Dror, Ron O.

How fast-folding proteins fold

Lindorff-Larsen, K., Piana, S., Dror, R. O., & Shaw, D. E. (2011) · Science

Protein Structure and DynamicsRNA and protein synthesis mechanisms

Cited by 1,980

Atomic-level characterization of the structural dynamics of proteins

Shaw, D. E., Maragakis, P., Lindorff-Larsen, K., Piana, S., Dror, R. O., Eastwood, M. P., Bank, J. A., Jumper, J. M., Salmon, J. K., Shan, Y., et al. (2010) · Science

Protein Structure and DynamicsRNA and protein synthesis mechanisms

Cited by 1,923

How Does a Drug Molecule Find Its Target Binding Site?

Shan, Y., Kim, E. T., Eastwood, M. P., Dror, R. O., Seeliger, M. A., & Shaw, D. E. (2011) · Journal of the American Chemical Society

Computational Drug Discovery MethodsProtein Structure and Dynamics

Cited by 614

Millisecond-scale molecular dynamics simulations on Anton

Shaw, D. E., Dror, R. O., Salmon, J. K., Grossman, J. P., Mackenzie, K. M., Bank, J. A., Young, C., Deneroff, M. M., Batson, B., Bowers, K. J., et al. (2009) · Proceedings of the Conference on High Performance Computing Networking, Storage and Analysis

Parallel Computing and Optimization TechniquesProtein Structure and Dynamics

Cited by 382

Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms

Billesbølle, C. B., Azumaya, C. M., Kretsch, R. C., Powers, A. S., Gonen, S., Schneider, S., Arvedson, T., Dror, R. O., Cheng, Y., & Manglik, A. (2020) · Nature

Iron Metabolism and DisordersFerroptosis and cancer prognosis

Cited by 344

Parallel random numbers: as easy as 1, 2, 3

Salmon, J. K., Moraes, M. A., Dror, R. O., & Shaw, D. E. (2011) · Proceedings of 2011 International Conference for High Performance Computing, Networking, Storage and Analysis

Mathematical Approximation and IntegrationParallel Computing and Optimization Techniques

Cited by 227

Structural insights into binding specificity, efficacy and bias of a β2AR partial agonist

Masureel, M., Zou, Y., Picard, L.-P., van der Westhuizen, E., Mahoney, J. P., Rodrigues, J. P. G. L. M., Mildorf, T. J., Dror, R. O., Shaw, D. E., Bouvier, M., et al. (2018) · Nature Chemical Biology

Receptor Mechanisms and SignalingNeuroscience and Neuropharmacology Research

Cited by 194

Structural and functional characterization of G protein–coupled receptors with deep mutational scanning

Jones, E. M., Lubock, N. B., Venkatakrishnan, A., Wang, J., Tseng, A. M., Paggi, J. M., Latorraca, N. R., Cancilla, D., Satyadi, M., Davis, J. E., et al. (2020) · eLife

Receptor Mechanisms and SignalingNeuroscience and Neuropharmacology Research

Cited by 168

Structural and Functional Analysis of a β2-Adrenergic Receptor Complex with GRK5

Komolov, K. E., Du, Y., Duc, N. M., Betz, R. M., Rodrigues, J. P. G. L. M., Leib, R. D., Patra, D., Skiniotis, G., Adams, C. M., Dror, R. O., et al. (2017) · Cell

Receptor Mechanisms and SignalingProtein Kinase Regulation and GTPase Signaling

Cited by 152

Structural basis for channel conduction in the pump-like channelrhodopsin ChRmine

Kishi, K. E., Kim, Y. S., Fukuda, M., Inoue, M., Kusakizako, T., Wang, P. Y., Ramakrishnan, C., Byrne, E. F. X., Thadhani, E., Paggi, J. M., et al. (2022) · Cell

Photoreceptor and optogenetics researchIon channel regulation and function

Cited by 149

Revealing Atomic-Level Mechanisms of Protein Allostery with Molecular Dynamics Simulations

Hertig, S., Latorraca, N. R., & Dror, R. O. (2016) · PLOS Computational Biology

Protein Structure and DynamicsReceptor Mechanisms and Signaling

Cited by 118

Cryptic pocket formation underlies allosteric modulator selectivity at muscarinic GPCRs

Hollingsworth, S. A., Kelly, B., Valant, C., Michaelis, J. A., Mastromihalis, O., Thompson, G., Venkatakrishnan, A. J., Hertig, S., Scammells, P. J., Sexton, P. M., et al. (2019) · Nature Communications

Receptor Mechanisms and SignalingNeuroscience and Neuropharmacology Research

Cited by 73

How accurately can one predict drug binding modes using AlphaFold models?

Karelina, M., Noh, J. J., & Dror, R. O. (2023) · eLife

Computational Drug Discovery MethodsReceptor Mechanisms and Signaling

Cited by 16