) · Nature Genetics

Cerebrovascular and Carotid Artery DiseasesGenetic Associations and Epidemiology

Cited by 231

Differential lesion patterns in CADASIL and sporadic subcortical arteriosclerotic encephalopathy: MR imaging study with statistical parametric group comparison

Auer, D. P., Pütz, B., Gössl, C., Elbel, G.-K., Gasser, T., & Dichgans, M. (2001) · Radiology

Cerebrovascular and genetic disordersNeurological Complications and Syndromes

Cited by 223

Incident subcortical infarcts induce focal thinning in connected cortical regions

Duering, M., Righart, R., Csanadi, E., Jouvent, E., Hervé, D., Chabriat, H., & Dichgans, M. (2012) · Neurology

Cerebrovascular and genetic disordersAdvanced Neuroimaging Techniques and Applications

Cited by 218

Acute infarcts cause focal thinning in remote cortex via degeneration of connecting fiber tracts

Duering, M., Righart, R., Wollenweber, F. A., Zietemann, V., Gesierich, B., & Dichgans, M. (2015) · Neurology

Advanced Neuroimaging Techniques and ApplicationsAcute Ischemic Stroke Management

Cited by 212

Integrating genetic, transcriptional, and functional analyses to identify 5 novel genes for atrial fibrillation

Sinner, M. F., Tucker, N. R., Lunetta, K. L., Ozaki, K., Smith, J. G., Trompet, S., Bis, J. C., Lin, H., Chung, M. K., Nielsen, J. B., et al. (2014) · Circulation

Cardiac electrophysiology and arrhythmiasAtrial Fibrillation Management and Outcomes

Cited by 205

Strategic role of frontal white matter tracts in vascular cognitive impairment: a voxel-based lesion-symptom mapping study in CADASIL

Duering, M., Zieren, N., Hervé, D., Jouvent, E., Reyes, S., Peters, N., Pachai, C., Opherk, C., Chabriat, H., & Dichgans, M. (2011) · Brain

Cerebrovascular and genetic disordersNeurological Disease Mechanisms and Treatments

Cited by 200

Convergent genetic and expression data implicate immunity in Alzheimer's disease

International Genomics of Alzheimer's Disease Consortium (IGAP), Jones, L., Lambert, J., Wang, L., Choi, S., Harold, D., Vedernikov, A., Escott‐Price, V., Stone, T., Richards, A., et al. (2015) · Alzheimer's & Dementia

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 199

White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer’s disease

Araque Caballero, M. Á., Suárez-Calvet, M., Duering, M., Franzmeier, N., Benzinger, T., Fagan, A. M., Bateman, R. J., Jack, C. R., Levin, J., Dichgans, M., et al. (2018) · Brain

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 184

Incident lacunes preferentially localize to the edge of white matter hyperintensities: insights into the pathophysiology of cerebral small vessel disease

Duering, M., Csanadi, E., Gesierich, B., Jouvent, E., Herve, D., Seiler, S., Belaroussi, B., Ropele, S., Schmidt, R., Chabriat, H., et al. (2013) · Brain

Cerebrovascular and genetic disordersIntracerebral and Subarachnoid Hemorrhage Research

Cited by 183

The Pattern of Cognitive Performance in CADASIL: A Monogenic Condition Leading to Subcortical Ischemic Vascular Dementia

Peters, N., Opherk, C., Danek, A., Ballard, C., Herzog, J., & Dichgans, M. (2005) · American Journal of Psychiatry

Cerebrovascular and genetic disordersNeurological Disease Mechanisms and Treatments

Cited by 178

The effect of NOTCH3 pathogenic variant position on CADASIL disease severity: NOTCH3 EGFr 1-6 pathogenic variant are associated with a more severe phenotype and lower survival compared with EGFr 7-34 pathogenic variant

Rutten, J. W., Van Eijsden, B. J., Duering, M., Jouvent, E., Opherk, C., Pantoni, L., Federico, A., Dichgans, M., Markus, H. S., Chabriat, H., et al. (2019) · Genetics in Medicine

Cerebrovascular and genetic disordersGenetic Neurodegenerative Diseases

Cited by 169

Lacunar lesions are independently associated with disability and cognitive impairment in CADASIL

Viswanathan, A., Gschwendtner, A., Guichard, J. P., Buffon, F., Cumurciuc, R., O'Sullivan, M., Holtmannspötter, M., Pachai, C., Bousser, M. G., Dichgans, M., et al. (2007) · Neurology

Cerebrovascular and genetic disordersNeurological Disease Mechanisms and Treatments

Cited by 155

Cerebral small vessel disease-related protease HtrA1 processes latent TGF-β binding protein 1 and facilitates TGF-β signaling

Beaufort, N., Scharrer, E., Kremmer, E., Lux, V., Ehrmann, M., Huber, R., Houlden, H., Werring, D., Haffner, C., & Dichgans, M. (2014) · Proceedings of the National Academy of Sciences

TGF-β signaling in diseasesCerebrovascular and genetic disorders

Cited by 145

Strategic white matter tracts for processing speed deficits in age-related small vessel disease

Duering, M., Gesierich, B., Seiler, S., Pirpamer, L., Gonik, M., Hofer, E., Jouvent, E., Duchesnay, E., Chabriat, H., Ropele, S., et al. (2014) · Neurology

Cerebrovascular and genetic disordersDementia and Cognitive Impairment Research

Cited by 143

Diffusion Magnetic Resonance Histograms as a Surrogate Marker and Predictor of Disease Progression in CADASIL: A Two-Year Follow-Up Study

Holtmannspötter, M., Peters, N., Opherk, C., Martin, D., Herzog, J., Brückmann, H., Sämann, P., Gschwendtner, A., & Dichgans, M. (2005) · Stroke

Cerebrovascular and genetic disordersAdvanced Neuroimaging Techniques and Applications

Cited by 140