Integrating genetic, transcriptional, and functional analyses to identify 5 novel genes for atrial fibrillation
Open accessAbstract
BACKGROUND: Atrial fibrillation (AF) affects >30 million individuals worldwide and is associated with an increased risk of stroke, heart failure, and death. AF is highly heritable, yet the genetic basis for the arrhythmia remains incompletely understood. METHODS AND RESULTS: To identify new AF-related genes, we used a multifaceted approach, combining large-scale genotyping in 2 ethnically distinct populations, cis-eQTL (expression quantitative trait loci) mapping, and functional validation. Four novel loci were identified in individuals of European descent near the genes NEURL (rs12415501; relative risk [RR]=1.18; 95% confidence interval [CI], 1.13-1.23; P=6.5×10(-16)), GJA1 (rs13216675; RR=1.10; 95% CI, 1.06-1.14; P=2.2×10(-8)), TBX5 (rs10507248; RR=1.12; 95% CI, 1.08-1.16; P=5.7×10(-11)), and CAND2 (rs4642101; RR=1.10; 95% CI, 1.06-1.14; P=9.8×10(-9)). In Japanese, novel loci were identified near NEURL (rs6584555; RR=1.32; 95% CI, 1.26-1.39; P=2.0×10(-25)) and CUX2 (rs6490029; RR=1.12; 95% CI, 1.08-1.16; P=3.9×10(-9)). The top single-nucleotide polymorphisms or their proxies were identified as cis-eQTLs for the genes CAND2 (P=2.6×10(-19)), GJA1 (P=2.66×10(-6)), and TBX5 (P=1.36×10(-5)). Knockdown of the zebrafish orthologs of NEURL and CAND2 resulted in prolongation of the atrial action potential duration (17% and 45%, respectively). CONCLUSIONS: We have identified 5 novel loci for AF. Our results expand the diversity of genetic pathways implicated in AF and provide novel molecular targets for future biological and pharmacological investigation.
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Several AF risk variants are also associated with cardioembolic or ischaemic stroke, possibly due to silent AF.
“Several of the AF risk variants are also associated with cardioembolic or ischaemic stroke, possibly due to silent AF (see section 4.1).62,65,66”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [62]
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Cites
Benjamin, E. J. (1994) · JAMA · doi:10.1001/jama.1994.03510350050036 · Cited by 2,613 · see citing works
Self-citationNew ideas about atrial fibrillation 50 years on
Nattel, S. (2002) · Nature · doi:10.1038/415219a · Cited by 1,481 · see citing works
Wann, L. S., Curtis, A. B., January, C. T., Ellenbogen, K. A., Lowe, J. E., Estes, N. A. M., Page, R. L., Ezekowitz, M. D., Slotwiner, D. J., Jackman, W. M., et al. (2010) · Circulation · doi:10.1161/cir.0b013e3181fa3cf4 · Cited by 1,338 · see citing works
Meta-analysis identifies six new susceptibility loci for atrial fibrillation
Ellinor, P. T., Lunetta, K. L., Albert, C. M., Glazer, N. L., Ritchie, M. D., Smith, A. V., Arking, D. E., Müller-Nurasyid, M., Krijthe, B. P., Lubitz, S. A., et al. (2012) · Nature Genetics · doi:10.1038/ng.2261 · Cited by 601 · cited 11× · see citing works
“Potential novel AF susceptibility signals in Europeans and Japanese were selected from a discovery sample consisting of cohorts with incident and prevalent AF, which has been previously described.(4) To replicate variants from the discovery sample, we recruited additional samples and cohorts with available DNA for dir…”
BackgroundMethodInfluentialSelf-citationRecent advances in the molecular pathophysiology of atrial fibrillation
Wakili, R., Voigt, N., Kääb, S., Dobrev, D., & Nattel, S. (2011) · Journal of Clinical Investigation · doi:10.1172/jci46315 · Cited by 543 · see citing works
Self-citationA sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke
Gudbjartsson, D. F., Holm, H., Gretarsdottir, S., Thorleifsson, G., Walters, G. B., Thorgeirsson, G., Gulcher, J., Mathiesen, E. B., Njølstad, I., Nyrnes, A., et al. (2009) · Nature Genetics · doi:10.1038/ng.417 · Cited by 489 · see citing works
Self-citationTraylor, M., Farrall, M., Holliday, E. G., Sudlow, C. L. M., Hopewell, J. C., Cheng, Y., Fornage, M., Ikram, M. A., Malik, R., Bevan, S., et al. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70234-x · Cited by 475 · see citing works
Self-citationSeveral common variants modulate heart rate, PR interval and QRS duration
Hólm, H., Gudbjartsson, D., Arnar, D., Thorleifsson, G., Thorgeirsson, G., Stefánsdóttir, H., Gudjonsson, S. A., Jónasdóttir, Á., Mathiesen, E., Njølstad, I., et al. (2010) · Nature Genetics · doi:10.1038/ng.511 · Cited by 441 · see citing works
Genome-wide association study of PR interval
Pfeufer, A., van Noord, C., Marciante, K. D., Arking, D. E., Larson, M. G., Smith, A. V., Tarasov, K. V., Müller‐Nurasyid, M., Sotoodehnia, N., Sinner, M. F., et al. (2010) · Nature Genetics · doi:10.1038/ng.517 · Cited by 434 · see citing works
Self-citationRaychaudhuri, S., Plenge, R. M., Rossin, E. J., Ng, A., Purcell, S., Sklar, P. B., Scolnick, E. M., Xavier, R. J., Altshuler, D., & Daly, M. J. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000534 · Cited by 422 · see citing works
Wann, L. S., Curtis, A. B., Ellenbogen, K. A., Estes, N. A. M., Ezekowitz, M. D., Jackman, W. M., January, C. T., Lowe, J. E., Page, R. L., Slotwiner, D. J., et al. (2011) · Heart Rhythm · doi:10.1016/j.hrthm.2011.01.032 · Cited by 396 · see citing works
Pitx2c and Nkx2-5 Are Required for the Formation and Identity of the Pulmonary Myocardium
Mommersteeg, M. T. M., Brown, N. A., Prall, O. W. J., et al. (2007) · Circulation Research · doi:10.1161/circresaha.107.161182 · Cited by 385 · see citing works
Association Between Familial Atrial Fibrillation and Risk of New-Onset Atrial Fibrillation
Lubitz, S. A., Yin, X., Fontes, J. D., Magnani, J. W., Rienstra, M., Pai, M., Villalon, M. L., Vasan, R. S., Pencina, M. J., Levy, D., et al. (2010) · JAMA · doi:10.1001/jama.2010.1690 · Cited by 313 · see citing works
Self-citationRisk variants for atrial fibrillation on chromosome 4q25 associate with ischemic stroke
Grétarsdóttir, S., Þorleifsson, G., Manolescu, A. R., Styrkársdóttir, U., Helgadóttir, A., Gschwendtner, A., Kostulas, K., Kuhlenbäumer, G., Bevan, S., Jónsdóttir, Þ., et al. (2008) · Annals of Neurology · doi:10.1002/ana.21480 · Cited by 286 · see citing works
Self-citationMoskowitz, I. P. G., Kim, J. B., Moore, M. L. G., Wolf, C. M., Peterson, M. A., Shendure, J., Nóbrega, M. A., Yokota, Y., Berul, C. I., Izumo, S., et al. (2007) · Cell · doi:10.1016/j.cell.2007.04.036 · Cited by 284 · see citing works
Pavlopoulos, E., Trifilieff, P., Chevaleyre, V., Fioriti, L., Zairis, S., Pagano, A., Malleret, G., & Kandel, E. R. (2011) · Cell · doi:10.1016/j.cell.2011.09.056 · Cited by 189 · see citing works
Postma, A. V., van de Meerakker, J. B. A., Mathijssen, I. B., Barnett, P., Christoffels, V. M., Ilgun, A., Lam, J., Wilde, A. A. M., Deprez, R. H. L., & Moorman, A. F. M. (2008) · Circulation Research · doi:10.1161/circresaha.107.168294 · Cited by 187 · see citing works
Paradigm of Genetic Mosaicism and Lone Atrial Fibrillation
Thibodeau, I. L., Xu, J., Li, Q., Liu, G., Lam, K., Veinot, J. P., BIRNIE, D. H., Jones, D. L., Krahn, A. D., Lemery, R., et al. (2010) · Circulation · doi:10.1161/circulationaha.110.961227 · Cited by 172 · see citing works
Self-citationConnexin 43 gene therapy prevents persistent atrial fibrillation in a porcine model
Bikou, O., Thomas, D., Trappe, K., Lugenbiel, P., Kelemen, K., Koch, M., Soucek, R., Voss, F., Becker, R., Katus, H. A., et al. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvr209 · Cited by 161 · see citing works
Genome-wide association analysis identifies multiple loci related to resting heart rate
Eijgelsheim, M., Newton‐Cheh, C., Sotoodehnia, N., de Bakker, P. I. W., Müller‐Nurasyid, M., Morrison, A. C., Smith, A. V., Isaacs, A. J., Sanna, S., Dörr, M., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq303 · Cited by 141 · see citing works
Self-citationA genome-wide association study of a coronary artery disease risk variant
Lee, J.-Y., Lee, B.-S., Shin, D.-J., Park, K. W., Shin, Y.-A., Kim, K. J., Heo, L., Lee, J. Y., Kim, Y. K., Kim, Y. J., et al. (2013) · Journal of Human Genetics · doi:10.1038/jhg.2012.124 · Cited by 139 · see citing works
Huang, J., Ellinghaus, D., Franke, A., Howie, B., & Li, Y. (2012) · European Journal of Human Genetics · doi:10.1038/ejhg.2012.3 · Cited by 131 · see citing works
Milan, D. J., Kim, A. M., Winterfield, J. R., Jones, I. L., Pfeufer, A., Sanna, S., Arking, D. E., Amsterdam, A., Sabeh, K., Mably, J. D., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.821082 · Cited by 109 · see citing works
Self-citationZou, W., Chen, X., Shim, J., Huang, Z., Brady, N. J., Hu, D. Z., Drapp, R., Sigrist, K. S., Glimcher, L. H., & Jones, D. C. (2010) · Nature Cell Biology · doi:10.1038/ncb2134 · Cited by 104 · see citing works
Wann, L. S., Curtis, A. B., January, C. T., Ellenbogen, K. A., Lowe, J. E., Estes, N. A. M., Page, R. L., Ezekowitz, M. D., Slotwiner, D. J., Jackman, W. M., et al. (2010) · Heart Rhythm · doi:10.1016/j.hrthm.2010.11.047 · Cited by 103 · see citing works
Iulianella, A., Sharma, M., Durnin, M., Heuvel, G. B. V., & Trainor, P. A. (2008) · Development · doi:10.1242/dev.013276 · Cited by 66 · see citing works
Atrial tachycardia/fibrillation in the connexin 43 G60S mutant (Oculodentodigital dysplasia) mouse
Tuomi, J. M., Tyml, K., & Jones, D. L. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01094.2010 · Cited by 49 · see citing works
TIP120B: A Novel TIP120-Family Protein That Is Expressed Specifically in Muscle Tissues
Aoki, T., Okada, N., Ishida, M., et al. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1147 · Cited by 36 · see citing works
Timmusk, T. (2002) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2002.1148 · Cited by 26 · see citing works
Li, J., Hou, X.-E., & Dahlström, A. (1995) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(94)00101-o · Cited by 21 · see citing works
吉岡, 淳. (2006) · Vascular Medicine · Cited by 1 · see citing works
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2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castella, M., Diener, H.-C., Heidbuchel, H., Hendriks, J., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw210 · Cited by 6,418 · see citing works
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castella, M., Diener, H.-C., Heidbuchel, H., Hendriks, J., et al. (2016) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezw313 · Cited by 1,403 · see citing works
Genetics of atrial fibrillation: from families to genomes
Christophersen, I. E., & Ellinor, P. T. (2016) · Journal of Human Genetics · doi:10.1038/jhg.2015.44 · Cited by 92 · see citing works
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- Authors
- Sinner, M. F., Tucker, N. R., Lunetta, K. L., Ozaki, K., Smith, J. G., Trompet, S., Bis, J. C., Lin, H., Chung, M. K., Nielsen, J. B., Lubitz, S. A., Krijthe, B. P., Magnani, J. W., Ye, J., Gollob, M. H., Tsunoda, T., Müller-Nurasyid, M., Lichtner, P., Peters, A., Dolmatova, E., Kubo, M., Smith, J. D., Psaty, B. M., Smith, N. L., Jukema, J. W., Chasman, D. I., Albert, C. M., Ebana, Y., Furukawa, T., Macfarlane, P. W., Harris, T. B., Darbar, D., Dörr, M., Holst, A. G., Svendsen, J. H., Hofman, A., Uitterlinden, A. G., Gudnason, V., Isobe, M., Malik, R., Dichgans, M., Rosand, J., Van Wagoner, D. R., Benjamin, E. J., Milan, D. J., Melander, O., Heckbert, S. R., Ford, I., Liu, Y., Barnard, J., Olesen, M. S., Stricker, B. H. C., Tanaka, T., Kääb, S., & Ellinor, P. T.
- Affiliations
- LMU Klinikum (DE)
- Massachusetts General Hospital (US)
- Boston University (US)
- RIKEN Center for Integrative Medical Sciences (JP)
- Leiden University Medical Center (NL)
- University of Washington (US)
- Cleveland Clinic (US)
- University of Copenhagen (DK)
- Erasmus MC (NL)
- Ottawa Heart Institute (CA)
- Helmholtz Munich (DE)
- Kaiser Permanente Washington Health Research Institute (US)
- United States Department of Veterans Affairs (US)
- Brigham and Women's Hospital (US)
- Tokyo Medical and Dental University (JP)
- University of Glasgow (GB)
- National Institutes of Health (US)
- Vanderbilt University (US)
- Universität Greifswald (DE)
- University of Iceland (IS)
- Ludwig-Maximilians-Universität München (DE)
- Munich Cluster for Systems Neurology (DE)
- Broad Institute (US)
- Lund University (SE)
- Wake Forest University (US)
- ORCID
- Sinner, Moritz F.
- Tucker, Nathan R.
- Lunetta, Kathryn L.
- Ozaki, Kouichi
- Trompet, Stella
- Bis, Joshua C.
- Lin, Honghuang
- Chung, Mina K.
- Nielsen, Jonas B.
- Lubitz, Steven A.
- Magnani, Jared W.
- Gollob, Michael H.
- Tsunoda, Tatsuhiko
- Lichtner, Peter
- Peters, Annette
- Dolmatova, Elena
- Kubo, Michiaki
- Smith, Jonathan D.
- Psaty, Bruce M.
- Smith, Nicholas L.
- Jukema, J. Wouter
- Chasman, Daniel I.
- Albert, Christine M.
- Ebana, Yusuke
- Furukawa, Tetsushi
- Macfarlane, Peter W.
- Harris, Tamara B.
- Darbar, Dawood
- Dörr, Marcus
- Holst, Anders G.
- Svendsen, Jesper H.
- Gudnason, Vilmundur
- Isobe, Mitsuaki
- Malik, Rainer
- Dichgans, Martin
- Rosand, Jonathan
- Benjamin, Emelia J.
- Milan, David J.
- Melander, Olle
- Heckbert, Susan R.
- Ford, Ian
- Barnard, John
- Olesen, Morten S.
- Stricker, Bruno H.C.
- Tanaka, Toshihiro
- Kääb, Stefan
- Ellinor, Patrick T.
- Venue
- Circulation
- Published
- 2014-10-07
- Volume
- 130
- Issue
- 15
- Pages
- 1225-1235
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- PMC
- PMC4190011
- OpenAlex
- W2112387318
- Cited by
- 205
- References
- 31
- Citations by year
- 2026: 8 · 2025: 7 · 2024: 15 · 2023: 8 · 2022: 12 · 2021: 14 · 2020: 18 · 2019: 18 · 2018: 19 · 2017: 35 · 2016: 33 · 2015: 15 · 2014: 2 · 2013: 1
- FWCI
- 19.43
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
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- Lund University Publications (Lund University) (submittedVersion)
- Site cant be reached (submittedVersion)
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- Funders
- Donald W. Reynolds Foundation
- American Heart Association (09SDG2280087, N01-HC-25195, HL092577, 13EIA14220013, 09FTF2190028, R01HL092577)
- Amgen (T32HL007208)
- Bristol-Myers Squibb (2001 D 032)
- Heart and Stroke Foundation of Canada
- Wake Forest University
- School of Medicine, Boston University (HL076784, N01-HC25195)
- Cleveland Clinic
- Hjerteforeningen (07-10-R60-A1815-B573-22398)
- Arvid Nilssons Fond
- Johns Hopkins University (HHSN268200782096C)
- Government of Ontario
- Georgia Clinical and Translational Science Alliance
- European Commission (01ZZ0103, 01ZZ0403, 03ZIK012, 01ZZ9603, 223004)
- National Research Foundation
- Fondation Leducq (K24HL105780, T32HL007208)
- Danmarks Grundforskningsfond
- ZonMw (050-060-810)
- Erasmus Universiteit Rotterdam
- Bundesministerium für Bildung und Forschung (01ZZ9603, 01ZZ0103, and 01ZZ0403, 03IS2061A, 03ZIK012, 01ZZ0403, and 01ZZ0403, 01ZZ0103, 01ZZ9603)
- Erasmus Medisch Centrum
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (050.060.810, 911-03-012, 175.010.200, 175.010.2005.011, 22398)
- Lunds Universitet
- Hjärt-Lungfonden
- Siemens
- Rigshospitalet
- Malmö Högskola
- Novo Nordisk Fonden (NNF14OC0009819, NNF13OC0005339)
- Villadsen Family Foundation
- Region Skåne
- Stiftung zur Erforschung der Vaskulären Demenz
- Universität Greifswald
- Ministry of Cultural Affairs
- National Institutes of Health (N01-AG-6-2103, 5r01ag032098-05, n01hc085082-026, n01hc085081-021, n01ag062101-007, n01ag12100-57-0-2, n01hc085079-024, 5rc1hl099452-02, n01hc55021-47-0-1, n01ag062103-006, n01hc085083-027, n01hc55020-39-0-0, n01hc085080-026, n01hc55016-37-0-0, n01hc055022-024, N01‐AG‐6‐2106, n01ag062106-007, UL1TR000124, N01-AG-1-2100, n01hc085086-022, n01hc55019-35-0-1, HHSN268200800007C, n01hc55018-38-0-1, N01-AG-6-2101, NHLBI R01, n01hc025195-11-0-0, 5r01hl043851-10, HHSN268200782096C, HHSN268201200036C, n01hc055222-001, 5u01ns069208-04, N01HC85086, N01-HC-85082, N01HC85079, N01HC85080, N01-HC 25195, N01HC85083, DK-063491, N01-HC-85081, RR024989, HL080295, HL69757, n01hc55015-48-0-1)
- Canadian Institutes of Health Research
- Medical Research Council (HHSN268200782096C)
- Japan Society for the Promotion of Science (221S0001, 26293052)
- National Institute on Aging (N01‐AG‐6–2101, N01HC85081, N01HC85079, N01-HC-85080, N01-HC-85082, R01AG032098, N01-AG12100, R56AG023629, N01-AG012100, N02-HL-6-4278, N01HC55222, N01-HC-25195, HHSN268200800007C, R01AG028321, N01-HC-85083, AG023629, N01 AG062106, N01AG62106, HL080295, N01‐HC‐85086, R01AG023629, 1R01AG032098‐01A1, N01-AG-62103, N01 AG062103, HHSN268201200036C, N01 AG062101)
- National Heart, Lung, and Blood Institute (N01-HC-85081, DK-063491, HL-076784, R01HL111314, N01-HC55022, N01 HC085086, AG-023629, N01HC-85083, N01 HC055016, N01-HC-55018, R01HL073410, HL043851, R01HL085251, HL-093613, N01 HC 55020, HL-105756, N01 HC085079, HL 073410, R01‐HL043851, N01 HC085083, N01‐HC25195, HL-087652, N01 HC 55019, N01HC85082, N01 HC85086, R01 HL-59367, N01 HC085080, R01HL087652, U19HL069757, R01HL068986, HHSN 268200800007C, N01 HC055020, N01HC85080, N02- HL-64278, R01HL104156, N01AG62101, N01 HC055018, N01 HC55222, U01HL069757, 6R01-NS-17950, HL065962, R21HL093613, N01-HC-025195, U10HL054512, N01-HC55016, N01AG62106, R01HL087641, N01 HC055022, HHSN268201200036C, HL085251, HL 69757, R01HL059367, N01HC085082, R01HL105756, U01HL080295, R01HL076784, N01 HC055019, N01 HC055222, N01AG62103, 09SDG2280087, R01HL090620, HL092577, N01 HC085081, HL080295, K23HL114724, R01HL080295, N01‐HC‐55015, N01-HC55021, N01 HC055021, K24HL105780, N01 HC055015, AG028321, R01HL092577, T32HL007208, R01HL086694, N01-HC85079, RC1-HL099452)
- National Human Genome Research Institute (U01HG004402)
- National Cancer Institute (CA 047988, R01CA047988)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK063491, P30DK063491)
- National Institute of Neurological Disorders and Stroke (AG023629, HHSN268200800007C, N01-HC-85080, HL080295, N01-HC-85083, N01‐HC‐25195, N01HC85082, U01-NS069208, DK063491, N01-HC-85081, N02-HL-6-4278, N01-HC-85086, N01 HC-55222, N01HC85079, HHSN268201200036C, R01NS017950)
- National Center for Research Resources (RR 024989, UL1RR024989, HL105756, UL1RR025005, 1 UL RR024989, N01HC85083, N01HC85086)
- National Center for Advancing Translational Sciences (RR024989, DK063491)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- atrial fibrillation, genetic susceptibility, cis-eQTL, gene expression regulation, connexin 43, TBX5, CUX2, atrial action potential duration, zebrafish knockdown, cardiac arrhythmias, single nucleotide polymorphisms, atrial remodeling, atrial fibrosis, atrial fibroblasts
- MeSH terms
- Homeobox Protein PITX2, Aged, Animals, Atrial Fibrillation, Chromosome Mapping, Europe, Female, Genotype, Humans, Japan, Male, Middle Aged, Muscle Proteins, Nuclear Proteins, Repressor Proteins, Transcription Factors, Zebrafish, Connexin 43, Homeodomain Proteins, Genetic Predisposition to Disease, T-Box Domain Proteins, Zebrafish Proteins, Quantitative Trait Loci, Ubiquitin-Protein Ligases, Gene Knockdown Techniques, Genetic Loci
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