Huber, Kilian V M

The promise and peril of chemical probes

Arrowsmith, C. H., Audia, J. E., Austin, C., Baell, J., Bennett, J., Blagg, J., Bountra, C., Brennan, P. E., Brown, P. J., Bunnage, M. E., et al. (2015) · Nature Chemical Biology

Click Chemistry and ApplicationsComputational Drug Discovery Methods

Cited by 839

SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1

Rebsamen, M., Pochini, L., Stasyk, T., de Araújo, M. E. G., Galluccio, M., Kandasamy, R. K., Snijder, B., Fauster, A., Rudashevskaya, E. L., Bruckner, M., et al. (2015) · Nature

PI3K/AKT/mTOR signaling in cancerAutophagy in Disease and Therapy

Cited by 673

Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening

Resnick, E., Bradley, A., Gan, J., Douangamath, A., Krojer, T., Sethi, R., Geurink, P. P., Aimon, A., Amitai, G., Bellini, D., et al. (2019) · Journal of the American Chemical Society

Click Chemistry and ApplicationsChemical Synthesis and Analysis

Cited by 335

Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia

Grebien, F., Vedadi, M., Getlik, M., Giambruno, R., Grover, A., Avellino, R., Skucha, A., Vittori, S., Kuznetsova, E., Smil, D., et al. (2015) · Nature Chemical Biology

Acute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processes

Cited by 284

The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity

Winter, G. E., Radic, B., Mayor-Ruiz, C., Blomen, V. A., Trefzer, C., Kandasamy, R. K., Huber, K. V. M., Gridling, M., Chen, D., Klampfl, T., et al. (2014) · Nature Chemical Biology

Drug Transport and Resistance MechanismsCancer therapeutics and mechanisms

Cited by 175

Heme drives hemolysis-induced susceptibility to infection via disruption of phagocyte functions

Martins, R., Maier, J., Gorki, A.-D., Huber, K. V. M., Sharif, O., Starkl, P., Saluzzo, S., Quattrone, F., Gawish, R., Lakovits, K., et al. (2016) · Nature Immunology

Sepsis Diagnosis and TreatmentPhagocytosis and Immune Regulation

Cited by 142

Global survey of the immunomodulatory potential of common drugs

Vladimer, G. I., Snijder, B., Krall, N., Bigenzahn, J. W., Huber, K. V. M., Lardeau, C.-H., Sanjiv, K., Ringler, A., Berglund, U. W., Sabler, M., et al. (2017) · Nature Chemical Biology

Cancer Immunotherapy and BiomarkersImmunotoxicology and immune responses

Cited by 87