Der, Channing J.

Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer

Wasko, U. N., Jiang, J., Dalton, T. C., Curiel-Garcia, A., Edwards, A. C., Wang, Y., Lee, B., Orlen, M., Tian, S., Stalnecker, C. A., et al. (2024) · Nature

Pancreatic and Hepatic Oncology ResearchProtein Kinase Regulation and GTPase Signaling

Cited by 209

The Ras-related Protein Rheb Is Farnesylated and Antagonizes Ras Signaling and Transformation

Clark, G. J., Kinch, M. S., Rogers-Graham, K., Sebti, S. M., Hamilton, A. D., & Der, C. J. (1997) · Journal of Biological Chemistry

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

Cited by 177

KRAS/BRAF mutation status and ERK1/2 activation as biomarkers for MEK1/2 inhibitor therapy in colorectal cancer

Yeh, J. J., Routh, E. D., Rubinas, T., Peacock, J., Martin, T. D., Shen, X. J., Sandler, R. S., Kim, H. J., Keku, T. O., & Der, C. J. (2009) · Molecular Cancer Therapeutics

Colorectal Cancer Treatments and StudiesMelanoma and MAPK Pathways

Cited by 172

Combination Therapies with CDK4/6 Inhibitors to Treat KRAS- Mutant Pancreatic Cancer

Goodwin, C. M., Waters, A. M., Klomp, J. E., Javaid, S., Bryant, K. L., Stalnecker, C. A., Drizyte-Miller, K., Papke, B., Yang, R., Amparo, A. M., et al. (2023) · Cancer Research

Pancreatic and Hepatic Oncology ResearchAdvanced Breast Cancer Therapies

Cited by 168

XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC

Arthur, W. T., Ellerbroek, S. M., Der, C. J., Burridge, K., & Wennerberg, K. (2002) · Journal of Biological Chemistry

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

Cited by 137

The role of wild type RAS isoforms in cancer

Zhou, B., Der, C. J., & Cox, A. D. (2016) · Seminars in Cell & Developmental Biology

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 130

Characterization of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases

Onesto, C., Shutes, A., Picard, V., Schweighoffer, F., & Der, C. J. (2008) · Methods in Enzymology

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

Cited by 126

Aurora-A Phosphorylates, Activates, and Relocalizes the Small GTPase RalA

Lim, K.-H., Brady, D. C., Kashatus, D. F., Ancrile, B. B., Der, C. J., Cox, A. D., & Counter, C. M. (2010) · Molecular and Cellular Biology

Protein Kinase Regulation and GTPase SignalingMicrotubule and mitosis dynamics

Cited by 126

Oncogenic Ras Blocks Anoikis by Activation of a Novel Effector Pathway Independent of Phosphatidylinositol 3-Kinase

McFall, A., ülkuü, A., Lambert, Q. T., Kusa, A., Rogers-Graham, K., & Der, C. J. (2001) · Molecular and Cellular Biology

Protein Kinase Regulation and GTPase SignalingPI3K/AKT/mTOR signaling in cancer

Cited by 120

M-Ras/R-Ras3, a Transforming Ras Protein Regulated by Sos1, GRF1, and p120 Ras GTPase-activating Protein, Interacts with the Putative Ras Effector AF6

Quilliam, L. A., Castro, A. F., Rogers-Graham, K. S., Martin, C. B., Der, C. J., & Bi, C. (1999) · Journal of Biological Chemistry

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 119

Molecular basis for Rac1 recognition by guanine nucleotide exchange factors.

Karnoub, A. E., Worthylake, D. K., Rossman, K. L., Pruitt, W. M., Campbell, S. L., Sondek, J., & Der, C. J. (2001) · Nature Structural Biology

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

Cited by 93

TEAD Inhibition Overcomes YAP1/TAZ-Driven Primary and Acquired Resistance to KRASG12C Inhibitors

Edwards, A. C., Stalnecker, C. A., Jean Morales, A., Taylor, K. E., Klomp, J. E., Klomp, J. A., Waters, A. M., Sudhakar, N., Hallin, J., Tang, T. T., et al. (2023) · Cancer Research

Hippo pathway signaling and YAP/TAZProtein Kinase Regulation and GTPase Signaling

Cited by 91

RAS, wanted dead or alive: Advances in targeting RAS mutant cancers

Stalnecker, C. A., & Der, C. J. (2020) · Science Signaling

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 90

Determining the ERK-regulated phosphoproteome driving KRAS-mutant cancer

Klomp, J. E., Diehl, J. N., Klomp, J. A., Edwards, A. C., Yang, R., Morales, A. J., Taylor, K. E., Drizyte-Miller, K., Bryant, K. L., Schaefer, A., et al. (2024) · Science

Protein Kinase Regulation and GTPase SignalingMelanoma and MAPK Pathways

Cited by 83

A Landscape of Therapeutic Cooperativity in KRAS Mutant Cancers Reveals Principles for Controlling Tumor Evolution

Anderson, G. R., Winter, P. S., Lin, K. H., Nussbaum, D. P., Cakir, M., Stein, E. M., Soderquist, R. S., Crawford, L., Leeds, J. C., Newcomb, R., et al. (2017) · Cell Reports

Protein Kinase Regulation and GTPase SignalingMelanoma and MAPK Pathways

Cited by 80

The RalB Small GTPase Mediates Formation of Invadopodia through a GTPase-Activating Protein-Independent Function of the RalBP1/RLIP76 Effector

Neel, N. F., Rossman, K. L., Martin, T. D., Hayes, T. K., Yeh, J. J., & Der, C. J. (2012) · Molecular and Cellular Biology

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

Cited by 71

Auto-inhibition of the Dbl Family Protein Tim by an N-terminal Helical Motif

Yohe, M. E., Rossman, K. L., Gardner, O. S., Karnoub, A. E., Snyder, J. T., Gershburg, S., Graves, L. M., Der, C. J., & Sondek, J. (2007) · Journal of Biological Chemistry

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

Cited by 45

Phosphorylation by Protein Kinase Cα Regulates RalB Small GTPase Protein Activation, Subcellular Localization, and Effector Utilization

Martin, T. D., Mitin, N., Cox, A. D., Yeh, J. J., & Der, C. J. (2012) · Journal of Biological Chemistry

Cellular transport and secretionProtein Kinase Regulation and GTPase Signaling

Cited by 38

Differential involvement of RalA and RalB in colorectal cancer

Martin, T. D., & Der, C. J. (2012) · Small GTPases

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

Cited by 36

RAS Mutations Are Not Created Equal

Hobbs, G. A., & Der, C. J. (2019) · Cancer Discovery

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 35

Ras-related small GTPases RalA and RalB regulate cellular survival after ionizing radiation

Kidd, A. R., Snider, J. L., Martin, T. D., Graboski, S. F., Der, C. J., & Cox, A. D. (2010) · International Journal of Radiation Oncology*Biology*Physics

Protein Kinase Regulation and GTPase SignalingEffects of Radiation Exposure

Cited by 25

Tumor suppressor mediated ubiquitylation of hnRNPK is a barrier to oncogenic translation

Mucha, B., Qie, S., Bajpai, S., Tarallo, V., Diehl, J. N., Tedeschi, F., Zhou, G., Gao, Z., Flashner, S., Klein-Szanto, A. J., et al. (2022) · Nature Communications

Ubiquitin and proteasome pathwaysRNA Research and Splicing

Cited by 23

Silencing of Oncogenic KRAS by Mutant-Selective Small Interfering RNA

Papke, B., Azam, S. H., Feng, A. Y., Gutierrez-Ford, C., Huggins, H., Pallan, P. S., Van Swearingen, A. E. D., Egli, M., Cox, A. D., Der, C. J., et al. (2021) · ACS Pharmacology & Translational Science

RNA Interference and Gene DeliveryProtein Kinase Regulation and GTPase Signaling

Cited by 22

Mutant and wild-type Ras: co-conspirators in cancer

Hayes, T. K., & Der, C. J. (2013) · Cancer Discovery

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 13