Phosphorylation-mediated conformational change regulates human SLFN11

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Codon-usage-based inhibition of HIV protein synthesis by human schlafen 11

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Putative DNA/RNA helicase Schlafen-11 (SLFN11) sensitizes cancer cells to DNA-damaging agents

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PARP Inhibitor Activity Correlates with SLFN11 Expression and Demonstrates Synergy with Temozolomide in Small Cell Lung Cancer

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Resistance to PARP inhibitors by SLFN11 inactivation can be overcome by ATR inhibition

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SLFN11 Blocks Stressed Replication Forks Independently of ATR

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Dynamic variations in epithelial-to-mesenchymal transition (EMT), ATM, and SLFN11 govern response to PARP inhibitors and cisplatin in small cell lung cancer

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Epigenetic inactivation of the putative DNA/RNA helicase SLFN11 in human cancer confers resistance to platinum drugs

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SLFN11 inhibits checkpoint maintenance and homologous recombination repair

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DNA damage induces p53-independent apoptosis through ribosome stalling

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BRCAness, SLFN11, and RB1 loss predict response to topoisomerase I inhibitors in triple-negative breast cancers

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DNA damage-induced cell death relies on SLFN11-dependent cleavage of distinct type II tRNAs

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Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control

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Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase

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Mechanistic understanding of human SLFN11

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SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors

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3D Flexible Refinement: Structure and Motion of Flexible Proteins from Cryo-EM

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SLFN11 informs on standard of care and novel treatments in a wide range of cancer models

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Chromatin Remodeling and Immediate Early Gene Activation by SLFN11 in Response to Replication Stress

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Sensitivity of Mesothelioma Cells to PARP Inhibitors Is Not Dependent on BAP1 but Is Enhanced by Temozolomide in Cells With High-Schlafen 11 and Low-O6-methylguanine-DNA Methyltransferase Expression

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Structural, molecular, and functional insights into Schlafen proteins

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The Indenoisoquinoline TOP1 Inhibitors Selectively Target Homologous Recombination-Deficient and Schlafen 11-Positive Cancer Cells and Synergize with Olaparib

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Schlafen-11 sensitizes colorectal carcinoma cells to irinotecan

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Non-human Primate Schlafen11 Inhibits Production of Both Host and Viral Proteins

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Structure of PDE3A–SLFN12 complex and structure-based design for a potent apoptosis inducer of tumor cells

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Dephosphorylation activates the interferon-stimulated Schlafen family member 11 in the DNA damage response

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Structural and biochemical characterization of human Schlafen 5

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Velcrin-induced selective cleavage of tRNALeu(TAA) by SLFN12 causes cancer cell death

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Schlafen-11 expression is associated with immune signatures and basal-like phenotype in breast cancer

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Schlafens Can Put Viruses to Sleep

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Schlafen 11 triggers innate immune responses through its ribonuclease activity upon detection of single-stranded DNA

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Identification of Schlafen-11 as a Target of CD47 Signaling That Regulates Sensitivity to Ionizing Radiation and Topoisomerase Inhibitors

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Schlafen11 Expression Is Associated With the Antitumor Activity of Trabectedin in Human Sarcoma Cell Lines

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Structural and biochemical characterization of Schlafen11 N-terminal domain

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The crucial role of single-stranded DNA binding in enhancing sensitivity to DNA-damaging agents for Schlafen 11 and Schlafen 13

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SLFN11-mediated ribosome biogenesis impairment induces TP53-independent apoptosis

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SLFN11: a pan-cancer biomarker for DNA-targeted drugs sensitivity and therapeutic strategy guidance

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CryoEM structure of the SLFN14 endoribonuclease reveals insight into RNA binding and cleavage

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From predictive biomarker to therapeutic target: the dual role of SLFN11 in chemotherapy sensitivity

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Molecular Determinants of Response and Rational Drug Combinations for Antibody-Drug Conjugates (ADCs) with Topoisomerase I (TOP1) Inhibitor Payloads

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Structural and functional characterization of human SLFN14

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Lost in translation: SLFN11 induces p53-independent apoptosis

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Human Schlafen 14 Cleavage of Short Double‐Stranded RNAs Underpins its Antiviral Activity

Li, M., Sun, D., Hao, W., Fu, H., Zhang, Y., Li, Z., Qin, B., Wang, Y., & Cui, S. (2025) · Advanced Science · doi:10.1002/advs.202501727 · Cited by 2 · see citing works

Schlafen 11 as a predictive biomarker and therapeutic target in cancer: From mechanisms to clinical application

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EEPD1 evolved a unique DNA clamping dimer protecting reversed replication forks

Shen, R., Sarker, A. H., Chen, Y., Liu, M., Roy, S., Arvai, A. S., Bacolla, A., Ahmed, Z., Katsonis, P., Hammel, M., et al. (2026) · Nucleic Acids Research · doi:10.1093/nar/gkag188 · Cited by 1 · see citing works

Baseline and Change in Peripheral Blood Transcriptome Enhance Outcome Prediction in Fibrotic Hypersensitivity Pneumonitis: A Prospective Multicenter Cohort StudyPreprint

Pérez, E. R. F., Leach, S. M., Humphries, S. M., Lynch, D. A., Moua, T., Chaudhary, S., Adams, T. N., Adegunsoye, A., Scholand, M. B., Sood, N., et al. (2025) · medRxiv · doi:10.1101/2025.11.13.25340198

Ubiquitin-dependent recruitment of SLFN11 to chromatin is regulated by deubiquitinase (DUB) and RNF168Preprint

Jo, U., Taniyama, D., Pegoraro, G., Wu, Y., Huang, S.-Y., Thomas, C. J., Ozbun, L., Tran, A. D., Saha, L., Murai, J., et al. (2026) · Research Square · doi:10.21203/rs.3.rs-9297013/v1

Accurate Identification of Functional Residues Across the Human Proteome with TAMALEPreprint

Riper, J. M. V., Corsaro, B. J., & Pillon, M. C. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.28.728550

Mechanistic understanding of human SLFN11

Metzner, F. J., Wenzl, S. J., Kugler, M., Krebs, S., Hopfner, K., & Lammens, K. (2022) · Nature Communications · doi:10.1038/s41467-022-33123-0 · Cited by 79 · see citing works

Dephosphorylation activates the interferon-stimulated Schlafen family member 11 in the DNA damage response

Malone, D., Lardelli, R. M., Li, M., & David, M. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.006588 · Cited by 43 · see citing works

The crucial role of single-stranded DNA binding in enhancing sensitivity to DNA-damaging agents for Schlafen 11 and Schlafen 13

Fujiwara, K., Maekawa, M., Iimori, Y., Ogawa, A., Urano, T., Kono, N., Takeda, H., Higashiyama, S., Arita, M., & Murai, J. (2023) · iScience · doi:10.1016/j.isci.2023.108529 · Cited by 15 · see citing works

The Regulation and Activity of Schlafen11

Malone, D. (2017) · eScholarship (California Digital Library)

Crucial Role of Single-Stranded DNA Binding in Enhancing Sensitivity to DNA-Damaging Agents for Schlafen 11 and Schlafen 13Preprint

Fujiwara, K., Maekawa, M., Iimori, Y., Ogawa, A., Urano, T., Kono, N., Takeda, H., Higashiyama, S., Arita, M., & Murai, J. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4551355 · Cited by 1 · see citing works