Heistek, Tim S.

Human neocortical expansion involves glutamatergic neuron diversification

Berg, J., Sorensen, S. A., Ting, J. T., Miller, J. A., Chartrand, T., Buchin, A., Bakken, T. E., Budzillo, A., Dee, N., Ding, S.-L., et al. (2021) · Nature

Single-cell and spatial transcriptomicsNeuroscience and Neuropharmacology Research

Cited by 285

Early restoration of parvalbumin interneuron activity prevents memory loss and network hyperexcitability in a mouse model of Alzheimer’s disease

Hijazi, S., Heistek, T. S., Scheltens, P., Neumann, U., Shimshek, D. R., Mansvelder, H. D., Smit, A. B., & van Kesteren, R. E. (2020) · Molecular Psychiatry

Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

Cited by 216

Astrocyte lipid metabolism is critical for synapse development and function in vivo

van Deijk, A. F., Camargo, N., Timmerman, J., Heistek, T., Brouwers, J. F., Mogavero, F., Mansvelder, H. D., Smit, A. B., & Verheijen, M. H. G. (2017) · Glia

Neuroscience and Neuropharmacology ResearchLipid metabolism and biosynthesis

Cited by 201

Hippocampal extracellular matrix alterations contribute to cognitive impairment associated with a chronic depressive-like state in rats

Riga, D., Kramvis, I., Koskinen, M. K., van Bokhoven, P., van der Harst, J. E., Heistek, T. S., Jaap Timmerman, A., van Nierop, P., van der Schors, R. C., Pieneman, A. W., et al. (2017) · Science Translational Medicine

Treatment of Major DepressionMemory and Neural Mechanisms

Cited by 128

Signature morphoelectric properties of diverse GABAergic interneurons in the human neocortex

Lee, B. R., Dalley, R., Miller, J. A., Chartrand, T., Close, J., Mann, R., Mukora, A., Ng, L., Alfiler, L., Baker, K., et al. (2023) · Science

Neuroscience and Neuropharmacology ResearchSingle-cell and spatial transcriptomics

Cited by 125

Morphoelectric and transcriptomic divergence of the layer 1 interneuron repertoire in human versus mouse neocortex

Chartrand, T., Dalley, R., Close, J., Goriounova, N. A., Lee, B. R., Mann, R., Miller, J. A., Molnar, G., Mukora, A., Alfiler, L., et al. (2023) · Science

Neuroscience and Neuropharmacology ResearchNeural dynamics and brain function

Cited by 88

Prefrontal cortical ChAT-VIP interneurons provide local excitation by cholinergic synaptic transmission and control attention

Obermayer, J., Luchicchi, A., Heistek, T. S., de Kloet, S. F., Terra, H., Bruinsma, B., Mnie-Filali, O., Kortleven, C., Galakhova, A. A., Khalil, A. J., et al. (2019) · Nature Communications

Neuroscience and Neuropharmacology ResearchNeuropeptides and Animal Physiology

Cited by 83

Prefrontal cortical ChAT-VIP interneurons provide local excitation by cholinergic synaptic transmission and control attention

Obermayer, J., Luchicchi, A., de Kloet, S. F., Terra, H., Bruinsma, B., Heistek, T. S., Mnie-Filali, O., Kortleven, C., Kroon, T., Jonker, A. J., et al. (2018) · Nature Communications

Neuroscience and Neuropharmacology ResearchNeuropeptides and Animal Physiology

Cited by 83