Serrano, Manuel

The Hallmarks of Aging

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 14,982

Hallmarks of aging: An expanding universe

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2023) · Cell

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 6,549

Cellular Senescence: Defining a Path Forward

Gorgoulis, V., Adams, P. D., Alimonti, A., Bennett, D. C., Bischof, O., Bishop, C., Campisi, J., Collado, M., Evangelou, K., Ferbeyre, G., et al. (2019) · Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 3,225

Cellular senescence: from physiology to pathology

Muñoz-Espín, D., & Serrano, M. (2014) · Nature Reviews Molecular Cell Biology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 2,818

Cellular senescence in cancer and aging.

Collado, M., Blasco, M. A., & Serrano, M. (2007) · Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 1,708

Role of the INK4a Locus in Tumor Suppression and Cell Mortality

Serrano, M., Lee, H.-W., Chin, L., Cordon-Cardo, C., Beach, D., & DePinho, R. A. (1996) · Cell

Cancer-related Molecular PathwaysTelomeres, Telomerase, and Senescence

Cited by 1,585

Senescence in premalignant tumours

Collado, M., Gil, J., Efeyan, A., Guerra, C., Schuhmacher, A. J., Barradas, M., Benguría, A., Zaballos, A., Flores, J. M., Barbacid, M., et al. (2005) · Nature

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 1,482

Programmed cell senescence during mammalian embryonic development

Muñoz-Espín, D., Cañamero, M., Maraver, A., Gómez-López, G., Contreras, J., Murillo-Cuesta, S., Rodríguez-Baeza, A., Varela-Nieto, I., Ruberte, J., Collado, M., et al. (2013) · Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 1,428

Senescence in tumours: evidence from mice and humans

Collado, M., & Serrano, M. (2010) · Nature Reviews Cancer

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 1,124

A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity

Marión, R. M., Strati, K., Li, H., Murga, M., Blanco, R., Ortega, S., Fernandez-Capetillo, O., Serrano, M., & Blasco, M. A. (2009) · Nature

Pluripotent Stem Cells ResearchTelomeres, Telomerase, and Senescence

Cited by 1,028

The common biology of cancer and ageing

Finkel, T., Serrano, M., & Blasco, M. A. (2007) · Nature

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 988

The Ink4/Arf locus is a barrier for iPS cell reprogramming

Li, H., Collado, M., Villasante, A., Strati, K., Ortega, S., Cañamero, M., Blasco, M. A., & Serrano, M. (2009) · Nature

Pluripotent Stem Cells ResearchEpigenetics and DNA Methylation

Cited by 968

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

Lin, A. W., Barradas, M., Stone, J. C., van Aelst, L., Serrano, M., & Lowe, S. W. (1998) · Genes & Development

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 945

Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer

Herranz, D., Muñoz-Martin, M., Cañamero, M., Mulero, F., Martinez-Pastor, B., Fernandez-Capetillo, O., & Serrano, M. (2010) · Nature Communications

Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model Organisms

Cited by 612

GLP-1 agonism stimulates brown adipose tissue thermogenesis and browning through hypothalamic AMPK

Beiroa, D., Imbernon, M., Gallego, R., Senra, A., Herranz, D., Villarroya, F., Serrano, M., Fernø, J., Salvador, J., Escalada, J., et al. (2014) · Diabetes

Adipose Tissue and MetabolismRegulation of Appetite and Obesity

Cited by 602

Tissue damage and senescence provide critical signals for cellular reprogramming in vivo

Mosteiro, L., Pantoja, C., Alcazar, N., Marión, R. M., Chondronasiou, D., Rovira, M., Fernandez-Marcos, P. J., Muñoz-Martin, M., Blanco-Aparicio, C., Pastor, J., et al. (2016) · Science

Pluripotent Stem Cells ResearchTelomeres, Telomerase, and Senescence

Cited by 589

Reprogramming in vivo produces teratomas and iPS cells with totipotency features

Abad, M., Mosteiro, L., Pantoja, C., Cañamero, M., Rayon, T., Ors, I., Graña, O., Megías, D., Domínguez, O., Martínez, D., et al. (2013) · Nature

Pluripotent Stem Cells ResearchDevelopmental Biology and Gene Regulation

Cited by 547

'Super p53' mice exhibit enhanced DNA damage response, are tumor resistant and age normally

García‐Cao, I., García‐Cao, M., Martín‐Caballero, J., Criado, L. M., Klatt, P., Flores, J. M., Weill, J., Blasco, M. A., & Serrano, M. (2002) · The EMBO Journal

Cancer-related Molecular PathwaysTelomeres, Telomerase, and Senescence

Cited by 529

Pancreatitis-induced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescence

Guerra, C., Collado, M., Navas, C., Schuhmacher, A. J., Hernández-Porras, I., Cañamero, M., Rodriguez-Justo, M., Serrano, M., & Barbacid, M. (2011) · Cancer Cell

Pancreatic and Hepatic Oncology ResearchPancreatitis Pathology and Treatment

Cited by 516

Telomerase Reverse Transcriptase Delays Aging in Cancer-Resistant Mice

Tomás-Loba, A., Flores, I., Fernández-Marcos, P. J., Cayuela, M. L., Maraver, A., Tejera, A., Borrás, C., Matheu, A., Klatt, P., Flores, J. M., et al. (2008) · Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 484

Delayed ageing through damage protection by the Arf/p53 pathway

Matheu, A., Maraver, A., Klatt, P., Flores, I., Garcia-Cao, I., Borras, C., Flores, J. M., Viña, J., Blasco, M. A., & Serrano, M. (2007) · Nature

Genetics, Aging, and Longevity in Model OrganismsCancer-related Molecular Pathways

Cited by 466

Putting the stress on senescence

Serrano, M., & Blasco, M. A. (2001) · Current Opinion in Cell Biology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 413

The power and the promise of oncogene-induced senescence markers

Collado, M., & Serrano, M. (2006) · Nature Reviews Cancer

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 404

Specific lipofuscin staining as a novel biomarker to detect replicative and stress-induced senescence. A method applicable in cryo-preserved and archival tissues

Georgakopoulou, E., Tsimaratou, K., Evangelou, K., Fernandez, M.-P., Zoumpourlis, V, Trougakos, I., Kletsas, D., Bartek, J., Serrano, M., & Gorgoulis, V. (2012) · Aging

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 390