Thyroid hormone receptor and ERRα coordinately regulate mitochondrial fission, mitophagy, biogenesis, and function
Open accessAbstract
The thyroid hormone receptor mediates its effects on key mitochondrial processes through ERRα.
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T3 did not trigger a global rise in Hep-ID transcription factor expression in healthy mice, in contrast to its effect in dedifferentiated hepatocytes.
“This was in contrast with T3 not triggering a global rise in Hep‐ID TF expression in healthy mice (Appendix Fig S13; Singh et al, 2018) further substantiating a role for THRB in controlling Hep‐ID TF genes only in context of dedifferentiated hepatocytes.”
From An extended transcription factor regulatory network controls hepatocyte identity (2023) · cites this paper as Singh et al, 2018
Cites
Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625 · see citing works
Fission and selective fusion govern mitochondrial segregation and elimination by autophagy
Twig, G., Elorza, A., Molina, A. J. A., Mohamed, H., Wikstrom, J. D., Walzer, G., Stiles, L., Haigh, S. E., Katz, S., Las, G., et al. (2008) · The EMBO Journal · doi:10.1038/sj.emboj.7601963 · Cited by 3,082 · see citing works
Muoio, D. M., Noland, R. C., Kovalik, J.-P., Seiler, S. E., Davies, M. N., DeBalsi, K. L., Ilkayeva, O. R., Stevens, R. D., Kheterpal, I., Zhang, J., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.005 · Cited by 372 · cited 1× · see citing works
“Metabolic profiling of acylcarnitines and organic acids Methods of extraction and metabolic profiling for acylcarnitines and organic acids were performed, with some modifications, as described elsewhere (79, 85).”
MethodERRα: a metabolic function for the oldest orphan
Villena, J. A., & Kralli, A. (2008) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2008.07.005 · Cited by 252 · see citing works
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Thyroid hormone signaling and the liver
Ritter, M. J., Amano, I., Hollenberg, A. N., et al. (2020) · Hepatology · doi:10.1002/hep.31296 · Cited by 188 · see citing works
Self-citationNAFLD and thyroid function: pathophysiological and therapeutic considerations
Hatziagelaki, E., Paschou, S. A., Schön, M., Psaltopoulou, T., & Roden, M. (2022) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2022.08.001 · Cited by 93 · see citing works
Sawicka-Gutaj, N., Zawalna, N., Gut, P., & Ruchała, M. (2022) · Pharmacological Reports · doi:10.1007/s43440-022-00377-w · Cited by 57 · see citing works
A Liver-Specific Thyromimetic, VK2809, Decreases Hepatosteatosis in Glycogen Storage Disease Type Ia
Zhou, J., Waskowicz, L. R., Lim, A., Liao, X.-H., Lian, B., Masamune, H., Refetoff, S., Tran, B., Koeberl, D. D., & Yen, P. M. (2019) · Thyroid® · doi:10.1089/thy.2019.0007 · Cited by 60 · see citing works
Self-citationAn extended transcription factor regulatory network controls hepatocyte identity
Dubois‐Chevalier, J., Gheeraert, C., Berthier, A., Boulet, C., Dubois, V., Guille, L., Fourcot, M., Marot, G., Gauthier, K., Dubuquoy, L., et al. (2023) · EMBO Reports · doi:10.15252/embr.202357020 · Cited by 6 · see citing works
“In line, mining genes associated with phenotypes from the Mammalian Phenotype Ontology resource (Smith et al , 2005; Chen et al , 2007) revealed that, albeit less significant when compared to Hep-ID TFs, Hep-ID CONNECT TF-encoding genes are linked to abnormal liver phenotypes and metabolic…”
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- Authors
- Singh, B. K., Sinha, R. A., Tripathi, M., Mendoza, A., Ohba, K., Sy, J. A. C., Xie, S. Y., Zhou, J., Ho, J. P., Chang, C.-Y., Wu, Y., Giguère, V., Bay, B.-H., Vanacker, J.-M., Ghosh, S., Gauthier, K., Hollenberg, A. N., McDonnell, D. P., & Yen, P. M.
- Affiliations
- National University of Singapore (SG)
- Sanjay Gandhi Post Graduate Institute of Medical Sciences (IN)
- Beth Israel Deaconess Medical Center (US)
- Duke University (US)
- McGill University (CA)
- Lyon 1 Université (FR)
- JA Shizuoka Koseiren ENSHU hospital (JP)
- Corresponding author
- Singh, Brijesh K.
- Yen, Paul M.
- ORCID
- Venue
- Science Signaling
- Published
- 2018-06-26
- Volume
- 11
- Issue
- 536
- ISSN
- 1937-9145 (ISSN-L)
- 1945-0877
- OpenAlex
- W2810974346
- Cited by
- 145
- References
- 4
- Citations by year
- 2026: 15 · 2025: 14 · 2024: 33 · 2023: 22 · 2022: 17 · 2021: 17 · 2020: 18 · 2019: 7 · 2018: 2
- FWCI
- 8.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Science Signaling (publishedVersion)
- PubMed (publishedVersion)
- National University of Singapore (submittedVersion)
- Funders
- National Medical Research Council (NMRC/CIRG/ 1340/2012, NMRC/CSA/MH95:03/1-8, NMRC/OFYIRG/0002/2016)
- Topics
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- thyroid hormone receptor, estrogen-related receptor alpha, mitochondrial fission, mitophagy, mitochondrial biogenesis, PGC-1α, ULK1, oxidative phosphorylation, mitochondrial quality control, metabolic disorders
- MeSH terms
- Autophagy-Related Protein-1 Homolog, Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, ERRalpha Estrogen-Related Receptor, Animals, Autophagy, Cells, Cultured, Humans, Male, Membrane Proteins, Mice, Inbred C57BL, Mitochondria, Phosphorylation, Receptors, Estrogen, Mice, Knockout, Mitochondrial Proteins, Dynamins, Thyroid Hormone Receptors beta, Mice, Mitochondrial Dynamics, Mitophagy
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