Hughes, Stephen H.

Specific HIV integration sites are linked to clonal expansion and persistence of infected cells

Maldarelli, F., Wu, X., Su, L., Simonetti, F. R., Shao, W., Hill, S., Spindler, J., Ferris, A. L., Mellors, J. W., Kearney, M. F., et al. (2014) · Science

HIV Research and TreatmentVirus-based gene therapy research

Cited by 849

Reprogramming human T cell function and specificity with non-viral genome targeting

Roth, T. L., Puig-Saus, C., Yu, R., Shifrut, E., Carnevale, J., Li, P. J., Hiatt, J., Saco, J., Krystofinski, P., Li, H., et al. (2018) · Nature

CRISPR and Genetic EngineeringCAR-T cell therapy research

Cited by 839

H3K4me3 Interactions with TAF3 Regulate Preinitiation Complex Assembly and Selective Gene Activation

Lauberth, S. M., Nakayama, T., Wu, X., Ferris, A. L., Tang, Z., Hughes, S. H., & Roeder, R. G. (2013) · Cell

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 473

Clonally expanded CD4 + T cells can produce infectious HIV-1 in vivo

Simonetti, F. R., Sobolewski, M. D., Fyne, E., Shao, W., Spindler, J., Hattori, J., Anderson, E. M., Watters, S. A., Hill, S., Wu, X., et al. (2016) · Proceedings of the National Academy of Sciences

HIV Research and TreatmentHIV/AIDS drug development and treatment

Cited by 372

A reference human induced pluripotent stem cell line for large-scale collaborative studies

Pantazis, C. B., Yang, A., Lara, E., McDonough, J. A., Blauwendraat, C., Peng, L., Oguro, H., Kanaujiya, J., Zou, J., Sebesta, D., et al. (2022) · Cell Stem Cell

Pluripotent Stem Cells ResearchCRISPR and Genetic Engineering

Cited by 310

Structural and Functional Analyses of the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir (S/GSK1349572)

Hare, S., Smith, S. J., Métifiot, M., Jaxa-Chamiec, A., Pommier, Y., Hughes, S. H., & Cherepanov, P. (2011) · Molecular Pharmacology

HIV/AIDS drug development and treatmentHIV Research and Treatment

Cited by 264

Capsid-CPSF6 Interaction Licenses Nuclear HIV-1 Trafficking to Sites of Viral DNA Integration

Achuthan, V., Perreira, J. M., Sowd, G. A., Puray-Chavez, M., McDougall, W. M., Paulucci-Holthauzen, A., Wu, X., Fadel, H. J., Poeschla, E. M., Multani, A. S., et al. (2018) · Cell Host & Microbe

HIV Research and TreatmentVirus-based gene therapy research

Cited by 205

Differential Effects of Human Immunodeficiency Virus Type 1 Capsid and Cellular Factors Nucleoporin 153 and LEDGF/p75 on the Efficiency and Specificity of Viral DNA Integration

Koh, Y., Wu, X., Ferris, A. L., Matreyek, K. A., Smith, S. J., Lee, K., KewalRamani, V. N., Hughes, S. H., & Engelman, A. (2013) · Journal of Virology

HIV Research and TreatmentVirus-based gene therapy research

Cited by 122

Efficacies of Cabotegravir and Bictegravir against drug-resistant HIV-1 integrase mutants

Smith, S. J., Zhao, X. Z., Burke, T. R., & Hughes, S. H. (2018) · Retrovirology

HIV/AIDS drug development and treatmentHIV Research and Treatment

Cited by 114

LEDGF/p75 interacts with mRNA splicing factors and targets HIV-1 integration to highly spliced genes

Singh, P. K., Plumb, M. R., Ferris, A. L., Iben, J. R., Wu, X., Fadel, H. J., Luke, B. T., Esnault, C., Poeschla, E. M., Hughes, S. H., et al. (2015) · Genes & Development

Virus-based gene therapy researchRNA Research and Splicing

Cited by 109

Structural basis for strand-transfer inhibitor binding to HIV intasomes

Passos, D. O., Li, M., Jóźwik, I. K., Zhao, X. Z., Santos-Martins, D., Yang, R., Smith, S. J., Jeon, Y., Forli, S., Hughes, S. H., et al. (2020) · Science

HIV/AIDS drug development and treatmentHIV Research and Treatment

Cited by 106

Enhancers Are Major Targets for Murine Leukemia Virus Vector Integration

De Ravin, S. S., Su, L., Theobald, N., Choi, U., Macpherson, J. L., Poidinger, M., Symonds, G., Pond, S. M., Ferris, A. L., Hughes, S. H., et al. (2014) · Journal of Virology

Virus-based gene therapy researchCRISPR and Genetic Engineering

Cited by 103

Oncogenicity of DNA in vivo: Tumor induction with expression plasmids for activated H-ras and c-myc

Sheng, L., Cai, F., Zhu, Y., Pal, A., Athanasiou, M., Orrison, B., Blair, D. G., Hughes, S. H., Coffin, J. M., Lewis, A. M., et al. (2008) · Biologicals

Carcinogens and Genotoxicity AssessmentImmunotherapy and Immune Responses

Cited by 35

Tumors Induced in Mice by Direct Inoculation of Plasmid DNA Expressing Both Activated H-ras and c-myc

Sheng-Fowler, L., Cai, F., Fu, H., Zhu, Y., Orrison, B., Foseh, G., Blair, D. G., Hughes, S. H., Coffin, J. M., Lewis Jr, A. M., et al. (2010) · International Journal of Biological Sciences

Carcinogens and Genotoxicity AssessmentImmunotherapy and Immune Responses

Cited by 11

A Mouse Strain Defective in Both T Cells and NK Cells Has Enhanced Sensitivity to Tumor Induction by Plasmid DNA Expressing Both Activated H-Ras and c-Myc

Sheng-Fowler, L., Tu, W., Fu, H., Murata, H., Lanning, L., Foseh, G., Macauley, J., Blair, D., Hughes, S. H., Coffin, J. M., et al. (2014) · PLoS ONE

Carcinogens and Genotoxicity AssessmentImmunotherapy and Immune Responses

Cited by 7