Chronic oral supplementation with sepiapterin prevents endothelial dysfunction and oxidative stress in small mesenteric arteries from diabetic (db/db) mice

Endothelial Dysfunction, Oxidative Stress, and Risk of Cardiovascular Events in Patients With Coronary Artery Disease

Heitzer, T., Schlinzig, T., Krohn, K., Meinertz, T., & Münzel, T. (2001) · Circulation · doi:10.1161/hc4601.099485 · Cited by 1,961 · see citing works

Oxidative Stress and Diabetic Vascular Complications

Giugliano, D., Ceriello, A., & Paolisso, G. (1996) · Diabetes Care · doi:10.2337/diacare.19.3.257 · Cited by 1,938 · see citing works

Generation of superoxide by purified brain nitric oxide synthase

Pou, S., Pou, W. S., Bredt, D. S., Snyder, S. H., & Rosen, G. M. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)35745-4 · Cited by 750 · see citing works

Interactions of Peroxynitrite, Tetrahydrobiopterin, Ascorbic Acid, and Thiols

Kuzkaya, N., Weissmann, N., Harrison, D. G., & Dikalov, S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302227200 · Cited by 692 · see citing works

Oxidation of Tetrahydrobiopterin by Peroxynitrite: Implications for Vascular Endothelial Function

Milstien, S., & Katušić, Z. S. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1422 · Cited by 488 · see citing works

Tetrahydrobiopterin Improves Endothelium-Dependent Vasodilation in Chronic Smokers

Heitzer, T. A., Brockhoff, C. J., Mayer, B., Warnholtz, A., Mollnau, H., Henne, S., Meinertz, T., & Münzel, T. F. (2000) · Circulation Research · doi:10.1161/01.res.86.2.e36 · Cited by 449 · see citing works

Abnormal biopterin metabolism is a major cause of impaired endothelium-dependent relaxation through nitric oxide/O2- imbalance in insulin-resistant rat aorta.

Shinozaki, K., Kashiwagi, A., Nishio, Y., Okamura, T., Yoshida, Y., Masada, M., Toda, N., & Kikkawa, R. (1999) · Diabetes · doi:10.2337/diabetes.48.12.2437 · Cited by 329 · see citing works

Tetrahydrobiopterin and Dysfunction of Endothelial Nitric Oxide Synthase in Coronary Arteries

Cosentino, F., & Katušić, Z. S. (1995) · Circulation · doi:10.1161/01.cir.91.1.139 · Cited by 294 · see citing works

The ratio between tetrahydrobiopterin and oxidized tetrahydrobiopterin analogues controls superoxide release from endothelial nitric oxide synthase: an EPR spin trapping study

Vasquez-Vivar, J. M., Pavel Martasek, E., Whitsett, J., Joseph, J., & Kalyanaraman, B. (2002) · Biochemical Journal · doi:10.1042/0264-6021:3620733 · Cited by 287 · see citing works

The ratio between tetrahydrobiopterin and oxidized tetrahydrobiopterin analogues controls superoxide release from endothelial nitric oxide synthase: an EPR spin trapping study

VÁSQUEZ-VIVAR, J., MARTÁSEK, P., WHITSETT, J., JOSEPH, J., & KALYANARAMAN, B. (2002) · Biochemical Journal · doi:10.1042/bj3620733 · Cited by 287 · see citing works

Tetrahydrobiopterin Regulates Superoxide and Nitric Oxide Generation by Recombinant Endothelial Nitric Oxide Synthase

Wever, R. M. F., van Dam, T., van Rijn, H. J. M., de Groot, F. G., & Rabelink, T. J. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7069 · Cited by 281 · see citing works

Oral Administration of Tetrahydrobiopterin Prevents Endothelial Dysfunction and Vascular Oxidative Stress in the Aortas of Insulin-Resistant Rats

Shinozaki, K., Nishio, Y., Okamura, T., Yoshida, Y., Maegawa, H., Kojima, H., Masada, M., Toda, N., Kikkawa, R., & Kashiwagi, A. (2000) · Circulation Research · doi:10.1161/01.res.87.7.566 · Cited by 242 · see citing works

Acute Amelioration of Diabetic Endothelial Dysfunction with a Derivative of the Nitric Oxide Synthase Cofactor, Tetrahydrobiopterin

Pieper, G. M. (1997) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199701000-00002 · Cited by 222 · see citing works

The pteridine binding site of brain nitric oxide synthase. Tetrahydrobiopterin binding kinetics, specificity, and allosteric interaction with the substrate domain.

Klatt, P., Schmid, M., Leopold, E., Schmidt, K., Werner, E. R., & Mayer, B. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36726-1 · Cited by 219 · see citing works

Tetrahydrobiopterin Improves Endothelial Function in Patients with Coronary Artery Disease

Maier, W., Cosentino, F., Lütolf, R. B., Fleisch, M., Seiler, C., Hess, O. M., Meier, B., & Lüscher, T. F. (2000) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-200002000-00001 · Cited by 217 · see citing works

Formation of a Pterin Radical in the Reaction of the Heme Domain of Inducible Nitric Oxide Synthase with Oxygen

Hurshman, A. R., Krebs, C., Edmondson, D. E., Huynh, B. H., & Marletta, M. A. (1999) · Biochemistry · doi:10.1021/bi992026c · Cited by 208 · see citing works

Supplemention With Tetrahydrobiopterin Suppresses the Development of Hypertension in Spontaneously Hypertensive Rats

Hong, H.-J., Hsiao, G., Cheng, T.-H., & Yen, M.-H. (2001) · Hypertension · doi:10.1161/hy1101.095331 · Cited by 203 · see citing works

Impaired nitric oxide production in coronary endothelial cells of the spontaneously diabetic BB rat is due to tetrahydrobiopterin deficiency

Meininger, C. J., MARINOS, R. S., Hatakeyama, K., Martı́nez–Zaguilán, R., Rojas, J. D., Kelly, K. A., & Wu, G. (2000) · Biochemical Journal · doi:10.1042/0264-6021:3490353 · Cited by 189 · see citing works

Cellular basis of endothelial dysfunction in small mesenteric arteries from spontaneously diabetic (db/db−/−) mice: role of decreased tetrahydrobiopterin bioavailability

Pannirselvam, M., Verma, S., Anderson, T. J., & Triggle, C. R. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704683 · Cited by 177 · see citing works

Endothelial Dysfunction of Coronary Resistance Arteries Is Improved by Tetrahydrobiopterin in Atherosclerosis

Tiefenbacher, C., Bleeke, T., Vahl, C. F., Amann, K., Vogt, A. M., & Kübler, W. (2000) · Circulation · doi:10.1161/01.cir.102.18.2172 · Cited by 154 · see citing works

Restoration of Endothelium-Dependent Vasodilation After Reperfusion Injury by Tetrahydrobiopterin

Tiefenbacher, C., Chilian, W. M., Mitchell, M., & DeFily, D. V. (1996) · Circulation · doi:10.1161/01.cir.94.6.1423 · Cited by 140 · see citing works

Possible superoxide radical-induced alteration of vascular reactivity in aortas from streptozotocin-treated rats.

Chang, K. C., Chung, S. Y., Chong, W. S., Suh, J. S., Kim, S. H., Noh, H. K., Seong, B.-G., ko, H. J., & Chun, K. W. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)38436-3 · Cited by 138 · see citing works

In search of a function for tetrahydrobiopterin in the biosynthesis of nitric oxide

Mayer, B., & Werner, E. R. (1995) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00171035 · Cited by 130 · see citing works

Rapid Kinetic Studies Link Tetrahydrobiopterin Radical Formation to Heme-dioxy Reduction and Arginine Hydroxylation in Inducible Nitric-oxide Synthase

Wei, C., Wang, Z., Wang, Q., Meade, A. L., Hemann, C. F., Hille, R., & Stuehr, D. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008441200 · Cited by 129 · see citing works

Altered Tetrahydrobiopterin Metabolism in Atherosclerosis

Vasquez-Vivar, J. M., Duquaine, D. C., Whitsett, J., Kalyanaraman, B., & Rajagopalan, S. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000029122.79665.d9 · Cited by 121 · see citing works

Impaired nitric oxide production in coronary endothelial cells of the spontaneously diabetic BB rat is due to tetrahydrobiopterin deficiency

Meininger, C. J., MARINOS, R. S., Hatakeyama, K., et al. (2000) · Biochemical Journal · doi:10.1042/bj3490353 · Cited by 121 · see citing works

Antioxidative Activity of 5,6,7,8-Tetrahydrobiopterin and its Inhibitory Effect on Paraquat-Induced Cell Toxicity in Cultured Rat Hepatocytes

Kojima, S., Ona, S., Iizuka, I., Arai, T., Mori, H., & Kubota, K. (1995) · Free Radical Research · doi:10.3109/10715769509065263 · Cited by 98 · see citing works

Oxidation of tetrahydrobiopterin by biological radicals and scavenging of the trihydrobiopterin radical by ascorbate

Patel, K. B., Stratford, M. R. L., Wardman, P., & Everett, S. A. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00777-8 · Cited by 95 · see citing works

Inhibition of tetrahydrobiopterin biosynthesis impairs endothelium-dependent relaxations in canine basilar artery

Kinoshita, H., Milstien, S., Wambi, C. O., & Katušić, Z. S. (1997) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1997.273.2.h718 · Cited by 70 · see citing works

Estimation of tetrahydrobiopterin and other pterins in cerebrospinal fluid using reversed-phase high-performance liquid chromatography with electrochemical and fluorescence detection

Howells, D. W., Smith, I., & Hyland, Κ. (1986) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/s0378-4347(00)83594-x · Cited by 67 · see citing works

Generation of superoxide from nitric oxide synthase

Vasquez-Vivar, J. M., & Kalyanaraman, B. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)02001-9 · Cited by 46 · see citing works

Divergence in Regulation of Nitric-oxide Synthase and Its Cofactor Tetrahydrobiopterin by Tumor Necrosis Factor-α

Vann, L. R., Twitty, S., Spiegel, S., & Milstien, S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.18.13275 · Cited by 39 · see citing works

Roles of vascular oxidative stress and nitric oxide in the pathogenesis of atherosclerosis

Förstermann, U., Xia, N., & Li, H. (2017) · Circulation Research · doi:10.1161/circresaha.116.309326 · Cited by 1,519 · see citing works

Endothelial Dysfunction and Diabetes: Effects on Angiogenesis, Vascular Remodeling, and Wound Healing

Kolluru, G. K., Bir, S. C., & Kevil, C. G. (2012) · International Journal of Vascular Medicine · doi:10.1155/2012/918267 · Cited by 729 · see citing works

Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation

Tejero, J., Shiva, S., & Gladwin, M. T. (2019) · Physiological Reviews · doi:10.1152/physrev.00036.2017 · Cited by 541 · see citing works

Endothelial dysfunction due to eNOS uncoupling: molecular mechanisms as potential therapeutic targets

Janaszak-Jasiecka, A., Płoska, A., Wierońska, J. M., Dobrucki, L. W., & Kalinowski, L. (2023) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-023-00423-2 · Cited by 358 · see citing works

Vascular endothelial dysfunction, a major mediator in diabetic cardiomyopathy

Knapp, M., Tu, X., & Wu, R. (2018) · Acta Pharmacologica Sinica · doi:10.1038/s41401-018-0042-6 · Cited by 329 · see citing works

Adiponectin-Induced Endothelial Nitric Oxide Synthase Activation and Nitric Oxide Production Are Mediated by APPL1 in Endothelial Cells

Cheng, K. K. Y., Lam, K. S. L., Wang, Y., Huang, Y., Carling, D., Wu, D., Wong, C., & Xu, A. (2007) · Diabetes · doi:10.2337/db06-1580 · Cited by 318 · see citing works

Vascular NADPH oxidases as drug targets for novel antioxidant strategies

Guzik, T. J., & Harrison, D. G. (2006) · Drug Discovery Today · doi:10.1016/j.drudis.2006.04.003 · Cited by 234 · see citing works

The endothelium: influencing vascular smooth muscle in many ways

Triggle, C. R., Samuel, S. M., Ravishankar, S., Marei, I., Arunachalam, G., & Ding, H. (2012) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y2012-073 · Cited by 218 · see citing works

Tackling endothelial dysfunction by modulating NOS uncoupling: new insights into its pathogenesis and therapeutic possibilities

Kietadisorn, R., Juni, R. P., & Moens, A. L. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00540.2011 · Cited by 216 · see citing works

The Cerebral Circulation

Cipolla, M. J. (2009) · Colloquium Series on Integrated Systems Physiology From Molecule to Function · doi:10.4199/c00005ed1v01y200912isp002 · Cited by 202 · see citing works

Prevention of Atherosclerosis by Interference with the Vascular Nitric Oxide System

Li, H., & Förstermann, U. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209789058002 · Cited by 149 · see citing works

Regulation of Tetrahydrobiopterin Synthesis and Bioavailability in Endothelial Cells

Shi, W., Meininger, C. J., Haynes, T. E., Hatakeyama, K., & Wu, G. (2004) · Cell Biochemistry and Biophysics · doi:10.1385/cbb:41:3:415 · Cited by 137 · see citing works

Hyperglycaemic Impairment of PAR2-Mediated Vasodilation: Prevention by Inhibition of Aortic Endothelial Sodium-Glucose-Co-Transporter-2 and Minimizing Oxidative Stress

El-Daly, M., Pulakazhi Venu, V. K., Saifeddine, M., Mihara, K., Kang, S., Fedak, P. W. M., Alston, L. A., Hirota, S. A., Ding, H., Triggle, C. R., et al. (2018) · Vascular Pharmacology · doi:10.1016/j.vph.2018.06.006 · Cited by 117 · see citing works

Acute Inhibition of Guanosine Triphosphate Cyclohydrolase 1 Uncouples Endothelial Nitric Oxide Synthase and Elevates Blood Pressure

Wang, S., Xu, J., Song, P., Wu, Y., Zhang, J., Choi, H. C., & Zou, M. (2008) · Hypertension · doi:10.1161/hypertensionaha.108.112094 · Cited by 110 · see citing works

Endothelial dysfunction in the streptozotocin‐induced diabetic apoE‐deficient mouse

Ding, H., Hashem, M., Wiehler, W. B., Lau, W., Martín, J. M., Reid, J. J., & Triggle, C. R. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706417 · Cited by 109 · see citing works

Oxidative Stress and Increased eNOS and NADPH Oxidase Expression in Mouse Microvessel Endothelial Cells

Ding, H., Aljofan, M., & Triggle, C. R. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21063 · Cited by 107 · see citing works

The Cerebral Circulation

Cipolla, M. J. (2016) · Cited by 105 · see citing works

A review of endothelial dysfunction in diabetes: a focus on the contribution of a dysfunctional eNOS

Triggle, C. R., & Ding, H. (2010) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2010.02.004 · Cited by 100 · see citing works

Vascular endothelial function in health and diseases

Khazaei, M., Moien‐Afshari, F., & Laher, I. (2008) · Pathophysiology · doi:10.1016/j.pathophys.2008.02.002 · Cited by 99 · see citing works

Endothelial dysfunction in diabetes: multiple targets for treatment

Ding, H., & Triggle, C. R. (2010) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-010-0807-3 · Cited by 98 · see citing works

Can Metformin Exert as an Active Drug on Endothelial Dysfunction in Diabetic Subjects

Salvatore, T., Pafundi, P. C., Galiero, R., Rinaldi, L., Caturano, A., Vetrano, E., Aprea, C., Albanese, G., Di Martino, A., Ricozzi, C., et al. (2020) · Biomedicines · doi:10.3390/biomedicines9010003 · Cited by 97 · see citing works

The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) activator dh404 protects against diabetes-induced endothelial dysfunction

Sharma, A., Rizky, L., Stefanovic, N., Tate, M., Ritchie, R. H., Ward, K. W., & de Haan, J. B. (2017) · Cardiovascular Diabetology · doi:10.1186/s12933-017-0513-y · Cited by 97 · see citing works

Endothelium-derived reactive oxygen species: their relationship to endothelium-dependent hyperpolarization and vascular tone

Ellis, A., & Triggle, C. R. (2003) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y03-106 · Cited by 94 · see citing works

Enhanced vascular reactivity of small mesenteric arteries from diabetic mice is associated with enhanced oxidative stress and cyclooxygenase products

Pannirselvam, M., Wiehler, W. B., Anderson, T. J., & Triggle, C. R. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706121 · Cited by 92 · see citing works

Caloric restriction reverses high-fat diet-induced endothelial dysfunction and vascular superoxide production in C57Bl/6 mice

Ketonen, J., Pilvi, T. K., & Mervaala, E. M. A. (2010) · Heart and Vessels · doi:10.1007/s00380-009-1182-x · Cited by 81 · see citing works

Accelerated endothelial dysfunction in mild prediabetic insulin resistance: the early role of reactive oxygen species

Duncan, E. R., Walker, S. J., Ezzat, V., Wheatcroft, S. B., Li, J., Shah, A. M., & Kearney, M. T. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00299.2007 · Cited by 81 · see citing works

Improvement of endothelial nitric oxide synthase activity retards the progression of diabetic nephropathy in db/db mice

Cheng, H., Wang, H., Fan, X., Paueksakon, P., & Harris, R. C. (2012) · Kidney International · doi:10.1038/ki.2012.248 · Cited by 74 · see citing works

Increased oxidative stress in the streptozotocin-induced diabetic apoE-deficient mouse: Changes in expression of NADPH oxidase subunits and eNOS

Ding, H., Hashem, M., & Triggle, C. R. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.12.034 · Cited by 72 · see citing works

Inhibition of soluble epoxide hydrolase attenuates endothelial dysfunction in animal models of diabetes, obesity and hypertension

Zhang, L.-N., Vincelette, J., Chen, D., Gless, R. D., Anandan, S., Rubanyi, G. M., Webb, H. K., MacIntyre, D. E., & Wang, Y. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.12.016 · Cited by 71 · see citing works

Angiotensin II Type 1A Receptors in Vascular Smooth Muscle Cells Do Not Influence Aortic Remodeling in Hypertension

Sparks, M. A., Parsons, K. K., Stegbauer, J., Gurley, S. B., Vivekanandan‐Giri, A., Fortner, C. N., Snouwaert, J., Raasch, E. W., Griffiths, R. C., Haystead, T., et al. (2011) · Hypertension · doi:10.1161/hypertensionaha.110.165274 · Cited by 62 · see citing works

Reduction of Radiation-Induced Vascular Nitrosative Stress by the Vitamin E Analog γ-Tocotrienol: Evidence of a Role for Tetrahydrobiopterin

Berbée, M., Fu, Q., Boerma, M., Pathak, R., Zhou, D., Kumar, K. S., & Hauer‐Jensen, M. (2010) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2010.08.032 · Cited by 62 · see citing works

22-Oxacalcitriol prevents progression of endothelial dysfunction through antioxidative effects in rats with type 2 diabetes and early-stage nephropathy

Hirata, M., Serizawa, K., Aizawa, K., Yogo, K., Tashiro, Y., Takeda, S., Moriguchi, Y., Endo, K., & Fukagawa, M. (2012) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfs536 · Cited by 60 · see citing works

Role of Marginal Vitamin C Deficiency in Atherogenesis: In Vivo Models and Clinical Studies

Frikke‐Schmidt, H., & Lykkesfeldt, J. (2009) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2009.00420.x · Cited by 57 · see citing works

Chronic Co-Administration of Sepiapterin and l -Citrulline Ameliorates Diabetic Cardiomyopathy and Myocardial Ischemia/Reperfusion Injury in Obese Type 2 Diabetic Mice

Baumgardt, S. L., Paterson, M. R., Leucker, T. M., Fang, J., Zhang, D. X., Bosnjak, Z. J., Warltier, D. C., Kersten, J. R., & Ge, Z. (2016) · Circulation Heart Failure · doi:10.1161/circheartfailure.115.002424 · Cited by 57 · see citing works

Pharmacological characteristics of endothelium-derived hyperpolarizing factor-mediated relaxation of small mesenteric arteries from db/db mice

Pannirselvam, M., Ding, H., Anderson, T. J., & Triggle, C. R. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.08.086 · Cited by 55 · see citing works

Glucose enhances expression of TRPC1 and calcium entry in endothelial cells

Bishara, N. B., & Ding, H. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00699.2009 · Cited by 55 · see citing works

Tetrahydrobiopterin (BH4), a cofactor for nNOS, restores gastric emptying and nNOS expression in female diabetic rats

Gangula, P. R., Mukhopadhyay, S., Ravella, K., Cai, S., Channon, K. M., Garfield, R. E., & Pasricha, P. J. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00450.2009 · Cited by 55 · see citing works

Exercise restores coronary vascular function independent of myogenic tone or hyperglycemic status indb/dbmice

Moien‐Afshari, F., Ghosh, S., Elmi, S., Khazaei, M., Rahman, M. M., Sallam, N. A., & Laher, I. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00016.2008 · Cited by 53 · see citing works

Targeting Reactive Oxygen Species in Hypertension

Delles, C., Miller, W. H., & Dominiczak, A. F. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.2008 · Cited by 51 · see citing works

DAF-FM (4-Amino-5-methylamino-2′,7′-difluorofluorescein) Diacetate Detects Impairment of Agonist-Stimulated Nitric Oxide Synthesis by Elevated Glucose in Human Vascular Endothelial Cells: Reversal by Vitamin C and l-Sepiapterin

Sheng, J., Wang, D., & Braun, A. P. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.087932 · Cited by 51 · see citing works

The Role of the BH4 Cofactor in Nitric Oxide Synthase Activity and Cancer Progression: Two Sides of the Same Coin

Gonçalves, D. A., Jasiulionis, M. G., & de Melo, F. H. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179546 · Cited by 49 · see citing works

Hyperglycemia Adversely Modulates Endothelial Nitric Oxide Synthase during Anesthetic Preconditioning through Tetrahydrobiopterin– and Heat Shock Protein 90–mediated Mechanisms

Amour, J., Brzezinska, A. K., Jager, Z., Sullivan, C. D., Weihrauch, D., Du, J., Vladic, N., Shi, Y., Warltier, D. C., Pratt, P. F., et al. (2010) · Anesthesiology · doi:10.1097/aln.0b013e3181cded1f · Cited by 50 · see citing works

Why the endothelium? The endothelium as a target to reduce diabetes-associated vascular disease

Triggle, C. R., Ding, H., Marei, I., Anderson, T. J., & Hollenberg, M. D. (2020) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2019-0677 · Cited by 49 · see citing works

Modulating the NO generating system from a medicinal chemistry perspective: Current trends and therapeutic options in cardiovascular disease

Schade, D., Kotthaus, J., & Clement, B. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.02.005 · Cited by 39 · see citing works

Increasing dihydrobiopterin causes dysfunction of endothelial nitric oxide synthase in rats in vivo

Noguchi, K., Hamadate, N., Matsuzaki, T., Sakanashi, M., Nakasone, J., Uchida, T., Arakaki, K., Kubota, H., Ishiuchi, S., Masuzaki, H., et al. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01089.2010 · Cited by 38 · see citing works

Deletion of the Protein Kinase A/Protein Kinase G Target SMTNL1 Promotes an Exercise-adapted Phenotype in Vascular Smooth Muscle

Wooldridge, A. A., Fortner, C. N., Lontay, B., Akimoto, T., Neppl, R. L., Facemire, C. S., Datto, M., Kwon, A., McCook, E. C., Li, P., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m708628200 · Cited by 37 · see citing works

Sepiapterin reverses the changes in gastric nNOS dimerization and function in diabetic gastroparesis

Gangula, P. R., Mukhopadhyay, S., Pasricha, P. J., & Ravella, K. (2010) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2010.01588.x · Cited by 32 · see citing works

Traditional Chinese medicine xin-mai-jia recouples endothelial nitric oxide synthase to prevent atherosclerosis in vivo

Yin, Y., Zhu, M., Wan, J., Zhang, C., Pan, G., Lu, J., Song, P., Chen, Y., Zhao, F.-R., Hai-ya, Y., et al. (2017) · Scientific Reports · doi:10.1038/srep43508 · Cited by 29 · see citing works

Are we over oxidized? Oxidative stress, cardio-vascular disease, and the future of intervention studies with antioxidants

Dusting, G. J., & Triggle, C. R. (2005) · Vascular Health and Risk Management · doi:10.2147/vhrm.1.2.93.64080 · Cited by 30 · see citing works

Antihypertensive therapy increases tetrahydrobiopterin levels and NO/cGMP signaling in small arteries of angiotensin II-infused hypertensive rats

Kang, K.-T., Sullivan, J. C., Spradley, F. T., d’Uscio, L. V., Katušić, Z. S., & Pollock, J. S. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00393.2010 · Cited by 27 · see citing works

Endothelial dysfunction in Type 2 diabetes correlates with deregulated expression of the tail-anchored membrane protein SLMAP

Ding, H., Howarth, A. G., Pannirselvam, M., Anderson, T. J., Severson, D. L., Wiehler, W. B., Triggle, C. R., & Tuana, B. S. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00037.2005 · Cited by 26 · see citing works

The diabetic vasculature: Physiological mechanisms of dysfunction and influence of aerobic exercise training in animal models

Delbin, M. A., & Trask, A. J. (2014) · Life Sciences · doi:10.1016/j.lfs.2014.02.021 · Cited by 25 · see citing works

The microvasculature: a target for nutritional programming and later risk of cardio‐metabolic disease

Musa, M. G., Torrens, C., & Clough, G. F. (2013) · Acta Physiologica · doi:10.1111/apha.12131 · Cited by 25 · see citing works

Endothelium-derived hyperpolarizing factor and diabetes

Gao, X. J. (2011) · World Journal of Cardiology · doi:10.4330/wjc.v3.i1.25 · Cited by 25 · see citing works

BH4 Increases nNOS Activity and Preserves Left Ventricular Function in Diabetes

Carnicer, R., Duglan, D., Žiberna, K., Récalde, A., Reilly, S. N., Simon, J. N., Mafrici, S. F., Arya, R., Roselló‐Lletí, E., Chuaiphichai, S., et al. (2021) · Circulation Research · doi:10.1161/circresaha.120.316656 · Cited by 23 · see citing works

Vascular and renal effects of vasopeptidase inhibition and angiotensin-converting enzyme blockade in spontaneously diabetic Goto-Kakizaki rats

Cheng, Z. J., Grönholm, T., Louhelainen, M., Finckenberg, P., Merasto, S., Tikkanen, I. T., & Mervaala, E. M. A. (2005) · Journal of Hypertension · doi:10.1097/01.hjh.0000179765.48324.b4 · Cited by 24 · see citing works

Reprogramming of breast tumor–associated macrophages with modulation of arginine metabolism

Fernando, V., Zheng, X., Sharma, V., Sweef, O., Choi, E. S., & Furuta, S. (2024) · Life Science Alliance · doi:10.26508/lsa.202302339 · Cited by 23 · see citing works

The vascular endothelium in diabetes: a practical target fordrug treatment?

Andrews, K. L., Pannirselvam, M., Anderson, T. J., Jenkins, A. J., Triggle, C. R., & Hill, M. A. (2005) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.9.1.101 · Cited by 23 · see citing works

The Cerebral Circulation, Second Edition

Cipolla, M. J. (2016) · Colloquium Series on Integrated Systems Physiology From Molecule to Function · doi:10.4199/c00141ed2v01y201607isp066 · Cited by 22 · see citing works

Novel Strategies to Ameliorate Radiation Injury: A Possible Role for Tetrahydrobiopterin

Berbée, M., Fu, Q., Kumar, K. S., & Hauer‐Jensen, M. (2010) · Current Drug Targets · doi:10.2174/1389450111009011366 · Cited by 23 · see citing works

Effect of exercise on augmented aortic vasoconstriction in the db/db mouse model of type-II diabetes

Khazaei, M., Moien‐Afshari, F., Kieffer, T. J., & Laher, I. (2008) · Physiological Research · doi:10.33549/physiolres.931339 · Cited by 22 · see citing works

Calcium-activated potassium channel and connexin expression in small mesenteric arteries from eNOS-deficient (eNOS−/−) and eNOS-expressing (eNOS+/+) mice

Ceroni, L., Ellis, A., Wiehler, W. B., Jiang, Y., Ding, H., & Triggle, C. R. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.01.018 · Cited by 18 · see citing works

Reduced Basal Nitric Oxide Production Induces Precancerous Mammary Lesions via ERBB2 and TGFβ

Ren, G., Zheng, X., Bommarito, M., Metzger, S., Walia, Y., Letson, J., Schroering, A. G., Nestor‐Kalinoski, A. L., Weaver, D. A., Figy, C., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-43239-x · Cited by 18 · see citing works

Naringenin upregulates GTPCH1/eNOS to ameliorate high glucose‑induced retinal endothelial cell injury

Xue, B., & Wang, Y. (2022) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2022.11355 · Cited by 17 · see citing works

Lupus serum induces inflammatory interaction with neutrophils in human glomerular endothelial cells

Russell, D. A., Markiewicz, M., & Oates, J. C. (2020) · Lupus Science & Medicine · doi:10.1136/lupus-2020-000418 · Cited by 17 · see citing works

The Biosynthesis of Folate and Pterins and Their Enzymology

Fischer, M. J., Thöny, B., & Leimkühler, S. (2010) · Elsevier eBooks · doi:10.1016/b978-008045382-8.00150-7 · Cited by 17 · see citing works

Association of Impaired Vascular Endothelial Function with Increased Cardiovascular Risk in Asymptomatic Adults

Zhong, Q., Nong, Q., Mao, B., Pan, X., & Meng, L. (2018) · BioMed Research International · doi:10.1155/2018/3104945 · Cited by 16 · see citing works

Tetrahydrobiopterin analogues with NO-dependent pulmonary vasodilator properties

Kunuthur, S. P., Milliken, P. H., Gibson, C. L., Suckling, C. J., & Wadsworth, R. M. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.09.070 · Cited by 15 · see citing works

Mildly compromised tetrahydrobiopterin cofactor biosynthesis due to Pts variants leads to unusual body fat distribution and abdominal obesity in mice

Korner, G., Scherer, T., Adamsen, D., Rebuffat, A., Crabtree, M. J., Rassi, A., Scavelli, R., Homma, D., Ledermann, B., Konrad, D., et al. (2016) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-015-9909-6 · Cited by 14 · see citing works

Impairment of nitrergic system and delayed gastric emptying in low density lipoprotein receptor deficient female mice

Gangula, P. R., Chinnathambi, V., Hale, A., Mukhopadhyay, S., Channon, K. M., & Ravella, K. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2011.01695.x · Cited by 15 · see citing works

Enhanced Nanoencapsulation of Sepiapterin within PEG-PCL Nanoparticles by Complexation with Triacetyl-Beta Cyclodextrin

Kuplennik, N., & Sosnik, A. (2019) · Molecules · doi:10.3390/molecules24152715 · Cited by 12 · see citing works

A Nonthiazolidinedione Peroxisome Proliferator-Activated Receptor γ Agonist Reverses Endothelial Dysfunction in Diabetic (db/db-/-) Mice

Howarth, A. G., Wiehler, W. B., Pannirselvam, M., Jiang, Y., Berger, J. P., Severson, D. L., Anderson, T. J., & Triggle, C. R. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.086397 · Cited by 10 · see citing works

Tetrahydrobiopterin rescues impaired responses of cerebral resistance arterioles during type 1 diabetes

Mayhan, W. G., & Arrick, D. M. (2016) · Diabetes and Vascular Disease Research · doi:10.1177/1479164116675490 · Cited by 9 · see citing works

Metabolomics insights into the effects of pre-pregnancy lead exposure on bone metabolism in pregnant rats

Zhang, L., Lin, Y., Lu, A.-X., Liu, J., Li, J., & Yan, C. (2023) · Environmental Pollution · doi:10.1016/j.envpol.2023.122468 · Cited by 8 · see citing works

Vascular responses to 8‐nitro‐cyclic GMP in non‐diabetic and diabetic mice

Tokutomi, Y., Kataoka, K., Yamamoto, E., Nakamura, T., Fukuda, M., Nako, H., Toyama, K., Dong, Y., Ahmed, K. A., Sawa, T., et al. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01201.x · Cited by 8 · see citing works

Effect of Decreased Levels of Intrinsic Tetrahydrobiopterin on Endothelial Function in Anesthetized Rats

Hamadate, N., Noguchi, K., Sakanashi, M., Matsuzaki, T., Nakasone, J., & Sakanashi, M. (2008) · Journal of Pharmacological Sciences · doi:10.1254/jphs.fp0071967 · Cited by 6 · see citing works

Peroxynitrite Biology

Arunachalam, G., Samuel, S. M., Ding, H., & Triggle, C. R. (2014) · Springer eBooks · doi:10.1007/978-3-642-30018-9_5 · Cited by 5 · see citing works

Nitric Oxide Synthesis in Vascular Physiology and Pathophysiology

Li, H., Xia, N., & Förstermann, U. (2015) · Springer eBooks · doi:10.1007/978-1-4939-2907-8_16 · Cited by 5 · see citing works

Immunogenic shift of arginine metabolism triggers systemic metabolic and immunological reprogramming to suppress HER2 + breast cancer

Sharma, V., Fernando, V., Zheng, X., Choi, E. S., Sweef, O., Thomas, V. D., Szpendyk, J., & Furuta, S. (2025) · Cancer & Metabolism · doi:10.1186/s40170-025-00384-4 · Cited by 4 · see citing works

Cerebrovascular Disease in Type 1 Diabetes: Role of Oxidative Stress

Arrick, D. M., & Mayhan, W. G. (2014) · Oxidative stress in applied basic research and clinical practice · doi:10.1007/978-1-4899-8035-9_2 · Cited by 4 · see citing works

Uncoupling of eNOS in Cardiovascular Disease

Li, H., & Förstermann, U. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804273-1.00009-0 · Cited by 4 · see citing works

Targeting Oxidant Stress as a Strategy for Preventing Vascular Complications of Diabetes and Metabolic Syndrome

McCarty, M. F., & Inoguchi, T. (2008) · Wiley eBooks · doi:10.1002/9780813804149.ch11 · Cited by 3 · see citing works

Glycaemic Control and Protection of the Vasculature from Glucose Toxicity

Ding, H., & Chris, R. B. (2011) · InTech eBooks · doi:10.5772/24862 · Cited by 2 · see citing works

Tissue Granulation in Cutaneous Wound Healing is Improved by a Camel Milk Peptide in Streptozotocin-induced Diabetes in Rat Models

Ebaid, H., Al-Tamimi, J., Alhazza, I. M., & Metwalli, A. (2023) · Indian Journal of Animal Research · doi:10.18805/ijar.bf-1608 · Cited by 1 · see citing works

Mechanisms of Action of Drugs for Treating Endothelial Dysfunction in Diabetes Mellitus

Nizami, H. L., & Banerjee, S. (2017) · Springer eBooks · doi:10.1007/978-3-319-60324-7_22 · Cited by 1 · see citing works

Tetrahydrobiopterin and Endothelial Nitric Oxide Synthase: Implications for Radiation-Induced Endothelial Dysfunction and Normal Tissue Radiation Injury

Berbée, M., Fu, Q., Kumar, K. S., & Hauer‐Jensen, M. (2011) · Humana Press eBooks · doi:10.1007/978-1-61779-397-4_7 · Cited by 1 · see citing works

Vascular Targets for Ischemic Stroke Treatment

Palomares, S. M., & Cipolla, M. J. (2012) · Springer eBooks · doi:10.1007/978-1-4419-9530-8_1

Novel pharmacological strategies to reduce acute radiation injury

Berbée, M. (2011) · doi:10.26481/dis.20111021mb

The effects of diabetes on vascular function and potential treatment with a flavonol

Leo, C. H. (2012) · RMIT Research Repository (RMIT University Library) · doi:10.25439/rmt.27340482

OXIDATIVE STRESS-INDUCED VASCULAR DYSFUNCTION: MECHANISTIC PERSPECTIVES AND PREVENTIVE STRATEGIES

Vasamsetti, S. B., & Kotamraju, S. (2011)

Contribuição do receptor GPER para as alterações de reatividade vascular em artérias mesentéricas de resistência produzidas pela aldosterona: influência do diabetes mellitus

Ferreira, N. D. S. (2014) · doi:10.11606/d.17.2014.tde-14072014-094410

Cellular basis of endothelial dysfunction in small mesenteric arteries from spontaneously diabetic (db/db−/−) mice: role of decreased tetrahydrobiopterin bioavailability

Pannirselvam, M., Verma, S., Anderson, T. J., & Triggle, C. R. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704683 · Cited by 177 · see citing works

Sepiapterin Improves Vascular Reactivity and Insulin‐Stimulated Glucose in Wistar Rats

Keller, A. C., Knaub, L. A., Scalzo, R. L., Hull, S., Johnston, A., Walker, L. A., & Reusch, J. E. B. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/7363485 · Cited by 7 · see citing works

Oral Administration of Tetrahydrobiopterin Prevents Endothelial Dysfunction and Vascular Oxidative Stress in the Aortas of Insulin-Resistant Rats

KazuyaShinozaki, YoshihikoNishio, TomioOkamura, YuichiYoshida, HiroshiMaegawa, HidetoKojima, MasahiroMasada, NoboruToda, RyuichiKikkawa, & AtsunoriKashiwagi (2000) · Circulation Research · Cited by 1 · see citing works

Increasing dihydrobiopterin causes dysfunction of endothelial nitric oxide synthase in rats in vivo

Noguchi, K., Hamadate, N., Matsuzaki, T., Sakanashi, M., Nakasone, J., Uchida, T., Arakaki, K., Kubota, H., Ishiuchi, S., Masuzaki, H., et al. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01089.2010 · Cited by 38 · see citing works

Enhanced vascular reactivity of small mesenteric arteries from diabetic mice is associated with enhanced oxidative stress and cyclooxygenase products

Pannirselvam, M., Wiehler, W. B., Anderson, T. J., & Triggle, C. R. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706121 · Cited by 92 · see citing works