Lazarou, Michael

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

Lazarou, M., Sliter, D. A., Kane, L. A., Sarraf, S. A., Wang, C., Burman, J. L., Sideris, D. P., Fogel, A. I., & Youle, R. J. (2015) · Nature

Autophagy in Disease and TherapyParkinson's Disease Mechanisms and Treatments

Cited by 2,774

Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

Jin, S. M., Lazarou, M., Wang, C., Kane, L. A., Narendra, D. P., & Youle, R. J. (2010) · Journal of Cell Biology

Parkinson's Disease Mechanisms and TreatmentsMitochondrial Function and Pathology

Cited by 1,375

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

Kane, L. A., Lazarou, M., Fogel, A. I., Li, Y., Yamano, K., Sarraf, S. A., Banerjee, S., & Youle, R. J. (2014) · Journal of Cell Biology

Parkinson's Disease Mechanisms and TreatmentsUbiquitin and proteasome pathways

Cited by 1,298

BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis

McArthur, K., Whitehead, L. W., Heddleston, J. M., Li, L., Padman, B. S., Oorschot, V., Geoghegan, N. D., Chappaz, S., Davidson, S., San Chin, H., et al. (2018) · Science

Cell death mechanisms and regulationMitochondrial Function and Pathology

Cited by 1,072

Role of PINK1 Binding to the TOM Complex and Alternate Intracellular Membranes in Recruitment and Activation of the E3 Ligase Parkin

Lazarou, M., Jin, S. M., Kane, L. A., & Youle, R. J. (2012) · Developmental Cell

Parkinson's Disease Mechanisms and TreatmentsAutophagy in Disease and Therapy

Cited by 670

Mitochondrial degradation: Mitophagy and beyond

Uoselis, L., Nguyen, T. N., & Lazarou, M. (2023) · Molecular Cell

Autophagy in Disease and TherapyMitochondrial Function and Pathology

Cited by 270

Inhibition of Bak Activation by VDAC2 Is Dependent on the Bak Transmembrane Anchor

Lazarou, M., Stojanovski, D., Frazier, A. E., Kotevski, A., Dewson, G., Craigen, W. J., Kluck, R. M., Vaux, D. L., & Ryan, M. T. (2010) · Journal of Biological Chemistry

Cell death mechanisms and regulationMitochondrial Function and Pathology

Cited by 111

Mammalian Atg8 proteins and the autophagy factor IRGM control mTOR and TFEB at a regulatory node critical for responses to pathogens

Kumar, S., Jain, A., Choi, S. W., da Silva, G. P. D., Allers, L., Mudd, M. H., Peters, R. S., Anonsen, J. H., Rusten, T.-E., Lazarou, M., et al. (2020) · Nature Cell Biology

Autophagy in Disease and TherapyCalcium signaling and nucleotide metabolism

Cited by 95

Assembly of the Bak Apoptotic Pore

Ma, S., Hockings, C., Anwari, K., Kratina, T., Fennell, S., Lazarou, M., Ryan, M. T., Kluck, R. M., & Dewson, G. (2013) · Journal of Biological Chemistry

Cell death mechanisms and regulationMitochondrial Function and Pathology

Cited by 71

Structural basis for ATG9A recruitment to the ULK1 complex in mitophagy initiation

Ren, X., Nguyen, T. N., Lam, W. K., Buffalo, C. Z., Lazarou, M., Yokom, A. L., & Hurley, J. H. (2023) · Science Advances

Autophagy in Disease and TherapyUbiquitin and proteasome pathways

Cited by 68

Structural basis for ATG9A recruitment to the ULK1 complex in mitophagy initiation

Ren, X., Nguyen, T. N., Lam, W. K., Buffalo, C. Z., Lazarou, M., Yokom, A. L., & Hurley, J. H. (2022) · Science Advances

Autophagy in Disease and TherapyUbiquitin and proteasome pathways

Cited by 68

Reconstitution of BNIP3/NIX-mitophagy initiation reveals hierarchical flexibility of the autophagy machinery

Adriaenssens, E., Schaar, S., Cook, A. S. I., Stuke, J. F. M., Sawa-Makarska, J., Nguyen, T. N., Ren, X., Schuschnig, M., Romanov, J., Khuu, G., et al. (2025) · Nature Cell Biology

Autophagy in Disease and TherapyUbiquitin and proteasome pathways

Cited by 53

Reconstitution of BNIP3/NIX-mediated autophagy reveals two pathways and hierarchical flexibility of the initiation machinery

Adriaenssens, E., Schaar, S., Cook, A. S. I., Stuke, J. F. M., Sawa-Makarska, J., Nguyen, T. N., Ren, X., Schuschnig, M., Romanov, J., Khuu, G., et al. (2024) · Nature Cell Biology

Autophagy in Disease and TherapyUbiquitin and proteasome pathways

Cited by 53

Three-step docking by WIPI2, ATG16L1, and ATG3 delivers LC3 to the phagophore

Rao, S., Skulsuppaisarn, M., Strong, L. M., Ren, X., Lazarou, M., Hurley, J. H., & Hummer, G. (2024) · Science Advances

Autophagy in Disease and TherapyUbiquitin and proteasome pathways

Cited by 40

Structure and activation of the human autophagy-initiating ULK1C:PI3KC3-C1 supercomplex

Chen, M., Nguyen, T. N., Ren, X., Khuu, G., Cook, A. S. I., Zhao, Y., Yildiz, A., Lazarou, M., & Hurley, J. H. (2023) · Nature Structural & Molecular Biology

Autophagy in Disease and TherapyUbiquitin and proteasome pathways

Cited by 40

Structural pathway for PI3-kinase regulation by VPS15 in autophagy

Cook, A. S. I., Chen, M., Nguyen, T. N., Cabezudo, A. C., Khuu, G., Rao, S., Garcia, S. N., Yang, M., Iavarone, A. T., Ren, X., et al. (2025) · Science

Autophagy in Disease and TherapyCellular transport and secretion

Cited by 34

PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCF FBXL4

Nguyen-Dien, G. T., Townsend, B., Kulkarni, P., Kozul, K.-L., Ooi, S. S., Eldershaw, D., Weeratunga, S., Liu, M., Jones, M. J., Millard, S. S., et al. (2024) · EMBO Reports

Autophagy in Disease and TherapyUbiquitin and proteasome pathways

Cited by 30

PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCFFBXL4

Nguyen-Dien, G. T., Townsend, B., Kulkarni, P. G., Kozul, K.-L., Ooi, S. S., Eldershaw, D. N., Weeratunga, S., Liu, M., Jones, M. J., Millard, S. S., et al. (2024) · EMBO Reports

Autophagy in Disease and TherapyUbiquitin and proteasome pathways

Cited by 30

Interaction of PINK1 with nucleotides and kinetin

Gan, Z. Y., Callegari, S., Nguyen, T. N., Kirk, N. S., Leis, A., Lazarou, M., Dewson, G., & Komander, D. (2024) · Science Advances

Parkinson's Disease Mechanisms and TreatmentsAutophagy in Disease and Therapy

Cited by 14