Byrns, Michael C.

Steroid hormone transforming aldo–keto reductases and cancer

Penning, T. M., & Byrns, M. C. (2009) · Annals of the New York Academy of Sciences

Aldose Reductase and TaurineProstate Cancer Treatment and Research

Cited by 181

An indomethacin analogue, N-(4-chlorobenzoyl)-melatonin, is a selective inhibitor of aldo-keto reductase 1C3 (type 2 3α-HSD, type 5 17β-HSD, and prostaglandin F synthase), a potential target for the treatment of hormone dependent and hormone independent malignancies

Byrns, M. C., Steckelbroeck, S., & Penning, T. M. (2008) · Biochemical Pharmacology

Aldose Reductase and TaurineBioactive Compounds and Antitumor Agents

Cited by 145

Aldo–keto reductase 1C3 expression in MCF-7 cells reveals roles in steroid hormone and prostaglandin metabolism that may explain its over-expression in breast cancer

Byrns, M. C., Duan, L., Lee, S. H., Blair, I. A., & Penning, T. M. (2010) · The Journal of Steroid Biochemistry and Molecular Biology

Aldose Reductase and TaurineEstrogen and related hormone effects

Cited by 116

Overexpression of aldo–keto reductase 1C3 (AKR1C3) in LNCaP cells diverts androgen metabolism towards testosterone resulting in resistance to the 5α-reductase inhibitor finasteride

Byrns, M. C., Mindnich, R., Duan, L., & Penning, T. M. (2012) · The Journal of Steroid Biochemistry and Molecular Biology

Prostate Cancer Treatment and ResearchAldose Reductase and Taurine

Cited by 60