Klevit, Rachel E.

Proof of principle for epitope-focused vaccine design

Correia, B. E., Bates, J. T., Loomis, R. J., Baneyx, G., Carrico, C., Jardine, J. G., Rupert, P., Correnti, C., Kalyuzhniy, O., Vittal, V., et al. (2014) · Nature

vaccines and immunoinformatics approachesSARS-CoV-2 and COVID-19 Research

Cited by 555

E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages

Christensen, D. E., Brzovic, P. S., & Klevit, R. E. (2007) · Nature Structural & Molecular Biology

Ubiquitin and proteasome pathwaysGenomics and Chromatin Dynamics

Cited by 351

Binding and recognition in the assembly of an active BRCA1/BARD1 ubiquitin-ligase complex

Brzovic, P. S., Keeffe, J. R., Nishikawa, H., Miyamoto, K., Fox, D., Fukuda, M., Ohta, T., & Klevit, R. (2003) · Proceedings of the National Academy of Sciences

Ubiquitin and proteasome pathwaysBRCA gene mutations in cancer

Cited by 346

Structure of an E3:E2∼Ub Complex Reveals an Allosteric Mechanism Shared among RING/U-box Ligases

Pruneda, J. N., Littlefield, P. J., Soss, S. E., Nordquist, K. A., Chazin, W. J., Brzovic, P. S., & Klevit, R. E. (2012) · Molecular Cell

Ubiquitin and proteasome pathwaysEnzyme Structure and Function

Cited by 333

The Acidic Transcription Activator Gcn4 Binds the Mediator Subunit Gal11/Med15 Using a Simple Protein Interface Forming a Fuzzy Complex

Brzovic, P. S., Heikaus, C. C., Kisselev, L., Vernon, R., Herbig, E., Pacheco, D., Warfield, L., Littlefield, P., Baker, D., Klevit, R. E., et al. (2011) · Molecular Cell

Protein Structure and DynamicsGenomics and Chromatin Dynamics

Cited by 203

Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis

Starita, L. M., Pruneda, J. N., Lo, R. S., Fowler, D. M., Kim, H. J., Hiatt, J. B., Shendure, J., Brzovic, P. S., Fields, S., & Klevit, R. E. (2013) · Proceedings of the National Academy of Sciences

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 183

Ubiquitin Transfer from the E2 Perspective: Why is UbcH5 So Promiscuous?

Brzovic, P. S., & Klevit, R. E. (2006) · Cell Cycle

Ubiquitin and proteasome pathwaysNF-κB Signaling Pathways

Cited by 89

Structural Studies of HHARI/UbcH7∼Ub Reveal Unique E2∼Ub Conformational Restriction by RBR RING1

Dove, K. K., Olszewski, J. L., Martino, L., Duda, D. M., Wu, X. S., Miller, D. J., Reiter, K. H., Rittinger, K., Schulman, B. A., & Klevit, R. E. (2017) · Structure

Ubiquitin and proteasome pathwaysEnzyme Structure and Function

Cited by 52