Serrano, Manuel

Specific lipofuscin staining as a novel biomarker to detect replicative and stress-induced senescence. A method applicable in cryo-preserved and archival tissues

Georgakopoulou, E., Tsimaratou, K., Evangelou, K., Fernandez, M.-P., Zoumpourlis, V, Trougakos, I., Kletsas, D., Bartek, J., Serrano, M., & Gorgoulis, V. (2012) · Aging

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Identification and characterization of Cardiac Glycosides as senolytic compounds

Triana-Martínez, F., Picallos-Rabina, P., Da Silva-Álvarez, S., Pietrocola, F., Llanos, S., Rodilla, V., Soprano, E., Pedrosa, P., Ferreirós, A., Barradas, M., et al. (2019) · Nature Communications

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

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Tumor suppressors and oncogenes in cellular senescence

Bringold, F., & Serrano, M. (2000) · Experimental Gerontology

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

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Pten positively regulates brown adipose function, energy expenditure, and longevity

Ortega-Molina, A., Efeyan, A., Lopez-Guadamillas, E., Muñoz-Martin, M., Gómez-López, G., Cañamero, M., Mulero, F., Pastor, J., Martinez, S., Romanos, E., et al. (2012) · Cell Metabolism

Adipose Tissue and MetabolismMetabolism, Diabetes, and Cancer

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A versatile drug delivery system targeting senescent cells

Muñoz‐Espín, D., Rovira, M., Galiana, I., Giménez, C., Lozano‐Torres, B., Paez‐Ribes, M., Llanos, S., Chaib, S., Muñoz‐Martín, M., Ucero, A. C., et al. (2018) · EMBO Molecular Medicine

Telomeres, Telomerase, and SenescenceNanoparticle-Based Drug Delivery

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The Atypical PKC-Interacting Protein p62 Is an Important Mediator of RANK-Activated Osteoclastogenesis

Durán, A., Serrano, M., Leitges, M., Flores, J. M., Picard, S., Brown, J. P., Moscat, J., & Diaz-Meco, M. T. (2004) · Developmental Cell

Bone Metabolism and DiseasesNF-κB Signaling Pathways

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Galacto‐conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity

González‐Gualda, E., Pàez‐Ribes, M., Lozano‐Torres, B., Macias, D., Wilson, J. R., González‐López, C., Ou, H., Mirón‐Barroso, S., Zhang, Z., Lérida‐Viso, A., et al. (2020) · Aging Cell

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Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62

Rodriguez, A., Durán, A., Selloum, M., Champy, M.-F., Diez-Guerra, F. J., Flores, J. M., Serrano, M., Auwerx, J., Diaz-Meco, M. T., & Moscat, J. (2006) · Cell Metabolism

Adipokines, Inflammation, and Metabolic DiseasesPeroxisome Proliferator-Activated Receptors

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Mutations associated with familial melanoma impair p16INK4 function

Ranade, K., Hussussian, C. J., Sikorski, R. S., Varmus, H. E., Goldstein, A. M., Tucker, M. A., Serrano, M., Hannon, G. J., Beach, D., & Dracopoli, N. C. (1995) · Nature Genetics

Cancer-related Molecular PathwaysCutaneous Melanoma Detection and Management

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TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence

Bird, T. G., Müller, M., Boulter, L., Vincent, D. F., Ridgway, R. A., Lopez-Guadamillas, E., Lu, W.-Y., Jamieson, T., Govaere, O., Campbell, A. D., et al. (2018) · Science Translational Medicine

Liver physiology and pathologyDrug-Induced Hepatotoxicity and Protection

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Robust, universal biomarker assay to detect senescent cells in biological specimens

Evangelou, K., Lougiakis, N., Rizou, S. V., Kotsinas, A., Kletsas, D., Muñoz‐Espín, D., Kastrinakis, N. G., Pouli, N., Marakos, P., Townsend, P., et al. (2017) · Aging Cell

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Iron accumulation drives fibrosis, senescence and the senescence-associated secretory phenotype

Maus, M., López-Polo, V., Mateo, L., Lafarga, M., Aguilera, M., De Lama, E., Meyer, K., Sola, A., Lopez-Martinez, C., López-Alonso, I., et al. (2023) · Nature Metabolism

Telomeres, Telomerase, and SenescenceIron Metabolism and Disorders

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Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d

Brotherton, D. H., Dhanaraj, V., Wick, S., Brizuela, L., Domaille, P. J., Volyanik, E., Xu, X., Parisini, E., Smith, B. O., Archer, S. J., et al. (1998) · Nature

Cancer-related Molecular PathwaysProtein Kinase Regulation and GTPase Signaling

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Murine fibroblasts lacking p21 undergo senescence and are resistant to transformation by oncogenic Ras.

Pantoja, C., & Serrano, M. (1999) · Oncogene

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

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Cancer and ageing: convergent and divergent mechanisms

Serrano, M., & Blasco, M. A. (2007) · Nature Reviews Molecular Cell Biology

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Senescence promotes in vivo reprogramming through p16INK4a and IL‐6

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Pluripotent Stem Cells ResearchTelomeres, Telomerase, and Senescence

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Induction of p53-Dependent Senescence by the MDM2 Antagonist Nutlin-3a in Mouse Cells of Fibroblast Origin

Efeyan, A., Ortega-Molina, A., Velasco-Miguel, S., Herranz, D., Vassilev, L. T., & Serrano, M. (2007) · Cancer Research

Cancer-related Molecular PathwaysTelomeres, Telomerase, and Senescence

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The chemistry of senescence

Lozano-Torres, B., Estepa-Fernández, A., Rovira, M., Orzáez, M., Serrano, M., Martínez-Máñez, R., & Sancenón, F. (2019) · Nature Reviews Chemistry

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Multi‐omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming

Chondronasiou, D., Gill, D., Mosteiro, L., Urdinguio, R. G., Berenguer‐Llergo, A., Aguilera, M., Durand, S., Aprahamian, F., Nirmalathasan, N., Abad, M., et al. (2022) · Aging Cell

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In Vivo Reprogramming Ameliorates Aging Features in Dentate Gyrus Cells and Improves Memory in Mice.

Rodríguez-Matellán, A., Alcazar, N., Hernández, F., Serrano, M., & Ávila, J. (2020) · Stem Cell Reports

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The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2

Chaib, S., López-Domínguez, J. A., Lalinde-Gutiérrez, M., Prats, N., Marin, I., Boix, O., García-Garijo, A., Meyer, K., Muñoz, M. I., Aguilera, M., et al. (2024) · Nature Cancer

Telomeres, Telomerase, and SenescenceCancer Immunotherapy and Biomarkers

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Increased p53 activity does not accelerate telomere‐driven ageing

García‐Cao, I., García‐Cao, M., Tomás‐Loba, A., Martin‐Caballero, J., Flores, J. M., Klatt, P., Blasco, M. A., & Serrano, M. (2006) · The EMBO Reports

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WNT16B Is a New Marker of Cellular Senescence That Regulates p53 Activity and the Phosphoinositide 3-Kinase/AKT Pathway

Binet, R., Ythier, D., Robles, A. I., Collado, M., Larrieu, D., Fonti, C., Brambilla, E., Brambilla, C., Serrano, M., Harris, C. C., et al. (2009) · Cancer Research

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

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Lysosomal trapping of palbociclib and its functional implications

Llanos, S., Megias, D., Blanco-Aparicio, C., Hernández-Encinas, E., Rovira, M., Pietrocola, F., & Serrano, M. (2019) · Oncogene

Advanced Breast Cancer TherapiesNanoparticle-Based Drug Delivery

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