McDonnell, Donald P.

Bisphenol A interacts with the estrogen receptor α in a distinct manner from estradiol

Gould, J. C., Leonard, L. S., Maness, S. C., Wagner, B. L., Conner, K., Zacharewski, T., Safe, S., McDonnell, D. P., & Gaido, K. W. (1998) · Molecular and Cellular Endocrinology

Effects and risks of endocrine disrupting chemicalsEstrogen and related hormone effects

Cited by 510

The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells

Baek, A. E., Yu, Y.-R. A., He, S., Wardell, S. E., Chang, C.-Y., Kwon, S., Pillai, R. V., McDowell, H. B., Thompson, J. W., Dubois, L. G., et al. (2017) · Nature Communications

Cancer, Lipids, and MetabolismImmune cells in cancer

Cited by 427

Androgen receptor degradation by the proteolysis-targeting chimera ARCC-4 outperforms enzalutamide in cellular models of prostate cancer drug resistance

Salami, J., Alabi, S., Willard, R. R., Vitale, N. J., Wang, J., Dong, H., Jin, M., McDonnell, D. P., Crew, A. P., Neklesa, T. K., et al. (2018) · Communications Biology

Protein Degradation and InhibitorsProstate Cancer Treatment and Research

Cited by 349

Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation

Michalek, R. D., Gerriets, V. A., Nichols, A. G., Inoue, M., Kazmin, D., Chang, C.-Y., Dwyer, M. A., Nelson, E. R., Pollizzi, K. N., Ilkayeva, O., et al. (2011) · Proceedings of the National Academy of Sciences

T-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

Cited by 216

Development of a Small-Molecule Serum- and Glucocorticoid-Regulated Kinase-1 Antagonist and Its Evaluation as a Prostate Cancer Therapeutic

Sherk, A. B., Frigo, D. E., Schnackenberg, C. G., Bray, J. D., Laping, N. J., Trizna, W., Hammond, M., Patterson, J. R., Thompson, S. K., Kazmin, D., et al. (2008) · Cancer Research

Prostate Cancer Treatment and ResearchEstrogen and related hormone effects

Cited by 211

Small‐Molecule‐Mediated Degradation of the Androgen Receptor through Hydrophobic Tagging

Gustafson, J. L., Neklesa, T. K., Cox, C. S., Roth, A. G., Buckley, D. L., Tae, H. S., Sundberg, T. B., Stagg, D. B., Hines, J., McDonnell, D. P., et al. (2015) · Angewandte Chemie International Edition

Protein Degradation and InhibitorsProstate Cancer Treatment and Research

Cited by 206

Oral Selective Estrogen Receptor Downregulators (SERDs), a Breakthrough Endocrine Therapy for Breast Cancer

McDonnell, D. P., Wardell, S. E., & Norris, J. D. (2015) · Journal of Medicinal Chemistry

Estrogen and related hormone effectsAdvanced Breast Cancer Therapies

Cited by 178

Thyroid hormone receptor and ERRα coordinately regulate mitochondrial fission, mitophagy, biogenesis, and function

Singh, B. K., Sinha, R. A., Tripathi, M., Mendoza, A., Ohba, K., Sy, J. A. C., Xie, S. Y., Zhou, J., Ho, J. P., Chang, C.-Y., et al. (2018) · Science Signaling

Autophagy in Disease and TherapyMitochondrial Function and Pathology

Cited by 145

Research resource: nuclear receptor atlas of human retinal pigment epithelial cells: potential relevance to age-related macular degeneration

Dwyer, M. A., Kazmin, D., Hu, P., McDonnell, D. P., & Malek, G. (2011) · Molecular Endocrinology

Retinal Diseases and TreatmentsRetinal Development and Disorders

Cited by 61

PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation

Anderson, G. R., Wardell, S. E., Cakir, M., Crawford, L., Leeds, J. C., Nussbaum, D. P., Shankar, P. S., Soderquist, R. S., Stein, E. M., Tingley, J. P., et al. (2016) · Science Translational Medicine

PI3K/AKT/mTOR signaling in cancerAdvanced Breast Cancer Therapies

Cited by 53

Potentiation of progesterone receptor-mediated transcription by the immunosuppressant FK506.

Tai, P.-K. K., Albers, M. W., McDonnell, D. P., Chang, H., Schreiber, S. L., & Faber, L. E. (1994) · Biochemistry

Signaling Pathways in DiseaseEstrogen and related hormone effects

Cited by 52