Forbes, Stuart J.

Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair

Duffield, J. S., Forbes, S. J., Constandinou, C. M., Clay, S., Partolina, M., Vuthoori, S., Wu, S., Lang, R., & Iredale, J. P. (2005) · Journal of Clinical Investigation

Liver physiology and pathologyWound Healing and Treatments

Cited by 1,649

Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis

Ramachandran, P., Pellicoro, A., Vernon, M. A., Boulter, L., Aucott, R. L., Ali, A., Hartland, S. N., Snowdon, V. K., Cappon, A., Gordon-Walker, T. T., et al. (2012) · Proceedings of the National Academy of Sciences

Liver physiology and pathologyCardiac Fibrosis and Remodeling

Cited by 1,001

Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease

Boulter, L., Govaere, O., Bird, T. G., Radulescu, S., Ramachandran, P., Pellicoro, A., Ridgway, R. A., Seo, S. S., Spee, B., Van Rooijen, N., et al. (2012) · Nature Medicine

Liver physiology and pathologyWnt/β-catenin signaling in development and cancer

Cited by 747

Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells

Schrader, J., Gordon-Walker, T. T., Aucott, R. L., van Deemter, M., Quaas, A., Walsh, S., Benten, D., Forbes, S. J., Wells, R. G., & Iredale, J. P. (2011) · Hepatology

Cellular Mechanics and InteractionsCancer Cells and Metastasis

Cited by 720

Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration

Raven, A., Lu, W.-Y., Man, T. Y., Ferreira-Gonzalez, S., O’Duibhir, E., Dwyer, B. J., Thomson, J. P., Meehan, R. R., Bogorad, R., Koteliansky, V., et al. (2017) · Nature

Liver physiology and pathologyTissue Engineering and Regenerative Medicine

Cited by 533

Hepatic progenitor cells of biliary origin with liver repopulation capacity

Lu, W.-Y., Bird, T. G., Boulter, L., Tsuchiya, A., Cole, A. M., Hay, T., Guest, R. V., Wojtacha, D., Man, T. Y., Mackinnon, A., et al. (2015) · Nature Cell Biology

Liver physiology and pathologyMesenchymal stem cell research

Cited by 479

Ly6Chi monocytes direct alternatively activated profibrotic macrophage regulation of lung fibrosis

Gibbons, M. A., MacKinnon, A. C., Ramachandran, P., Dhaliwal, K., Duffin, R., Phythian-Adams, A. T., van Rooijen, N., Haslett, C., Howie, S. E., Simpson, A. J., et al. (2011) · American Journal of Respiratory and Critical Care Medicine

Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisTransplantation: Methods and Outcomes

Cited by 466

Generation of Functional Human Hepatic Endoderm From Human Induced Pluripotent Stem Cells

Sullivan, G. J., Hay, D. C., Park, I.-H., Fletcher, J., Hannoun, Z., Payne, C. M., Dalgetty, D., Black, J. R., Ross, J. A., Samuel, K., et al. (2010) · Hepatology

Pluripotent Stem Cells ResearchDrug-Induced Hepatotoxicity and Protection

Cited by 445

The RSPO–LGR4/5–ZNRF3/RNF43 module controls liver zonation and size

Planas-Paz, L., Orsini, V., Boulter, L., Calabrese, D., Pikiolek, M., Nigsch, F., Xie, Y., Roma, G., Donovan, A., Marti, P., et al. (2016) · Nature Cell Biology

Wnt/β-catenin signaling in development and cancerLiver physiology and pathology

Cited by 359

Macrophage therapy for murine liver fibrosis recruits host effector cells improving fibrosis, regeneration, and function

Thomas, J. A., Pope, C., Wojtacha, D., Robson, A. J., Gordon-Walker, T. T., Hartland, S., Ramachandran, P., Van Deemter, M., Hume, D. A., Iredale, J. P., et al. (2011) · Hepatology

Liver physiology and pathologyMesenchymal stem cell research

Cited by 346

Liver regeneration and inflammation: from fundamental science to clinical applications

Campana, L., Esser, H., Huch, M., & Forbes, S. (2021) · Nature Reviews Molecular Cell Biology

Liver physiology and pathologyTissue Engineering and Regenerative Medicine

Cited by 307

TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence

Bird, T. G., Müller, M., Boulter, L., Vincent, D. F., Ridgway, R. A., Lopez-Guadamillas, E., Lu, W.-Y., Jamieson, T., Govaere, O., Campbell, A. D., et al. (2018) · Science Translational Medicine

Liver physiology and pathologyDrug-Induced Hepatotoxicity and Protection

Cited by 261

Alternatively activated macrophages promote resolution of necrosis following acute liver injury

Starkey Lewis, P., Campana, L., Aleksieva, N., Cartwright, J. A., Mackinnon, A., O'Duibhir, E., Kendall, T., Vermeren, M., Thomson, A., Gadd, V., et al. (2020) · Journal of Hepatology

Drug-Induced Hepatotoxicity and ProtectionLiver physiology and pathology

Cited by 209

Safety profile of autologous macrophage therapy for liver cirrhosis

Moroni, F., Dwyer, B. J., Graham, C., Pass, C., Bailey, L., Ritchie, L., Mitchell, D., Glover, A., Laurie, A., Doig, S., et al. (2019) · Nature Medicine

Liver physiology and pathologyLiver Disease and Transplantation

Cited by 202

Characterisation of a stereotypical cellular and extracellular adult liver progenitor cell niche in rodents and diseased human liver

Lorenzini, S., Bird, T. G., Boulter, L., Bellamy, C., Samuel, K., Aucott, R., Clayton, E., Andreone, P., Bernardi, M., Golding, M., et al. (2010) · Gut

Liver physiology and pathologyMesenchymal stem cell research

Cited by 190

Bone marrow injection stimulates hepatic ductular reactions in the absence of injury via macrophage-mediated TWEAK signaling

Bird, T. G., Lu, W.-Y., Boulter, L., Gordon-Keylock, S., Ridgway, R. A., Williams, M. J., Taube, J., Thomas, J. A., Wojtacha, D., Gambardella, A., et al. (2013) · Proceedings of the National Academy of Sciences

Liver physiology and pathologyMesenchymal stem cell research

Cited by 166

Granulocyte colony-stimulating factor and autologous CD133-positive stem-cell therapy in liver cirrhosis (REALISTIC): an open-label, randomised, controlled phase 2 trial

Newsome, P. N., Fox, R., King, A. L., Barton, D., Than, N.-N., Moore, J., Corbett, C., Townsend, S., Thomas, J., Guo, K., et al. (2018) · The Lancet Gastroenterology & Hepatology

Liver Disease and TransplantationMesenchymal stem cell research

Cited by 162

Paracrine cellular senescence exacerbates biliary injury and impairs regeneration

Ferreira-Gonzalez, S., Lu, W.-Y., Raven, A., Dwyer, B., Man, T. Y., O’Duibhir, E., Lewis, P. J. S., Campana, L., Kendall, T. J., Bird, T. G., et al. (2018) · Nature Communications

Liver Diseases and ImmunityLiver physiology and pathology

Cited by 161

Epigenetic remodelling licences adult cholangiocytes for organoid formation and liver regeneration

Aloia, L., McKie, M. A., Vernaz, G., Cordero-Espinoza, L., Aleksieva, N., van den Ameele, J., Antonica, F., Font-Cunill, B., Raven, A., Aiese Cigliano, R., et al. (2019) · Nature Cell Biology

Liver physiology and pathologyEpigenetics and DNA Methylation

Cited by 160

The new stem cell biology: something for everyone

Preston, S. L., Alison, M. R., Forbes, S. J., Direkze, N. C., Poulsom, R., & Wright, N. A. (2003) · Molecular Pathology

Pluripotent Stem Cells ResearchMesenchymal stem cell research

Cited by 158

Mesenchymal stem cells and induced bone marrow-derived macrophages synergistically improve liver fibrosis in mice

Watanabe, Y., Tsuchiya, A., Seino, S., Kawata, Y., Kojima, Y., Ikarashi, S., Starkey Lewis, P. J., Lu, W.-Y., Kikuta, J., Kawai, H., et al. (2019) · Stem Cells Translational Medicine

Mesenchymal stem cell researchLiver physiology and pathology

Cited by 155

Epithelial Plasticity during Liver Injury and Regeneration

Gadd, V. L., Aleksieva, N., & Forbes, S. J. (2020) · Cell Stem Cell

Liver physiology and pathologyTissue Engineering and Regenerative Medicine

Cited by 142

Cell therapy for advanced liver diseases: repair or rebuild

Dwyer, B. J., Macmillan, M. T., Brennan, P. N., & Forbes, S. J. (2021) · Journal of Hepatology

Liver physiology and pathologyTissue Engineering and Regenerative Medicine

Cited by 141

Interleukin-13 Activates Distinct Cellular Pathways Leading to Ductular Reaction, Steatosis, and Fibrosis

Gieseck, R. L., Ramalingam, T. R., Hart, K. M., Vannella, K. M., Cantu, D. A., Lu, W.-Y., Ferreira-González, S., Forbes, S. J., Vallier, L., & Wynn, T. A. (2016) · Immunity

Liver physiology and pathologyLiver Diseases and Immunity

Cited by 132