Triggle, Chris R.

Metformin: An Old Drug for the Treatment of Diabetes But a New Drug for the Protection of the Endothelium

Kinaan, M., Ding, H., & Triggle, C. R. (2015) · Medical Principles and Practice

Blood Pressure and Hypertension StudiesDiabetes Treatment and Management

Cited by 1,515

FGF21 maintains glucose homeostasis by mediating the cross talk between liver and brain during prolonged fasting

Liang, Q., Zhong, L., Zhang, J., Wang, Y., Bornstein, S. R., Triggle, C. R., Ding, H., Lam, K. S. L., & Xu, A. (2014) · Diabetes

Fibroblast Growth Factor ResearchRegulation of Appetite and Obesity

Cited by 299

A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan

Mohammed, I., Hollenberg, M. D., Ding, H., & Triggle, C. R. (2021) · Frontiers in Endocrinology

Metabolism, Diabetes, and CancerGenetics, Aging, and Longevity in Model Organisms

Cited by 278

Metformin modulates hyperglycaemia‐induced endothelial senescence and apoptosis through SIRT1

Arunachalam, G., Samuel, S. M., Marei, I., Ding, H., & Triggle, C. R. (2014) · British Journal of Pharmacology

Sirtuins and Resveratrol in MedicineNitric Oxide and Endothelin Effects

Cited by 221

Hyperglycaemic Impairment of PAR2-Mediated Vasodilation: Prevention by Inhibition of Aortic Endothelial Sodium-Glucose-Co-Transporter-2 and Minimizing Oxidative Stress

El-Daly, M., Pulakazhi Venu, V. K., Saifeddine, M., Mihara, K., Kang, S., Fedak, P. W. M., Alston, L. A., Hirota, S. A., Ding, H., Triggle, C. R., et al. (2018) · Vascular Pharmacology

Nitric Oxide and Endothelin EffectsBlood Coagulation and Thrombosis Mechanisms

Cited by 117

Oxidative Stress and Increased eNOS and NADPH Oxidase Expression in Mouse Microvessel Endothelial Cells

Ding, H., Aljofan, M., & Triggle, C. R. (2007) · Journal of Cellular Physiology

Nitric Oxide and Endothelin EffectsRedox biology and oxidative stress

Cited by 107

Chronic oral supplementation with sepiapterin prevents endothelial dysfunction and oxidative stress in small mesenteric arteries from diabetic (db/db) mice

Pannirselvam, M., Simon, V., Verma, S., Anderson, T., & Triggle, C. R. (2003) · British Journal of Pharmacology

Nitric Oxide and Endothelin EffectsFolate and B Vitamins Research

Cited by 91

Metformin: The Answer to Cancer in a Flower? Current Knowledge and Future Prospects of Metformin as an Anti-Cancer Agent in Breast Cancer

Samuel, S., Varghese, E., Kubatka, P., Triggle, C., & Büsselberg, D. (2019) · Biomolecules

Metabolism, Diabetes, and CancerCancer, Hypoxia, and Metabolism

Cited by 81

Why the endothelium? The endothelium as a target to reduce diabetes-associated vascular disease

Triggle, C. R., Ding, H., Marei, I., Anderson, T. J., & Hollenberg, M. D. (2020) · Canadian Journal of Physiology and Pharmacology

Nitric Oxide and Endothelin EffectsDiabetes Treatment and Management

Cited by 49

Metformin Improves Endothelial Function in Aortic Tissue and Microvascular Endothelial Cells Subjected to Diabetic Hyperglycaemic Conditions

Ghosh, S., Lakshmanan, A. P., Hwang, M. J., Kubba, H., Mushannen, A., Triggle, C. R., & Ding, H. (2015) · Biochemical Pharmacology

Nitric Oxide and Endothelin EffectsMetabolism, Diabetes, and Cancer

Cited by 45

Metformin Represses Glucose Starvation Induced Autophagic Response in Microvascular Endothelial Cells and Promotes Cell Death

Samuel, S. M., Ghosh, S., Majeed, Y., Arunachalam, G., Emara, M. M., Ding, H., & Triggle, C. R. (2017) · Biochemical Pharmacology

Metabolism, Diabetes, and CancerAutophagy in Disease and Therapy

Cited by 37

Treatment With a Combination of Metformin and 2-Deoxyglucose Upregulates Thrombospondin-1 in Microvascular Endothelial Cells: Implications in Anti-Angiogenic Cancer Therapy

Mathews Samuel, S., Satheesh, N. J., Ghosh, S., Büsselberg, D., Majeed, Y., Ding, H., & Triggle, C. R. (2019) · Cancers

Metabolism, Diabetes, and CancerAngiogenesis and VEGF in Cancer

Cited by 28