Umbilical cord plasma concentrate has beneficial effects on DNA methylation GrimAge and human clinical biomarkers
Open accessAbstract
Plasma transfusions are standard treatments to replace missing proteins in people with rare genetic diseases. Prior studies have demonstrated that heterochronic parabiosis has beneficial effects on several tissues of old animals receiving young blood. Human clinical trials are currently underway to investigate whether the infusion of plasma or plasma‐derived factors from young donors can be used to mitigate human age‐related conditions. Here, we use data from a safety study (n = 18, mean age 74) to investigate whether human umbilical cord plasma concentrate (hereinafter Plasma Concentrate) injected weekly (1 ml intramuscular) into elderly human subjects over a 10‐week period affects different biomarkers, including epigenetic age measures, standard clinical biomarkers of organ dysfunction, mitochondrial DNA copy number (mtDNA‐CN), and leukocyte telomere length. This study shows that treatment with plasma concentrate is safe. More than 20 clinical biomarkers were significantly and beneficially altered following the treatments. For example, creatinine was significantly decreased (p = 0.0039), while estimated glomerular filtration rate (eGFR) was increased (p = 0.0044), indicating the treatment may improve biomarkers of kidney function. Three of four immunoglobulin biomarkers decreased, while telomere length and mtDNA‐CN were not significantly affected by the treatment. The treatment reduced DNA methylation‐based GrimAge by an average of 0.82 years (p = 0.0093), suggests a reduction in morbidity and mortality risk. By contrast, no significant results could be observed for epigenetic clocks that estimate chronological age. Our results support the view that plasma concentrate contains youth‐promoting factors.
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Injections of human umbilical cord plasma into elderly individuals reduce epigenetic age by 0.82 years and improve clinical parameters such as creatinine levels and glomerular filtration rate.
“Injections of human umbilical cord plasma into elderly individuals reduce the epigenetic age by 0.82 years and improve several clinical parameters, such as creatinine levels and the glomerular filtration rate.452”
From Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances (2025) · cites this paper as [452]
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- Authors
- Clement, J., Yan, Q., Agrawal, M., Coronado, R. E., Sturges, J. A., Horvath, M., Lu, A. T., Brooke, R. T., & Horvath, S.
- Affiliations
- University of Ferrara (IT)
- Epigenetic Clock Development Foundation Torrance California USA
- Betterhumans Inc. Gainesville Florida USA
- The University of Texas at San Antonio Health Science Center (US)
- John A Sturges, M.D. Coeur d'Alene Idaho USA
- University of California, Los Angeles (US)
- Corresponding author
- Clement, James
- Horvath, Steve
- Venue
- Aging Cell
- Publisher
- Wiley
- Published
- 2022-09-02
- Volume
- 21
- Issue
- 10
- Pages
- e13696-e13696
- ISSN
- 1474-9718 (ISSN-L)
- 1474-9726
- PMC
- PMC9577957
- OpenAlex
- W4294218735
- Cited by
- 34
- References
- 46
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 12 · 2023: 6 · 2022: 2
- FWCI
- 4.33
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Aging Cell (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (1U01AG060908)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- plasma transfusion, epigenetic age, GrimAge, DNA methylation, mitochondrial DNA copy number, telomere length, renal function markers, estimated glomerular filtration rate, creatinine, immunoglobulins, heterochronic parabiosis, anti-aging therapy, elderly patients, treatment safety
- MeSH terms
- Adolescent, Aged, Aging, Creatinine, DNA, Mitochondrial, Humans, Infant, Umbilical Cord, Biomarkers, DNA Methylation, Epigenesis, Genetic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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