Der, Channing J.

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., et al. (2016) · Autophagy

Autophagy in Disease and TherapyCalcium signaling and nucleotide metabolism

Cited by 5,894

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1

Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., Abeliovich, H., Abildgaard, M. H., Abudu, Y. P., Acevedo-Arozena, A., et al. (2021) · Autophagy

Autophagy in Disease and TherapyCalcium signaling and nucleotide metabolism

Cited by 2,897

Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer

Roberts, P. J., & Der, C. J. (2007) · Oncogene

Melanoma and MAPK PathwaysProtein Kinase Regulation and GTPase Signaling

Cited by 2,788

Drugging the undruggable RAS: Mission Possible?

Cox, A. D., Fesik, S. W., Kimmelman, A. C., Luo, J., & Der, C. J. (2014) · Nature Reviews Drug Discovery

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 1,997

GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors

Rossman, K. L., Der, C. J., & Sondek, J. (2005) · Nature Reviews Molecular Cell Biology

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

Cited by 1,697

Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts

Irani, K., Xia, Y., Zweier, J. L., Sollott, S. J., Der, C. J., Fearon, E. R., Sundaresan, M., Finkel, T., & Goldschmidt-Clermont, P. J. (1997) · Science

Protein Kinase Regulation and GTPase SignalingRedox biology and oxidative stress

Cited by 1,588

Increasing complexity of Ras signaling

Campbell, S. L., Khosravi-Far, R., Rossman, K. L., Clark, G. J., & Der, C. J. (1998) · Oncogene

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 1,079

RAS isoforms and mutations in cancer at a glance

Hobbs, G. A., Der, C. J., & Rossman, K. L. (2016) · Journal of Cell Science

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 973

KRAS: The Critical Driver and Therapeutic Target for Pancreatic Cancer

Waters, A. M., & Der, C. J. (2018) · Cold Spring Harbor Perspectives in Medicine

Pancreatic and Hepatic Oncology ResearchProtein Kinase Regulation and GTPase Signaling

Cited by 875

Ras history: The saga continues

Cox, A. D., & Der, C. J. (2010) · Small GTPases

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 706

Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer

Bryant, K. L., Stalnecker, C. A., Zeitouni, D., Klomp, J. E., Peng, S., Tikunov, A. P., Gunda, V., Pierobon, M., Waters, A. M., George, S. D., et al. (2019) · Nature Medicine

Autophagy in Disease and TherapyPancreatic and Hepatic Oncology Research

Cited by 692

Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation

Khosravi-Far, R., Solski, P. A., Clark, G. J., Kinch, M. S., & Der, C. J. (1995) · Molecular and Cellular Biology

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 683

GTP-binding mutants of rab1 and rab2 are potent inhibitors of vesicular transport from the endoplasmic reticulum to the Golgi complex

Tisdale, E. J., Bourne, J. R., Khosravi-Far, R., Der, C. J., & Balch, W. E. (1992) · The Journal of cell biology

Cellular transport and secretionProtein Kinase Regulation and GTPase Signaling

Cited by 500

Drugging RAS: know the enemy

Papke, B., & Der, C. J. (2017) · Science

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 399

Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease

Cook, D. R., Rossman, K. L., & Der, C. J. (2014) · Oncogene

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

Cited by 378

Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy

Holderfield, M., Lee, B. J., Jiang, J., Tomlinson, A., Seamon, K. J., Mira, A., Patrucco, E., Goodhart, G., Dilly, J., Gindin, Y., et al. (2024) · Nature

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 369

Rho Family GTPase modification and dependence on CAAX motif-signaled posttranslational modification

Roberts, P. J., Mitin, N., Keller, P. J., Chenette, E. J., Madigan, J. P., Currin, R. O., Cox, A. D., Wilson, O., Kirschmeier, P., & Der, C. J. (2008) · Journal of Biological Chemistry

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

Cited by 362

Activation of RalA is critical for Ras-induced tumorigenesis of human cells

Lim, K.-H., Baines, A. T., Fiordalisi, J. J., Shipitsin, M., Feig, L. A., Cox, A. D., Der, C. J., & Counter, C. M. (2005) · Cancer Cell

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

Cited by 355

Rho family proteins and Ras transformation: the RHOad less traveled gets congested

Zohn, I. M., Campbell, S. L., Khosravi-Far, R., Rossman, K. L., & Der, C. J. (1998) · Oncogene

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

Cited by 352

Targeting RAS Membrane Association: Back to the Future for Anti-RAS Drug Discovery?

Cox, A. D., Der, C. J., & Philips, M. R. (2015) · Clinical Cancer Research

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 351

Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases

Shutes, A., Onesto, C., Picard, V., Leblond, B., Schweighoffer, F., & Der, C. J. (2007) · Journal of Biological Chemistry

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

Cited by 336

Divergent Roles for RalA and RalB in Malignant Growth of Human Pancreatic Carcinoma Cells

Lim, K.-H., O'Hayer, K., Adam, S. J., Kendall, S. D., Campbell, P. M., Der, C. J., & Counter, C. M. (2006) · Current Biology

Protein Kinase Regulation and GTPase SignalingPancreatic and Hepatic Oncology Research

Cited by 250

Atypical KRASG12R Mutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer

Hobbs, G. A., Baker, N. M., Miermont, A. M., Thurman, R. D., Pierobon, M., Tran, T. H., Anderson, A. O., Waters, A. M., Diehl, J. N., Papke, B., et al. (2020) · Cancer Discovery

Protein Kinase Regulation and GTPase SignalingPancreatic and Hepatic Oncology Research

Cited by 231

Structural basis for the selective activation of Rho GTPases by Dbl exchange factors

Snyder, J. T., Worthylake, D. K., Rossman, K. L., Betts, L., Pruitt, W. M., Siderovski, D. P., Der, C. J., & Sondek, J. (2002) · Nature Structural Biology

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

Cited by 209