Miller, Walter L.

Why boys will be boys: two pathways of fetal testicular androgen biosynthesis are needed for male sexual differentiation

Flück, C. E., Meyer-Böni, M., Pandey, A. V., Kempná, P., Miller, W. L., Schoenle, E. J., & Biason-Lauber, A. (2011) · The American Journal of Human Genetics

Sexual Differentiation and DisordersGenetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities

Cited by 248

Coordinate tropic hormone regulation of mRNAs for insulin-like growth factor II and the cholesterol side-chain-cleavage enzyme, P450scc [corrected], in human steroidogenic tissues.

Voutilainen, R., & Miller, W. L. (1987) · Proceedings of the National Academy of Sciences

Growth Hormone and Insulin-like Growth FactorsAdrenal Hormones and Disorders

Cited by 238

The regulation of 17,20 lyase activity

Miller, W. L., Auchus, R. J., & Geller, D. H. (1997) · Steroids

Adrenal Hormones and DisordersSexual Differentiation and Disorders

Cited by 227

The active form of the steroidogenic acute regulatory protein, StAR, appears to be a molten globule

Bose, H. S., Whittal, R. M., Baldwin, M. A., & Miller, W. L. (1999) · Proceedings of the National Academy of Sciences

Protein Structure and DynamicsLipid Membrane Structure and Behavior

Cited by 227

Steroidogenesis: Unanswered Questions

Miller, W. L. (2017) · Trends in Endocrinology & Metabolism

Adrenal Hormones and DisordersSteroid Chemistry and Biochemistry

Cited by 226

Disorders in the initial steps of steroid hormone synthesis

Miller, W. L. (2017) · The Journal of Steroid Biochemistry and Molecular Biology

Adrenal Hormones and DisordersSexual Differentiation and Disorders

Cited by 205

Genetics of P450 oxidoreductase: Sequence variation in 842 individuals of four ethnicities and activities of 15 missense mutations

Huang, N., Agrawal, V., Giacomini, K. M., & Miller, W. L. (2008) · Proceedings of the National Academy of Sciences

Pharmacogenetics and Drug MetabolismGenetic Associations and Epidemiology

Cited by 198

Heterozygous mutation in the cholesterol side chain cleavage enzyme (P450scc) gene in a patient with 46,XY sex reversal and adrenal insufficiency

Tajima, T., Fujieda, K., Kouda, N., Nakae, J., & Miller, W. L. (2001) · The Journal of Clinical Endocrinology & Metabolism

Adrenal Hormones and DisordersSexual Differentiation and Disorders

Cited by 196

Nonclassic Congenital Lipoid Adrenal Hyperplasia: A New Disorder of the Steroidogenic Acute Regulatory Protein with Very Late Presentation and Normal Male Genitalia

Baker, B. Y., Lin, L., Kim, C. J., Raza, J., Smith, C. P., Miller, W. L., & Achermann, J. C. (2006) · The Journal of Clinical Endocrinology & Metabolism

Adrenal Hormones and DisordersSexual Differentiation and Disorders

Cited by 194

Molecular Modeling of Human P450c17 (17α-Hydroxylase/ 17,20-Lyase): Insights into Reaction Mechanisms and Effects of Mutations

Auchus, R. J., & Miller, W. L. (1999) · Molecular Endocrinology

Metal-Catalyzed Oxygenation MechanismsProtein Structure and Dynamics

Cited by 185

Developmental Expression of Genes for the Stereoidogenic Enzymes P450scc (20,22-Desmolase), P450cl7 (17αHydroxylase/17,20-Lyase), and P450c21 (21-Hydroxylase) in the Human Fetus*

VOUTILAINEN, R., & MILLER, W. L. (1986) · The Journal of Clinical Endocrinology & Metabolism

Sexual Differentiation and DisordersAdrenal Hormones and Disorders

Cited by 185

Molecular pathology and mechanism of action of the steroidogenic acute regulatory protein, StARProceedings of Xth International Congress on Hormonal Steroids, Quebec, Canada, 17–21 June 1998.

Miller, W. L., & Strauss, J. F. (1999) · The Journal of Steroid Biochemistry and Molecular Biology

Adrenal Hormones and DisordersSexual Differentiation and Disorders

Cited by 184

P450c17 Mutations R347H and R358Q Selectively Disrupt 17,20-Lyase Activity by Disrupting Interactions with P450 Oxidoreductase and Cytochrome b5

Geller, D. H., Auchus, R. J., & Miller, W. L. (1999) · Molecular Endocrinology

Steroid Chemistry and BiochemistryPharmacogenetics and Drug Metabolism

Cited by 183

Androgen biosynthesis from cholesterol to DHEA

Miller, W. L. (2002) · Molecular and Cellular Endocrinology

Adrenal Hormones and DisordersSteroid Chemistry and Biochemistry

Cited by 179

The 17, 20-Lyase Activity of Cytochrome P450c17 from Human Fetal Testis Favors the Δ5Steroidogenic Pathway

Flück, C. E., Miller, W. L., & Auchus, R. J. (2003) · The Journal of Clinical Endocrinology & Metabolism

Steroid Chemistry and BiochemistrySexual Differentiation and Disorders

Cited by 173

Clinical review 54: genetics, diagnosis, and management of 21-hydroxylase deficiency

Miller, W. L. (1994) · Journal of Clinical Endocrinology & Metabolism

Sexual Differentiation and DisordersAdrenal Hormones and Disorders

Cited by 167

Regulation of 17,20 lyase activity by cytochrome b5 and by serine phosphorylation of P450c17

Pandey, A. V., & Miller, W. L. (2005) · Journal of Biological Chemistry

Adrenal Hormones and DisordersSteroid Chemistry and Biochemistry

Cited by 165

Spontaneous Feminization in a 46,XX Female Patient with Congenital Lipoid Adrenal Hyperplasia Due to a Homozygous Frameshift Mutation in the Steroidogenic Acute Regulatory Protein*

Bose, H. S., Pescovitz, O. H., & Miller, W. L. (1997) · The Journal of Clinical Endocrinology & Metabolism

Sexual Differentiation and DisordersAdrenal Hormones and Disorders

Cited by 160

ASSIGNMENT OF THE GENE FOR ADRENAL P450cl7 (STEROID 17α-HYDR0XYLASE⁄17,20 LYASE) TO HUMAN CHROMOSOME 10.

MATTESON, K. J., PICADO-LEONARD, J., CHUNG, B.-C., MOHANDAS, T. K., & MILLER, W. L. (1986) · The Journal of Clinical Endocrinology & Metabolism

Adrenal Hormones and DisordersSexual Differentiation and Disorders

Cited by 160

Transcript encoded on the opposite strand of the human steroid 21-hydroxylase/complement component/C4 gene locus

Morel, Y., Bristow, J., Gitelman, S. E., & Miller, W. L. (1989) · Proceedings of the National Academy of Sciences

Adrenal Hormones and DisordersSexual Differentiation and Disorders

Cited by 158

Clinical and Molecular Genetics of Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency

Morel, Y., & Miller, W. L. (1991) · Advances in Human Genetics

Sexual Differentiation and DisordersAdrenal Hormones and Disorders

Cited by 158

Thiazolidinediones but not metformin directly inhibit the steroidogenic enzymes P450c17 and 3β-hydroxysteroid dehydrogenase

Arlt, W., Auchus, R. J., & Miller, W. L. (2001) · Journal of Biological Chemistry

Ovarian function and disordersAdrenal Hormones and Disorders

Cited by 157

Regional mapping of genes encoding human steroidogenic enzymes: P450scc to 15q23–q24, adrenodoxin to 11q22; adrenodoxin reductase to 17q24-q25; and P450c17 to 10q24–q25

SPARKES, R. S., KLISAK, I., & MILLER, W. L. (1991) · DNA and Cell Biology

Adrenal Hormones and DisordersHormonal Regulation and Hypertension

Cited by 149

The syndrome of 17,20 lyase deficiency

Miller, W. L. (2012) · The Journal of Clinical Endocrinology & Metabolism

Sexual Differentiation and DisordersAdrenal Hormones and Disorders

Cited by 143