Hopfner, Karl-Peter

Molecular mechanisms and cellular functions of cGAS–STING signalling

Hopfner, K.-P., & Hornung, V. (2020) · Nature Reviews Molecular Cell Biology

interferon and immune responsesImmune Response and Inflammation

Cited by 2,052

CGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING.

Ablasser, A., Goldeck, M., Cavlar, T., Deimling, T., Witte, G., Röhl, I., Hopfner, K.-P., Ludwig, J., & Hornung, V. (2013) · Nature

interferon and immune responsesDNA and Nucleic Acid Chemistry

Cited by 1,695

cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein-DNA ladders

Andreeva, L., Hiller, B., Kostrewa, D., Lässig, C., de Oliveira Mann, C. C., Jan Drexler, D., Maiser, A., Gaidt, M., Leonhardt, H., Hornung, V., et al. (2017) · Nature

interferon and immune responsesDNA and Nucleic Acid Chemistry

Cited by 511

5′-triphosphate RNA requires base-paired structures to activate antiviral signaling via RIG-I

Schmidt, A., Schwerd, T., Hamm, W., Hellmuth, J. C., Cui, S., Wenzel, M., Hoffmann, F. S., Michallet, M.-C., Besch, R., Hopfner, K.-P., et al. (2009) · Proceedings of the National Academy of Sciences

interferon and immune responsesImmune Response and Inflammation

Cited by 398

Structural basis for sequestration and autoinhibition of cGAS by chromatin

Michalski, S., de Oliveira Mann, C. C., Stafford, C. A., Witte, G., Bartho, J., Lammens, K., Hornung, V., & Hopfner, K.-P. (2020) · Nature

interferon and immune responsesDNA and Nucleic Acid Chemistry

Cited by 256

Functional and biochemical dissection of the structure-specific nuclease ARTEMIS

Pannicke, U., Ma, Y., Hopfner, K., Niewolik, D., Lieber, M. R., & Schwarz, K. (2004) · The EMBO Journal

DNA Repair MechanismsCRISPR and Genetic Engineering

Cited by 127

Phosphorylation-mediated conformational change regulates human SLFN11

Kugler, M., Metzner, F. J., Witte, G., Hopfner, K.-P., & Lammens, K. (2024) · Nature Communications

RNA and protein synthesis mechanismsDNA and Nucleic Acid Chemistry

Cited by 13