Lingel, Andreas

An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED

Qi, W., Zhao, K., Gu, J., Huang, Y., Wang, Y., Zhang, H., Zhang, M., Zhang, J., Yu, Z., Li, L., et al. (2017) · Nature Chemical Biology

Epigenetics and DNA MethylationCancer-related gene regulation

Cited by 316

JDQ443, a Structurally Novel, Pyrazole-Based, Covalent Inhibitor of KRAS G12C for the Treatment of Solid Tumors

Lorthiois, E., Gerspacher, M., Beyer, K. S., Vaupel, A., Leblanc, C., Stringer, R., Weiss, A., Wilcken, R., Guthy, D. A., Lingel, A., et al. (2022) · Journal of Medicinal Chemistry

Protein Kinase Regulation and GTPase SignalingHeterocyclic Compound Synthesis and Bioactivity

Cited by 110

A small-molecule VHL molecular glue degrader for cysteine dioxygenase 1

Tutter, A., Buckley, D., Golosov, A. A., Ma, X., Shu, W., McKay, D. J. J., Darsigny, V., Dovala, D., Beckwith, R., Solomon, J., et al. (2025) · Nature Chemical Biology

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

Cited by 36

Intrinsically disordered regions in the transcription factor MYC:MAX modulate DNA binding via intramolecular interactions

Schütz, S., Bergsdorf, C., Hänni-Holzinger, S., Lingel, A., Renatus, M., Gossert, A. D., & Jahnke, W. (2023) · Biochemistry

Protein Structure and DynamicsGenomics and Chromatin Dynamics

Cited by 9

Intrinsically Disordered Regions in the Transcription Factor MYC:MAX Modulate DNA Binding via Intramolecular Interactions

Schütz, S., Bergsdorf, C., Hänni-Holzinger, S., Lingel, A., Renatus, M., Gossert, A. D., & Jahnke, W. (2024) · Biochemistry

Protein Structure and DynamicsGenomics and Chromatin Dynamics

Cited by 9