Brooke, Robert T.

Reversal of epigenetic aging and immunosenescent trends in humans.

Fahy, G. M., Brooke, R. T., Watson, J. P., Good, Z., Vasanawala, S. S., Maecker, H., Leipold, M. D., Lin, D. T. S., Kobor, M. S., & Horvath, S. (2019) · Aging Cell

Telomeres, Telomerase, and SenescenceEpigenetics and DNA Methylation

Cited by 477

Small extracellular vesicles from young adipose-derived stem cells prevent frailty, improve health span, and decrease epigenetic age in old mice

Sanz-Ros, J., Romero-García, N., Mas-Bargues, C., Monleón, D., Gordevicius, J., Brooke, R. T., Dromant, M., Díaz, A., Derevyanko, A., Guío-Carrión, A., et al. (2022) · Science Advances

Extracellular vesicles in diseaseMesenchymal stem cell research

Cited by 131

DNA methylation networks underlying mammalian traits

Haghani, A., Li, C. Z., Robeck, T. R., Zhang, J., Lu, A. T., Ablaeva, J., Acosta-Rodríguez, V. A., Adams, D. M., Alagaili, A. N., Almunia, J., et al. (2023) · Science

Epigenetics and DNA MethylationGenetic Syndromes and Imprinting

Cited by 128

Umbilical cord plasma concentrate has beneficial effects on DNA methylation GrimAge and human clinical biomarkers

Clement, J., Yan, Q., Agrawal, M., Coronado, R. E., Sturges, J. A., Horvath, M., Lu, A. T., Brooke, R. T., & Horvath, S. (2022) · Aging Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 34

DNA repair‐deficient premature aging models display accelerated epigenetic age

Perez, K., Parras, A., Picó, S., Rechsteiner, C., Haghani, A., Brooke, R., Mrabti, C., Schoenfeldt, L., Horvath, S., & Ocampo, A. (2024) · Aging Cell

Epigenetics and DNA MethylationGenetics, Aging, and Longevity in Model Organisms

Cited by 31

Initiation phase cellular reprogramming ameliorates DNA damage in the ERCC1 mouse model of premature aging

Paine, P. T., Rechsteiner, C., Morandini, F., Desdín-Micó, G., Mrabti, C., Parras, A., Haghani, A., Brooke, R., Horvath, S., Seluanov, A., et al. (2024) · Frontiers in Aging

Pluripotent Stem Cells ResearchTelomeres, Telomerase, and Senescence

Cited by 13

Initiation phase cellular reprogramming ameliorates DNA damage in the ERCC1 mouse model of premature aging

Paine, P. T., Rechsteiner, C., Morandini, F., Desdin Mico, G., Mrabti, C., Parras, A., Haghani, A., Brooke, R., Horvath, S., Seluanov, A., et al. (2023) · Frontiers in Aging

Pluripotent Stem Cells ResearchTelomeres, Telomerase, and Senescence

Cited by 13